{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:12:25Z","timestamp":1790244745303,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.cellimm.2021.104316","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:55:38Z","timestamp":1614315338000},"page":"104316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Eosinophils increase macrophage ability to control intracellular Leishmania amazonensis infection via PGD2 paracrine activity in vitro"],"prefix":"10.1016","volume":"363","author":[{"given":"Patr\u00edcia","family":"da Silva Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M.","family":"da Fonseca-Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique Pacheco Duarte","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia R.T.","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila R. Rodrigues","family":"de P\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Canetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno L.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert L.","family":"de Matos Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne","family":"Bandeira-Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cellimm.2021.104316_b0005","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104316_b0010","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41385-020-0281-y","article-title":"The emerging roles of eosinophils in mucosal homeostasis","volume":"13","author":"Shah","year":"2020","journal-title":"Mucosal Immunol."},{"issue":"1-3","key":"10.1016\/j.cellimm.2021.104316_b0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12026-014-8536-x","article-title":"Eosinophils and mast cells in leishmaniasis","volume":"59","author":"Rodr\u00edguez","year":"2014","journal-title":"Immunol. Res."},{"issue":"12","key":"10.1016\/j.cellimm.2021.104316_b0020","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1086\/652870","article-title":"Immunopathological studies of Leishmania amazonensis infection in resistant and in susceptible mice","volume":"201","author":"de Oliveira Cardoso","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cellimm.2021.104316_b0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1089\/1044549041474805","article-title":"IL-5-Induced eosinophils suppress the growth of Leishmania amazonensis in vivo and kill promastigotes in vitro in response to either IL-4 or IFN-gamma","volume":"23","author":"Watanabe","year":"2004","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.cellimm.2021.104316_b0030","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2613.2010.00717.x","article-title":"Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis","volume":"91","author":"Guerra","year":"2010","journal-title":"Int. J. Exp. Pathol."},{"issue":"46","key":"10.1016\/j.cellimm.2021.104316_b0035","doi-asserted-by":"crossref","first-page":"eaaz4415","DOI":"10.1126\/sciimmunol.aaz4415","article-title":"M2-like, dermal macrophages are maintained via IL-4\/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis","volume":"5","author":"Lee","year":"2020","journal-title":"Sci. Immunol."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104316_b0040","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"Dyer","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104316_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02139","article-title":"Leptin elicits LTC4 synthesis by eosinophils mediated by sequential two-step autocrine activation of CCR3 and PGD2 receptors","volume":"9","author":"Amorim","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104316_b0050","doi-asserted-by":"crossref","first-page":"e0007146","DOI":"10.1371\/journal.pntd.0007146","article-title":"The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy","volume":"13","author":"Pratti","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"34","key":"10.1016\/j.cellimm.2021.104316_b0055","doi-asserted-by":"crossref","first-page":"20496","DOI":"10.1016\/S0021-9258(19)47089-0","article-title":"Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages","volume":"264","author":"Kwon","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104316_b0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/JLB.4MR0119-035R","article-title":"Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation","volume":"106","author":"Pereira\u2010Dutra","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104316_b0065","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/cells8060619","article-title":"Therapeutic potential of hematopoietic prostaglandin D2 synthase in allergic inflammation","volume":"8","author":"Rittchen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cellimm.2021.104316_b0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejps.2015.07.001","article-title":"Prostaglandin D2-loaded microspheres effectively activate macrophage effector functions","volume":"78","author":"Pereira","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104316_b0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1194\/jlr.M078162","article-title":"Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum","volume":"59","author":"Pereira","year":"2018","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104316_b0080","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1124\/jpet.108.137992","article-title":"Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2)","volume":"326","author":"Tajima","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104316_b0085","doi-asserted-by":"crossref","first-page":"e2185","DOI":"10.1371\/journal.pntd.0002185","article-title":"Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis","volume":"7","author":"Hassani","year":"2013","journal-title":"PLoS Negl Trop Dis."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:05:16Z","timestamp":1757804716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921000356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":17,"alternative-id":["S0008874921000356"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104316","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eosinophils increase macrophage ability to control intracellular Leishmania amazonensis infection via PGD2 paracrine activity in vitro","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104316"}}