{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:39:12Z","timestamp":1791916752689,"version":"4.3.4"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C1009616"],"award-info":[{"award-number":["NRF-2021R1A2C1009616"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-RS-2024-00347514"],"award-info":[{"award-number":["NRF-RS-2024-00347514"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cellimm.2026.105062","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T15:40:00Z","timestamp":1768664400000},"page":"105062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis"],"prefix":"10.1016","volume":"419","author":[{"given":"Jae-Eun","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Eun","family":"Seon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Min","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Su","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Hee","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Jin","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja-Hun","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Man","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harim","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Sik","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellimm.2026.105062_bb0005","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0010","first-page":"14","article-title":"Interaction between the gut microbiome and mucosal immune system","volume":"4","author":"Shi","year":"2017","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.cellimm.2026.105062_bb0015","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2147\/JIR.S318327","article-title":"Role of goblet cells in intestinal barrier and mucosal immunity","volume":"14","author":"Yang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cellimm.2026.105062_bb0020","article-title":"Antimicrobial peptides against bacterial pathogens: innovative delivery Nanosystems for pharmaceutical applications","volume":"12","author":"Imperlini","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.cellimm.2026.105062_bb0025","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115230119","article-title":"Intestinal commensal microbiota and cytokines regulate Fut2 Paneth cells for gut defense","volume":"119","author":"Kamioka","year":"2022","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.cellimm.2026.105062_bb0030","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.it.2017.11.003","article-title":"Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier","volume":"39","author":"Olivares-Villagomez","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0035","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2017.08.046","article-title":"Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection","volume":"171","author":"Hoytema van Konijnenburg","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2026.105062_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103114","article-title":"The gut ecosystem and immune tolerance","volume":"141","author":"Shao","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.cellimm.2026.105062_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/gmic.19320","article-title":"The role of gut microbiota in immune homeostasis and autoimmunity","volume":"3","author":"Wu","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.cellimm.2026.105062_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020294","article-title":"Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy","volume":"11","author":"Campbell","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellimm.2026.105062_bb0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12934-022-01769-6","article-title":"Assess the diversity of gut microbiota among healthy adults for forensic application","volume":"21","author":"Wang","year":"2022","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.cellimm.2026.105062_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.cellimm.2026.105062_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22602","article-title":"Association of Lactobacillus, Firmicutes, Bifidobacterium, Clostridium, and Enterococcus with colorectal cancer in Iranian patients","volume":"9","author":"Elahi","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.cellimm.2026.105062_bb0070","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/ars.2017.7057","article-title":"The role of Bacillithiol in gram-positive Firmicutes","volume":"28","author":"Chandrangsu","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cellimm.2026.105062_bb0075","first-page":"2","article-title":"Bifidobacteria: insights into the biology of a key microbial group of early life gut microbiota","volume":"1","author":"Turroni","year":"2021","journal-title":"Microbiome Res Rep"},{"key":"10.1016\/j.cellimm.2026.105062_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.948795","article-title":"Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by northern winds of Arctic origin","volume":"10","author":"Sarmiento-Vizcaino","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.cellimm.2026.105062_bb0085","article-title":"The \u201cJack-of-all-trades\u201d flagellum from Salmonella and E. Coli was horizontally acquired from an ancestral beta-proteobacterium","volume":"12","author":"Ferreira","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.dld.2018.02.012","article-title":"Actinobacteria: a relevant minority for the maintenance of gut homeostasis","volume":"50","author":"Binda","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.cellimm.2026.105062_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/nu16111695","article-title":"Insights into the mechanisms of action of Akkermansia muciniphila in the treatment of non-communicable diseases","volume":"16","author":"Mruk-Mazurkiewicz","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.cellimm.2026.105062_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107024","article-title":"Gut microbiome and multiple sclerosis: new insights and perspective","volume":"88","author":"Esmaeil Amini","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0105","article-title":"Gut microbiota dysbiosis: triggers, consequences","volume":"10","author":"Hrncir","year":"2022","journal-title":"Diagnostic and Therapeutic Options. Microorganisms"},{"key":"10.1016\/j.cellimm.2026.105062_bb0110","first-page":"440","article-title":"Intestinal dysbiosis: exploring definition, associated symptoms, and perspectives for a comprehensive understanding - a scoping review. Probiotics Antimicrob","volume":"17","author":"Carias Dominguez","year":"2025","journal-title":"Proteins"},{"key":"10.1016\/j.cellimm.2026.105062_bb0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/phar.2731","article-title":"Gut microbiome health and dysbiosis: a clinical primer","volume":"42","author":"Bidell","year":"2022","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.cellimm.2026.105062_bb0120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/1751-7915.13479","article-title":"Problems with the concept of gut microbiota dysbiosis","volume":"13","author":"Brussow","year":"2020","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11010013","article-title":"Gallstone disease, obesity and the Firmicutes\/Bacteroidetes ratio as a possible biomarker of gut dysbiosis","volume":"11","author":"Grigor\u2019eva","year":"2020","journal-title":"J Pers Med"},{"key":"10.1016\/j.cellimm.2026.105062_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020308","article-title":"The relationships between gut microbiota and diabetes mellitus, and treatments for diabetes mellitus","volume":"10","author":"Craciun","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellimm.2026.105062_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9351507","article-title":"Proteobacteria: a common factor in human diseases","volume":"2017","author":"Rizzatti","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cellimm.2026.105062_bb0140","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3389\/fimmu.2020.01810","article-title":"NLR and intestinal dysbiosis-associated inflammatory illness: drivers or dampers?","volume":"11","author":"Elias-Oliveira","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0145","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cellimm.2026.105062_bb0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/DCR.0000000000002037","article-title":"The American Society of Colon and Rectal Surgeons clinical practice guidelines for the surgical Management of Ulcerative Colitis","volume":"64","author":"Holubar","year":"2021","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.cellimm.2026.105062_bb0155","article-title":"Role of substance P in the pathophysiology of inflammatory bowel disease and its correlation with the degree of inflammation","volume":"12","author":"Patel","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.cellimm.2026.105062_bb0160","doi-asserted-by":"crossref","first-page":"260","DOI":"10.15430\/JCP.2015.20.4.260","article-title":"Adequate dextran sodium Sulfate-induced colitis model in mice and effective outcome measurement method","volume":"20","author":"Park","year":"2015","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.cellimm.2026.105062_bb0165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10620-011-1883-8","article-title":"Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice","volume":"57","author":"Park","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cellimm.2026.105062_bb0170","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1038\/s41598-021-84761-1","article-title":"DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice","volume":"11","author":"Kwon","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellimm.2026.105062_bb0175","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/ibd\/izad312","article-title":"Unveiling colitis: a journey through the dextran sodium Sulfate-induced model","volume":"30","author":"Yang","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.cellimm.2026.105062_bb0180","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-019-0341-6","article-title":"Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels","volume":"12","author":"Alam","year":"2020","journal-title":"Gut Pathog"},{"key":"10.1016\/j.cellimm.2026.105062_bb0190","article-title":"Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0195","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.immuni.2015.08.019","article-title":"Differential roles for Interleukin-23 and Interleukin-17 in intestinal immunoregulation","volume":"43","author":"Maxwell","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.cellimm.2026.105062_bb0200","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4014\/jmb.2103.03053","article-title":"IL-17A secreted by Th17 cells is essential for the host against Streptococcus agalactiae infections","volume":"31","author":"Chen","year":"2021","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0205","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cytogfr.2022.07.005","article-title":"The involvement of TH17 cells in the pathogenesis of IBD","volume":"69","author":"Jiang","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cellimm.2026.105062_bb0210","article-title":"Exploring the impact of TREM2 in tumor-associated macrophages","volume":"10","author":"Khantakova","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cellimm.2026.105062_bb0215","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.1102836","article-title":"TREM2 and beta-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis","volume":"188","author":"Otero","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0220","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1111\/bph.14618","article-title":"Microglial inflammation and phagocytosis in Alzheimer\u2019s disease: potential therapeutic targets","volume":"176","author":"Nizami","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0225","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12967-014-0293-z","article-title":"The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis","volume":"12","author":"Genua","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellimm.2026.105062_bb0230","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/j.gastro.2012.10.040","article-title":"Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response","volume":"144","author":"Correale","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellimm.2026.105062_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101124","article-title":"TREM receptors connecting bowel inflammation to neurodegenerative disorders","volume":"8","author":"Natale","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cellimm.2026.105062_bb0240","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.3748\/wjg.v10.i21.3141","article-title":"Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene","volume":"10","author":"Ge","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0245","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2337\/db13-1869","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity","volume":"64","author":"Park","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cellimm.2026.105062_bb0250","article-title":"TREM2 promotes Abeta phagocytosis by upregulating C\/EBPalpha-dependent CD36 expression in microglia","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellimm.2026.105062_bb0255","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2249.2006.03214.x","article-title":"Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice","volume":"146","author":"Ito","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0260","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2147\/IJGM.S448359","article-title":"Microbial disruptions in inflammatory bowel disease: a comparative analysis","volume":"17","author":"Ma","year":"2024","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.cellimm.2026.105062_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13040710","article-title":"Impact of microbiota diversity on inflammatory bowel disease","volume":"13","author":"Alzahrani","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.cellimm.2026.105062_bb0270","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002325RR","article-title":"Cyclophilin a is an endogenous ligand for the triggering receptor expressed on myeloid cells-2 (TREM2)","volume":"35","author":"Ji","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.cellimm.2026.105062_bb0275","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.3748\/wjg.v27.i43.7402","article-title":"Antimicrobial peptides and the gut microbiome in inflammatory bowel disease","volume":"27","author":"Gubatan","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0280","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.abq3178","article-title":"Peptide YY: a Paneth cell antimicrobial peptide that maintains Candida gut commensalism","volume":"381","author":"Pierre","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cellimm.2026.105062_bb0285","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2016.10.020","article-title":"Linking the human gut microbiome to inflammatory cytokine production capacity","volume":"167","author":"Schirmer","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cellimm.2026.105062_bb0290","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1021\/acs.biomac.1c00551","article-title":"Broad-Spectrum reactive oxygen species scavenging and activated macrophage-targeting microparticles ameliorate inflammatory bowel disease","volume":"22","author":"Li","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.cellimm.2026.105062_bb0295","article-title":"The role of Th17 cells in inflammatory bowel disease and the research progress","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1651063","article-title":"Th17\/Treg imbalance in inflammatory bowel disease: immunological mechanisms and microbiota-driven regulation","volume":"16","author":"Hu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0305","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/intimm\/dxz076","article-title":"Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production","volume":"32","author":"Tachibana","year":"2020","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1155388","article-title":"Microbiota as key factors in inflammatory bowel disease","volume":"14","author":"White","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0315","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-med-042320-021020","article-title":"The gut microbiome and inflammatory bowel diseases","volume":"73","author":"Shan","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cellimm.2026.105062_bb0320","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00616-22","article-title":"Dysbiosis in the gut microbiota in patients with inflammatory bowel disease during remission","volume":"10","author":"Pisani","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.cellimm.2026.105062_bb0325","article-title":"TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy","volume":"9, eadi5374","author":"Di Luccia","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0330","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12192","article-title":"Macrophages in intestinal homeostasis and inflammation","volume":"260","author":"Bain","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cellimm.2026.105062_bb0335","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jcmgh.2021.08.021","article-title":"The role of intestinal macrophages in gastrointestinal homeostasis: heterogeneity and implications in disease","volume":"12","author":"Yip","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0340","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1512969","article-title":"Functions of macrophages in the maintenance of intestinal homeostasis","volume":"2019","author":"Wang","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.cellimm.2026.105062_bb0345","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000180","article-title":"Paneth cells: maintaining dynamic microbiome-host homeostasis, protecting against inflammation and cancer","volume":"43","author":"Nikolenko","year":"2021","journal-title":"Bioessays"},{"key":"10.1016\/j.cellimm.2026.105062_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115263","article-title":"Metformin beyond an anti-diabetic agent: a comprehensive and mechanistic review on its effects against natural and chemical toxins","volume":"165","author":"Malaekeh-Nikouei","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellimm.2026.105062_bb0355","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216427","article-title":"Paneth cells as the cornerstones of intestinal and organismal health: a primer","volume":"15","author":"Wallaeys","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cellimm.2026.105062_bb0360","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fimmu.2012.00310","article-title":"Intestinal antimicrobial peptides during homeostasis, infection, and disease","volume":"3","author":"Muniz","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0370","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ilar\/ilv030","article-title":"The intestinal microbiota in inflammatory bowel disease","volume":"56","author":"Becker","year":"2015","journal-title":"ILAR J."},{"key":"10.1016\/j.cellimm.2026.105062_bb0375","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41420-023-01666-w","article-title":"The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cellimm.2026.105062_bb0380","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.928478","article-title":"Effects of pretreatment with Bifidobacterium bifidum using 16S ribosomal RNA gene sequencing in a mouse model of acute colitis induced by dextran Sulfate sodium","volume":"27","author":"Weng","year":"2021","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.cellimm.2026.105062_bb0385","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12328-023-01893-9","article-title":"Colitis induced by IL-17A-inhibitors","volume":"17","author":"Grumme","year":"2024","journal-title":"Clin. J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0390","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1736","article-title":"A protective function for interleukin 17A in T cell-mediated intestinal inflammation","volume":"10","author":"O\u2019Connor","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1124628","article-title":"IL-17 inhibitor-associated inflammatory bowel disease: a study based on literature and database analysis","volume":"14","author":"Deng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0400","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12967-021-02943-x","article-title":"Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17\/Treg cell balance","volume":"19","author":"Huang","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellimm.2026.105062_bb0405","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/909514","article-title":"Lactobacillus acidophilus suppresses colitis-associated activation of the IL-23\/Th17 axis","volume":"2015","author":"Chen","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.cellimm.2026.105062_bb0410","article-title":"Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2026.105062_bb0415","doi-asserted-by":"crossref","first-page":"18316","DOI":"10.3748\/wjg.v20.i48.18316","article-title":"Bifidobacterium infantis attenuates colitis by regulating T cell subset responses","volume":"20","author":"Zuo","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellimm.2026.105062_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079735","article-title":"Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules","volume":"8","author":"Miyauchi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellimm.2026.105062_bb0425","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/mi.2013.73","article-title":"New targets for mucosal healing and therapy in inflammatory bowel diseases","volume":"7","author":"Neurath","year":"2014","journal-title":"Mucosal Immunol."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887492600002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000887492600002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:43:49Z","timestamp":1770759829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000887492600002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":85,"alternative-id":["S000887492600002X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellimm.2026.105062","relation":{},"ISSN":["0008-8749"],"issn-type":[{"value":"0008-8749","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellimm.2026.105062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105062"}}