{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:00:01Z","timestamp":1790125201742,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.cellimm.2021.104286","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T03:50:24Z","timestamp":1611028224000},"page":"104286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"special_numbering":"C","title":["Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy"],"prefix":"10.1016","volume":"362","author":[{"given":"Adeleye Oluwatosin","family":"Adeshakin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funmilayo O.","family":"Adeshakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukman O.","family":"Afolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2021.104286_b0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s12276-018-0130-1","article-title":"Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance","volume":"50","author":"Park","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40425-019-0522-3","article-title":"Therapy with high-dose Interleukin-2 (HD IL-2) in metastatic melanoma and renal cell carcinoma following PD1 or PDL1 inhibition","volume":"7","author":"Buchbinder","year":"2019","journal-title":"J. ImmunoTher. Cancer"},{"key":"10.1016\/j.cellimm.2021.104286_b0015","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12967-019-2081-2","article-title":"Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm","volume":"17","author":"Tsur","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0020","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fimmu.2018.01310","article-title":"Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors","volume":"9","author":"Weber","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0025","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2021.104286_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.4467","article-title":"Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0035","doi-asserted-by":"crossref","first-page":"e20182005","DOI":"10.1084\/jem.20182005","article-title":"TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis","volume":"217","author":"Yan","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0040","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbrc.2019.11.155","article-title":"Blockade of myeloid-derived suppressor cell function by valproic acid enhanced anti-PD-L1 tumor immunotherapy","volume":"522","author":"Adeshakin","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellimm.2021.104286_b0045","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3389\/fimmu.2019.01399","article-title":"Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor","volume":"10","author":"Yan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0055","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3389\/fimmu.2018.02499","article-title":"Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression","volume":"9","author":"Ohl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0060","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1002\/eji.201343472","article-title":"Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK\/STAT3 pathway","volume":"43","author":"Yan","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0065","doi-asserted-by":"crossref","first-page":"e1344804","DOI":"10.1080\/2162402X.2017.1344804","article-title":"Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells","volume":"6","author":"Al-Khami","year":"2017","journal-title":"OncoImmunology"},{"key":"10.1016\/j.cellimm.2021.104286_b0070","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1158\/1538-7445.AM2018-5133","article-title":"Lipids and suppressive functions of MDSC in cancer","volume":"78","author":"Veglia","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellimm.2021.104286_b0075","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"Rohrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellimm.2021.104286_b0080","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3892\/or.2017.5864","article-title":"Exogenous lipids promote the growth of breast cancer cells via CD36","volume":"38","author":"Zhao","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellimm.2021.104286_b0085","first-page":"27","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun. (Lond)"},{"key":"10.1016\/j.cellimm.2021.104286_b0090","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.2172","article-title":"Lipid accumulation and dendritic cell dysfunction in cancer","volume":"16","author":"Herber","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0095","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1038\/s41598-017-07685-9","article-title":"Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellimm.2021.104286_b0100","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1158\/2326-6066.CIR-15-0036","article-title":"Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies","volume":"3","author":"Hossain","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cellimm.2021.104286_b0105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2021.104286_b0110","first-page":"1309","article-title":"Targeting lipid metabolism transferases DGAT1 and DGAT2 in MDSCs enhance the potential of cancer immunotherapy","volume":"49","author":"Adeshakin","year":"2019","journal-title":"Eur. J. Immunol."},{"issue":"1821","key":"10.1016\/j.cellimm.2021.104286_b0115","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbalip.2011.09.010","article-title":"Fatty acid transport proteins, implications in physiology and disease","volume":"2012","author":"Kazantzis","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"10.1016\/j.cellimm.2021.104286_b0120","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.mam.2012.07.010","article-title":"SLC27 fatty acid transport proteins","volume":"34","author":"Anderson","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0125","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1039\/C6MD00043F","article-title":"Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids","volume":"7","author":"Black","year":"2016","journal-title":"MedChemComm"},{"key":"10.1016\/j.cellimm.2021.104286_b0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-005-9034-1","article-title":"Translocation of long chain fatty acids across the plasma membrane\u2013lipid rafts and fatty acid transport proteins","volume":"284","author":"Ehehalt","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cellimm.2021.104286_b0135","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1158\/2159-8290.CD-17-1371","article-title":"Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins","volume":"8","author":"Zhang","year":"2018","journal-title":"Cancer Discovery"},{"key":"10.1016\/j.cellimm.2021.104286_b0140","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.molmet.2016.04.005","article-title":"Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation","volume":"5","author":"Johnson","year":"2016","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.cellimm.2021.104286_b0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.intimp.2017.12.003","article-title":"Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling","volume":"55","author":"Nishiyama","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellimm.2021.104286_b0150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.immuni.2010.05.010","article-title":"Tumor-induced tolerance and immune suppression depend on the C\/EBPbeta transcription factor","volume":"32","author":"Marigo","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2021.104286_b0155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.immuni.2014.08.015","article-title":"The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors","volume":"41","author":"Thevenot","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2021.104286_b0160","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910698","article-title":"Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages","volume":"11","author":"Wu","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cellimm.2021.104286_b0165","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3389\/fimmu.2018.01922","article-title":"GM-CSF quantity has a selective effect on granulocytic vs monocytic myeloid development and function","volume":"9","author":"Sun","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0170","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccr.2012.04.025","article-title":"Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer","volume":"21","author":"Bayne","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellimm.2021.104286_b0175","doi-asserted-by":"crossref","first-page":"56.19","DOI":"10.4049\/jimmunol.200.Supp.56.19","article-title":"TIPE2, an inflammation transfer switch, regulates the on-and-off immunosuppressive function of MDSCs in tumors","volume":"200","author":"Yan","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0180","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/cgt.2016.19","article-title":"Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases","volume":"23","author":"Thorn","year":"2016","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.cellimm.2021.104286_b0185","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41388-018-0449-z","article-title":"STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells","volume":"38","author":"Guha","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.cellimm.2021.104286_b0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/jmcb\/mjt009","article-title":"Polarization and reprogramming of myeloid-derived suppressor cells","volume":"5","author":"Yang","year":"2013","journal-title":"J. Mol. Cell. Biol."},{"key":"10.1016\/j.cellimm.2021.104286_b0195","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2015.09.001","article-title":"Metabolic reprogramming of immune cells in cancer progression","volume":"43","author":"Biswas","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2021.104286_b0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fimmu.2020.00131","article-title":"Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis","volume":"11","author":"Rosas-Ballina","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0205","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1189\/jlb.4MR1116-476R","article-title":"Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology","volume":"102","author":"Sica","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellimm.2021.104286_b0210","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/02841860410029708","article-title":"Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood","volume":"43","author":"Szuster-Ciesielska","year":"2004","journal-title":"Acta Oncol."},{"key":"10.1016\/j.cellimm.2021.104286_b0215","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cellimm.2021.104286_b0220","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.7150\/ijbs.41653","article-title":"Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration","volume":"16","author":"Xu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellimm.2021.104286_b0225","first-page":"4756","article-title":"Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients","volume":"61","author":"Schmielau","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellimm.2021.104286_b0230","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.4049\/jimmunol.0900092","article-title":"Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells","volume":"182","author":"Corzo","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0235","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/carcin\/bgq105","article-title":"Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung","volume":"31","author":"Satoh","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cellimm.2021.104286_b0240","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1158\/1940-6207.CAPR-14-0094","article-title":"Myeloid lineage\u2013specific deletion of antioxidant system enhances tumor metastasis","volume":"7","author":"Hiramoto","year":"2014","journal-title":"Cancer Prevent. Res."},{"key":"10.1016\/j.cellimm.2021.104286_b0245","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0250","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1158\/0008-5472.CAN-04-0465","article-title":"Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses","volume":"64","author":"Rodriguez","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellimm.2021.104286_b0255","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fimmu.2020.00938","article-title":"Myeloid Cell-Derived Arginase in Cancer Immune Response","volume":"11","author":"Grzywa","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0260","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrc3581","article-title":"History of myeloid-derived suppressor cells","volume":"13","author":"Talmadge","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellimm.2021.104286_b0265","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.it.2010.10.002","article-title":"Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function","volume":"32","author":"Condamine","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0270","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1189\/jlb.4RI0515-204R","article-title":"Transcriptional regulation of myeloid-derived suppressor cells","volume":"98","author":"Condamine","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellimm.2021.104286_b0275","doi-asserted-by":"crossref","first-page":"164.9","DOI":"10.4049\/jimmunol.204.Supp.164.9","article-title":"STAT3 induces the expression of fatty acid transport proteins (FATP2 and FATP4) to promote myeloid-derived suppressor cells function in tumor","volume":"204","author":"Adeshakin","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104286_b0280","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2567.2011.03429.x","article-title":"The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis","volume":"133","author":"Steding","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2021.104286_b0285","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4068\/cmj.2019.55.1.31","article-title":"IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment","volume":"55","author":"Choi","year":"2019","journal-title":"Chonnam. Med. J."},{"key":"10.1016\/j.cellimm.2021.104286_b0290","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1172\/JCI58814","article-title":"IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors","volume":"121","author":"Kerkar","year":"2011","journal-title":"J. Clin. Investig."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:04:38Z","timestamp":1757804678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":58,"alternative-id":["S0008874921000058"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104286","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.28.316091","asserted-by":"object"}]},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104286"}}