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Nod mice were divided into: Groups 1 and 2 (diabetic), Groups 3 and 4 (diabetic with insulin treatment) and Group 5 (non\u2010diabetic). Fragments from the salivary glands were processed for immunohistochemical analysis. The results showed that the prolonged diabetic state led to a steadily increased IGF\u2010I receptor expression. INS receptor expression was gradually decreased. It was concluded that not only was the IGF\u2010I receptor expression affected by the diabetic state but also the INS receptor expression. The period of the diabetic state was directly related to changes in the expression of these receptors. In spite of the insulin treatment having recovered the glycaemic levels, the expression of INS and the IGF\u2010I receptors did not reach the standard level, which certainly hampered glandular function.<\/jats:p>","DOI":"10.1016\/j.cellbi.2007.08.005","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T11:10:10Z","timestamp":1188213010000},"page":"16-21","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["IGF\u2010I and INS receptor expression in the salivary glands of diabetic Nod mice submitted to long\u2010term insulin treatment"],"prefix":"10.1002","volume":"32","author":[{"given":"Eduardo Jos\u00e9","family":"Caldeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Helena 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