{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:06:10Z","timestamp":1791302770611,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1737,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mesenchymal stem cells (MSC) have been characterized as multipotent cells which are able to differentiate into several mesodermal and nonmesodermal lineage cells and this feature along with their extensive growth and comprehensive immunomodulatory properties establish them as a promising tool for therapeutic applications, including cell\u2010based tissue engineering and treatment of immune\u2010mediated disorders. Although bone marrow (BM) is the most common MSC source, cells with similar characteristics have been shown to be present in several other adult tissues. Adipose tissue (AT), large quantities of which can be easily obtained, represents an attractive alternative to BM in isolating adipose tissue\u2010derived MSC (AT\u2010MSC). BM\u2010MSCs and AT\u2010MSCs share some immunomodulatory properties as they are both not inherently immunogenic and suppress the proliferation of alloantigen\u2010 or mitogen\u2010stimulated T\u2010cells. Our purpose was to comparatively examine under appropriate\n                    <jats:italic>in vitro<\/jats:italic>\n                    conditions, phenotypes, morphology and some functional properties of BM\u2010MSCs and AT\u2010MSCs, such as differentiation potential and especially the ability to suppress the immunoglobulin production by mitogen\u2010stimulated B\u2010cells. While the morphological, immunophenotypical, colony\u2010forming and adipogenic characteristics of both types of cells were almost identical, AT\u2010MSCs showed less potential for osteogenic differentiation than BM\u2010MSCs. We found that AT\u2010MSCs not only inhibited the Ig\u2010production but also suppressed this B\u2010cell function to a much greater extent compared to BM\u2010MSC. This finding supports the potential role of AT\u2010MSCs as an alternative to BM\u2010MSCs for clinical purposes.\n                  <\/jats:p>","DOI":"10.1016\/j.cellbi.2007.12.007","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T08:05:27Z","timestamp":1200038727000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen\u2010stimulated B\u2010cell immunoglobulin production\n                    <i>in 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