{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:13:01Z","timestamp":1778710381369,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"am","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007688","name":"Korean Academy of Medical Sciences","doi-asserted-by":"publisher","award":["NRF-20151A1A3A04001542"],"award-info":[{"award-number":["NRF-20151A1A3A04001542"]}],"id":[{"id":"10.13039\/501100007688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-99-013"],"award-info":[{"award-number":["DK-99-013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NRF-20151A1A3A04001542"],"award-info":[{"award-number":["NRF-20151A1A3A04001542"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.cellimm.2019.03.003","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T10:36:43Z","timestamp":1552991803000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["LPS enhances CTB-INSULIN induction of IDO1 and IL-10 synthesis in human dendritic cells"],"prefix":"10.1016","volume":"338","author":[{"given":"Nan-Sun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Torrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Langridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellimm.2019.03.003_b0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jama.2014.16425","article-title":"Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010","volume":"313","author":"Livingstone","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.cellimm.2019.03.003_b0010","first-page":"2843","volume":"37","author":"de Ferranti","year":"2014","journal-title":"Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association Diabetes Care 2014"},{"key":"10.1016\/j.cellimm.2019.03.003_b0015","unstructured":"Type 1 Diabetes, 2011; JDRF FACTS, www.jdrf.org, (> 15,000 children and 15,000 adults annually, approximately 80 people per day, are diagnosed with this tissue specific autoimmune disease in the U.S and there is a 3.0% increase in disease incidence annually)."},{"issue":"4","key":"10.1016\/j.cellimm.2019.03.003_b0020","first-page":"a007781","article-title":"Antigen Targets of Type 1 Diabetes Autoimmunity Cold Spring Harbor","volume":"2","author":"Roep Bart","year":"2012","journal-title":"Perspect Med. Apr"},{"issue":"4","key":"10.1016\/j.cellimm.2019.03.003_b0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1900\/RDS.2012.9.148","article-title":"Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease","volume":"9","author":"Graham","year":"2012","journal-title":"Rev. Diabet. Stud., Winter"},{"issue":"25","key":"10.1016\/j.cellimm.2019.03.003_b0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(95)90586-3","article-title":"Defective maturation and function of antigen-presenting cells in type 1 diabetes","volume":"345","author":"Jansen","year":"1995","journal-title":"The Lancet"},{"issue":"44","key":"10.1016\/j.cellimm.2019.03.003_b0035","first-page":"15995","article-title":"The role of TNF-alpha in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation","volume":"102","author":"Lee","year":"2005","journal-title":"PNAS, November 1"},{"key":"10.1016\/j.cellimm.2019.03.003_b0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fimmu.2013.00415","article-title":"Dendritic Cell Subsets in Type 1 Diabetes: Friend or Foe?","volume":"4","author":"Morel","year":"2013","journal-title":"Front Immunol."},{"issue":"8","key":"10.1016\/j.cellimm.2019.03.003_b0045","article-title":"1 Katharina Warncke, 2, 3 and Anette-G. Ziegler3,4 Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes","volume":"2","author":"Chatenoud","year":"2012","journal-title":"Cold Spring Harb Perspect Med. Aug"},{"issue":"11","key":"10.1016\/j.cellimm.2019.03.003_b0050","first-page":"a007542","article-title":"Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases Cold Spring","volume":"4","author":"Bluestone","year":"2012","journal-title":"Harb Perspect Biol."},{"key":"10.1016\/j.cellimm.2019.03.003_b0055","author":"Giannoukakis","year":"2000","journal-title":"Prolongation of Cardiac Allograft Survival Using Dendritic Cells treated with NF-kB Decoy Oligodeoxyribonucleotides. Molecular Therapy, Vol 1, No 5"},{"key":"10.1016\/j.cellimm.2019.03.003_b0060","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.3262237","article-title":"Effects of cyclosporine A on T cell development and clonal deletion","volume":"241","author":"Jenkins","year":"1988","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.cellimm.2019.03.003_b0065","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1097\/00007890-199712270-00031","article-title":"Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival","volume":"64","author":"Lu","year":"1997","journal-title":"Transplantation. Dec 27"},{"key":"10.1016\/j.cellimm.2019.03.003_b0070","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0041-1345(98)01774-6","article-title":"Transduction of Dendritic Cells With Adenoviral Vectors Encoding CTLA4-Ig Markedly Reduces Their Allostimulatory Activity","volume":"31","author":"Lu","year":"1999","journal-title":"Transplantation Proceedings"},{"issue":"12","key":"10.1016\/j.cellimm.2019.03.003_b0075","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1097\/00007890-199812270-00040","article-title":"Phenotype, Function, And In Vivo Migration And Survival Of Allogeneic Dendritic Cell Progenitors Genetically Engineered To Express TGF-\u03b21","volume":"66","author":"Lee","year":"1998","journal-title":"2 Transplantation: 27 December"},{"issue":"6","key":"10.1016\/j.cellimm.2019.03.003_b0080","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00007890-199809270-00003","article-title":"Protection against allograft rejection with intercellular adhesion molecule-1 antisense oligodeoxynucleotides","volume":"66","author":"Stepkowski","year":"1998","journal-title":"Transplantation. Sep 27"},{"issue":"3","key":"10.1016\/j.cellimm.2019.03.003_b0085","first-page":"1521","article-title":"Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities","volume":"154","author":"Stepkowski","year":"1995","journal-title":"J Immunol. February 1"},{"key":"10.1016\/j.cellimm.2019.03.003_b0090","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/immu.200390025","article-title":"Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit","volume":"33","author":"Phipps","year":"2003","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.cellimm.2019.03.003_b0095","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1365-2249.2003.02255.x","article-title":"Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes","volume":"134","author":"Petersen","year":"2003","journal-title":"Clin Exp Immunol. October"},{"issue":"3","key":"10.1016\/j.cellimm.2019.03.003_b0100","first-page":"311","article-title":"Oral tolerance induction by mucosal administration of cholera toxin B-coupled antigen involves T-cell proliferation in vivo and is not affected by depletion of CD25+ T cells","volume":"118","author":"Annie","year":"2006","journal-title":"Immunology. July"},{"key":"10.1016\/j.cellimm.2019.03.003_b0105","first-page":"16","article-title":"Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund's","volume":"2013","author":"B\u00e9la","year":"2013","journal-title":"Adjuvant. Clin Dev Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2019.03.003_b0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2249.2004.02520.x","article-title":"Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease","volume":"137","author":"Stanford","year":"2004","journal-title":"Clin Exp Immunol. Jul"},{"issue":"4","key":"10.1016\/j.cellimm.2019.03.003_b0115","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.4049\/jimmunol.1101771","article-title":"B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune encephalomyelitis","volume":"188","author":"Sun","year":"2012","journal-title":"J Immunol. Feb 15"},{"issue":"2","key":"10.1016\/j.cellimm.2019.03.003_b0120","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1365-2249.2002.01988.x","article-title":"Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice","volume":"130","author":"Aspord","year":"2002","journal-title":"Clin Exp Immunol. November"},{"key":"10.1016\/j.cellimm.2019.03.003_b0125","article-title":"Oral Administration of Cholera Toxin B-Insulin Conjugates Protects NOD Mice From Autoimmune Diabetes by Inducing CD4+ Regulatory T-Cells","volume":"4 8: 2 1 5","author":"Ploix","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2019.03.003_b0130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nbt1098-934","article-title":"A Plant-based Cholera Toxin B Subunit-insulin Fusion Protein Protects Against Development of Autoimmune Diabetes","volume":"16","author":"Arakawa","year":"1998","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellimm.2019.03.003_b0135","first-page":"1","article-title":"Suppression of Autoimmune Diabetes by a Plant-delivered Cholera Toxin B Subunit-Human Glutamate Decarboxylase Fusion Protein","volume":"3","author":"Arakawa","year":"1999","journal-title":"Transgenics"},{"issue":"5","key":"10.1016\/j.cellimm.2019.03.003_b0140","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/01.cji.0000171315.82997.9a","article-title":"Protection of NOD mice from type 1 diabetes after oral inoculation with vaccinia viruses expressing adjuvanted islet autoantigens","volume":"28","author":"Denes","year":"2005","journal-title":"J. Immunother. Sep-Oct"},{"key":"10.1016\/j.cellimm.2019.03.003_b0145","doi-asserted-by":"crossref","DOI":"10.1089\/dia.2009.0116","article-title":"Autoantigens plus Interleukin-10 Suppress Diabetes Autoimmunity","author":"Denes","year":"2010","journal-title":"Diabetes Technol. Therapeutics"},{"key":"10.1016\/j.cellimm.2019.03.003_b0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2014.09.012","article-title":"A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes","volume":"41","author":"Ferris","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2019.03.003_b0155","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.2337\/diabetes.53.8.1995","article-title":"Flt3ligand treatment prevents diabetes in NOD mice","volume":"53","author":"Chilton","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2019.03.003_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3083.2009.02321.x","article-title":"Mucosally induced Immunological Tolerance, Regulatory T Cells and the Adjuvant Effect by Cholera Toxin B Subunit","volume":"71","author":"Sun","year":"2010","journal-title":"Scandinavian J. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2019.03.003_b0165","first-page":"153","article-title":"Cholera toxin- A foe & a friend","volume":"133","author":"S\u00e1nchez Joaqu\u00edn and Jan Holmgren","year":"2011","journal-title":"Indian J Med Res. Feb"},{"key":"10.1016\/j.cellimm.2019.03.003_b0170","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.4049\/jimmunol.154.9.4322","article-title":"Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2\/B subunits","volume":"154","author":"Hajishengallis","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2019.03.003_b0175","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0092-8674(00)81106-X","article-title":"Insulin-Dependent Diabetes Mellitus","volume":"85","author":"Roland","year":"1996","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.cellimm.2019.03.003_b0180","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00006676-200004000-00011","article-title":"In Situ Characterization of Dendritic Cells Occurring in the Islets of Nonobese Diabetic Mice During the Development of Insulitis","volume":"20","author":"Shinomiya","year":"2000","journal-title":"Pancreas"},{"key":"10.1016\/j.cellimm.2019.03.003_b0185","article-title":"Induction of Indoleamine 2, 3 Dioxygenase in Human Dendritic Cells by a","author":"Mbongue","year":"2015","journal-title":"Cholera Toxin B Subunit - Proinsulin Vaccine PLOS ONE."},{"key":"10.1016\/j.cellimm.2019.03.003_b0190","doi-asserted-by":"crossref","unstructured":"Esebanmen, Grace, William H.R. Langridge, Mechanism of chimeric vaccine stimulation of indoleamine 2, 3-dioxygenase biosynthesis in human dendritic cells is independent of TGF-\u03b2 signaling (2017), Cellular Immunol. 8\/21 (available on line).","DOI":"10.1016\/j.cellimm.2017.08.002"},{"issue":"4","key":"10.1016\/j.cellimm.2019.03.003_b0195","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.imbio.2010.09.008","article-title":"Suppression of Dendritic Cell Activation by Diabetes Autoantigens Linked to the Cholera Toxin B Subunit","volume":"216","author":"Odumosu","year":"2010","journal-title":"Immunobiology. Apr"},{"issue":"46","key":"10.1016\/j.cellimm.2019.03.003_b0200","first-page":"8451","article-title":"Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function","volume":"29","author":"Odumosu","year":"2011","journal-title":"Vaccine Oct 26"},{"key":"10.1016\/j.cellimm.2019.03.003_b0205","first-page":"1","article-title":"Cholera Toxin B subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis. Doctoral Dissertation","author":"Odumosu","year":"2011","journal-title":"Loma Linda University, School of Medicine"},{"issue":"2","key":"10.1016\/j.cellimm.2019.03.003_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0147509","article-title":"Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Noncanonical NF-\u03baB pathway","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS ONE"},{"issue":"14","key":"10.1016\/j.cellimm.2019.03.003_b0215","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.4161\/cbt.8.14.8882","article-title":"IDO1 inhibits T-cell function through suppressing Vav1 expression and activation","volume":"8","author":"Li","year":"2009","journal-title":"Cancer Biol Ther."},{"key":"10.1016\/j.cellimm.2019.03.003_b0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/B978-0-12-380995-7.00004-5","article-title":"How tolerogenic dendritic cells induce regulatory T cells","volume":"108","author":"Maldonado","year":"2010","journal-title":"Adv Immunol."},{"issue":"7","key":"10.1016\/j.cellimm.2019.03.003_b0225","first-page":"1449","volume":"581","author":"Jung","year":"2007","journal-title":"Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells"},{"key":"10.1016\/j.cellimm.2019.03.003_b0230","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2006-11-056010","article-title":"Non-canonical NF-\u03baB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation","author":"Tas","year":"2007","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cellimm.2019.03.003_b0235","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1753425913481252","volume":"20","year":"2014","journal-title":"Innate Immun."},{"key":"10.1016\/j.cellimm.2019.03.003_b0240","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1002\/eji.200636704","article-title":"IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells","volume":"37","author":"Marcelo","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cellimm.2019.03.003_b0245","doi-asserted-by":"crossref","first-page":"43337","DOI":"10.1038\/srep43337","article-title":"The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs","volume":"7","author":"Fabi\u00e1n","year":"2017","journal-title":"Scientific Reports"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887491830488X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887491830488X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:53:37Z","timestamp":1778709217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000887491830488X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":49,"alternative-id":["S000887491830488X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2019.03.003","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LPS enhances CTB-INSULIN induction of IDO1 and IL-10 synthesis in human dendritic cells","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2019.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}