{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:11Z","timestamp":1777397111299,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1584,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enhancing effects of diethyldithiocarbamate (DDC) on increase of sodium channel by sulfur dioxide derivatives in ventricular myocytes were studied using the whole cell patch\u2010clamp technique to probe the mechanism of SO<jats:sub>2<\/jats:sub>on the cardiovascular system in this study. Firstly, the effects of DDC and\/or sulfur dioxide (SO<jats:sub>2<\/jats:sub>) derivatives on the activities of superoxide dismutase (SOD) were studied. The results showed that DDC decreased SOD activities significantly and SO<jats:sub>2<\/jats:sub>derivatives had no significant effect on SOD activities; however, DDC and SO<jats:sub>2<\/jats:sub>derivatives combined led to a significant decrease of SOD activities. In the electrophysiological test, DDC (1\u2013100 mM) increased sodium current (<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>) in a concentration\u2010dependent manner and the concentration for half\u2010maximum increase (EC<jats:sub>50<\/jats:sub>) was 20 mM. Addition of 20 mM DDC to the SO<jats:sub>2<\/jats:sub>derivatives\u2010containing medium significantly shifted the voltage\u2010dependent activation curve of<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>toward the hyperpolarizing direction (<jats:italic>V<\/jats:italic><jats:sub>h<\/jats:sub>are \u221251 mV, \u221253 mV and \u221254 mV, respectively) and shifted the steady\u2010state inactivation curve to more positive potentials (<jats:italic>V<\/jats:italic><jats:sub>h<\/jats:sub>are\u00a0\u221274 mV, \u221271 mV and \u221265 mV, respectively) compared with the control and 10 \u03bcM SO<jats:sub>2<\/jats:sub>derivatives exposure. These results indicated that DDC could enhance the increasing effects on Na<jats:sup>+<\/jats:sup>channels induced by SO<jats:sub>2<\/jats:sub>derivatives, and suggested that the toxicity of SO<jats:sub>2<\/jats:sub>on ventricular myocytes of rats was realized by free radical, especially O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>.<\/jats:p>","DOI":"10.1016\/j.cellbi.2008.06.004","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T08:14:05Z","timestamp":1213949645000},"page":"1143-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhancing effects of diethyldithiocarbamate on increase of sodium channel by sulfur dioxide derivatives in ventricular 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