{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:28:17Z","timestamp":1791872897196,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["REDE-00140\u201316"],"award-info":[{"award-number":["REDE-00140\u201316"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014226","name":"William Harvey Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305894\/2018\u20138"],"award-info":[{"award-number":["305894\/2018\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312474\/2017\u20132"],"award-info":[{"award-number":["312474\/2017\u20132"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.cellimm.2021.104427","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T09:28:38Z","timestamp":1630229318000},"page":"104427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease"],"prefix":"10.1016","volume":"369","author":[{"given":"Rafaela","family":"das Dores Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayane Aparecida Nonato","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Gaio","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allysson","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via Machado","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jader Santos","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiliam C\u00e9sar Bento","family":"R\u00e9gis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Perretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Sim\u00e3o","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2021.104427_b0005","unstructured":"World Health Organization (WHO): Chagas disease (American trypanosomiasis), 2020."},{"issue":"12","key":"10.1016\/j.cellimm.2021.104427_b0010","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1586\/14779072.2015.1103648","article-title":"Developments in the management of Chagas cardiomyopathy","volume":"13","author":"Tanowitz","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104427_b0015","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00281-012-0351-7","article-title":"Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease","volume":"34","author":"Machado","year":"2012","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-020117-043711","article-title":"Pathology and Pathogenesis of Chagas Heart Disease","volume":"14","author":"Bonney","year":"2019","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"issue":"11","key":"10.1016\/j.cellimm.2021.104427_b0025","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.pt.2016.08.009","article-title":"Putting Infection Dynamics at the Heart of Chagas Disease","volume":"32","author":"Lewis","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cellimm.2021.104427_b0030","doi-asserted-by":"crossref","unstructured":"A.W. Ashton, S. Mukherjee, F.N.U. Nagajyothi, H. Huang, V.L. Braunstein, M.S. Desruisseaux, S.M. Factor, L. Lopez, J.W. Berman, M. Wittner, P.E. Scherer, V. Capra, T.M. Coffman, C.N. Serhan, K. Gotlinger, K.K. Wu, L.M. Weiss, H.B. Tanowitz, Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection, J. Exp. Med. (2007). https:\/\/doi.org\/10.1084\/jem.20062432.","DOI":"10.1084\/jem.20062432"},{"key":"10.1016\/j.cellimm.2021.104427_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/568408","article-title":"Lipid mediators are critical in resolving inflammation: A review of the emerging roles of eicosanoids in diabetes mellitus","volume":"2015","author":"Tessaro","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cellimm.2021.104427_b0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2015.03.083","article-title":"Lipoxins and aspirin-triggered lipoxins in resolution of inflammation","volume":"760","author":"Romano","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104427_b0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nm1355","article-title":"Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent","volume":"12","author":"Machado","year":"2006","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0050","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ajpath.2012.03.042","article-title":"Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease","volume":"181","author":"Esper","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.cellimm.2021.104427_b0055","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/IAI.00575-16","article-title":"The aryl hydrocarbon receptor modulates production of cytokines and reactive oxygen species and development of myocarditis during Trypanosoma cruzi infection","volume":"84","author":"Barroso","year":"2016","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104427_b0060","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1074\/jbc.M113.509216","article-title":"Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands","volume":"289","author":"He","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104427_b0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/pr.109.001578","article-title":"International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family","volume":"61","author":"Ye","year":"2009","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104427_b0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/jm501051x","article-title":"FPR2\/ALXR agonists and the resolution of inflammation","volume":"58","author":"Corminboeuf","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cellimm.2021.104427_b0075","doi-asserted-by":"crossref","unstructured":"R. He, H. Sang, R.D. Ye, Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1\/LXA4R, Blood. (2003). https:\/\/doi.org\/10.1182\/blood-2002-05-1431.","DOI":"10.1182\/blood-2002-05-1431"},{"key":"10.1016\/j.cellimm.2021.104427_b0080","unstructured":"H. V.V., C. S., D.S. R., R. E., A. J., FPR2\/ALX activation reverses LPS-induced vascular hyporeactivity in aorta and increases survival in a pneumosepsis model, Eur. J. Pharmacol. (2015)."},{"key":"10.1016\/j.cellimm.2021.104427_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.3A1016-435RRR","article-title":"Therapeutic effect of Lipoxin A 4 in malaria-induced acute lung injury","author":"P\u00e1dua","year":"2018","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"issue":"8-9","key":"10.1016\/j.cellimm.2021.104427_b0095","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.micinf.2010.03.016","article-title":"5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection","volume":"12","author":"Pavanelli","year":"2010","journal-title":"Microbes Infect."},{"issue":"12","key":"10.1016\/j.cellimm.2021.104427_b0100","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1590\/s0100-736x2016001200011","article-title":"Computerized electrocardiography in healthy conscious guinea pigs (Cavia porcellus)","volume":"36","author":"Botelho","year":"2016","journal-title":"Pesqui. Vet. Bras."},{"issue":"9","key":"10.1016\/j.cellimm.2021.104427_b0105","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm748","article-title":"Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4","volume":"8","author":"Levy","year":"2002","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104427_b0110","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.cytogfr.2006.09.009","article-title":"Formyl peptide receptors: A promiscuous subfamily of G protein-coupled receptors controlling immune responses","volume":"17","author":"Migeotte","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104427_b0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.biopha.2007.02.016","article-title":"Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells","volume":"61","author":"Bonnans","year":"2007","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104427_b0120","doi-asserted-by":"crossref","first-page":"C178","DOI":"10.1152\/ajpcell.00284.2013","article-title":"ALX\/FPR2 receptor for RvD1 is expressed and functional in salivary glands","volume":"306","author":"Nelson","year":"2014","journal-title":"Am. J. Physiol. - Cell Physiol."},{"key":"10.1016\/j.cellimm.2021.104427_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00212","article-title":"Anatomy of a discovery: M1 and M2 macrophages","author":"Mills","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2021.104427_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108713","article-title":"Tityus serrulatus scorpion venom as a potential drug source for Chagas\u2019 disease : Trypanocidal and immunomodulatory activity","author":"Pimentel","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cellimm.2021.104427_b0135","doi-asserted-by":"crossref","unstructured":"M.A. Raj\u00e3o, D.G. Passos-Silva, W.D. DaRocha, G.R. Franco, A.M. Macedo, S.D.J. Pena, S.M. Teixeira, C.R. Machado, DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediate, Mol. Microbiol. (2009). https:\/\/doi.org\/10.1111\/j.1365-2958.2008.06521.x.","DOI":"10.1111\/j.1365-2958.2008.06521.x"},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0140","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0169-4758(98)01362-3","article-title":"How do protozoan parasites survive inside macrophages?","volume":"15","author":"Bogdan","year":"1999","journal-title":"Parasitol. Today."},{"issue":"02","key":"10.1016\/j.cellimm.2021.104427_b0145","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000317","article-title":"Macrophage Polarization in Chagas Disease","volume":"06","author":"Zanluqui","year":"2015","journal-title":"J. Clin. Cell. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10441-8","article-title":"Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing","volume":"7","author":"Kain","year":"2017","journal-title":"Sci. Rep."},{"issue":"52","key":"10.1016\/j.cellimm.2021.104427_b0155","doi-asserted-by":"crossref","first-page":"E8415","DOI":"10.1073\/pnas.1611944114","article-title":"Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy","volume":"113","author":"Nadkarni","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104427_b0160","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/expr.1996.0109","article-title":"Trypanosoma cruzi: IL-10, TNF, IFN-\u03b3 and IL-12 regulate innate and acquired immunity to infection","volume":"84","author":"Abrahamsohn","year":"1996","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cellimm.2021.104427_b0165","doi-asserted-by":"crossref","unstructured":"N. de S. Pereira, T.B.D. Queiroga, D.F. Nunes, C. de M. Andrade, M.S.L. Nascimento, M.A. Do-Valle-Matta, A.C.J. da C\u00e2mara, L.M. da C. Galv\u00e3o, P.M.M. Guedes, E. Chiari, Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients, PLoS Negl. Trop. Dis. (2018). https:\/\/doi.org\/10.1371\/journal.pntd.0006589.","DOI":"10.1371\/journal.pntd.0006589"},{"key":"10.1016\/j.cellimm.2021.104427_b0170","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.144.2.717","article-title":"Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi","author":"Tarleton","year":"1990","journal-title":"J. Immunol."},{"issue":"6367","key":"10.1016\/j.cellimm.2021.104427_b0175","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/356338a0","article-title":"Susceptibility of \u03b22-microglobulin-deficient mice to Trypanosoma cruzi infection","volume":"356","author":"Tarleton","year":"1992","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0180","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.0105-2896.2004.00183.x","article-title":"Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection","volume":"201","author":"Martin","year":"2004","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0185","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2334-12-123","article-title":"Blood leukocytes from benznidazole-treated indeterminate chagas disease patients display an overall type-1-modulated cytokine profile upon short-term in vitro stimulation with trypanosoma cruzi antigens","volume":"12","author":"Sathler-Avelar","year":"2012","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0190","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1365-3083.1997.d01-362.x","article-title":"Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection","volume":"45","author":"Dutra","year":"1997","journal-title":"Scand. J. Immunol."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104427_b0195","doi-asserted-by":"crossref","first-page":"e1630","DOI":"10.1371\/journal.pntd.0001630","article-title":"Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas\u2019 disease, PLoS Negl","volume":"6","author":"Guedes","year":"2012","journal-title":"Trop. Dis."},{"issue":"10","key":"10.1016\/j.cellimm.2021.104427_b0200","doi-asserted-by":"crossref","first-page":"e1005902","DOI":"10.1371\/journal.ppat.1005902","article-title":"Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi","volume":"12","author":"Cai","year":"2016","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104427_b0205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0002-9440(10)62976-8","article-title":"Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas\u2019 disease cardiomyopathy","volume":"167","author":"Cunha-Neto","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104427_b0210","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-3083.2005.01668.x","article-title":"Chagasic patients with indeterminate clinical form of the disease have high frequencies of circulating CD3 +CD16 -CD56 + natural killer T cells and CD4 +CD25 High regulatory T lymphocytes","volume":"62","author":"Vitelli-Avelar","year":"2005","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104427_b0215","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2249.2006.03123.x","article-title":"Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas\u2019 disease morbidity?","volume":"145","author":"Vitelli-Avelar","year":"2006","journal-title":"Clin. Exp. Immunol."},{"issue":"7","key":"10.1016\/j.cellimm.2021.104427_b0220","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.micinf.2008.04.009","article-title":"The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection","volume":"10","author":"Mariano","year":"2008","journal-title":"Microbes Infect."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104427_b0225","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.micinf.2008.03.008","article-title":"The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi","volume":"10","author":"Sales-Junior","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cellimm.2021.104427_b0230","article-title":"Clinical management of chronic Chagas cardiomyopathy","author":"Rocha","year":"2003","journal-title":"Front. Biosci."},{"issue":"9723","key":"10.1016\/j.cellimm.2021.104427_b0235","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet."},{"issue":"10","key":"10.1016\/j.cellimm.2021.104427_b0240","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2012.109","article-title":"Diagnosis and management of Chagas disease and cardiomyopathy","volume":"9","author":"Ribeiro","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cellimm.2021.104427_b0245","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000539","article-title":"Pathogenesis of Chagas cardiomyopathy: Role of inflammation and oxidative stress","author":"Machado","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104427_b0250","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2217\/nnm.14.185","article-title":"Nanomedicines against Chagas disease: An update on therapeutics, prophylaxis and diagnosis","volume":"10","author":"Morilla","year":"2015","journal-title":"Nanomedicine."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104427_b0255","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1128\/IAI.71.3.1185-1193.2003","article-title":"Evidence that development of severe cardiomyopathy in human Chagas\u2019 disease is due to a Th1-specific immune response","volume":"71","author":"Gomes","year":"2003","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104427_b0260","doi-asserted-by":"crossref","first-page":"165706","DOI":"10.1016\/j.bbadis.2020.165706","article-title":"Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans","volume":"1866","author":"Amezcua Vesely","year":"2020","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104427_b0265","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/CIRCEP.109.859108","article-title":"Predicting ventricular arrhythmias in patients with ischemic heart disease: Clinical application of the ECG-derived QRS-T angle","volume":"2","author":"Borleffs","year":"2009","journal-title":"Circ. Arrhythmia Electrophysiol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T18:23:33Z","timestamp":1762107813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921001465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":53,"alternative-id":["S0008874921001465"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104427","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104427"}}