{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:41:25Z","timestamp":1697524885639},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1403,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ultrastructural changes on capillaries of the dermis in diabetic and benfluorex\u2013vitamin C treated diabetic rats have been investigated. Three groups of 21 Wistar albino rats were used in the examination: control, diabetes, and benfluorex\u2013vitamin C treated diabetic rats. Diabetes was induced by injection of streptozotocin. The streptozotocin\u2010induced group was treated for 21 days with vitamin C and benfluorex, of which antidiabetic and antihyperlipidemic effects were experimentally proved. Samples taken from the skin of rats' legs were examined under transmission electron microscopy. Swollen endothelial cells, narrowed capillary lumens, a thickened basement membrane, and fusion of mitochondrial cristae in the capillaries of diabetic rat dermis were seen. In the benfluorex\u2013vitamin C treated group, contrary to the diabetic group, neither signs of degeneration in endothelial cells nor a significant difference with the control group with regard to capillary structure were observed. Amelioration in capillaries appears to be due to benfluorex and vitamin C treatment in diabetes.<\/jats:p>","DOI":"10.1016\/j.cellbi.2009.01.009","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T09:58:15Z","timestamp":1232791095000},"page":"442-446","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of benfluorex\u2013vitamin C supplementation on cutaneous capillaries of diabetic rats"],"prefix":"10.1002","volume":"33","author":[{"given":"Seda Mehtap","family":"Sar\u0131 K\u0131l\u0131\u00e7aslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90108-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90144-X"},{"key":"e_1_2_7_4_1","first-page":"311","article-title":"Serum angiotensin converting enzyme activity in streptozotocin\u2010induced diabetic rats","volume":"30","author":"Bor M.V.","year":"2000","journal-title":"Turk J Med Sci"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00295.x"},{"key":"e_1_2_7_6_1","first-page":"560","article-title":"Diabetic pigmented spots on the extrapretibial region: immunohistochemical study of type IV collagen in dermal vessel wall","volume":"8","author":"Chishiki M.","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_7_1","first-page":"23","article-title":"Further studies of diabetic microangiopathy in children with insulin dependent diabetes mellitus. 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