{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:58:27Z","timestamp":1785319107636,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002613","name":"Ulsan National Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009826","name":"Harvey L. Neiman Health Policy Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"publisher","award":["465771\/2014-9"],"award-info":[{"award-number":["465771\/2014-9"]}],"id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"Instituto Nacional de Ci\u00eancia e Tecnologia para Excitotoxicidade e Neuroprote\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016193","name":"University of Colorado School of Medicine, Anschutz Medical Campus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.cellimm.2021.104449","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T20:46:46Z","timestamp":1636490806000},"page":"104449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Protective immune response mediated by neutrophils in experimental visceral leishmaniasis is enhanced by IL-32\u03b3"],"prefix":"10.1016","volume":"371","author":[{"given":"Rodrigo Saar","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel Vilela Teodoro","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Adriano Pelli","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Ribeiro-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0005","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cellimm.2021.104449_b0010","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0240-2019","article-title":"Risk mapping of visceral leishmaniasis in Brazil","volume":"52","author":"de Azevedo","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"9496","key":"10.1016\/j.cellimm.2021.104449_b0015","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.cellimm.2021.104449_b0020","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host-pathogen interface","volume":"9","author":"Kaye","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cellimm.2021.104449_b0025","doi-asserted-by":"crossref","unstructured":"H. Goto, M. das G. Prianti, Immunoactivation and immunopathogeny during active visceral leishmaniasis., Rev. Inst. Med. Trop. Sao Paulo. 51 (n.d.) 241\u20136.","DOI":"10.1590\/S0036-46652009000500002"},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0030","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.clim.2005.06.015","article-title":"T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani","volume":"117","author":"Hailu","year":"2005","journal-title":"Clin. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4049\/jimmunol.167.2.893","article-title":"Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi","volume":"167","author":"Gantt","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104449_b0040","doi-asserted-by":"crossref","unstructured":"N.C. Peters, J.G. Egen, N. Secundino, A. Debrabant, N. Kimblin, S. Kamhawi, P. Lawyer, M.P. Fay, R.N. Germain, D. Sacks, In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies, Science (80-.). 321 (2008) 970\u2013974. doi:10.1126\/science.1159194.","DOI":"10.1126\/science.1159194"},{"key":"10.1016\/j.cellimm.2021.104449_b0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fcimb.2012.00059","article-title":"The influence of early neutrophil-Leishmania interactions on the host immune response to infection","volume":"2","author":"Ribeiro-Gomes","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104449_b0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pt.2009.01.001","article-title":"Leishmania commandeers the host inflammatory response through neutrophils","volume":"25","author":"Jochim","year":"2009","journal-title":"Trends Parasitol."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0055","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/IAI.01388-07","article-title":"Neutrophils Contribute to Development of a Protective Immune Response during Onset of Infection with Leishmania donovani","volume":"76","author":"McFarlane","year":"2008","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0060","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0966-842X(03)00075-1","article-title":"Neutrophil granulocytes - Trojan horses for Leishmania major and other intracellular microbes?","volume":"11","author":"Laskay","year":"2003","journal-title":"Trends Microbiol."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0065","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.pt.2016.02.003","article-title":"Different Leishmania Species Drive Distinct Neutrophil Functions","volume":"32","author":"Hurrell","year":"2016","journal-title":"Trends Parasitol."},{"issue":"16","key":"10.1016\/j.cellimm.2021.104449_b0070","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimaraes-Costa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0075","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-019-3530-8","article-title":"Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection","volume":"12","author":"Wei","year":"2019","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0080","doi-asserted-by":"crossref","DOI":"10.1038\/srep18302","article-title":"Classical ROS-dependent and early\/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites","volume":"5","author":"Rochael","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-017-2222-5","article-title":"Molecular signatures of neutrophil extracellular traps in human visceral leishmaniasis","volume":"10","author":"Gardinassi","year":"2017","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.4049\/jimmunol.1700899","article-title":"NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis","volume":"200","author":"Carneiro","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0095","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-016-1472-y","article-title":"Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection","volume":"9","author":"Roma","year":"2016","journal-title":"Parasites Vectors"},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2016.04.003","article-title":"Neutrophil-derived chemokines on the road to immunity","volume":"28","author":"Tecchio","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cellimm.2021.104449_b0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cimid.2015.03.003","article-title":"New insights into neutrophil and Leishmania infantum in vitro immune interactions","volume":"40","author":"Marques","year":"2015","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.cellimm.2021.104449_b0110","doi-asserted-by":"crossref","unstructured":"S. da C. Gon\u00e7alves-de-Albuquerque, R. Pessoa-e-Silva, L.A.M. Trajano-Silva, T.C. de Goes, R.C.S. de Morais, C.N. da C. Oliveira, V.M.B. de Lorena, M. de Paiva-Cavalcanti, The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis, Front. Immunol. 8 (2017) 1437. doi:10.3389\/fimmu.2017.01437.","DOI":"10.3389\/fimmu.2017.01437"},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/cei.12674","article-title":"Permissive and protective roles for neutrophils in leishmaniasis","volume":"182","author":"Carlsen","year":"2015","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.cellimm.2021.104449_b0120","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1590\/S0037-86822010000400010","article-title":"Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study","volume":"43","author":"Costa","year":"2010","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/IAI.00338-10","article-title":"Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan leishmania infantum chagasi","volume":"79","author":"Thalhofer","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellimm.2021.104449_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-1-17","article-title":"In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection","volume":"1","author":"Rousseau","year":"2001","journal-title":"BMC Microbiol."},{"issue":"7","key":"10.1016\/j.cellimm.2021.104449_b0135","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.4049\/jimmunol.164.7.3681","article-title":"B Cell-Deficient Mice Are Highly Resistant to Leishmania donovani Infection, but Develop Neutrophil-Mediated Tissue Pathology","volume":"164","author":"Smelt","year":"2000","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104449_b0140","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1096\/fj.15-277202","article-title":"IL-17A promotes susceptibility during experimental visceral leishmaniasis caused by Leishmania donovani","volume":"30","author":"Terrazas","year":"2016","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.cellimm.2021.104449_b0145","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1128\/IAI.00283-16","article-title":"Interleukin-27 (IL-27) mediates susceptibility to visceral leishmaniasis by suppressing the IL-17-neutrophil response","volume":"84","author":"Quirino","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellimm.2021.104449_b0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17 cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00796-17","article-title":"Human interleukin-32\u03b3 plays a protective role in an experimental model of visceral leishmaniasis in mice","volume":"86","author":"Gomes","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellimm.2021.104449_b0160","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.biochi.2014.01.013","article-title":"Interaction network mapping among IL-32 isoforms","volume":"101","author":"Kang","year":"2014","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1189\/jlb.4RU0416-175RR","article-title":"Interleukin 32: A novel player in the control of infectious diseases","volume":"101","author":"Ribeiro-Dias","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0170","first-page":"131","article-title":"Interleukin-32: A cytokine and inducer of TNF\u03b1","volume":"22","author":"Kim","year":"2005","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.cellimm.2021.104449_b0175","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1073\/pnas.0511233103","article-title":"IL-32, a proinflammatory cytokine in rheumatoid arthritis","volume":"103","author":"Joosten","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellimm.2021.104449_b0180","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.4049\/jimmunol.1003996","article-title":"IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production","volume":"186","author":"Jung","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104449_b0185","doi-asserted-by":"crossref","first-page":"21082","DOI":"10.1073\/pnas.1015418107","article-title":"Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis","volume":"107","author":"Choi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104449_b0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/S0074-02762004000300009","article-title":"Leishmania braziliensis: Partial control of experimental infection by interleukin-12 p40 deficient mice","volume":"99","author":"Souza-Neto","year":"2004","journal-title":"Mem. Inst. Oswaldo Cruz."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0195","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/pim.12078","article-title":"Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB\/c mice","volume":"36","author":"Sousa","year":"2014","journal-title":"Parasite Immunol."},{"issue":"9","key":"10.1016\/j.cellimm.2021.104449_b0200","doi-asserted-by":"crossref","first-page":"e1005852","DOI":"10.1371\/journal.ppat.1005852","article-title":"Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A","volume":"12","author":"Hartley","year":"2016","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.cellimm.2021.104449_b0205","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature09978","article-title":"Digoxin and its derivatives suppress T H17 cell differentiation by antagonizing ROR\u03b33t activity","volume":"472","author":"Huh","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cellimm.2021.104449_b0210","doi-asserted-by":"crossref","first-page":"e0003601","DOI":"10.1371\/journal.pntd.0003601","article-title":"Exposure to Leishmania braziliensis Triggers Neutrophil Activation and Apoptosis","volume":"9","author":"Falc\u00e3o","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0215","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2334-5-39","article-title":"A sensitive flow cytometric methodology for studying the binding of L. chagasi to canine peritoneal macrophages","volume":"5","author":"Gon\u00e7alves","year":"2005","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cellimm.2021.104449_b0220","first-page":"511","article-title":"Monoclonal antibodies that recognize distinct epitopes of the macrophage type three complement receptor differ in their ability to inhibit binding of Leishmania promastigotes harvested at different phases of their growth cycle","volume":"65","author":"Cooper","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2021.104449_b0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"M. T","year":"1983","journal-title":"J. Immunol. Methods."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0230","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(82)90185-3","article-title":"Quantitative determination of myeloperoxidase using tetramethylbenzidine as substrate","volume":"127","author":"Andrews","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cellimm.2021.104449_b0235","doi-asserted-by":"crossref","unstructured":"D.B. Kuhns D.A.L. Priel J. Chu K.A. Zarember . in: Curr. Protoc. Immunol., Isolation and Functional Analysis of Human Neutrophils 2015 John Wiley & Sons Inc Hoboken, NJ, USA pp. 7.23.1-7.23.16. 10.1002\/0471142735.im0723s111.","DOI":"10.1002\/0471142735.im0723s111"},{"issue":"4","key":"10.1016\/j.cellimm.2021.104449_b0240","doi-asserted-by":"crossref","first-page":"e0004609","DOI":"10.1371\/journal.pntd.0004609","article-title":"Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major","volume":"10","author":"Ricci-Azevedo","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104449_b0245","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0250","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.4049\/jimmunol.165.5.2628","article-title":"An Immunomodulatory Function for Neutrophils During the Induction of a CD4 + Th2 Response in BALB\/c Mice Infected with Leishmania major","volume":"165","author":"Tacchini-Cottier","year":"2000","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.cellimm.2021.104449_b0255","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/eji.200940115","article-title":"Human mucosal leishmaniasis: Neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines","volume":"40","author":"Boaventura","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0260","doi-asserted-by":"crossref","first-page":"e1004929","DOI":"10.1371\/journal.ppat.1004929","article-title":"Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion","volume":"11","author":"Hurrell","year":"2015","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.cellimm.2021.104449_b0265","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/IAI.00975-15","article-title":"Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection","volume":"83","author":"Sacramento","year":"2015","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0270","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ajpath.2011.03.009","article-title":"Compartment-specific remodeling of splenic micro-architecture during experimental visceral leishmaniasis","volume":"179","author":"Yurdakul","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0275","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.4049\/jimmunol.0713598","article-title":"IL-17 Promotes Progression of Cutaneous Leishmaniasis in Susceptible Mice","volume":"182","author":"Lopez Kostka","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2021.104449_b0280","first-page":"2379","article-title":"IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0285","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1590\/S0074-02762011000500010","article-title":"Analysis of the expression of toll-like receptors 2 and 4 and cytokine production during experimental leishmania chagasi infection","volume":"106","author":"Cez\u00e1rio","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0290","doi-asserted-by":"crossref","first-page":"e0005413","DOI":"10.1371\/journal.pntd.0005413","article-title":"Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species","volume":"11","author":"dos Santos","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.cellimm.2021.104449_b0295","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2334-14-249","article-title":"Interleukin 32\u03b3 (IL-32\u03b3) is highly expressed in cutaneous and mucosal lesions of American Tegumentary Leishmaniasis patients: association with tumor necrosis factor (TNF) and IL-10","volume":"14","author":"Galdino","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cellimm.2021.104449_b0300","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13071-017-2268-4","article-title":"IL-32\u03b3 promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis, Parasit","volume":"10","author":"Gomes","year":"2017","journal-title":"Vectors."},{"key":"10.1016\/j.cellimm.2021.104449_b0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008029","article-title":"Genetic variation in interleukin-32 influence the immune response against new world leishmania species and susceptibility to american tegumentary leishmaniasis, PLoS Negl","volume":"14","author":"Dos Santos","year":"2020","journal-title":"Trop. Dis."},{"key":"10.1016\/j.cellimm.2021.104449_b0310","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00262","article-title":"Toll-like receptor 2 is required for inflammatory process development during Leishmania infantum infection","volume":"8","author":"Sacramento","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cellimm.2021.104449_b0315","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cellimm.2018.11.003","article-title":"Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites","volume":"335","author":"Val\u00e9rio-Bolas","year":"2019","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.cellimm.2021.104449_b0320","doi-asserted-by":"crossref","DOI":"10.4172\/2329-9541.1000146","article-title":"Infection and Activation of Human Neutrophils with Fluorescent Leishmania infantum","volume":"5","author":"RE","year":"2016","journal-title":"J. Immunol. Tech. Infect. Dis."},{"issue":"5","key":"10.1016\/j.cellimm.2021.104449_b0325","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1189\/jlb.4HI0417-158R","article-title":"Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils","volume":"102","author":"Hurrell","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0330","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1128\/IAI.70.2.826-835.2002","article-title":"Intracellular survival of Leishmania major in neutrophil granulocytes after uptake in the absence of heat-labile serum factors","volume":"70","author":"Laufs","year":"2002","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.cellimm.2021.104449_b0335","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pt.2012.05.002","article-title":"Receptor-mediated phagocytosis of Leishmania: Implications for intracellular survival","volume":"28","author":"Ueno","year":"2012","journal-title":"Trends Parasitol."},{"issue":"6","key":"10.1016\/j.cellimm.2021.104449_b0340","doi-asserted-by":"crossref","first-page":"R259","DOI":"10.1186\/ar4104","article-title":"Interleukin-32-induced thymic stromal lymphopoietin plays a critical role in macrophage differentiation through the activation of caspase-1 in vitro","volume":"14","author":"Jeong","year":"2012","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.cellimm.2021.104449_b0345","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1189\/jlb.0108018","article-title":"Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis","volume":"84","author":"Afonso","year":"2008","journal-title":"J. Leukoc. Biol."},{"issue":"10","key":"10.1016\/j.cellimm.2021.104449_b0350","doi-asserted-by":"crossref","first-page":"e109256","DOI":"10.1371\/journal.pone.0109256","article-title":"IL-32\u03b3 Delays Spontaneous Apoptosis of Human Neutrophils through MCL-1, Regulated Primarily by the p38 MAPK Pathway","volume":"9","author":"Allaeys","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cellimm.2021.104449_b0355","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1039\/c3an01076g","article-title":"The role of p38 MAPK in neutrophil functions: Single cell chemotaxis and surface marker expression","volume":"138","author":"Kim","year":"2013","journal-title":"Analyst."},{"issue":"9","key":"10.1016\/j.cellimm.2021.104449_b0360","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.mad.2009.07.001","article-title":"Role PKA and p38 MAPK on ROS production in neutrophil age-related: Lack of IL-10 effect in older subjects","volume":"130","author":"Chaves","year":"2009","journal-title":"Mech. Ageing Dev."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874921001684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:08:00Z","timestamp":1757804880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874921001684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":72,"alternative-id":["S0008874921001684"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104449","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective immune response mediated by neutrophils in experimental visceral leishmaniasis is enhanced by IL-32\u03b3","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2021.104449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104449"}}