{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:09:11Z","timestamp":1791403751721,"version":"4.3.3"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation United States of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cellimm.2023.104729","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T21:08:19Z","timestamp":1684271299000},"page":"104729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Autoimmune susceptible HLA class II motifs facilitate the presentation of modified neoepitopes to potentially autoreactive T cells"],"prefix":"10.1016","volume":"390","author":[{"given":"Antonis K.","family":"Moustakas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2023.104729_b0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-065X.1999.tb01398.x","article-title":"The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases","volume":"167","author":"Price","year":"1999","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cellimm.2023.104729_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-genom-091212-153455","article-title":"Major histocompatibility complex genomics and human disease","volume":"14","author":"Trowsdale","year":"2013","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.cellimm.2023.104729_b0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"Stern","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2023.104729_b0020","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.2174\/138161209789105117","article-title":"Use of MHC II structural features in the design of vaccines for organ-specific autoimmune diseases","volume":"15","author":"Moustakas","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cellimm.2023.104729_b0025","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng.3625","article-title":"Genetic variation in MHC proteins is associated with T cell receptor expression biases","volume":"48","author":"Sharon","year":"2016","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.cellimm.2023.104729_b0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1615\/CritRevImmunol.2015014510","article-title":"MHC Genes Linked to Autoimmune Disease","volume":"35","author":"Deitiker","year":"2015","journal-title":"Crit. Rev. Immunol."},{"issue":"13","key":"10.1016\/j.cellimm.2023.104729_b0035","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S1286-4579(01)01477-0","article-title":"How the immune system protects the host from infection","volume":"3","author":"Janeway","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cellimm.2023.104729_b0040","unstructured":"K. Murphy, C. Weaver, Chapter 4: Antigen Recognition by B-cell and T-cell Receptors, pp. 139-171; Chapter 5: The Generation of Lymphocyte Antigen Receptors, pp 173-211, Janeway\u2019s Immunobiology, 9th edition, Garland Science, New York, NY, 2016."},{"key":"10.1016\/j.cellimm.2023.104729_b0045","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1084\/jem.20190993","article-title":"IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus","volume":"216","author":"Hemmers","year":"2019","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104729_b0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-immunol-032414-112334","article-title":"T cell antigen receptor recognition of antigen-presenting molecules","volume":"33","author":"Rossjohn","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0055","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41577-018-0007-5","article-title":"Understanding the drivers of MHC restriction of T cell receptors","volume":"18","author":"La Gruta","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0060","series-title":"77-135, Janeway\u2019s Immunobiology","article-title":"Chapter 3: The Induced Responses of Innate Immunity","author":"Murphy","year":"2016"},{"key":"10.1016\/j.cellimm.2023.104729_b0065","doi-asserted-by":"crossref","unstructured":"J. Pettmann, A. Huhn, E. Abu Shah, M.A. Kutuzov, D.B. Wilson, M.L. Dustin, S.J. Davis, P.A. van der Merwe, O. Dushek, The discriminatory power of the T cell receptor, Elife, 10 (2021) e67092.","DOI":"10.7554\/eLife.67092"},{"key":"10.1016\/j.cellimm.2023.104729_b0070","unstructured":"K. Murphy, C. Weaver, Chapter 15: Autoimmunity and Transplantation, pp 643-699, Janeway\u2019s Immunobiology, 9th edition, Garland Science, New York, N.Y, 2016."},{"issue":"2020","key":"10.1016\/j.cellimm.2023.104729_b0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00251-019-01141-w","article-title":"nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4(+) T cells","volume":"72","author":"Sollid","year":"2020","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0080","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2337\/dbi19-0022","article-title":"T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal","volume":"69","author":"James","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1313.001","article-title":"Posttranslational modifications of self-antigens","volume":"1050","author":"Doyle","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellimm.2023.104729_b0090","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.337487","article-title":"Posttranslational covalent modification of proteins","volume":"198","author":"Uy","year":"1977","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.cellimm.2023.104729_b0095","doi-asserted-by":"crossref","first-page":"e2244","DOI":"10.1038\/cddis.2016.150","article-title":"Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death","volume":"7","author":"Tatsukawa","year":"2016","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.cellimm.2023.104729_b0100","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nrrheum.2015.59","article-title":"Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens","volume":"11","author":"Koning","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cellimm.2023.104729_b0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbpa.2021.01.010","article-title":"Chemical biology of protein citrullination by the protein A arginine deiminases","volume":"63","author":"Mondal","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cellimm.2023.104729_b0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/ard.2003.012211","article-title":"Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages","volume":"63","author":"Vossenaar","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cellimm.2023.104729_b0115","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104729_b0120","doi-asserted-by":"crossref","first-page":"e0158773","DOI":"10.1371\/journal.pone.0158773","article-title":"The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse","volume":"11","author":"Engelmann","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2023.104729_b0125","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/ni.3271","article-title":"T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex","volume":"16","author":"Beringer","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0130","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41590-019-0414-1","article-title":"A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3(+) T(reg) cell development","volume":"20","author":"Stadinski","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0135","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ki.2010.237","article-title":"The rise and fall of horror autotoxicus and forbidden clones","volume":"78","author":"Jennette","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellimm.2023.104729_b0140","first-page":"31","article-title":"Transglutamines and endocrine system (minireview)","volume":"36","author":"Dvorcakova","year":"2002","journal-title":"Endocr. Regul."},{"issue":"2007","key":"10.1016\/j.cellimm.2023.104729_b0145","first-page":"539","article-title":"a listing correlating sequence and structure with function","volume":"59","author":"Bondinas","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/378457a0","article-title":"The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3","volume":"378","author":"Ghosh","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2023.104729_b0155","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00251-008-0310-6","article-title":"Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule","volume":"60","author":"Wiesner","year":"2008","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0160","doi-asserted-by":"crossref","first-page":"9218","DOI":"10.1074\/jbc.M117.785139","article-title":"Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides","volume":"292","author":"Nguyen","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellimm.2023.104729_b0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00251-018-1095-x","article-title":"Class II MHC antigen processing in immune tolerance and inflammation","volume":"71","author":"Jurewicz","year":"2019","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/imr.12003","article-title":"Conformational variation in structures of classical and non-classical MHCII proteins and functional implications","volume":"250","author":"Painter","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cellimm.2023.104729_b0175","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1021\/bi9923656","article-title":"A three-step kinetic mechanism for peptide binding to MHC class II proteins","volume":"39","author":"Joshi","year":"2000","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.cellimm.2023.104729_b0180","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ni835","article-title":"A functional and structural basis for TCR cross-reactivity in multiple sclerosis","volume":"3","author":"Lang","year":"2002","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cellimm.2023.104729_b0185","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1073\/pnas.0306885101","article-title":"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease","volume":"101","author":"Kim","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.cellimm.2023.104729_b0190","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1084\/jem.20131241","article-title":"A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis","volume":"210","author":"Scally","year":"2013","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.cellimm.2023.104729_b0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2015.11.001","article-title":"Celiac disease: Autoimmunity in response to food antigen","volume":"27","author":"Stamnaes","year":"2015","journal-title":"Semin. Immunol."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104729_b0200","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/88694","article-title":"Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes","volume":"2","author":"Lee","year":"2001","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.cellimm.2023.104729_b0205","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1074\/jbc.RA118.005736","article-title":"Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes","volume":"294","author":"Dahal-Koirala","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104729_b0210","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0698-713","article-title":"Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease","volume":"4","author":"Molberg","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathmechdis-031521-032634","article-title":"The Immunobiology and Pathogenesis of Celiac Disease","volume":"18","author":"Iversen","year":"2023","journal-title":"Annu Rev Pathol"},{"issue":"11","key":"10.1016\/j.cellimm.2023.104729_b0220","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cellimm.2023.104729_b0225","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/BOR.0b013e328336ba63","article-title":"The rheumatoid arthritis HLA-DRB1 shared epitope","volume":"22","author":"Holoshitz","year":"2010","journal-title":"Curr. Opin. Rheumatol."},{"issue":"8-9","key":"10.1016\/j.cellimm.2023.104729_b0230","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00251-017-0987-5","article-title":"HLA class II and rheumatoid arthritis: the bumpy road of revelation","volume":"69","author":"Kampstra","year":"2017","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108680","article-title":"Current insights and future prospects for the pathogenesis and treatment for rheumatoid arthritis","volume":"225","author":"Koga","year":"2021","journal-title":"Clin. Immunol."},{"issue":"3","key":"10.1016\/j.cellimm.2023.104729_b0240","first-page":"e214","article-title":"The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis, Lancet","volume":"3","author":"Toes","year":"2021","journal-title":"Rheumatol"},{"key":"10.1016\/j.cellimm.2023.104729_b0245","article-title":"Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0250","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/498651","article-title":"Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4","volume":"77","author":"Plenge","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cellimm.2023.104729_b0255","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/dmrr.455","article-title":"Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence","volume":"20","author":"Hermann","year":"2004","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.cellimm.2023.104729_b0260","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db07-1331","article-title":"Type 1 Diabetes Genetics, HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families","volume":"57","author":"Erlich","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0265","doi-asserted-by":"crossref","first-page":"9514","DOI":"10.1074\/jbc.M111.313940","article-title":"Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire","volume":"287","author":"van Lummel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellimm.2023.104729_b0270","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2337\/db19-0273","article-title":"Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes","volume":"68","author":"Zhao","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0275","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2337\/db20-0075","article-title":"Motifs of Three HLA-DQ Amino Acid Residues (alpha44, beta57, beta135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children","volume":"69","author":"Zhao","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0280","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.156.2.450","article-title":"The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders","volume":"156","author":"Carrasco-Marin","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0285","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.4049\/jimmunol.161.11.6439","article-title":"Exceptional stability of the HLA-DQA1*0102\/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus","volume":"161","author":"Ettinger","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0290","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1084\/jem.185.6.1013","article-title":"A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB\/H mice","volume":"185","author":"Harrison","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0295","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1002\/eji.1830271003","article-title":"Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g)7 protein of non-obese diabetic mice","volume":"27","author":"Reizis","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0300","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s001250051350","article-title":"Modelling of the MHC II allele I-A(g7) of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule","volume":"43","author":"Moustakas","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.cellimm.2023.104729_b0305","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/1521-4141(200208)32:8<2105::AID-IMMU2105>3.0.CO;2-Q","article-title":"Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-A(g7)","volume":"32","author":"M\u00fcnz","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0310","first-page":"102","article-title":"Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation, Precis","volume":"1","author":"Wan","year":"2018","journal-title":"Clin. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0315","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/dbi18-0048","article-title":"The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity","volume":"68","author":"Unanue","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0320","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41586-018-0341-6","article-title":"Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides","volume":"560","author":"Wan","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2023.104729_b0325","doi-asserted-by":"crossref","first-page":"eaav7517","DOI":"10.1126\/sciimmunol.aav7517","article-title":"How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes","volume":"4","author":"Wang","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0330","doi-asserted-by":"crossref","first-page":"e20192135","DOI":"10.1084\/jem.20192135","article-title":"Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation","volume":"218","author":"Reed","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0335","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/MED.0000000000000490","article-title":"Hybrid insulin peptides are neo-epitopes for CD4 T cells in autoimmune diabetes","volume":"26","author":"Baker","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.cellimm.2023.104729_b0340","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2018.04.016","article-title":"Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?","volume":"52","author":"Liepe","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0345","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.2337\/db22-0303","article-title":"Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes","volume":"71","author":"Crawford","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0350","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1042\/BCJ20200910","article-title":"Mechanistic diversity in MHC class I antigen recognition","volume":"478","author":"Barbosa","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.cellimm.2023.104729_b0355","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/cei.13589","article-title":"Spliced HLA-bound peptides: a Black Swan event in immunology","volume":"204","author":"Faridi","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0360","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1038\/s41467-021-25404-x","article-title":"T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8","volume":"12","author":"Tran","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2023.104729_b0365","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.180.5.3268","article-title":"Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2","volume":"180","author":"Stepniak","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0370","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2337\/db18-0501","article-title":"Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes","volume":"68","author":"van Lummel","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.658601","article-title":"Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A(b) in C57BL\/6 Mouse Thymus","volume":"12","author":"Nanaware","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0380","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1021\/acs.jproteome.0c00355","article-title":"Peptide-Spectrum Match Validation with Internal Standards (P-VIS): Internally-Controlled Validation of Mass Spectrometry-Based Peptide Identifications","volume":"20","author":"Wiles","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cellimm.2023.104729_b0385","doi-asserted-by":"crossref","unstructured":"P. Wei, K.R. Jordan, J.D. Buhrman, J. Lei, H. Deng, P. Marrack, S. Dai, J.W. Kappler, J.E. Slansky, L. Yin, Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer, Proc Natl Acad Sci U S A, 118 (2021) e2100588118.","DOI":"10.1073\/pnas.2100588118"},{"key":"10.1016\/j.cellimm.2023.104729_b0390","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4049\/jimmunol.2000756","article-title":"Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells","volume":"207","author":"Man","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0395","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.coi.2011.12.003","article-title":"Autoantigenesis: the evolution of protein modifications in autoimmune disease","volume":"24","author":"Doyle","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0400","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2337\/dbi17-0030","article-title":"Immune Recognition of beta-Cells: Neoepitopes as Key Players in the Loss of Tolerance","volume":"67","author":"James","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0405","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/biomedicines9020202","article-title":"Non-Genetically Encoded Epitopes Are Relevant Targets in Autoimmune Diabetes","volume":"9","author":"Nguyen","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellimm.2023.104729_b0410","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.1203198","article-title":"Antibody and antigen contact residues define epitope and paratope size and structure","volume":"191","author":"Stave","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0415","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/12.3.375","article-title":"Minimal peptide length requirements for CD4(+) T cell clones\u2013implications for molecular mimicry and T cell survival","volume":"12","author":"Hemmer","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0420","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"van de Wal","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0425","doi-asserted-by":"crossref","first-page":"R1421","DOI":"10.1186\/ar1845","article-title":"Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis","volume":"7","author":"Kinloch","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cellimm.2023.104729_b0430","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/ar4458","article-title":"How citrullination invaded rheumatoid arthritis research","volume":"16","author":"van Venrooij","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cellimm.2023.104729_b0435","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.2337\/db13-1952","article-title":"Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes","volume":"63","author":"McGinty","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0440","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.2337\/db18-0295","article-title":"Overbergh, Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes","volume":"67","author":"Buitinga","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0445","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/s41467-022-29512-0","article-title":"Citrullination of glucokinase is linked to autoimmune diabetes","volume":"13","author":"Yang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2023.104729_b0450","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1096\/fj.13-247254","article-title":"Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity","volume":"28","author":"Dwivedi","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.cellimm.2023.104729_b0455","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1038\/s41598-020-62480-3","article-title":"Native\/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus","volume":"10","author":"Lande","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104729_b0460","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ana.410400106","article-title":"Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein","volume":"40","author":"Wood","year":"1996","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.cellimm.2023.104729_b0465","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/135245850000600402","article-title":"Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients","volume":"6","author":"Tranquill","year":"2000","journal-title":"Mult. Scler."},{"issue":"1-2","key":"10.1016\/j.cellimm.2023.104729_b0470","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-5728(01)00312-5","article-title":"IgG reactivity against citrullinated myelin basic protein in multiple sclerosis","volume":"117","author":"de Seze","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0475","doi-asserted-by":"crossref","unstructured":"J.A. Hill, S. Southwood, A. Sette, A.M. Jevnikar, D.A. Bell, E. Cairns, Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule, J Immunol, 171 (2003) 538-541.","DOI":"10.4049\/jimmunol.171.2.538"},{"key":"10.1016\/j.cellimm.2023.104729_b0480","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13075-016-1153-4","article-title":"The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules","volume":"18","author":"Kampstra","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cellimm.2023.104729_b0485","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2337\/db17-1166","article-title":"Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4(+) T Cells in Patients With Type 1 Diabetes","volume":"67","author":"Marre","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0490","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/imm.12640","article-title":"Immune recognition of citrullinated epitopes","volume":"149","author":"Nguyen","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2023.104729_b0495","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fimmu.2016.00494","article-title":"Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis","volume":"7","author":"Gerstner","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0500","doi-asserted-by":"crossref","first-page":"e145217","DOI":"10.1172\/jci.insight.145217","article-title":"Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis","volume":"6","author":"Song","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellimm.2023.104729_b0505","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/cei.12775","article-title":"Human islets and dendritic cells generate post-translationally modified islet autoantigens","volume":"185","author":"McLaughlin","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0510","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.622647","article-title":"Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors","volume":"12","author":"Landry","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellimm.2023.104729_b0515","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.908248","article-title":"Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation","volume":"13","author":"Callebaut","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellimm.2023.104729_b0520","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1084\/jem.20051251","article-title":"The insulin A-chain epitope recognized by human T cells is posttranslationally modified","volume":"202","author":"Mannering","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0525","article-title":"Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes","author":"Strollo","year":"2022","journal-title":"Diabetologia"},{"key":"10.1016\/j.cellimm.2023.104729_b0530","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.2337\/db21-0989","article-title":"Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity","volume":"71","author":"Yang","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0535","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.132254199","article-title":"Predominant selection of T cells specific for the glycosylated collagen type II epitope (263\u2013270) in humanized transgenic mice and in rheumatoid arthritis","volume":"99","author":"B\u00e4cklund","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.cellimm.2023.104729_b0540","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/art.34459","article-title":"Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis","volume":"64","author":"Snir","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cellimm.2023.104729_b0545","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2337\/db12-1214","article-title":"Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes","volume":"63","author":"van Lummel","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0550","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2337\/db14-0621","article-title":"Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes","volume":"64","author":"Rondas","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0555","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm.4289","article-title":"Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes","volume":"23","author":"Kracht","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0560","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/nm.4203","article-title":"Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes","volume":"22","author":"Babon","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0565","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.sbi.2019.01.024","article-title":"Peptidyl arginine deiminases: detection and functional analysis of protein citrullination","volume":"59","author":"Tilvawala","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"Suppl 2","key":"10.1016\/j.cellimm.2023.104729_b0570","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/dom.13387","article-title":"Islet stress, degradation and autoimmunity","volume":"20","author":"Thomaidou","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cellimm.2023.104729_b0575","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2337\/db19-0984","article-title":"beta-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1","volume":"69","author":"Thomaidou","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0580","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13287-019-1523-3","article-title":"Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells","volume":"11","author":"Demine","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.cellimm.2023.104729_b0585","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1136\/annrheumdis-2017-211300","article-title":"Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis","volume":"76","author":"Scally","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cellimm.2023.104729_b0590","doi-asserted-by":"crossref","first-page":"eabe0896","DOI":"10.1126\/sciimmunol.abe0896","article-title":"The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR","volume":"6","author":"Lim","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0595","doi-asserted-by":"crossref","first-page":"24512","DOI":"10.1038\/s41598-021-04291-8","article-title":"Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis","volume":"11","author":"Sharma","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellimm.2023.104729_b0600","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1101400","article-title":"Human PAD4 regulates histone arginine methylation levels via demethylimination","volume":"306","author":"Wang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cellimm.2023.104729_b0605","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0610","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41467-017-02763-y","article-title":"T cells specific for post-translational modifications escape intrathymic tolerance induction","volume":"9","author":"Raposo","year":"2018","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellimm.2023.104729_b0615","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF00172063","article-title":"MHC ligands and peptide motifs: first listing","volume":"41","author":"Rammensee","year":"1995","journal-title":"Immunogenetics"},{"key":"10.1016\/j.cellimm.2023.104729_b0620","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2018.10.003","article-title":"Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development","volume":"204","author":"Santamaria","year":"2018","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104729_b0625","doi-asserted-by":"crossref","first-page":"e201800164","DOI":"10.26508\/lsa.201800164","article-title":"Absence of MHC-II expression by lymph node stromal cells results in autoimmunity","volume":"1","author":"Dubrot","year":"2018","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.cellimm.2023.104729_b0630","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3390\/cells11101667","article-title":"Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease","volume":"11","author":"B\u00fcchold","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellimm.2023.104729_b0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115040","article-title":"Peptidylarginine deiminase-4: Medico-formulative strategy towards management of rheumatoid arthritis","volume":"200","author":"Thirugnanasambandham","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellimm.2023.104729_b0640","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/intimm\/11.10.1625","article-title":"Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10","volume":"11","author":"Burkhart","year":"1999","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cellimm.2023.104729_b0645","doi-asserted-by":"crossref","first-page":"eaaf7779","DOI":"10.1126\/scitranslmed.aaf7779","article-title":"Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes","volume":"9","author":"Alhadj Ali","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cellimm.2023.104729_b0650","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.2337\/db20-0845","article-title":"Soluble Antigen Arrays Efficiently Deliver Peptides and Arrest Spontaneous Autoimmune Diabetes","volume":"70","author":"Firdessa-Fite","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0655","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nature16962","article-title":"Expanding antigen-specific regulatory networks to treat autoimmunity","volume":"530","author":"Clemente-Casares","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2023.104729_b0660","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.ymthe.2017.04.015","article-title":"Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates","volume":"25","author":"Pearson","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cellimm.2023.104729_b0665","doi-asserted-by":"crossref","first-page":"eabc9317","DOI":"10.1126\/sciadv.abc9317","article-title":"Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease","volume":"6","author":"Saito","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cellimm.2023.104729_b0670","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00125-016-4122-1","article-title":"Type 1 Diabetes TrialNet Study, GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis","volume":"60","author":"Beam","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.cellimm.2023.104729_b0675","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2337\/db21-0728","article-title":"Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple beta-Cell Peptides in Type 1 Diabetes","volume":"71","author":"Liu","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2023.104729_b0680","doi-asserted-by":"crossref","unstructured":"S. Gertel, G. Serre, Y. Shoenfeld, H. Amital, Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats, J Immunol, 194 (2015) 5674-5680.","DOI":"10.4049\/jimmunol.1402457"},{"issue":"1","key":"10.1016\/j.cellimm.2023.104729_b0685","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2020.03.007","article-title":"Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases","volume":"181","author":"Fugger","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2023.104729_b0690","first-page":"234","article-title":"The role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes","volume":"2","author":"Paschou","year":"2012","journal-title":"J. Clinical Cellular Immunol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874923000680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874923000680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:11:08Z","timestamp":1757805068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874923000680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":138,"alternative-id":["S0008874923000680"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2023.104729","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoimmune susceptible HLA class II motifs facilitate the presentation of modified neoepitopes to potentially autoreactive T cells","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2023.104729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104729"}}