{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:27:26Z","timestamp":1758050846261,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013385","name":"National Science and Technology Program during the Twelfth Five-year Plan Period","doi-asserted-by":"publisher","award":["2012BAI05B02"],"award-info":[{"award-number":["2012BAI05B02"]}],"id":[{"id":"10.13039\/501100013385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670032","81770049","81870032","81971510","82071805"],"award-info":[{"award-number":["81670032","81770049","81870032","81971510","82071805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7192023"],"award-info":[{"award-number":["7192023"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901102"],"award-info":[{"award-number":["2016YFC0901102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cellimm.2021.104395","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T12:51:36Z","timestamp":1623761496000},"page":"104395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["IL-33 amplifies airways inflammation in a murine surrogate of asthma putatively via activation of dendritic cells"],"prefix":"10.1016","volume":"366","author":[{"given":"Wenjun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.","family":"Corrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2021.104395_b0005","unstructured":"Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015, Lancet Respir Med, 5 (2017) 691-706."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104395_b0010","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaip.2019.11.020","article-title":"Diagnosis and management of T2-High asthma","volume":"8","author":"Coverstone","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104395_b0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104395_b0020","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/imm.12465","article-title":"Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate","volume":"145","author":"Li","year":"2015","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.cellimm.2021.104395_b0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000442413","article-title":"Serum IL-33 Is elevated in children with asthma and is associated with disease severity","volume":"168","author":"Bahrami Mahneh","year":"2016","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.cellimm.2021.104395_b0030","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am. J. Respirat. Crit. Care Med."},{"key":"10.1016\/j.cellimm.2021.104395_b0035","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4049\/jimmunol.1701455","article-title":"Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease","volume":"200","author":"Li","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104395_b0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2021.104395_b0045","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/eji.201041033","article-title":"IL-33-activated dendritic cells are critical for allergic airway inflammation","volume":"41","author":"Besnard","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"187\u2013200","key":"10.1016\/j.cellimm.2021.104395_b0050","first-page":"e181","article-title":"IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization","volume":"131","author":"Chu","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104395_b0055","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/resp.13711","article-title":"Combined blockade of IL-25, IL-33 and TSLP mediates amplified inhibition of airway inflammation and remodelling in a murine model of asthma","volume":"25","author":"An","year":"2020","journal-title":"Respirology"},{"key":"10.1016\/j.cellimm.2021.104395_b0060","doi-asserted-by":"crossref","unstructured":"D.K. Chu, A. Llop-Guevara, T.D. Walker, K. Flader, S. Goncharova, J.E. Boudreau, C.L. Moore, T. Seunghyun In, S. Waserman, A.J. Coyle, R. Kolbeck, A.A. Humbles, M. Jordana, IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization, J Allergy Clin Immunol, 131 (2013) 187-200.e181-188.","DOI":"10.1016\/j.jaci.2012.08.002"},{"key":"10.1016\/j.cellimm.2021.104395_b0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2011.01.024","article-title":"M(3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice","volume":"655","author":"Cao","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellimm.2021.104395_b0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cellimm.2021.104395_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1756-8722-4-52","article-title":"Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines","volume":"4","author":"Wudtiwai","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellimm.2021.104395_b0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12543","article-title":"Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma","volume":"278","author":"Hansbro","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cellimm.2021.104395_b0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.iac.2016.03.006","article-title":"Eosinophilic endotype of asthma","volume":"36","author":"Aleman","year":"2016","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"10.1016\/j.cellimm.2021.104395_b0090","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellimm.2021.104395_b0095","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3389\/fphys.2019.01514","article-title":"Interleukin-5 in the pathophysiology of severe asthma","volume":"10","author":"Pelaia","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellimm.2021.104395_b0100","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellimm.2021.104395_b0105","first-page":"281","article-title":"CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines","volume":"80","author":"Hartnell","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2021.104395_b0110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1084\/jem.20170449","article-title":"IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow","volume":"215","author":"Stier","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2021.104395_b0115","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1038\/nrdp.2015.25","article-title":"Asthma","volume":"1","author":"Holgate","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"5","key":"10.1016\/j.cellimm.2021.104395_b0120","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/mi.2012.130","article-title":"Potential autocrine regulation of interleukin-33\/ST2 signaling of dendritic cells in allergic inflammation","volume":"6","author":"Su","year":"2013","journal-title":"Mucosal Immunol."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104395_b0125","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.02.026","article-title":"IL-33-activated dendritic cells induce an atypical TH2-type response","volume":"123","author":"Rank","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cellimm.2021.104395_b0130","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaci.2016.05.031","article-title":"Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells","volume":"139","author":"Kannan","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cellimm.2021.104395_b0135","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids\u2013new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellimm.2021.104395_b0140","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-2007-980195","article-title":"Effects of dexamethasone on rat dendritic cell function","volume":"39","author":"Butts","year":"2007","journal-title":"Hormone Metab. Res."},{"key":"10.1016\/j.cellimm.2021.104395_b0145","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1182\/blood-2012-05-432336","article-title":"Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans","volume":"121","author":"Cao","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2021.104395_b0150","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1189\/jlb.3A0316-125R","article-title":"Dexamethasone rapidly suppresses IL-33-stimulated mast cell function by blocking transcription factor activity","volume":"100","author":"Paranjape","year":"2016","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.cellimm.2021.104395_b0155","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jaci.2017.07.051","article-title":"Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity","volume":"141","author":"Werder","year":"2018","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:06:46Z","timestamp":1757804806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921001143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":31,"alternative-id":["S0008874921001143"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104395","relation":{},"ISSN":["0008-8749"],"issn-type":[{"type":"print","value":"0008-8749"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-33 amplifies airways inflammation in a murine surrogate of asthma putatively via activation of dendritic cells","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104395"}}