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The cellular and molecular events involved in the progression of skin cancers are largely unknown. Increased protein synthesis is necessary for the transition of cells from quiescence to proliferation. Translational control is critical for the proper regulation of the cell cycle, tissue induction and growth. Eukaryotic initiation factor eIF4E, an important regulator of translation, plays critical roles in neo\u2010plastic transformation and cancer progression. We investigated eIF4E expression in 49 skin samples (six normal tissues, eight Bowen diseases, seven stage I, 10 stage II, 13 stage III and five stage IV SCCs). Results obtained demonstrated that all SCC samples, evaluated by SDS\u2010PAGE, Western blotting and cap\u2010affinity chromatography using m<jats:sup>7<\/jats:sup>GTP\u2010sepharose, presented eIF4E expression (13.6 \u00b1 1.2), whereas, starting from stage 0 (4.1 \u00b1 0.9) to stage I (7.4 \u00b1 1.4), stage II (12.1 \u00b1 2.4), stage III (18.1 \u00b1 3.0) and stage IV (26.2 \u00b1 3.8) SCCs, a constant and significant increase of protein over expression (<jats:italic>P<\/jats:italic> &lt; 0.001) was observed. A high expression of eIF4E is correlated with advanced stages. The results presented in this study demonstrate a possible role of eIF4E in SCC.<\/jats:p>","DOI":"10.1016\/j.cellbi.2007.06.006","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T11:20:29Z","timestamp":1183202429000},"page":"1400-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Significance of eIF4E expression in skin squamous cell carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Z.","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mashayekhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Shahosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"663","article-title":"Expression of the translation initiation factor eIF4E in the polyp\u2010cancer sequence in the colon","volume":"10","author":"Berkel H.J.","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_3_1","first-page":"4477","article-title":"The incidence of p53 mutations increases with progression of head and neck cancer","volume":"53","author":"Jo Boyle","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502163320704"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00127-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.0894"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207545"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/archderm.1995.01690140048007","article-title":"Sunlight exposure, pigmentation factors, risk of nonmelanocytic skin cancer. 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