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Astrocytes play a vital role in regulating aspects of inflammation and in the homeostatic maintenance of the CNS. However, the responses of different human astroglial cell\u2010lines in viral encephalitis mediated inflammation are not well documented. We have shown that Japanese encephalitis virus (JEV) infection causes morphological and functional changes in astrocytic cell\u2010lines. We have demonstrated that besides reactive oxygen species (ROS) JEV infection differentially regulated the induction pattern of IL\u20106, IL\u20101\u03b2 and IL\u20108. IP\u201010, MCP\u20101, MIG and RANTES secretions in different astroglial cell\u2010lines. The expression of different proteins such as astrocyte\u2010specific glial fibrillary acidic protein (GFAP), the glutamate aspartate transporter\/essential amino acid transporter\u20101 (GLAST\/EAAT\u20101), glutamate transporter\u20101\/essential amino acid transporter\u20102 (GLT\u20101\/EAAT\u20102), Ceruloplasmin and Thioredoxin (TRX) expression level also differ in different human astrocyte cell\u2010lines following infection.<\/jats:p>","DOI":"10.1016\/j.cellbi.2008.08.020","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T15:04:56Z","timestamp":1220799896000},"page":"1506-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Japanese encephalitis virus differentially modulates the induction of multiple pro\u2010inflammatory mediators in human astrocytoma and astroglioma cell\u2010lines"],"prefix":"10.1002","volume":"32","author":[{"given":"Manoj 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