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Tomato suspension cells were exposed to treatments with CdSO<jats:sub>4<\/jats:sub> and cell death was calculated after fluorescein diacetate staining of the living cells. Ethylene was measured in a flow\u2010through system using a laser\u2010driven photo acoustic detector; hydrogen peroxide was determined by chemiluminescence in a ferricyanide\u2010catalysed oxidation of luminol. We have demonstrated that cadmium induces cell death in tomato suspension cells involving caspase\u2010like proteases, indicating that programmed cell death took place. Using range of inhibitors, we found that cysteine and serine peptidases, oxidative stress, calcium and ethylene are players in the cadmium\u2010induced cell death signaling. Cadmium\u2010induced cell death in tomato suspension cells exhibits morphological and biochemical similarities to plant hypersensitive response and to cadmium effects in animal systems.<\/jats:p>","DOI":"10.1016\/j.cellbi.2008.08.021","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T19:04:56Z","timestamp":1220814296000},"page":"1521-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Cadmium toxicity in cultured tomato cells\u2014Role of ethylene, proteases and oxidative stress in cell death signaling"],"prefix":"10.1002","volume":"32","author":[{"given":"Elena T.","family":"Iakimova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst J.","family":"Woltering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veneta 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