{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:48:10Z","timestamp":1776196090819,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271843"],"award-info":[{"award-number":["82271843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cellimm.2025.104996","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T07:20:28Z","timestamp":1750058428000},"page":"104996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis"],"prefix":"10.1016","volume":"414","author":[{"given":"Min","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2025.104996_bb0005","doi-asserted-by":"crossref","DOI":"10.7326\/AITC202006020","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cellimm.2025.104996_bb0010","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2024.2315","article-title":"Systemic lupus erythematosus: a review","volume":"331","author":"Siegel","year":"2024","journal-title":"Jama"},{"key":"10.1016\/j.cellimm.2025.104996_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030712","article-title":"New horizons in the genetic etiology of systemic lupus erythematosus and lupus-like disease: monogenic lupus and beyond","volume":"9","author":"Demirkaya","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellimm.2025.104996_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01088","article-title":"Aberrant T cell signaling and subsets in systemic lupus erythematosus","volume":"9","author":"Katsuyama","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0025","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1172\/JCI78087","article-title":"T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity","volume":"125","author":"Moulton","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellimm.2025.104996_bb0030","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/030097498441001","article-title":"Double-negative (CD4-CD8-) TCRalphabeta+ cells in patients with systemic lupus erythematosus","volume":"27","author":"Liu","year":"1998","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0035","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.4049\/jimmunol.165.9.5338","article-title":"Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c","volume":"165","author":"Sieling","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/0961203314524467","article-title":"Increased IL-17 and IL-21 producing TCR\u03b1\u03b2+CD4-CD8- T cells in Chinese systemic lupus erythematosus patients","volume":"23","author":"Wang","year":"2014","journal-title":"Lupus"},{"key":"10.1016\/j.cellimm.2025.104996_bb0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/pcmedi\/pbaa001","article-title":"Double negative T cells, a potential biomarker for systemic lupus erythematosus","volume":"3","author":"Alexander","year":"2020","journal-title":"Precision Clinical Med."},{"key":"10.1016\/j.cellimm.2025.104996_bb0050","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1038\/s41467-020-16636-4","article-title":"Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2025.104996_bb0055","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/rheumatology\/kex078","article-title":"Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-a potential biomarker of disease activity","volume":"56","author":"Stratigou","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0060","article-title":"CD3(+)CD4(\u2212)CD8(\u2212) (double-negative) T cells in inflammation, Immune Disorders and Cancer","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0065","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/art.42840","article-title":"Phosphatidic acid promoting the generation of interleukin-17A producing double-negative T cells by enhancing mTORC1 signaling in lupus","volume":"76","author":"Li","year":"2024","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cellimm.2025.104996_bb0070","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1191\/0961203302lu234oa","article-title":"Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4","volume":"11","author":"Dean","year":"2002","journal-title":"Lupus"},{"key":"10.1016\/j.cellimm.2025.104996_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118884","article-title":"Jieduquyuziyin prescription alleviates lupus development via inhibiting neddylation pathway to promote Bim-induced apoptosis of double negative T cells","volume":"337","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0080","article-title":"Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellimm.2025.104996_bb0085","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(13)60889-2","article-title":"Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment","volume":"382","author":"Murphy","year":"2013","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.coph.2013.04.005","article-title":"New biologic therapy for systemic lupus erythematosus","volume":"13","author":"Ding","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1741-7015-11-88","article-title":"Biologic therapy for autoimmune diseases: an update","volume":"11","author":"Rosman","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.cellimm.2025.104996_bb0105","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/ijc.30224","article-title":"Curcumin: a new candidate for melanoma therapy?","volume":"139","author":"Mirzaei","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellimm.2025.104996_bb0110","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.autrev.2017.11.016","article-title":"Curcumin: a natural modulator of immune cells in systemic lupus erythematosus","volume":"17","author":"Momtazi-Borojeni","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cellimm.2025.104996_bb0120","first-page":"2075","article-title":"Curcumin attenuates lupus nephritis in MRL\/lpr mice by suppressing macrophage-secreted B cell activating factor (BAFF)","volume":"12","author":"Li","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.intimp.2019.01.046","article-title":"Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome","volume":"69","author":"Zhao","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0130","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2024-001220","article-title":"Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K\/AKT\/NF-\u03baB signalling pathway","volume":"11","author":"Yang","year":"2024","journal-title":"Lupus Sci. & Med."},{"key":"10.1016\/j.cellimm.2025.104996_bb0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/CRIAI:25:1:49","article-title":"Systemic lupus erythematosus and apoptosis: a question of balance","volume":"25","author":"Mevorach","year":"2003","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0140","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/annrheumdis-2012-201511","article-title":"IL-17-producing CD4-CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren\u2019s syndrome","volume":"72","author":"Alunno","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cellimm.2025.104996_bb0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.clim.2017.06.002","article-title":"TCR(+)CD3(+)CD4(\u2212)CD8(\u2212) effector T cells in psoriasis","volume":"181","author":"Brandt","year":"2017","journal-title":"Clinical Immunol. (Orlando, Fla.)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0150","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crisp\u00edn","year":"2008","journal-title":"J. Immunol. (Baltimore Md: 1950)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.143.1.103","article-title":"T cell receptor alpha\/beta expressing double-negative (CD4-\/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis","volume":"143","author":"Shivakumar","year":"1989","journal-title":"J. Immunol. (BaltimoreMd: 1950)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0160","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/icb.2014.99","article-title":"Double negative (DN) \u03b1\u03b2 T cells: misperception and overdue recognition","volume":"93","author":"Martina","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.jrn.2011.03.002","article-title":"Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study","volume":"22","author":"Khajehdehi","year":"2012","journal-title":"J. Renal Nutr. : the Official J. Council on Renal Nutr. National Kidney Foundation"},{"key":"10.1016\/j.cellimm.2025.104996_bb0170","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3389\/fimmu.2019.00391","article-title":"Altered Th17\/Treg ratio in peripheral blood of systemic lupus erythematosus but not primary antiphospholipid syndrome","volume":"10","author":"\u00c1lvarez-Rodr\u00edguez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2014.12.027","article-title":"Th1\/Th2\/Th17\/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity","volume":"72","author":"Talaat","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.cellimm.2025.104996_bb0180","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/08916934.2015.1037441","article-title":"Interleukin-17 in systemic lupus erythematosus: a comprehensive review","volume":"48","author":"Li","year":"2015","journal-title":"Autoimmunity"},{"key":"10.1016\/j.cellimm.2025.104996_bb0185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11926-018-0714-8","article-title":"Tregs in SLE: an update","volume":"20","author":"La Cava","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.cellimm.2025.104996_bb0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.arcmed.2020.02.005","article-title":"CpG Oligodeoxynucleotides induces apoptosis of human bladder Cancer cells via Caspase-3-Bax\/Bcl-2-p53 Axis","volume":"51","author":"Luo","year":"2020","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.cellimm.2025.104996_bb0195","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41467-023-36755-y","article-title":"Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage","volume":"14","author":"Nappi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellimm.2025.104996_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102423","article-title":"p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3","volume":"56","author":"Rius-P\u00e9rez","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellimm.2025.104996_bb0205","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.38298","article-title":"Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic lupus erythematosus","volume":"66","author":"Yokogawa","year":"2014","journal-title":"Arthritis & Rheumatol. (Hoboken, N.J.)"},{"key":"10.1016\/j.cellimm.2025.104996_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105351","article-title":"Human and murine toll-like receptor-driven disease in systemic lupus erythematosus","volume":"25","author":"von Hofsten","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874925000826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874925000826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T16:20:43Z","timestamp":1752682843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874925000826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":42,"alternative-id":["S0008874925000826"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2025.104996","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2025.104996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104996"}}