{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:51:34Z","timestamp":1770821494408,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016-I2M-2-006"],"award-info":[{"award-number":["2016-I2M-2-006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017-I2M-1-015"],"award-info":[{"award-number":["2017-I2M-1-015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770183"],"award-info":[{"award-number":["81770183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970155"],"award-info":[{"award-number":["81970155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET-08-0329"],"award-info":[{"award-number":["NCET-08-0329"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences & Peking Union Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011342","name":"State Key Laboratory of Experimental Hematology","doi-asserted-by":"publisher","award":["Z20-06"],"award-info":[{"award-number":["Z20-06"]}],"id":[{"id":"10.13039\/501100011342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cellimm.2021.104377","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:06:16Z","timestamp":1620432376000},"page":"104377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["MiR-451a enhances the phagocytosis and affects both M1 and M2 polarization in macrophages"],"prefix":"10.1016","volume":"365","author":[{"given":"Xiaoli","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-3501","authenticated-orcid":false,"given":"Guoguang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2021.104377_b0005","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.3389\/fimmu.2019.02694","article-title":"Understanding the heterogeneity of resident liver macrophages","volume":"10","author":"Bleriot","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cellimm.2018.01.001","article-title":"Fetal monocytes and the origins of tissue-resident macrophages","volume":"330","author":"Hoeffel","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0015","doi-asserted-by":"crossref","first-page":"341308","DOI":"10.1155\/2015\/341308","article-title":"Current concept and update of the macrophage plasticity concept: intracellular mechanisms of reprogramming and M3 macrophage \u201cswitch\u201d phenotype","volume":"2015","author":"Malyshev","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cellimm.2021.104377_b0020","doi-asserted-by":"crossref","unstructured":"X. Lin, Z. Wen, J. Xu, Tissue-resident macrophages: from zebrafish to mouse 1 (2019) 57\u201360. https:\/\/doi.org\/10.1097\/bs9.0000000000000013.","DOI":"10.1097\/BS9.0000000000000013"},{"key":"10.1016\/j.cellimm.2021.104377_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061411","article-title":"Transcriptional, epigenetic and metabolic programming of tumor-associated macrophages","volume":"12","author":"Larionova","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.cellimm.2021.104377_b0030","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.4049\/jimmunol.1400451","article-title":"Organ-specific microenvironment modifies diverse functional and phenotypic characteristics of leukemia-associated macrophages in mouse T cell acute lymphoblastic leukemia","volume":"194","author":"Chen","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molimm.2016.11.014","article-title":"Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia","volume":"81","author":"Chen","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0040","doi-asserted-by":"crossref","unstructured":"L. Wang, G. Zheng, Macrophages in leukemia microenvironment 1 (2019) 29\u201333. https:\/\/doi.org\/10.1097\/bs9.0000000000000014.","DOI":"10.1097\/BS9.0000000000000014"},{"key":"10.1016\/j.cellimm.2021.104377_b0045","doi-asserted-by":"crossref","first-page":"e1412910","DOI":"10.1080\/2162402X.2017.1412910","article-title":"Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects","volume":"7","author":"Yang","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cellimm.2021.104377_b0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nri2708","article-title":"Physiological and pathological roles for microRNAs in the immune system","volume":"10","author":"O'Connell","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cellimm.2021.104377_b0060","first-page":"651","article-title":"Recent molecular genetic explorations of Caenorhabditis elegans microRNAs","volume":"209","author":"Ambros","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.cellimm.2021.104377_b0065","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","article-title":"MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response","volume":"46","author":"Essandoh","year":"2016","journal-title":"Shock (Augusta, Ga.)"},{"key":"10.1016\/j.cellimm.2021.104377_b0070","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3389\/fimmu.2018.01175","article-title":"Transcriptional regulation of macrophages polarization by microRNAs","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0075","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2016.71","article-title":"miR-181a induces macrophage polarized to M2 phenotype and promotes M2 macrophage-mediated tumor cell metastasis by targeting KLF6 and C\/EBPalpha","volume":"5","author":"Bi","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.cellimm.2021.104377_b0080","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0085","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3892\/ijmm.2013.1260","article-title":"Expression profiles of miRNAs in polarized macrophages","volume":"31","author":"Zhang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cellimm.2021.104377_b0090","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2021.104377_b0095","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1182\/blood-2015-01-623645","article-title":"Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation","volume":"126","author":"Cheng","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2021.104377_b0100","article-title":"Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model","author":"Wang","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellimm.2021.104377_b0105","article-title":"P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3","author":"Feng","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.cellimm.2021.104377_b0110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41419-018-0440-1","article-title":"Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-kappaB and beta-catenin\/TCF signaling pathways","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellimm.2021.104377_b0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2021.104377_b0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4049\/jimmunol.1701798","article-title":"Genome-wide posttranscriptional dysregulation by microRNAs in human asthma as revealed by Frac-seq","volume":"201","author":"Martinez-Nunez","year":"2018","journal-title":"J. Immunol. (Baltimore Md.: 1950)"},{"key":"10.1016\/j.cellimm.2021.104377_b0125","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-kappaB-microRNA regulatory network tunes macrophage inflammatory responses","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2021.104377_b0130","doi-asserted-by":"crossref","first-page":"e0181270","DOI":"10.1371\/journal.pone.0181270","article-title":"The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases","volume":"12","author":"Goto","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2021.104377_b0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2010.08.074","article-title":"MiRNA-451 plays a role as tumor suppressor in human glioma cells","volume":"1359","author":"Nan","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.cellimm.2021.104377_b0140","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s12026-017-8919-x","article-title":"miR-451 limits CD4(+) T cell proliferative responses to infection in mice","volume":"65","author":"Chapman","year":"2017","journal-title":"Immunol. Res."},{"key":"10.1016\/j.cellimm.2021.104377_b0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/neuonc\/nov244","article-title":"Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia\/macrophages in the brain","volume":"18","author":"van der Vos","year":"2016","journal-title":"Neuro-oncology"},{"key":"10.1016\/j.cellimm.2021.104377_b0150","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1158\/0008-5472.CAN-20-0034","article-title":"Monocyte-derived leukemia-associated macrophages facilitate extramedullary distribution of T-cell acute lymphoblastic leukemia cells","volume":"80","author":"Yang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellimm.2021.104377_b0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1189\/jlb.2A0914-458R","article-title":"CD13 mediates phagocytosis in human monocytic cells","volume":"98","author":"Licona-Lim\u00f3n","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellimm.2021.104377_b0160","doi-asserted-by":"crossref","first-page":"E5434","DOI":"10.1073\/pnas.1521069113","article-title":"Cd47-Sirp\u03b1 interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells","volume":"113","author":"Bian","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cellimm.2021.104377_b0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.imbio.2017.11.001","article-title":"Macrophages: their role, activation and polarization in pulmonary diseases","volume":"223","author":"Arora","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.cellimm.2021.104377_b0170","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1152\/physrev.00068.2017","article-title":"Macrophages and cardiovascular health","volume":"98","author":"Frodermann","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellimm.2021.104377_b0175","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/glia.23757","article-title":"Activated microglia desialylate their surface, stimulating complement receptor 3-mediated phagocytosis of neurons","volume":"68","author":"Allendorf","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.cellimm.2021.104377_b0180","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.3390\/ijms19123805","article-title":"Regulation of iNOS on immune cells and its role in diseases","volume":"19","author":"Xue","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellimm.2021.104377_b0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.01.021","article-title":"Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2","volume":"117","author":"Wang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellimm.2021.104377_b0190","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/375408a0","article-title":"Altered immune responses in mice lacking inducible nitric oxide synthase","volume":"375","author":"Wei","year":"1995","journal-title":"Nature"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921000964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:08:28Z","timestamp":1757804908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921000964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":38,"alternative-id":["S0008874921000964"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104377","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-451a enhances the phagocytosis and affects both M1 and M2 polarization in macrophages","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104377"}}