{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:23:18Z","timestamp":1791145398325,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1889,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The C\u2010type lectin family is a group of animal proteins which can be distinguished from other lectins by the presence of a Ca<jats:sup>2+<\/jats:sup>\u2010dependent carbohydrate recognition domain (CRD) in their protein sequence. They are classified into 17 groups according to their domain architecture and have a wide variety of functions. The human chondrolectin gene encodes transmembrane (CHODL, CHODL<jats:sub>f<\/jats:sub>) and soluble proteins (CHODL<jats:sub>\u0394E<\/jats:sub>, CHODL<jats:sub>f\u0394E<\/jats:sub>) belonging to the family of C\u2010type lectins because of the presence of one CRD domain in their N\u2010terminal region. The <jats:italic>CHODL<\/jats:italic> splice variants (<jats:italic>CHODL<jats:sub>f<\/jats:sub>, CHODL<jats:sub>\u0394E<\/jats:sub><\/jats:italic> and <jats:italic>CHODL<jats:sub>f\u0394E<\/jats:sub><\/jats:italic>) are differentially expressed in T lymphocytes. The transmembrane\u2010containing isoform CHODL<jats:sub>f<\/jats:sub> is localized in the ER\u2014Golgi apparatus. CHODL<jats:sub>\u0394E<\/jats:sub> and CHODL<jats:sub>f\u0394E<\/jats:sub> are devoid of the transmembrane domain and terminate in QDEL, an ER retention signal. In this paper we have investigated the expression of the CHODL<jats:sub>\u0394E<\/jats:sub>\/CHODL<jats:sub>f\u0394E<\/jats:sub> protein. This variant localizes in the late endoplasmic reticulum. We detected the protein in spleen and tonsils in a small population of lymphocytes. Moreover, the isoform seems to be differentially expressed in thymocytes and lymphocytes suggesting an important biological function during T cell development.<\/jats:p>","DOI":"10.1016\/j.cellbi.2007.05.014","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T11:10:39Z","timestamp":1180350639000},"page":"1323-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression and localization of CHODL<sub>\u0394E<\/sub>\/CHODL<sub>f\u0394E<\/sub>, the soluble isoform of chondrolectin"],"prefix":"10.1002","volume":"31","author":[{"given":"An","family":"Claessens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van de Vijver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk R.","family":"Van 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