{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:53:01Z","timestamp":1790787181010,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1016\/j.cellimm.2011.09.003","type":"journal-article","created":{"date-parts":[[2011,9,18]],"date-time":"2011-09-18T12:34:10Z","timestamp":1316349250000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation"],"prefix":"10.1016","volume":"272","author":[{"given":"Elsa N.","family":"Bou Ghanem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.F.","family":"D\u2019Orazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2011.09.003_b0005","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0","article-title":"Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18","volume":"32","author":"Berg","year":"2002","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0010","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.4049\/jimmunol.172.11.7002","article-title":"TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells","volume":"172","author":"Papadakis","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0015","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.4049\/jimmunol.178.8.4786","article-title":"Profound enhancement of the IL-12\/IL-18 pathway of IFN-gamma secretion in human CD8+ memory T cell subsets via IL-15","volume":"178","author":"Smeltz","year":"2007","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0020","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<548::AID-IMMU548>3.0.CO;2-Z","article-title":"Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation","volume":"29","author":"Yang","year":"1999","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0025","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/eji.200323398","article-title":"Bystander polarization of CD4+ T cells: activation with high-dose IL-2 renders naive T cells responsive to IL-12 and\/or IL-18 in the absence of TCR ligation","volume":"33","author":"Chakir","year":"2003","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0030","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.161.7.3400","article-title":"IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production","volume":"161","author":"Yoshimoto","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0035","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.4049\/jimmunol.173.11.6873","article-title":"Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18","volume":"173","author":"Raue","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0040","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.4049\/jimmunol.1001960","article-title":"T cell intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN\u03b3 in the absence of antigen","volume":"186","author":"Bou Ghanem","year":"2011","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0045","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"Berg","year":"2003","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.cellimm.2011.09.003_b0050","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.4049\/jimmunol.177.10.7146","article-title":"Cytosolic localization of Listeria monocytogenes triggers an early IFN-gamma response by CD8+ T cells that correlates with innate resistance to infection","volume":"177","author":"D\u2019Orazio","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0055","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"Lertmemongkolchai","year":"2001","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0060","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.175.3.1751","article-title":"Relative contributions of NK and CD8 T cells to IFN-gamma mediated innate immune protection against Listeria monocytogenes","volume":"175","author":"Berg","year":"2005","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/cimm.2000.1644","article-title":"Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB\/c and C57BL\/6 mice","volume":"202","author":"Liu","year":"2000","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0070","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1128\/IAI.70.12.6638-6645.2002","article-title":"Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB\/c and C57BL\/6 mice","volume":"70","author":"Liu","year":"2002","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.cellimm.2011.09.003_b0075","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-2362.2005.01564.x","article-title":"Severely impaired IL-12\/IL-18\/IFNgamma axis in patients with hyper IgE syndrome","volume":"35","author":"Netea","year":"2005","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1016\/j.cellimm.2011.09.003_b0080","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2172-11-47","article-title":"Bystander T cells in human immune responses to dengue antigens","volume":"11","author":"Suwannasaen","year":"2010","journal-title":"BMC Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clim.2003.12.006","article-title":"In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis","volume":"111","author":"El-Mezayen","year":"2004","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0090","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1371\/journal.pntd.0000407","article-title":"Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei","volume":"3","author":"Tippayawat","year":"2009","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/j.cellimm.2011.09.003_b0095","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.micinf.2007.05.011","article-title":"The epidemiology of human listeriosis","volume":"9","author":"Swaminathan","year":"2007","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.cellimm.2011.09.003_b0100","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/0140-6736(90)90411-W","article-title":"Detection of anti-listeriolysin O for serodiagnosis of human listeriosis","volume":"335","author":"Berche","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.cellimm.2011.09.003_b0105","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/iai.63.6.2288-2294.1995","article-title":"Human T-cell recognition of Listeria monocytogenes: recognition of listeriolysin O by TcR alpha beta + and TcR gamma delta + T cells","volume":"63","author":"Guo","year":"1995","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.cellimm.2011.09.003_b0110","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.182.5.1527","article-title":"Interleukin 12 inhibits antigen-induced airway hyperresponsiveness inflammation and Th2 cytokine expression in mice","volume":"182","author":"Gavett","year":"1995","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.cellimm.2011.09.003_b0115","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.4049\/jimmunol.161.9.5054","article-title":"Prevention of Th2-like cell responses by coadministration of IL12 and-IL-18 is associated with inhibition of antigen-induced airway Hyperresponsiveness eosinophilia and serum IgE levels","volume":"161","author":"Hofstra","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0120","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1073\/pnas.94.8.3948","article-title":"Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells","volume":"94","author":"Yoshimoto","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.cellimm.2011.09.003_b0125","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.4049\/jimmunol.175.8.4956","article-title":"Prevention of allergen-specific Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness","volume":"175","author":"Lewkowich","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0130","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1182\/blood-2008-02-139147","article-title":"Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation","volume":"113","author":"Sattler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2011.09.003_b0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0928-8244(02)00470-4","article-title":"Production of IL-12 IL-18 in human dendritic cells upon infection by Listeria monocytogenes","volume":"35","author":"Kolb-Maurer","year":"2003","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0140","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.4049\/jimmunol.169.7.3863","article-title":"Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice","volume":"169","author":"Seki","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cellimm.2011.09.003_b0145","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/IAI.72.4.2131-2139.2004","article-title":"Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection","volume":"72","author":"Torres","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.cellimm.2011.09.003_b0150","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.4049\/jimmunol.180.12.7859","article-title":"Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin Listeriolysin O after Evasion from Phagosome into the Cytoplasm","volume":"180","author":"Hara","year":"2008","journal-title":"Journal of Immunology"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887491100236X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887491100236X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:47:01Z","timestamp":1757803621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000887491100236X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"alternative-id":["S000887491100236X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2011.09.003","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2011]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2011.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}