{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:09:19Z","timestamp":1791032959362,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2009]]},"DOI":"10.1016\/j.cellimm.2009.06.013","type":"journal-article","created":{"date-parts":[[2009,7,11]],"date-time":"2009-07-11T04:23:39Z","timestamp":1247286219000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo"],"prefix":"10.1016","volume":"259","author":[{"given":"Rebecca A.","family":"Shilling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan S.","family":"Clay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Tesciuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamson V.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hozefa S.","family":"Bandukwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel V.","family":"Weinstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Horan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve K.","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Welcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy L.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne I.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2009.06.013_bib1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.4049\/jimmunol.147.8.2461","article-title":"CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells","volume":"147","author":"Jenkins","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/16717","article-title":"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28","volume":"397","author":"Hutloff","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2009.06.013_bib3","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.4049\/jimmunol.165.9.5035","article-title":"Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4(+) T cells","volume":"165","author":"McAdam","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib4","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.175.4.2061","article-title":"Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and th2 cytokine production","volume":"175","author":"Shilling","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib5","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1172\/JCI119093","article-title":"Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model","volume":"98","author":"Krinzman","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellimm.2009.06.013_bib6","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.4049\/jimmunol.158.5.2042","article-title":"B7-CD28\/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens","volume":"158","author":"Keane-Myers","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1165\/ajrcmb.18.4.3055","article-title":"CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1\/Th2 subsets in a murine model of asthma","volume":"18","author":"Padrid","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1165\/ajrcmb.21.4.3714","article-title":"CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice","volume":"21","author":"Mathur","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1074-7613(00)00011-X","article-title":"The CD28-related molecule ICOS is required for effective T cell-dependent immune responses","volume":"13","author":"Coyle","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2009.06.013_bib10","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.4049\/jimmunol.167.4.1996","article-title":"Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease","volume":"167","author":"Tesciuba","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35051100","article-title":"ICOS co-stimulatory receptor is essential for T-cell activation and function","volume":"409","author":"Dong","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2009.06.013_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/35051107","article-title":"ICOS is critical for CD40-mediated antibody class switching","volume":"409","author":"McAdam","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2009.06.013_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35051113","article-title":"ICOS is essential for effective T-helper-cell responses","volume":"409","author":"Tafuri","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2009.06.013_bib14","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.156.12.4576","article-title":"CD28 is required for germinal center formation","volume":"156","author":"Ferguson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(03)00144-4","article-title":"Transcriptional regulation of th2 differentiation by inducible costimulator","volume":"18","author":"Nurieva","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2009.06.013_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.clim.2004.07.002","article-title":"ICOS deficiency in patients with common variable immunodeficiency","volume":"113","author":"Salzer","year":"2004","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib18","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood-2005-07-2955","article-title":"Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency","volume":"107","author":"Warnatz","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2009.06.013_bib19","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"Breitfeld","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2009.06.013_bib20","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.192.11.1553","article-title":"CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function","volume":"192","author":"Schaerli","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2009.06.013_bib21","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.175.4.2340","article-title":"The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo","volume":"175","author":"Akiba","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib22","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.4049\/jimmunol.172.10.5917","article-title":"The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28","volume":"172","author":"Suh","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib23","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.4049\/jimmunol.175.11.7288","article-title":"Cooperation between 401BB and ICOS in the immune response to influenza virus revealed by studies of CD28\/ICOS-deficient mice","volume":"175","author":"Vidric","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib24","first-page":"255","article-title":"Methods used to study immunoregulation of schistosome egg granulomas","volume":"9","author":"Elliott","year":"1996","journal-title":"Immunol. Methods"},{"key":"10.1016\/j.cellimm.2009.06.013_bib25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4049\/jimmunol.154.3.985","article-title":"Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation","volume":"154","author":"Abe","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1067\/mai.2003.1616","article-title":"Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma","volume":"112","author":"Bryce","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib27","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/45582","article-title":"T-cell co-stimulation through B7RP-1 and ICOS","volume":"402","author":"Yoshinaga","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2009.06.013_bib28","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.4049\/jimmunol.166.9.5578","article-title":"Stimulatory effects of b7-related protein-1 on cellular and humoral immune responses in mice","volume":"166","author":"Guo","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib29","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1172\/JCI11710","article-title":"B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4","volume":"107","author":"Mandelbrot","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellimm.2009.06.013_bib30","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/eji.200636136","article-title":"Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression","volume":"36","author":"Rasheed","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib31","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.4049\/jimmunol.177.7.4927","article-title":"ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells","volume":"177","author":"Bossaller","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib32","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.170.5.2310","article-title":"Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells","volume":"170","author":"Smith","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib33","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.4049\/jimmunol.177.4.2365","article-title":"B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses","volume":"177","author":"Wilson","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib34","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.4049\/jimmunol.157.9.3909","article-title":"CD28\/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation","volume":"157","author":"Sperling","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.4049\/jimmunol.158.2.658","article-title":"CD28 costimulation promotes the production of Th2 cytokines","volume":"158","author":"Rulifson","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib36","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.4049\/jimmunol.174.5.3000","article-title":"B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance","volume":"174","author":"Gajewska","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib37","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni947","article-title":"Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses","volume":"4","author":"Mak","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nri1714","article-title":"Follicular B helper T cells in antibody responses and autoimmunity","volume":"5","author":"Vinuesa","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib39","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ygeno.2006.08.012","article-title":"A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors","volume":"88","author":"Zang","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.cellimm.2009.06.013_bib40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4049\/jimmunol.171.1.166","article-title":"CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes","volume":"171","author":"Parry","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2009.06.013_bib41","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa063842","article-title":"Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412","volume":"355","author":"Suntharalingam","year":"2006","journal-title":"N. Engl. J. Med."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874909001270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874909001270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:44:01Z","timestamp":1757803441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874909001270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"alternative-id":["S0008874909001270"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2009.06.013","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2009.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}