{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:45:31Z","timestamp":1761662731890,"version":"3.37.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":1128,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since contractility of the uterus appears to be the major source of pain during dysmenorrhoea, alleviation of the contractions is believed to be a possible treatment strategy. Bak Foong Pills, a traditional Chinese formulation for use in gynaecological disorders, has long been thought as effective in the treatment of dysmenorrhoeal symptoms. The present study thus aims to investigate whether ethanol extract of Bak Foong Pills (BFP\u2010Ex) or its constituent herbs may have direct effects on alleviating dysmenorrhoeal symptoms by altering uterine tone. This was investigated using isolated uterine preparations and intracellular messenger analysis of adenylate cyclase, via [<jats:sup>3<\/jats:sup>H]\u2010adenine assay, and calcium, with fluorometry imaging, in myometrial cultures. BFP\u2010Ex can stimulate uterine relaxation following oxytocin\u2010induced contractions<jats:italic>ex\u2010vivo<\/jats:italic>. Attempted inhibition of BFP\u2010Ex's relaxatory response with a nitric oxide inhibitor and adenylate cyclase inhibitor, however, had no significant effect, suggesting that most of BFP\u2010Ex's relaxatory response was not due to increases in NO or cAMP. Further studies on tetramethylpyrazine (TMP), a major active ingredient of BFP\u2010Ex, indicated that TMP could modulate intracellular calcium levels in favour of uteri relaxation. The ability of Bak Foong Pills to alleviate menstrual pain may be due to direct regulation of uterine tone.<\/jats:p>","DOI":"10.1016\/j.cellbi.2009.03.003","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T10:07:06Z","timestamp":1238580426000},"page":"1207-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Traditional Chinese medicine Bak Foong Pills alters uterine quiescence \u2013 Possible role in alleviation of dysmenorrhoeal symptoms"],"prefix":"10.1002","volume":"33","author":[{"given":"Dewi Kenneth","family":"Rowlands","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Gui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau Yan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Lin","family":"Gou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67010072.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.5.1051"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06235.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.629"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.241"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i27.4173"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00055.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021342"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602182"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2001.0746"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0022-3565(24)36793-X","article-title":"Ethodin: pharmacological evidence of the interaction between smooth muscle and mast cells in the myometrium","volume":"282","author":"Rudolph M.I.","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(74)90222-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00089-3"},{"volume-title":"Pharmacopoeia of the People's Republic of China","year":"2000","author":"Zheng X.Y.","key":"e_1_2_6_15_1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2006.03.003"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.cellbi.2009.03.003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.cellbi.2009.03.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.cellbi.2009.03.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T20:02:15Z","timestamp":1739044935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.cellbi.2009.03.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1016\/j.cellbi.2009.03.003"],"URL":"https:\/\/doi.org\/10.1016\/j.cellbi.2009.03.003","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"type":"print","value":"1065-6995"},{"type":"electronic","value":"1095-8355"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"2013-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}