{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:20:06Z","timestamp":1760170806988,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":259,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Brazilian National Research Council","award":["472880\/2009-8"],"award-info":[{"award-number":["472880\/2009-8"]}]},{"name":"Coordination of Improvement of Higher Level Personnel","award":["23038 003155\/2011-37"],"award-info":[{"award-number":["23038 003155\/2011-37"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.cellimm.2012.11.006","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:32:40Z","timestamp":1354149160000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure"],"prefix":"10.1016","volume":"279","author":[{"given":"Maria Carolina Accioly","family":"Brelaz-de-Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Ferreira","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andresa Pereira","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"de Assis-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Ferreira","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria R\u00eago Alves","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2012.11.006_b0005","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(07)70209-8","article-title":"Cutaneous Leishmaniasis","volume":"7","author":"Reithinger","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cellimm.2012.11.006_b0010","unstructured":"WHO. World Health Organization <http:\/\/www.who.int\/leishmaniasis\/burden\/en\/> (accessed January 2012)."},{"key":"10.1016\/j.cellimm.2012.11.006_b0015","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2230.2010.03851.x","article-title":"Cutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics","volume":"35","author":"Ameen","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.cellimm.2012.11.006_b0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2334-6-75","article-title":"Differential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine production","volume":"6","author":"Leopoldo","year":"2006","journal-title":"BMC Infect. Dis."},{"issue":"4","key":"10.1016\/j.cellimm.2012.11.006_b0025","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-3024.2012.01351.x","article-title":"Leishmania (Viannia) braziliensisantigenic fractions: the immune response characterization of patients at the initial phase of disease","volume":"34","author":"Brelaz","year":"2012","journal-title":"Parasite Immunol."},{"issue":"6","key":"10.1016\/j.cellimm.2012.11.006_b0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.humimm.2009.01.007","article-title":"Th1\/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production","volume":"70","author":"Castellano","year":"2009","journal-title":"Hum. Immunol."},{"issue":"5","key":"10.1016\/j.cellimm.2012.11.006_b0035","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1590\/S0074-02762007005000069","article-title":"T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis","volume":"102","author":"Bittar","year":"2007","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.cellimm.2012.11.006_b0040","doi-asserted-by":"crossref","unstructured":"L.R. Antonelli, W.O. Dutra, R.P. Almeida, O. Barcellar, E.M. Carvalho, K.J. Gollob, Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis, Immunol. Lett. 101 (2005) 226\u2013230.","DOI":"10.1016\/j.imlet.2005.06.004"},{"key":"10.1016\/j.cellimm.2012.11.006_b0045","doi-asserted-by":"crossref","unstructured":"A.M. Da-Cruz, A.L. Bertho, M.P. Oliveira-Neto, S.G. Coutinho, Flow cytometric analysis of cellular infiltrate from American tegumentary leishmaniasis lesions, Br. J. Dermatol. 153 (3) (2005) 537\u2013543.","DOI":"10.1111\/j.1365-2133.2005.06647.x"},{"key":"10.1016\/j.cellimm.2012.11.006_b0050","doi-asserted-by":"crossref","unstructured":"A. Gomes-Silva, R.C. Bittar, R.S. Nogueira, V.S. Amato, M.S. Mattos, M.P. Oliveira-Neto, S.G. Coutinho, A.M. da-Cruz, Can interferon-\u03b3 and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection? Clin. Exp. Immunol. 149 (2007) 440\u2013444.","DOI":"10.1111\/j.1365-2249.2007.03436.x"},{"key":"10.1016\/j.cellimm.2012.11.006_b0055","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2741\/2106","article-title":"Mixed cytokine profile during active cutaneous leishmaniasis and in natural resistance","volume":"12","author":"Baratta-Masini","year":"2007","journal-title":"Front. Biosci."},{"issue":"3","key":"10.1016\/j.cellimm.2012.11.006_b0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2249.2011.04536.x","article-title":"Multifunctional CD4+ T cells in patients with American cutaneous leishmaniasis","volume":"167","author":"Macedo","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2012.11.006_b0065","doi-asserted-by":"crossref","unstructured":"M.E.F. Brito, M.G. Mendon\u00e7a, Y.M. Gomes, M.L. Jardim, F.G.C. Abath, Dynamics of the antibody response in patients with therapeutic or spontaneous cure of American cutaneous leishmaniasis, Trans. R. Soc. Trop. Med. Hyg. 95 (2001) 203\u2013206.","DOI":"10.1016\/S0035-9203(01)90168-3"},{"key":"10.1016\/j.cellimm.2012.11.006_b0070","doi-asserted-by":"crossref","unstructured":"S.G. Coutinho, A.M. Da-Cruz, A.L. Bertho, M.A. Santiago, P. De-Luca, Immunologic patterns associated with cure in human American cutaneous leishmaniasis, Braz. J. Med. Biol. Res. 31 (1998) 139\u2013142.","DOI":"10.1590\/S0100-879X1998000100019"},{"issue":"6","key":"10.1016\/j.cellimm.2012.11.006_b0075","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1128\/iai.62.6.2614-2618.1994","article-title":"Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis","volume":"62","author":"Da-Cruz","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellimm.2012.11.006_b0080","doi-asserted-by":"crossref","unstructured":"R.L.A. Bottrel, W.O. Dutra, F.A. Martins, B. Gontijo, E. Carvalho, M. Barral-Netto, R.P. Almeida, W. Mayrink, R. Locksley, K.J. Gollob, Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble leishmania antigen in human cutaneous leishmaniasis, Infect. Immun. 69 (5) (2001) 3232\u20133239.","DOI":"10.1128\/IAI.69.5.3232-3239.2001"},{"key":"10.1016\/j.cellimm.2012.11.006_b0085","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri2189","article-title":"Regulatory T cells and infections: a dangerous necessity","volume":"7","author":"Belkaid","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2012.11.006_b0090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/expr.1996.0100","article-title":"T-cell responsiveness of American cutaneous leishmaniasis patients to purified leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: immunologic patterns associated with cure","volume":"84","author":"Coutinho","year":"1996","journal-title":"Exp. Parasitol."},{"issue":"2","key":"10.1016\/j.cellimm.2012.11.006_b0095","first-page":"251","article-title":"T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy","volume":"9","author":"Da-Cruz","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2012.11.006_b0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S0074-02762001000100010","article-title":"Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment","volume":"96","author":"Toledo","year":"2001","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.cellimm.2012.11.006_b0105","doi-asserted-by":"crossref","unstructured":"P. Autissier, C. Soulas, T.H. Burdo, K.C. Williams, Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans, Cytometry Part A 77 (5) (2010) 410\u2013419.","DOI":"10.1002\/cyto.a.20859"},{"key":"10.1016\/j.cellimm.2012.11.006_b0110","doi-asserted-by":"crossref","unstructured":"A.M. Faria, S.M. de Moraes, L.H. de Freitas, E. Speziali, T.F. Soares, S.P. Figueiredo-Neves, D.M. Vitelli-Avelar, M.A. Martins, K.V. Barbosa, E.B. Soares, R. Sathler-Avelar, V. Peruhype-Magalh\u00e3es, G.M. Cardoso, F. Comin, R. Teixeira, S.M. El\u00f3i-Santos, D.M. Queiroz, R. Corr\u00eaa-Oliveira, M.E. Bauer, A. Teixeira-Carvalho, O.A. Martins-Filho, Variation rhythms of lymphocyte subsets during healthy aging, Neuroimmunomodulation 15 (4\u20136) (2008) 365\u2013379.","DOI":"10.1159\/000156478"},{"issue":"2","key":"10.1016\/j.cellimm.2012.11.006_b0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.actatropica.2009.07.012","article-title":"Alterations in phenotypic profiles of peripheral blood cells from patients with human American cutaneous leishmaniasis following treatment with an antimonial drug and a vaccine","volume":"12","author":"Botelho","year":"2009","journal-title":"Acta Trop."},{"key":"10.1016\/j.cellimm.2012.11.006_b0120","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.2007.03436.x","article-title":"Can interferon-\u03b3 and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection?","volume":"149","author":"Gomes-Silva","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2012.11.006_b0125","doi-asserted-by":"crossref","unstructured":"L.C. Reis, M.E.F. Brito, M.A. Souza, A.C. Medeiros, C.J. Silva, C.F. Luna, V.R.A. Pereira, Cellular immune response profile in patients with American tegumentary leishmaniasis prior and post chemotherapy treatment, J. Clin. Lab. Anal. 23 (2009) 63\u201369.","DOI":"10.1002\/jcla.20291"},{"key":"10.1016\/j.cellimm.2012.11.006_b0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2249.2006.02995.x","article-title":"In vitro responses of human peripheral blood mononuclear cells to whole-cell, particulate and soluble extracts of Leishmania promastigotes","volume":"143","author":"Telino","year":"2005","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.cellimm.2012.11.006_b0135","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.4049\/jimmunol.180.9.6139","article-title":"Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis","volume":"180","author":"Salhi","year":"2008","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cellimm.2012.11.006_b0140","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/QCO.0b013e32830d0ee8","article-title":"Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasis","volume":"21","author":"Schriefer","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.cellimm.2012.11.006_b0145","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1128\/IAI.68.4.1760-1764.2000","article-title":"Comparison of the immune profile of nonhealing cutaneous Leishmaniasis patients with those with active lesions and those who have recovered from infection","volume":"68","author":"Ajdary","year":"2000","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.cellimm.2012.11.006_b0150","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/IAI.01398-08","article-title":"Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis","volume":"77","author":"Bourreau","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellimm.2012.11.006_b0155","doi-asserted-by":"crossref","unstructured":"M.A. Souza, M.C.A.B. Castro, A.P. Oliveira, A.F. Almeida, L.C. Reis, C.J. Silva, M.E.F. Brito, V.R.A. Pereira, American tegumentary leishmaniasis: cytokines and nitric oxide in active disease and after clinical cure, with or without chemotherapy, Scand. J. Immunol. 76 (2) (2012) 175\u2013180.","DOI":"10.1111\/j.1365-3083.2012.02717.x"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874912002006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874912002006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:49:51Z","timestamp":1757803791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874912002006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0008874912002006"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2012.11.006","relation":{},"ISSN":["0008-8749"],"issn-type":[{"type":"print","value":"0008-8749"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2012.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}