{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:12:41Z","timestamp":1790806361190,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003022","name":"International Educational Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.cellimm.2017.10.006","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T02:16:11Z","timestamp":1508120171000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"C","title":["Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool"],"prefix":"10.1016","volume":"322","author":[{"given":"Lindsey","family":"Devisscher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte L.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Lefere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Raevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliene","family":"Bogaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Paridaens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Verhelst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Geerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Guilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Van Vlierberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2017.10.006_b0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2017.10.006_b0010","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cellimm.2017.10.006_b0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2017.10.006_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00486","article-title":"Ontogeny of tissue-resident macrophages","volume":"6","author":"Hoeffel","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0025","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1038\/ncomms10321","article-title":"Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells","volume":"7","author":"Scott","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2017.10.006_b0030","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2017.10.006_b0035","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0040","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cellimm.2017.10.006_b0045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1084\/jem.20141539","article-title":"A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2 + monocytes at a site of sterile injury","volume":"212","author":"Dal-Secco","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2017.10.006_b0050","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2016.08.007","article-title":"Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals","volume":"45","author":"Sawai","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2017.10.006_b0055","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1186\/1755-1536-5-S1-S27","article-title":"Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo","volume":"5","author":"Tacke","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.cellimm.2017.10.006_b0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.1400574","article-title":"Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury","volume":"193","author":"Zigmond","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bl\u00e9riot","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2017.10.006_b0070","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/hep.28682","article-title":"Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury","author":"Mossanen","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0075","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.3748\/wjg.v22.i8.2494","article-title":"Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play","volume":"22","author":"Charrez","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0168-8278(98)80073-1","article-title":"Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance","volume":"29","author":"James","year":"1998","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0085","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0090","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity","volume":"51","author":"Stienstra","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0095","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0100","doi-asserted-by":"crossref","first-page":"e107265","DOI":"10.1371\/journal.pone.0107265","article-title":"IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis","volume":"9","author":"Negrin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2017.10.006_b0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/db09-0016","article-title":"Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance","volume":"59","author":"Huang","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2017.10.006_b0110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jhep.2014.09.015","article-title":"Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis","volume":"62","author":"Navarro","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0115","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gut.2005.071118","article-title":"Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice","volume":"55","author":"Tomita","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.cellimm.2017.10.006_b0120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0125","doi-asserted-by":"crossref","first-page":"40161","DOI":"10.1074\/jbc.M112.417014","article-title":"Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production","volume":"287","author":"Tosello-Trampont","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellimm.2017.10.006_b0130","doi-asserted-by":"crossref","first-page":"G107","DOI":"10.1152\/ajpgi.00391.2009","article-title":"Kupffer cell activation is a causal factor for hepatic insulin resistance","volume":"298","author":"Lanthier","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0135","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1096\/fj.11-189472","article-title":"I. a. Leclercq, Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet","volume":"25","author":"Lanthier","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.cellimm.2017.10.006_b0140","doi-asserted-by":"crossref","first-page":"G1310","DOI":"10.1152\/ajpgi.00365.2011","article-title":"Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2","volume":"302","author":"Miura","year":"2012","journal-title":"AJP Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0145","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/hep.26783","article-title":"Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice","volume":"59","author":"Baeck","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0150","doi-asserted-by":"crossref","first-page":"e0158156","DOI":"10.1371\/journal.pone.0158156","article-title":"Antifibrotic Effects of the Dual CCR2\/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis","volume":"11","author":"Lefebvre","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2017.10.006_b0155","article-title":"Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis","author":"Krenkel","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0160","first-page":"5","article-title":"A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis","author":"Friedman","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0959-9673.2006.00465.x","article-title":"Mouse models in non-alcoholic fatty liver disease and steatohepatitis research","volume":"87","author":"Anstee","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0170","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jhep.2011.04.010","article-title":"NASH animal models: are we there yet?","volume":"55","author":"Kohli","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0175","first-page":"1","article-title":"Nonalcoholic steatohepatitis: lessons from different diet-induced animal models","volume":"1","author":"Schultz","year":"2014","journal-title":"J. Diabetes, Metab. Disord Control."},{"key":"10.1016\/j.cellimm.2017.10.006_b0180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1017\/S0954422415000128","article-title":"Murine models provide insight to the development of non-alcoholic fatty liver disease","volume":"28","author":"Reid","year":"2015","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.cellimm.2017.10.006_b0185","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0190","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1189\/jlb.5RU0116-016R","article-title":"The role of macrophages in obesity-driven chronic liver disease","author":"Devisscher","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0195","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800042-JLR200","article-title":"Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet","volume":"49","author":"Rinella","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cellimm.2017.10.006_b0200","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/ars.2010.3749","article-title":"New insights from rodent models of fatty liver disease","volume":"15","author":"Maher","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cellimm.2017.10.006_b0205","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/hep.26219","article-title":"Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models","volume":"57","author":"Coulon","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2017.10.006_b0210","first-page":"2683","article-title":"Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL\/6 mice","volume":"6","author":"Itagaki","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.cellimm.2017.10.006_b0215","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/labinvest.2010.143","article-title":"Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet","volume":"90","author":"Kassel","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cellimm.2017.10.006_b0220","doi-asserted-by":"crossref","first-page":"e0159524","DOI":"10.1371\/journal.pone.0159524","article-title":"Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation","volume":"11","author":"Reid","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2017.10.006_b0225","doi-asserted-by":"crossref","first-page":"34466","DOI":"10.1038\/srep34466","article-title":"Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells\/macrophages in diet-induced steatohepatitis in FGF5 deficient mice","volume":"6","author":"Nakashima","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellimm.2017.10.006_b0230","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jhep.2016.05.037","article-title":"Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions","volume":"65","author":"Beattie","year":"2016","journal-title":"J. Hepatol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874917301697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874917301697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:57:34Z","timestamp":1757804254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874917301697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":46,"alternative-id":["S0008874917301697"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2017.10.006","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2017.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}