{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:33:28Z","timestamp":1759937608446,"version":"3.44.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1016\/j.cellimm.2003.08.003","type":"journal-article","created":{"date-parts":[[2003,10,11]],"date-time":"2003-10-11T01:52:40Z","timestamp":1065837160000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener\u2019s granulomatosis"],"prefix":"10.1016","volume":"224","author":[{"given":"Peter","family":"Lamprecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"Vargas Cuero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Csernok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Voswinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Maass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Solbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2003.08.003_BIB1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0140-6736(97)80118-3","article-title":"Primary systemic vasculitis","volume":"349","author":"Savage","year":"1997","journal-title":"Lancet"},{"issue":"Suppl. 2","key":"10.1016\/j.cellimm.2003.08.003_BIB2","first-page":"SII40","article-title":"Granuloma formation, implications for pathogenesis of vasculitis","volume":"69","author":"Sneller","year":"2002","journal-title":"Cleveland Clin. J. Med."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH656>3.0.CO;2-M","article-title":"Localized Wegener\u2019s granulomatosis: predominance of CD26 and IFN-\u03b3 expression","volume":"192","author":"Muller","year":"2000","journal-title":"J. Pathol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-3083.1999.00544.x","article-title":"Irregular cytokine pattern of CD4+ T lymphocytes in response to Staphylococcus aurues in patients with Wegener\u2018s granulomatosis","volume":"49","author":"Mayet","year":"1999","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/ar392","article-title":"Staphylococcus aureus and Wegener\u2018s granulomatosis","volume":"4","author":"Popa","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/thorax.56.10.751","article-title":"CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener\u2019s granulomatosis","volume":"56","author":"Lamprecht","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.cellimm.2003.08.003_BIB7","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0002-9440(10)61118-2","article-title":"Peripheral blood and granuloma CD4+CD28\u2212 T-cells are a major source of IFN-\u03b3 and TNF-\u03b1 in Wegener\u2018s granulomatosis","volume":"160","author":"Komocsi","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1521-6616(03)00121-9","article-title":"Differences in CCR5 expression on peripheral blood CD4+CD28\u2212 T-cells and in granulomatous lesions between localized and generalized Wegener\u2018s granulomatosis","volume":"108","author":"Lamprecht","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB9","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1128\/JVI.74.17.8140-8150.2000","article-title":"Functional heterogeneity and high frequencies of cytomegalovirus-specfic CD8+ T lymphocytes in healthy seropositive donors","volume":"74","author":"Gillespie","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1365-2249.2001.01614.x","article-title":"Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes","volume":"125","author":"Vargas","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections","volume":"8","author":"Appay","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s002960000063","article-title":"Cytomegalovirus infection in systemic necrotizing vasculitis: causative agent or opportunistic infection?","volume":"20","author":"Meyer","year":"2000","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB13","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.4049\/jimmunol.168.11.5538","article-title":"Differentiation of human CD8+ T cells from a memory to memory\/effector phenotype","volume":"168","author":"Tomiyama","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB14","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.4049\/jimmunol.168.11.5455","article-title":"Identification of naive or antigen-experienced human CD8+ T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8+ T cell response","volume":"168","author":"Wills","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S1471-4906(02)02338-4","article-title":"Premature ageing of the immune system: the cause of AIDS?","volume":"23","author":"Appay","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB16","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S1471-4906(02)02326-8","article-title":"Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue","volume":"23","author":"Van Baarle","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1182\/blood.V98.3.754","article-title":"Differentiation of cytomegalovirus-specific CD8 (+) T cells in healthy and immunosuppressed virus carriers","volume":"98","author":"Gamadia","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2003.08.003_BIB18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0091-6749(99)70434-3","article-title":"Differential B- and T-cell activation in Wegener\u2019s granulomatosis","volume":"103","author":"Popa","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2249.1998.00695.x","article-title":"Costimulatory molecules in Wegener\u2019s granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells","volume":"114","author":"Moosig","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2249.2002.01801.x","article-title":"Elevated monocytic IL-12 and TNF-\u03b1 production in Wegener\u2018s granulomatosis is normalized by cyclophophamide and corticosteroid therapy","volume":"128","author":"Lamprecht","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB21","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/rheumatology\/41.11.1303","article-title":"Effectiveness of TNF-\u03b1 blockade with infliximab in refractory Wegener\u2018s granulomatosis","volume":"41","author":"Lamprecht","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.cellimm.2003.08.003_BIB22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00393-003-0527-6","article-title":"Treatment of primary systemic vasculitis with TNF-\u03b1 antagonists","volume":"62","author":"Gause","year":"2003","journal-title":"Z. Rheumatol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00002281-200305000-00014","article-title":"Laboratory changes on anti-tumor necrosis factor treatment in rheumatoid arthritis","volume":"15","author":"Ziolkowska","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1365-2249.2003.02098.x","article-title":"Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T-cells recognizing CMVpp65 are present but display functional impairment","volume":"132","author":"Engstrand","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/art.1780390606","article-title":"Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings","volume":"39","author":"Waase","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cellimm.2003.08.003_BIB26","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/315445","article-title":"Cytotoxic T lymphocyte (CTL) responses to human cytomegalovirus pp65, IE1-exon 4, gB, pp150, and pp28 in healthy individuals: reevaluation of prevalence of IE1-specific CTLs","volume":"181","author":"Gyulai","year":"2000","journal-title":"J. Infect. Dis."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874903001758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874903001758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:37:35Z","timestamp":1757803055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874903001758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0008874903001758"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2003.08.003","relation":{},"ISSN":["0008-8749"],"issn-type":[{"type":"print","value":"0008-8749"}],"subject":[],"published":{"date-parts":[[2003,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener\u2019s granulomatosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2003.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}