{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:06:43Z","timestamp":1786986403581,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.cellsig.2010.02.008","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T04:56:24Z","timestamp":1267505784000},"page":"1054-1062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p"],"prefix":"10.1016","volume":"22","author":[{"given":"Shweta","family":"Rane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Vatner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Abdellatif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cellsig.2010.02.008_bib1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","volume":"104","author":"Rane","year":"2009","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jsre.1997.5142","volume":"71","author":"Rowland","year":"1997","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10863-009-9205-y","volume":"41","author":"Miyamoto","year":"2009","journal-title":"J. Bioenerg. Biomembr."},{"issue":"4","key":"10.1016\/j.cellsig.2010.02.008_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.87.4.309","volume":"87","author":"Tong","year":"2000","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.cellsig.2010.02.008_bib6","first-page":"363","volume":"12","author":"Jiang","year":"2001","journal-title":"Cell Growth Differ."},{"issue":"33","key":"10.1016\/j.cellsig.2010.02.008_bib7","doi-asserted-by":"crossref","first-page":"31277","DOI":"10.1074\/jbc.M300763200","volume":"278","author":"Mottet","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2010.02.008_bib8","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","volume":"90","author":"Wang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.cellsig.2010.02.008_bib9","first-page":"5447","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2010.02.008_bib10","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.cellsig.2010.02.008_bib11","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1074\/jbc.M010144200","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"38","key":"10.1016\/j.cellsig.2010.02.008_bib12","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","volume":"269","author":"Semenza","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2010.02.008_bib13","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","volume":"272","author":"Lee","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2010.02.008_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.RES.86.3.319","volume":"86","author":"Jung","year":"2000","journal-title":"Circ. Res."},{"issue":"16","key":"10.1016\/j.cellsig.2010.02.008_bib15","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6692","key":"10.1016\/j.cellsig.2010.02.008_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"issue":"6 Pt 2","key":"10.1016\/j.cellsig.2010.02.008_bib17","first-page":"H1822","volume":"259","author":"Thornton","year":"1990","journal-title":"Am. J. Physiol."},{"issue":"19 Suppl 3","key":"10.1016\/j.cellsig.2010.02.008_bib18","first-page":"III312","volume":"102","author":"Matsuyama","year":"2000","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cellsig.2010.02.008_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/cvr\/cvm035","volume":"77","author":"Cai","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCULATIONAHA.107.758516","volume":"118","author":"Eckle","year":"2008","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.cellsig.2010.02.008_bib21","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/01.CIR.98.13.1329","volume":"98","author":"Communal","year":"1998","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.cellsig.2010.02.008_bib22","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/01.RES.85.11.1077","volume":"85","author":"Cross","year":"1999","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib23","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nm1750","volume":"14","author":"Liggett","year":"2008","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib24","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1097\/00005344-199006165-00019","volume":"16","author":"Schomig","year":"1990","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2007.05.038","volume":"130","author":"Yan","year":"2007","journal-title":"Cell"},{"issue":"16","key":"10.1016\/j.cellsig.2010.02.008_bib26","doi-asserted-by":"crossref","first-page":"12864","DOI":"10.1074\/jbc.M001492200","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"40","key":"10.1016\/j.cellsig.2010.02.008_bib27","doi-asserted-by":"crossref","first-page":"37242","DOI":"10.1074\/jbc.M105089200","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.cellsig.2010.02.008_bib28","doi-asserted-by":"crossref","first-page":"10698","DOI":"10.1074\/jbc.M109432200","volume":"277","author":"Doronin","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"49","key":"10.1016\/j.cellsig.2010.02.008_bib29","doi-asserted-by":"crossref","first-page":"34795","DOI":"10.1074\/jbc.274.49.34795","volume":"274","author":"Klein","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2010.02.008_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1152\/ajpendo.00079.2004","volume":"289","author":"Mulder","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cellsig.2010.02.008_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cardiores.2007.07.012","volume":"76","author":"Morisco","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellsig.2010.02.008_bib32","doi-asserted-by":"crossref","first-page":"15423","DOI":"10.1016\/S0021-9258(17)40695-8","volume":"269","author":"Abdellatif","year":"1994","journal-title":"JBC"},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib33","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1172\/JCI29576","volume":"117","author":"Peter","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2010.02.008_bib34","series-title":"Methods in Molecular Biology","author":"Graham","year":"1991"},{"key":"10.1016\/j.cellsig.2010.02.008_bib35","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1091\/mbc.e08-02-0159","volume":"18","author":"Sayed","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.cellsig.2010.02.008_bib36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","volume":"100","author":"Sayed","year":"2007","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2010.02.008_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1006\/jmcc.2002.2006","volume":"34","author":"Mocanu","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/ajpregu.00520.2006","volume":"292","author":"Katakam","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cellsig.2010.02.008_bib39","first-page":"17","volume":"17","author":"Fuglesteg","year":"2008","journal-title":"Acta Physiol."},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib40","first-page":"E25","volume":"90","author":"Kim","year":"2002","journal-title":"Circ. Res."},{"issue":"6 Pt 2","key":"10.1016\/j.cellsig.2010.02.008_bib41","first-page":"I11","volume":"67","author":"Frishman","year":"1983","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1124\/jpet.106.102160","volume":"318","author":"Hu","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1\u20133","key":"10.1016\/j.cellsig.2010.02.008_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(02)02247-0","volume":"512","author":"Stiehl","year":"2002","journal-title":"FEBS Lett."},{"issue":"31","key":"10.1016\/j.cellsig.2010.02.008_bib44","doi-asserted-by":"crossref","first-page":"27975","DOI":"10.1074\/jbc.M204152200","volume":"277","author":"Treins","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.cellsig.2010.02.008_bib45","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/emboj\/17.17.5085","volume":"17","author":"Zelzer","year":"1998","journal-title":"Embo J."},{"issue":"19","key":"10.1016\/j.cellsig.2010.02.008_bib46","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.95.19.11211","volume":"95","author":"Delcommenne","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cellsig.2010.02.008_bib47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1535-6108(03)00281-2","volume":"5","author":"Tan","year":"2004","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.cellsig.2010.02.008_bib48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/CIRCULATIONAHA.105.595918","volume":"114","author":"Lee","year":"2006","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.cellsig.2010.02.008_bib49","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1161\/01.CIR.102.23.2873","volume":"102","author":"Aikawa","year":"2000","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.cellsig.2010.02.008_bib50","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1161\/CIRCULATIONAHA.107.698662","volume":"116","author":"Okumura","year":"2007","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cellsig.2010.02.008_bib52","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/01.hco.0000240588.22086.43","volume":"21","author":"Bhatt","year":"2006","journal-title":"Curr. Opin. Cardiol."},{"issue":"10","key":"10.1016\/j.cellsig.2010.02.008_bib53","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ. Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656810000616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656810000616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:45:22Z","timestamp":1760265922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656810000616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0898656810000616"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2010.02.008","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2010.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}