{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:41:28Z","timestamp":1773171688273,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.cellsig.2008.12.008","type":"journal-article","created":{"date-parts":[[2008,12,26]],"date-time":"2008-12-26T09:25:34Z","timestamp":1230283534000},"page":"567-576","source":"Crossref","is-referenced-by-count":12,"title":["Reduced amyloidogenic processing of the amyloid \u03b2-protein precursor by the small-molecule Differentiation Inducing Factor-1"],"prefix":"10.1016","volume":"21","author":[{"given":"Michael A.","family":"Myre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Washicosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Moir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Tesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma","family":"Wasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2008.12.008_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1385\/JMN:20:2:203","volume":"20","author":"Hardy","year":"2003","journal-title":"Mol. Neurosci."},{"key":"10.1016\/j.cellsig.2008.12.008_bib2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.2949367","volume":"235","author":"Tanzi","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2008.12.008_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2008.12.008_bib4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"Haass","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2008.12.008_bib5","doi-asserted-by":"crossref","first-page":"10758","DOI":"10.1073\/pnas.89.22.10758","volume":"89","author":"Wasco","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.cellsig.2008.12.008_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.1996.tb34404.x","volume":"777","author":"Sisodia","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellsig.2008.12.008_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","volume":"258","author":"Shoji","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2008.12.008_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.1411529","volume":"258","author":"Nitsch","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2008.12.008_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","volume":"44","author":"Walsh","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cellsig.2008.12.008_bib10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jnen\/59.10.880","volume":"59","author":"Zhu","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0143-4160(03)00128-3","volume":"34","author":"Mattson","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cellsig.2008.12.008_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0306-4522(98)00293-0","volume":"87","author":"Nagy","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.cellsig.2008.12.008_bib13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/1097-4547(20000715)61:2<128::AID-JNR2>3.0.CO;2-H","volume":"61","author":"Raina","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cellsig.2008.12.008_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/JAD-2002-4315","volume":"4","author":"Herrup","year":"2002","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cellsig.2008.12.008_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.3707-05.2006","volume":"26","author":"Yang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cellsig.2008.12.008_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cub.2005.12.042","volume":"16","author":"Khurana","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib17","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998","volume":"18","author":"Busser","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cellsig.2008.12.008_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1155>3.0.CO;2-H","volume":"92","author":"Meng","year":"2001","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.cellsig.2008.12.008_bib19","first-page":"7032","volume":"63","author":"Hansel","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2008.12.008_bib20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ijc.20328","volume":"111","author":"Ko","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2008.12.008_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1440-169x.2004.00753.x","volume":"46","author":"Thompson","year":"2004","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.cellsig.2008.12.008_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0092-8674(89)90771-X","volume":"59","author":"Williams","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2008.12.008_bib23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/303242a0","volume":"303","author":"Kay","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2008.12.008_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(99)00548-8","volume":"381","author":"Kubohara","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib25","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bbrc.2005.10.018","volume":"16","author":"Yasmin","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2008.12.008_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-6-24","volume":"6","author":"Alao","year":"2007","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2008.12.008_bib27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P","volume":"12","author":"Morin","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.cellsig.2008.12.008_bib28","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1097\/00001756-199705260-00054","volume":"8","author":"Zhou","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.cellsig.2008.12.008_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2008.12.008_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0002-9440(10)62962-8","volume":"167","author":"Chevallier","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib31","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1078\/0171-9335-00117","volume":"79","author":"Hoffmann","year":"2000","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib32","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1046\/j.1460-9568.1999.00601.x","volume":"11","author":"Ohsawa","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cellsig.2008.12.008_bib33","doi-asserted-by":"crossref","first-page":"18146","DOI":"10.1074\/jbc.M311601200","volume":"279","author":"Eggert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2008.12.008_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.200301115","volume":"163","author":"Lee","year":"2003","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.nbd.2005.05.004","volume":"2","author":"Vingtdeux","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cellsig.2008.12.008_bib36","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.283.5406.1325","volume":"283","author":"Lu","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2008.12.008_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/77929","volume":"7","author":"Verdecia","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1471-4159.1996.67020699.x","volume":"67","author":"Aplin","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cellsig.2008.12.008_bib39","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1471-4159.2000.0751085.x","volume":"75","author":"Iijima","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cellsig.2008.12.008_bib40","first-page":"125","volume":"5","author":"Crews","year":"2003","journal-title":"Prog. Cell Cycle Res."},{"key":"10.1016\/j.cellsig.2008.12.008_bib41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pneurobio.2003.09.007","volume":"71","author":"Arendt","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib42","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1093\/emboj\/17.24.7151","volume":"17","author":"Ciechanover","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2008.12.008_bib43","doi-asserted-by":"crossref","first-page":"32240","DOI":"10.1074\/jbc.M603106200","volume":"281","author":"Hiltunen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2008.12.008_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.200110151","volume":"158","author":"Chen","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2008.12.008_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0000051","volume":"1","author":"Sano","year":"2006","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cellsig.2008.12.008_bib46","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1096\/fasebj.11.14.9409540","volume":"11","author":"Hicke","year":"1997","journal-title":"FASEB J."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865680800394X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865680800394X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:11:30Z","timestamp":1558030290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865680800394X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S089865680800394X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2008.12.008","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}