{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:41:06Z","timestamp":1792176066567,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","award":["09150161910024"],"award-info":[{"award-number":["09150161910024"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["833247"],"award-info":[{"award-number":["833247"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cellimm.2024.104862","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T11:07:45Z","timestamp":1723720065000},"page":"104862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["ROR\u03b1 negatively regulates BCG-induced trained immunity"],"prefix":"10.1016","volume":"403-404","author":[{"given":"Gizem","family":"Kilic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Matzaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilayda","family":"Baydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anaisa V.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Rabold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J.C.F.M.","family":"Moorlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.C.M.","family":"Koeken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Charlotte J.","family":"de Bree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera P.","family":"Mourits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Dom\u00ednguez-Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6284","key":"10.1016\/j.cellimm.2024.104862_b0005","doi-asserted-by":"crossref","first-page":"p. aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: A program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cellimm.2024.104862_b0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-102119-073855","article-title":"Trained Immunity: Reprogramming Innate Immunity in Health and Disease","volume":"39","author":"Bekkering","year":"2021","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1152\/physrev.00031.2021","article-title":"Trained immunity: adaptation within innate immune mechanisms","volume":"103","author":"Dominguez-Andres","year":"2023","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.immuni.2023.12.005","article-title":"Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity","volume":"57","author":"Moorlag","year":"2024","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.cellimm.2024.104862_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells10050971","article-title":"Glutathione Metabolism Contributes to the Induction of Trained Immunity","volume":"10","author":"Ferreira","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.cellimm.2024.104862_b0035","doi-asserted-by":"crossref","first-page":"e1004485","DOI":"10.1371\/journal.ppat.1004485","article-title":"Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer","volume":"10","author":"Buffen","year":"2014","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.cellimm.2024.104862_b0040","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tem.2012.05.012","article-title":"Action of RORs and their ligands in (patho)physiology","volume":"23","author":"Solt","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.cellimm.2024.104862_b0045","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s12276-021-00679-8","article-title":"Unraveling the physiological roles of retinoic acid receptor-related orphan receptor alpha","volume":"53","author":"Lee","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.cellimm.2024.104862_b0050","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/D0NP00047G","article-title":"Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)","volume":"38","author":"Ladurner","year":"2021","journal-title":"Nat. Prod. Rep."},{"issue":"31","key":"10.1016\/j.cellimm.2024.104862_b0055","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0060","doi-asserted-by":"crossref","first-page":"L144","DOI":"10.1152\/ajplung.00348.2004","article-title":"Enhanced susceptibility of staggerer (RORalphasg\/sg) mice to lipopolysaccharide-induced lung inflammation","volume":"289","author":"Stapleton","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cellimm.2024.104862_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2019.05.003","article-title":"ROR alpha protects against LPS-induced inflammation by down-regulating SIRT1\/NF-kappa B pathway","volume":"668","author":"Han","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/embo-reports\/kve007","article-title":"The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response","volume":"2","author":"Delerive","year":"2001","journal-title":"EMBO Rep."},{"issue":"11","key":"10.1016\/j.cellimm.2024.104862_b0075","doi-asserted-by":"crossref","first-page":"e0207374","DOI":"10.1371\/journal.pone.0207374","article-title":"RORalpha controls inflammatory state of human macrophages","volume":"13","author":"Nejati Moharrami","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.cellimm.2024.104862_b0080","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1172\/JCI133935","article-title":"BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner","volume":"130","author":"Koeken","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.cellimm.2024.104862_b0085","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/eji.202149577","article-title":"An integrative genomics approach identifies KDM4 as a modulator of trained immunity","volume":"52","author":"Moorlag","year":"2022","journal-title":"Eur. J. Immunol."},{"issue":"10","key":"10.1016\/j.cellimm.2024.104862_b0090","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","article-title":"Matrix eQTL: ultra fast eQTL analysis via large matrix operations","volume":"28","author":"Shabalin","year":"2012","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0095","doi-asserted-by":"crossref","first-page":"e1004714","DOI":"10.1371\/journal.pcbi.1004714","article-title":"Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics","volume":"12","author":"Lamparter","year":"2016","journal-title":"PLoS Comput. Biol."},{"issue":"9","key":"10.1016\/j.cellimm.2024.104862_b0100","doi-asserted-by":"crossref","first-page":"e3001765","DOI":"10.1371\/journal.pbio.3001765","article-title":"Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination","volume":"20","author":"Koeken","year":"2022","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100365","article-title":"In vitro induction of trained immunity in adherent human monocytes","volume":"2","author":"Dominguez-Andres","year":"2021","journal-title":"STAR Protoc"},{"issue":"4","key":"10.1016\/j.cellimm.2024.104862_b0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0115","doi-asserted-by":"crossref","first-page":"17908","DOI":"10.1038\/s41598-019-54500-8","article-title":"Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages","volume":"9","author":"Geiss","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2144\/04371RR03","article-title":"Validation of housekeeping genes for normalizing RNA expression in real-time PCR","volume":"37","author":"Dheda","year":"2004","journal-title":"Biotechniques"},{"issue":"2","key":"10.1016\/j.cellimm.2024.104862_b0125","first-page":"317","article-title":"Aldosterone induces trained immunity: the role of fatty acid synthesis","volume":"116","author":"van der Heijden","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellimm.2024.104862_b0130","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fimmu.2020.00353","article-title":"LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes","volume":"11","author":"Sohrabi","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0135","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1038\/s41467-023-43315-x","article-title":"Fatty acid desaturation and lipoxygenase pathways support trained immunity","volume":"14","author":"Ferreira","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.cellimm.2024.104862_b0140","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/CVI.00349-16","article-title":"In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes","volume":"23","author":"Bekkering","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"issue":"10","key":"10.1016\/j.cellimm.2024.104862_b0145","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic Pathways in BCG-Induced Trained Immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep."},{"issue":"43","key":"10.1016\/j.cellimm.2024.104862_b0150","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.cellimm.2024.104862_b0155","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1159\/000346706","article-title":"Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor RORalpha","volume":"5","author":"Friesenhagen","year":"2013","journal-title":"J. Innate Immun."},{"issue":"42","key":"10.1016\/j.cellimm.2024.104862_b0160","doi-asserted-by":"crossref","first-page":"21140","DOI":"10.1073\/pnas.1907595116","article-title":"RORalpha is crucial for attenuated inflammatory response to maintain intestinal homeostasis","volume":"116","author":"Oh","year":"2019","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2014.11.046","article-title":"Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway","volume":"358","author":"Zhao","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellimm.2024.104862_b0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.semcancer.2022.11.007","article-title":"Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics","volume":"87","author":"Sharma","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cellimm.2024.104862_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114164","article-title":"LDHA as a regulator of T cell fate and its mechanisms in disease","volume":"158","author":"Dai","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.cellimm.2024.104862_b0185","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41419-022-04857-y","article-title":"POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway","volume":"13","author":"Xiao","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.cellimm.2024.104862_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071684","article-title":"N-Terminal Domain Mediated Regulation of RORalpha1 Inhibits Invasive Growth in Prostate Cancer","volume":"20","author":"Park","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.cellimm.2024.104862_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109682","article-title":"RORalpha is critical for mTORC1 activity in T cell-mediated colitis","volume":"36","author":"Chi","year":"2021","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.cellimm.2024.104862_b0200","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1161\/ATVBAHA.108.171546","article-title":"Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling","volume":"28","author":"Kim","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.cellimm.2024.104862_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072043","article-title":"Role of mTOR in Glucose and Lipid Metabolism","volume":"19","author":"Mao","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellimm.2024.104862_b0210","doi-asserted-by":"crossref","unstructured":"Bekkering, S., R.J.W. Arts, B. Novakovic, I. Kourtzelis, C. van der Heijden, et al., Metabolic Induction of Trained Immunity through the Mevalonate Pathway. Cell, 2018. 172(1-2): p. 135-46 e9. doi: 10.1016\/j.cell.2017.11.025.","DOI":"10.1016\/j.cell.2017.11.025"},{"issue":"6","key":"10.1016\/j.cellimm.2024.104862_b0215","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cellimm.2024.104862_b0220","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/ATVBAHA.120.314216","article-title":"Trained Immunity in Atherosclerotic Cardiovascular Disease","volume":"41","author":"Flores-Gomez","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"24","key":"10.1016\/j.cellimm.2024.104862_b0225","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1161\/01.CIR.98.24.2738","article-title":"Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha","volume":"98","author":"Mamontova","year":"1998","journal-title":"Circulation"},{"issue":"1\u20133","key":"10.1016\/j.cellimm.2024.104862_b0230","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(01)03275-6","article-title":"Expression and regulation of the nuclear receptor RORalpha in human vascular cells","volume":"511","author":"Besnard","year":"2002","journal-title":"FEBS Lett."},{"issue":"6472","key":"10.1016\/j.cellimm.2024.104862_b0235","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax9198","article-title":"A genome-wide transcriptomic analysis of protein-coding genes in human blood cells","volume":"366","author":"Uhlen","year":"2019","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.cellimm.2024.104862_b0240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clim.2014.10.005","article-title":"BCG-induced trained immunity in NK cells: Role for non-specific protection to infection","volume":"155","author":"Kleinnijenhuis","year":"2014","journal-title":"Clin. Immunol."},{"issue":"2","key":"10.1016\/j.cellimm.2024.104862_b0245","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.cellimm.2024.104862_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112487","article-title":"A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellimm.2024.104862_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.07.010","article-title":"Seasonal variation in BCG-induced trained immunity","author":"Kilic","year":"2024","journal-title":"Vaccine"}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874924000650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874924000650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:12:33Z","timestamp":1777392753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874924000650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":51,"alternative-id":["S0008874924000650"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2024.104862","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROR\u03b1 negatively regulates BCG-induced trained immunity","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2024.104862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104862"}}