{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:23:12Z","timestamp":1792754592075,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cellimm.2023.104781","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:29:03Z","timestamp":1698946143000},"page":"104781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-\u03b2\/Smad3 signaling to promote Th17\/Treg cell rebalance"],"prefix":"10.1016","volume":"395-396","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0368-7359","authenticated-orcid":false,"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cellimm.2023.104781_b0005","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and detection of sarcoidosis. an official american thoracic society clinical practice guideline","volume":"201","author":"Crouser","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellimm.2023.104781_b0010","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3389\/fimmu.2020.01340","article-title":"Environmental risk factors for sarcoidosis","volume":"11","author":"Judson","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104781_b0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-019-0096-x","article-title":"Sarcoidosis","volume":"5","author":"Grunewald","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.cellimm.2023.104781_b0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12931-017-0515-z","article-title":"High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis","volume":"18","author":"Zhao","year":"2017","journal-title":"Respir. Res."},{"issue":"4","key":"10.1016\/j.cellimm.2023.104781_b0025","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.chest.2021.06.003","article-title":"Sarcoidosis: an occupational disease?","volume":"160","author":"Oliver","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.cellimm.2023.104781_b0030","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3389\/fimmu.2019.02933","article-title":"Sarcoidosis as an autoimmune disease","volume":"10","author":"Starshinova","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cellimm.2023.104781_b0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/BOR.0000000000000489","article-title":"Current management of sarcoidosis I: pulmonary, cardiac, and neurologic manifestations","volume":"30","author":"West","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.cellimm.2023.104781_b0040","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fimmu.2020.00779","article-title":"Derangement of metabolic and lysosomal gene profiles in response to dexamethasone treatment in sarcoidosis","volume":"11","author":"Talreja","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2023.104781_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.105936","article-title":"Randomised, placebo-controlled trial of dexamethasone for quality of life in pulmonary sarcoidosis","volume":"165","author":"Vis","year":"2020","journal-title":"Respir. Med."},{"issue":"8","key":"10.1016\/j.cellimm.2023.104781_b0050","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s12325-019-00989-4","article-title":"Intravitreal dexamethasone implant for treatment of sarcoidosis-related uveitis","volume":"36","author":"Kim","year":"2019","journal-title":"Adv. Ther."},{"issue":"10","key":"10.1016\/j.cellimm.2023.104781_b0055","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10072-018-3491-2","article-title":"Neurosarcoidosis: clinical characteristics, diagnosis, and treatment in eight Chinese patients","volume":"39","author":"Wang","year":"2018","journal-title":"Neurol. Sci."},{"issue":"5","key":"10.1016\/j.cellimm.2023.104781_b0060","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1021\/acsbiomaterials.2c00026","article-title":"Dexamethasone: insights into pharmacological aspects, therapeutic mechanisms, and delivery systems","volume":"8","author":"Madamsetty","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.cellimm.2023.104781_b0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.thromres.2020.04.004","article-title":"Dexamethasone suppresses the Th17\/1 cell polarization in the CD4(+) T cells from patients with primary immune thrombocytopenia","volume":"190","author":"Li","year":"2020","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104781_b0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/cei.12870","article-title":"Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4(+) T cells partly via transforming growth factor-\u03b21","volume":"187","author":"Anderson","year":"2017","journal-title":"Clin. Exp. Immunol."},{"issue":"11","key":"10.1016\/j.cellimm.2023.104781_b0075","doi-asserted-by":"crossref","first-page":"21463","DOI":"10.3390\/ijms141121463","article-title":"Imbalance between Th17 and regulatory T-cells in sarcoidosis","volume":"14","author":"Huang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cellimm.2023.104781_b0080","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1513\/pats.200606-130MS","article-title":"Role of CD4+ T cells in sarcoidosis","volume":"4","author":"Grunewald","year":"2007","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0085","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20050648","article-title":"The immune paradox of sarcoidosis and regulatory T cells","volume":"203","author":"Miyara","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104781_b0090","article-title":"The role of diverse immune cells in sarcoidosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2023.104781_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.545413","article-title":"Treatment of sarcoidosis: a multidisciplinary approach","volume":"11","author":"Gerke","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cellimm.2023.104781_b0100","doi-asserted-by":"crossref","first-page":"19911","DOI":"10.1002\/jcp.28589","article-title":"Phosphoinositide 3-kinase\/protein kinase B inhibition restores regulatory T cell's function in pulmonary sarcoidosis","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cellimm.2023.104781_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108784","article-title":"Serum amyloid A\/anti-CCL20 induced the rebalance of Th17\/regulatory T cells in SodA-induced sarcoidosis","volume":"109","author":"Meng","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104781_b0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imm.12938","article-title":"The role of transforming growth factor \u03b2 in T helper 17 differentiation","volume":"155","author":"Zhang","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.cellimm.2023.104781_b0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.intimp.2018.08.030","article-title":"Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis","volume":"64","author":"Zhang","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.cellimm.2023.104781_b0120","first-page":"2645","article-title":"Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-\u03b2, Smad3 and JAK-STAT pathway","volume":"7","author":"Shi","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.cellimm.2023.104781_b0125","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3389\/fimmu.2019.01923","article-title":"IL-17A can promote propionibacterium acnes-induced sarcoidosis-like granulomatosis in mice","volume":"10","author":"Song","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0130","doi-asserted-by":"crossref","first-page":"e0148207","DOI":"10.1371\/journal.pone.0148207","article-title":"The circulating Treg\/Th17 cell ratio is correlated with relapse and treatment response in pulmonary sarcoidosis patients after corticosteroid withdrawal","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"issue":"9363","key":"10.1016\/j.cellimm.2023.104781_b0135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(03)12888-7","article-title":"Sarcoidosis","volume":"361","author":"Baughman","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cellimm.2023.104781_b0140","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.ajpath.2013.08.021","article-title":"ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells","volume":"183","author":"Kamata","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.cellimm.2023.104781_b0145","first-page":"262","article-title":"Role of propionibacterium acnes in sarcoidosis: a meta-analysis","volume":"30","author":"Zhou","year":"2013","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"issue":"5","key":"10.1016\/j.cellimm.2023.104781_b0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/etm.2023.11923","article-title":"Inhibition of phosphoinositide-3 kinases \u03b3\/\u03b4 ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model","volume":"25","author":"Zhang","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cellimm.2023.104781_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01923","article-title":"IL-17A can promote propionibacterium acnes-induced sarcoidosis-like granulomatosis in mice","volume":"10","author":"Song","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0160","first-page":"154","article-title":"Th17 and Treg cell levels in patients with sarcoidosis and their relation to disease activation","volume":"44","author":"Weng","year":"2015","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"11","key":"10.1016\/j.cellimm.2023.104781_b0165","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1164\/rccm.201512-2419ED","article-title":"Sarcoidosis and T-helper cells. Th1, Th17, or Th17.1?","volume":"193","author":"Georas","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellimm.2023.104781_b0170","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fphar.2014.00233","article-title":"Interleukin-12 family cytokines and sarcoidosis","volume":"5","author":"Ringkowski","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellimm.2023.104781_b0175","unstructured":"D. Jiang, et al., Interleukin-17A plays a key role in pulmonary fibrosis following Propionibacterium acnes\u2013induced sarcoidosis-like inflammation. Experimental Biology and Medicine. 0(0): p. 15353702231182224."},{"key":"10.1016\/j.cellimm.2023.104781_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/986789","article-title":"Th17 cells in immunity and autoimmunity","volume":"2013","author":"Bedoya","year":"2013","journal-title":"Clin. Dev. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2023.104781_b0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/rheumatology\/ker316","article-title":"Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis","volume":"51","author":"Ten Berge","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/cei.12403","article-title":"Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with L\u00f6fgren's syndrome","volume":"178","author":"Ostadkarampour","year":"2014","journal-title":"Clin. Exp. Immunol."},{"issue":"23","key":"10.1016\/j.cellimm.2023.104781_b0195","doi-asserted-by":"crossref","first-page":"33703","DOI":"10.18632\/oncotarget.9397","article-title":"Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0200","doi-asserted-by":"crossref","first-page":"L83","DOI":"10.1152\/ajplung.00258.2012","article-title":"TGF-\u03b2-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?","volume":"304","author":"Warburton","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cellimm.2023.104781_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118399","article-title":"Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-\u03b2\/SMAD3 and PI3K\/AKT signaling pathway","volume":"260","author":"Fang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cellimm.2023.104781_b0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/5584_2014_106","article-title":"TGF-\u03b2 and SMADs mRNA expression in pulmonary sarcoidosis","volume":"852","author":"Piotrowski","year":"2015","journal-title":"Adv. Experimental Med. Biol."},{"issue":"11","key":"10.1016\/j.cellimm.2023.104781_b0215","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210777","article-title":"Arkadia-SKI\/SnoN signaling differentially regulates TGF-\u03b2-induced iTreg and Th17 cell differentiation","volume":"218","author":"Xu","year":"2021","journal-title":"J. Exp. Med."},{"issue":"Pt B","key":"10.1016\/j.cellimm.2023.104781_b0220","article-title":"Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis","volume":"113","author":"Lu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104781_b0225","doi-asserted-by":"crossref","first-page":"537","DOI":"10.29271\/jcpsp.2019.06.537","article-title":"Effect of dexamethasone on TGF-\u03b21\/Smad3 signalling pathway in airway remodelling model of asthmatic rats","volume":"29","author":"Feng","year":"2019","journal-title":"J. Coll. Physicians Surg. Pak."},{"issue":"2","key":"10.1016\/j.cellimm.2023.104781_b0230","first-page":"927","article-title":"Synergistic effect of halofuginone and dexamethasone on LPS-induced acute lung injury in type II alveolar epithelial cells and a rat model","volume":"21","author":"Du","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.cellimm.2023.104781_b0235","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/0960327117721961","article-title":"Dexamethasone ameliorates H(2)S-induced acute lung injury by increasing claudin-5 expression via the PI3K pathway","volume":"37","author":"Geng","year":"2018","journal-title":"Hum. Exp. Toxicol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887492300120X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887492300120X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T23:12:41Z","timestamp":1757805161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000887492300120X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":47,"alternative-id":["S000887492300120X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2023.104781","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-\u03b2\/Smad3 signaling to promote Th17\/Treg cell rebalance","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2023.104781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104781"}}