{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T18:25:45Z","timestamp":1762107945432,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017584","name":"SRM Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017584","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cellimm.2025.104959","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:09:38Z","timestamp":1745579378000},"page":"104959","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["miRNA-186-5p modulates placental inflammation via Inflammasome activation in gestational diabetes mellitus"],"prefix":"10.1016","volume":"411-412","author":[{"given":"Bhatnagar","family":"Megha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.L.","family":"Milan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anuradha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunka Mohanram","family":"Ramkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2025.104959_bb0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.cellimm.2025.104959_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8030383","article-title":"Prediction of glucose intolerance in early postpartum in women with gestational diabetes mellitus based on the 2013 WHO criteria","volume":"8","author":"Benhalima","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112183","article-title":"Gestational diabetes mellitus - a metabolic and reproductive disorder","volume":"143","author":"Choudhury","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellimm.2025.104959_bb0020","first-page":"734","article-title":"What neonatal complications should the pediatrician be aware of in case of maternal gestational diabetes?, world","volume":"6","author":"Mitanchez","year":"2015","journal-title":"J. Diabetes"},{"key":"10.1016\/j.cellimm.2025.104959_bb0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2015.04.006","article-title":"Inflammation in maternal obesity and gestational diabetes mellitus","volume":"36","author":"Pantham","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.cellimm.2025.104959_bb0030","doi-asserted-by":"crossref","first-page":"1172831","DOI":"10.3389\/fendo.2023.1172831","article-title":"Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin","volume":"14","author":"Guadix","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0035","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/09513590802653825","article-title":"High resistin and interleukin-6 levels are associated with gestational diabetes mellitus","volume":"25","author":"Kuzmicki","year":"2009","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/aam.aam_53_16","article-title":"Correlation between circulating level of tumor necrosis factor-alpha and insulin resistance in Nigerian women with gestational diabetes mellitus","volume":"17","author":"Mohammed","year":"2018","journal-title":"Ann. Afr. Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0045","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1055\/s-2008-1073166","article-title":"Circulating pro- and anti-inflammatory cytokines in polish women with gestational diabetes","volume":"40","author":"Kuzmicki","year":"2008","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cellimm.2025.104959_bb0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.14310\/horm.2002.1202","article-title":"Pre- and early post-partum adiponectin and interleukin-1beta levels in women with and without gestational diabetes","volume":"7","author":"Vitoratos","year":"2008","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0055","doi-asserted-by":"crossref","first-page":"9687925","DOI":"10.1155\/2022\/9687925","article-title":"Relevance of NLRP3 Inflammasome-related pathways in the pathology of diabetic wound healing and possible therapeutic targets","volume":"2022","author":"Ding","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cellimm.2025.104959_bb0060","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016287","article-title":"Inflammasomes","volume":"6","author":"de Zoete","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0065","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176241","article-title":"Crosstalk between inflammasomes, inflammation, and Nrf2: Implications for gestational diabetes mellitus pathogenesis and therapeutics","volume":"963","author":"Gayatri","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0075","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2025.104959_bb0080","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-arplant-050718-100334","article-title":"MicroRNAs and their regulatory roles in plant-environment interactions","volume":"70","author":"Song","year":"2019","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0085","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/hed.26089","article-title":"MicroRNA-based risk scoring system to identify early-stage oral squamous cell carcinoma patients at high-risk for cancer-specific mortality","volume":"42","author":"Yoon","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.cellimm.2025.104959_bb0090","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pathol.4.110807.092222","article-title":"MicroRNAs in cancer","volume":"4","author":"Lee","year":"2009","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0095","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2025.104959_bb0100","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4049\/jimmunol.1801416","article-title":"Dysregulation of Inflammasome priming and activation by MicroRNAs in human immune-mediated diseases","volume":"202","author":"Boxberger","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109428","article-title":"Functions and mechanisms of miR-186 in human cancer","volume":"119","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellimm.2025.104959_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0115","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrg3162","article-title":"MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship","volume":"13","author":"Pasquinelli","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cellimm.2025.104959_bb0125","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.2147\/IJN.S383904","article-title":"miR-186-5p dysregulation in serum exosomes from patients with AMI aggravates atherosclerosis via targeting LOX-1","volume":"17","author":"Ding","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellimm.2025.104959_bb0130","article-title":"CD8 T cell-derived Exosomal miR-186-5p elicits renal inflammation via activating tubular TLR7\/8 signal Axis","volume":"10","author":"Xu","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0135","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s11845-024-03720-7","article-title":"Relationship of lncRNA FTX and miR-186-5p levels with diabetic peripheral neuropathy in type 2 diabetes and its bioinformatics analysis","volume":"193","author":"Guo","year":"2024","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.cellimm.2025.104959_bb0140","first-page":"627","article-title":"Inhibition of miR-186-5p contributes to high glucose-induced injury in AC16 cardiomyocytes","volume":"15","author":"Jiang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0145","article-title":"Role of oxidative stress and inflammation in gestational diabetes mellitus","volume":"12","author":"Saucedo","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0150","doi-asserted-by":"crossref","first-page":"R689","DOI":"10.1016\/j.cub.2020.04.065","article-title":"Inflammasomes","volume":"30","author":"Ketelut-Carneiro","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coi.2019.11.007","article-title":"Inflammasomes and the fine line between defense and disease","volume":"62","author":"Christgen","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0160","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0165","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/14767058.2016.1199671","article-title":"Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus","volume":"30","author":"Fatima","year":"2017","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3892\/etm.2021.11017","article-title":"NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency","volume":"23","author":"Wu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cellimm.2025.104959_bb0175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-8227(01)00355-2","article-title":"Tumor necrosis factor system in insulin resistance in gestational diabetes","volume":"56","author":"Winkler","year":"2002","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.cellimm.2025.104959_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.104143","article-title":"Impact of vitamin D resistance genes on vitamin D deficiency during pregnancy among the south Indian population","volume":"160","author":"Milan","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.cellimm.2025.104959_bb0185","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cellimm.2025.104959_bb0190","doi-asserted-by":"crossref","unstructured":"I. Muela-Zarzuela, A. Gallardo-Orihuela, A. Pino-\u00c1ngeles, J.M. Suarez-Rivero, D. Boy-Ruiz, M. de Gregorio-Procopio, J. Oroz, G. Mbalaviele, M.D. Cordero, NEK7 activates the NLRP1 Inflammasome, (2022) 2022.2012.2021.521400.","DOI":"10.1101\/2022.12.21.521400"},{"key":"10.1016\/j.cellimm.2025.104959_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.892587","article-title":"A big role for microRNAs in gestational diabetes mellitus","volume":"13","author":"Masete","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/genes8110296","article-title":"The pattern of microRNA binding site distribution","volume":"8","author":"Zhang","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0205","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-017-0856-5","article-title":"MicroRNAs in pregnancy and gestational diabetes mellitus: emerging role in maternal metabolic regulation","volume":"17","author":"Poirier","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.cellimm.2025.104959_bb0210","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3892\/mmr.2014.2058","article-title":"MicroRNA-518d regulates PPARalpha protein expression in the placentas of females with gestational diabetes mellitus","volume":"9","author":"Zhao","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cellimm.2025.104959_bb0215","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1042\/CS20160305","article-title":"Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA","volume":"130","author":"Tryggestad","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.cellimm.2025.104959_bb0220","doi-asserted-by":"crossref","first-page":"4632745","DOI":"10.1155\/2021\/4632745","article-title":"MiRNAs in gestational diabetes mellitus: potential mechanisms and clinical applications","volume":"2021","author":"Liu","year":"2021","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.cellimm.2025.104959_bb0225","first-page":"1650","article-title":"miR-186 inhibits cell proliferation of prostate cancer by targeting GOLPH3","volume":"6","author":"Hua","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellimm.2025.104959_bb0230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1155\/2009\/641082","article-title":"MicroRNA microarray expression profiling in human myocardial infarction","volume":"27","author":"Bostjancic","year":"2009","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cellimm.2025.104959_bb0235","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.7314\/APJCP.2014.15.10.4245","article-title":"miR-186 regulates glycolysis through Glut1 during the formation of cancer-associated fibroblasts","volume":"15","author":"Sun","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874925000449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874925000449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T18:24:34Z","timestamp":1762107874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874925000449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"alternative-id":["S0008874925000449"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2025.104959","relation":{},"ISSN":["0008-8749"],"issn-type":[{"type":"print","value":"0008-8749"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNA-186-5p modulates placental inflammation via Inflammasome activation in gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2025.104959","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104959"}}