{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:25:42Z","timestamp":1776979542241,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770565"],"award-info":[{"award-number":["81770565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2012ZX10002003"],"award-info":[{"award-number":["2012ZX10002003"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.cellimm.2022.104575","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T23:26:01Z","timestamp":1656026761000},"page":"104575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver"],"prefix":"10.1016","volume":"378","author":[{"given":"Jingshu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangkang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangfeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2022.104575_b0005","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s00535-011-0421-y","article-title":"Present status of autoimmune hepatitis in Japan: a nationwide survey","volume":"46","author":"Abe","year":"2011","journal-title":"Journal of gastroenterology"},{"key":"10.1016\/j.cellimm.2022.104575_b0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00365529850166284","article-title":"Incidence and Prevalence of Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Hepatitis in a Norwegian Population","volume":"33","author":"Boberg","year":"1998","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.cellimm.2022.104575_b0015","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1046\/j.1440-1746.2003.03165.x","article-title":"Epidemiology of autoimmune liver disease","volume":"18","author":"Feld","year":"2003","journal-title":"Journal of gastroenterology and hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0020","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1111\/j.1440-1746.2010.06384.x","article-title":"Population-based epidemiology study of autoimmune hepatitis: a disease of older women?","volume":"25","author":"Ngu","year":"2010","journal-title":"Journal of gastroenterology and hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/jhep.2002.30991","article-title":"Current and novel immunosuppressive therapy for autoimmune hepatitis","volume":"35","author":"Heneghan","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0030","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJM199510123331502","article-title":"Azathioprine for long-term maintenance of remission in autoimmune hepatitis","volume":"333","author":"Johnson","year":"1995","journal-title":"The New England journal of medicine"},{"key":"10.1016\/j.cellimm.2022.104575_b0035","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.1840080414","article-title":"Maintenance of remission in autoimmune chronic active hepatitis with azathioprine after corticosteroid withdrawal","volume":"8","author":"Stellon","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0040","first-page":"237","article-title":"The use of concanavalin A to study the immunoregulation of human T cells","volume":"46","author":"Dwyer","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cellimm.2022.104575_b0045","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"The Journal of clinical investigation"},{"key":"10.1016\/j.cellimm.2022.104575_b0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3748\/wjg.v18.i2.119","article-title":"Immune mechanisms of Concanavalin A model of autoimmune hepatitis","volume":"18","author":"Wang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cellimm.2022.104575_b0055","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jhep.2007.06.022","article-title":"Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury","volume":"47","author":"Knight","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.cellimm.2022.104575_b0060","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"K\u00fcsters","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellimm.2022.104575_b0065","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"issue":"1990","key":"10.1016\/j.cellimm.2022.104575_b0070","first-page":"2920","article-title":"The role of IFN-gamma in the pathology of experimental endotoxemia, Journal of immunology (Baltimore","volume":"145","author":"Heinzel","year":"1950","journal-title":"Md."},{"key":"10.1016\/j.cellimm.2022.104575_b0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/excr.1996.0351","article-title":"T cell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release","volume":"229","author":"Gantner","year":"1996","journal-title":"Experimental cell research"},{"key":"10.1016\/j.cellimm.2022.104575_b0080","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/hep.20865","article-title":"CCR5 deficiency exacerbates T-cell\u2013mediated hepatitis in mice","volume":"42","author":"Moreno","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/cs1040047","article-title":"Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles","volume":"104","author":"Simpson","year":"2002","journal-title":"Clinical Science"},{"key":"10.1016\/j.cellimm.2022.104575_b0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2010.158","article-title":"CXCR3 ligands: redundant, collaborative and antagonistic functions","volume":"89","author":"Groom","year":"2011","journal-title":"Immunology and cell biology"},{"key":"10.1016\/j.cellimm.2022.104575_b0095","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.4049\/jimmunol.169.4.2026","article-title":"Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells","volume":"169","author":"Tsuboi","year":"2002","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0100","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2567.2004.01898.x","article-title":"Toll-like receptor (TLR) expression and TLR-mediated cytokine\/chemokine production by human uterine epithelial cells","volume":"112","author":"Schaefer","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0105","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI28349","article-title":"Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling","volume":"116","author":"Lang","year":"2006","journal-title":"The Journal of clinical investigation"},{"key":"10.1016\/j.cellimm.2022.104575_b0110","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(12)62163-1","article-title":"Autoimmune hepatitis","volume":"382","author":"Heneghan","year":"2013","journal-title":"The Lancet"},{"key":"10.1016\/j.cellimm.2022.104575_b0115","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2015.03.005","article-title":"Autoimmune hepatitis\u2013Update 2015","volume":"62","author":"Manns","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.cellimm.2022.104575_b0120","doi-asserted-by":"crossref","first-page":"9257","DOI":"10.3748\/wjg.v22.i42.9257","article-title":"Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis","volume":"22","author":"Czaja","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cellimm.2022.104575_b0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cellimm.2018.03.003","article-title":"High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier","volume":"328","author":"Hu","year":"2018","journal-title":"Cell Immunol"},{"key":"10.1016\/j.cellimm.2022.104575_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2017.08.005","article-title":"Sodium butyrate ameliorates S100\/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor signaling pathway","volume":"190","author":"Wu","year":"2017","journal-title":"Immunology Letters"},{"key":"10.1016\/j.cellimm.2022.104575_b0140","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1128\/AAC.48.7.2604-2609.2004","article-title":"Absorption of ester prodrugs in Caco-2 and rat intestine models","volume":"48","author":"He","year":"2004","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"10.1016\/j.cellimm.2022.104575_b0145","doi-asserted-by":"crossref","unstructured":"A. Subramanian, P. Tamayo, K. Mootha Vamsi, S. Mukherjee, L. Ebert Benjamin, A. Gillette Michael, A. Paulovich, L. Pomeroy Scott, R. Golub Todd, S. Lander Eric, P. Mesirov Jill, Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Proceedings of the National Academy of Sciences, 102 (2005) 15545-15550.","DOI":"10.1073\/pnas.0506580102"},{"key":"10.1016\/j.cellimm.2022.104575_b0150","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"Krzywinski","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.cellimm.2022.104575_b0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nature Methods"},{"key":"10.1016\/j.cellimm.2022.104575_b0160","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2022.104575_b0165","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1182\/blood.V95.10.3032","article-title":"Chemokine receptors and their role in inflammation and infectious diseases","volume":"95","author":"Murdoch","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cellimm.2022.104575_b0170","first-page":"232","article-title":"IFN-\u03b3 Production by Th1 Cells Generated from Naive CD4<sup>+<\/sup>","volume":"166","author":"Swanson","year":"2001","journal-title":"T Cells Exposed to Norepinephrine, The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0175","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/jn\/137.3.665","article-title":"Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice","volume":"137","author":"Petursdottir","year":"2007","journal-title":"The Journal of nutrition"},{"key":"10.1016\/j.cellimm.2022.104575_b0180","doi-asserted-by":"crossref","unstructured":"T. Derfuss, K. Parikh, S. Velhin, M. Braun, E. Mathey, M. Krumbholz, T. K\u00fcmpfel, A. Moldenhauer, C. Rader, P. Sonderegger, W. P\u00f6llmann, C. Tiefenthaller, J. Bauer, H. Lassmann, H. Wekerle, D. Karagogeos, R. Hohlfeld, C. Linington, E. Meinl, Contactin-2\/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals, Proceedings of the National Academy of Sciences of the United States of America, 106 (2009) 8302-8307.","DOI":"10.1073\/pnas.0901496106"},{"issue":"2011","key":"10.1016\/j.cellimm.2022.104575_b0185","first-page":"3410","article-title":"Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function, Journal of immunology (Baltimore","volume":"186","author":"Yamashita","year":"1950","journal-title":"Md."},{"key":"10.1016\/j.cellimm.2022.104575_b0190","first-page":"1608","article-title":"Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis","volume":"23","author":"Mizuhara","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0195","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/cyto.1999.0561","article-title":"ESSENTIAL PATHOGENETIC ROLE FOR INTERFERON (IFN-)\u03b3 IN CONCANAVALIN A-INDUCED T CELL-DEPENDENT HEPATITIS: EXACERBATION BY EXOGENOUS IFN-\u03b3 AND PREVENTION BY IFN-\u03b3 RECEPTOR-IMMUNOGLOBULIN FUSION PROTEIN","volume":"12","author":"Nicoletti","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.cellimm.2022.104575_b0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.26027","article-title":"Interferon-gamma\u2013mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice","volume":"57","author":"Kato","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0205","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.immunol.17.1.331","article-title":"TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS","volume":"17","author":"Wallach","year":"1999","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0210","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.iy.10.040192.002211","article-title":"The pathophysiology of tumor necrosis factors","volume":"10","author":"Vassalli","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cellimm.2022.104575_b0215","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2022.104575_b0220","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jlb.67.1.90","article-title":"Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice","volume":"67","author":"Tagawa","year":"2000","journal-title":"Journal of leukocyte biology"},{"key":"10.1016\/j.cellimm.2022.104575_b0225","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1172\/JCI17129","article-title":"Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation","volume":"112","author":"McLoughlin","year":"2003","journal-title":"The Journal of clinical investigation"},{"key":"10.1016\/j.cellimm.2022.104575_b0230","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbadis.2010.11.009","article-title":"Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling","volume":"1812","author":"Malchow","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/j.cellimm.2022.104575_b0235","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2022.104575_b0240","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.4049\/jimmunol.0901221","article-title":"Inflammatory Regulation by TLR3 in Acute Hepatitis","volume":"183","author":"Xiao","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.cellimm.2022.104575_b0245","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.24763","article-title":"Activation of chemokine and inflammatory cytokine response in hepatitis C virus\u2013infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates","volume":"55","author":"Li","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cellimm.2022.104575_b0250","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/icb.2014.51","article-title":"STAT1 plays a role in TLR signal transduction and inflammatory responses","volume":"92","author":"Luu","year":"2014","journal-title":"Immunology & Cell Biology"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874922001009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874922001009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:08:41Z","timestamp":1757804921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874922001009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":50,"alternative-id":["S0008874922001009"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2022.104575","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2022.104575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104575"}}