{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:20:54Z","timestamp":1791055254096,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1554,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystin\u20102 (PC\u20102), a protein encoded by <jats:italic>PKD2<\/jats:italic> and involved in autosomal dominant polycystic kidney disease (ADPKD), is a non\u2010selective cationic channel recently implicated in the function of primary cilia. We recently constructed a new animal model in the form of a transgenic mouse with a BAC\u2010containing human <jats:italic>PKD2<\/jats:italic> inserted in its genome. Two transgenic mouse lines overexpressing human <jats:italic>PKD2<\/jats:italic> showed mitotic instability. Fibroblasts from these transgenic mouse lines have abnormal chromosomal numbers. These lines also have supernumerary centrosomes. PC\u20102 overexpression is associated with mitotic instability and centrosome overduplication. PC\u20102 therefore seems to play a role in centrosome duplication, and this hypothesis is being evaluated in other models.<\/jats:p>","DOI":"10.1016\/j.cellbi.2008.07.021","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T09:09:36Z","timestamp":1218100176000},"page":"1193-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Centrosome overduplication and mitotic instability in <i>PKD2<\/i> transgenic lines"],"prefix":"10.1002","volume":"32","author":[{"given":"St\u00e9phane","family":"Burtey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9milie","family":"Ribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Pennenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyne","family":"Rance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Luciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Dworniczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Genevi\u00e8ve","family":"Mattei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Font\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.005231"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00716-X"},{"key":"e_1_2_1_4_1","article-title":"Overexpression of PKD2 in the mouse is associated with renal tubulopathy","author":"Burtey S.","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(00)00025-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1701"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.12.028"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000046963.60910.63"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050128"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006121344"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405023"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6371"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.292.5516.426"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065693"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5266.1339"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1076"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20069"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201875200"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00869-2"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400544200"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/1044549041562276"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.cellbi.2008.07.021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.cellbi.2008.07.021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T08:14:16Z","timestamp":1700036056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.cellbi.2008.07.021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1016\/j.cellbi.2008.07.021"],"URL":"https:\/\/doi.org\/10.1016\/j.cellbi.2008.07.021","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"2013-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}