{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:17:07Z","timestamp":1789942627174,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81072686"],"award-info":[{"award-number":["81072686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81273526"],"award-info":[{"award-number":["81273526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.cellsig.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T20:41:48Z","timestamp":1350506508000},"page":"355-358","source":"Crossref","is-referenced-by-count":21,"title":["DNA methylation: New therapeutic implications for hepatic fibrosis"],"prefix":"10.1016","volume":"25","author":[{"given":"Er-Bao","family":"Bian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong-wen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellsig.2012.10.007_bb0005","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cellsig.2012.10.007_bb0010","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0168-8278(98)80269-9","volume":"29","author":"Olaso","year":"1998","journal-title":"Journal of Hepatology"},{"issue":"Suppl. 3","key":"10.1016\/j.cellsig.2012.10.007_bb0015","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1440-1746.2006.04585.x","volume":"21","author":"Friedman","year":"2006","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.biocel.2006.10.006","volume":"39","author":"Muddu","year":"2007","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"5","key":"10.1016\/j.cellsig.2012.10.007_bb0025","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10495-005-1055-4","volume":"10","author":"Elsharkawy","year":"2005","journal-title":"Apoptosis"},{"issue":"24","key":"10.1016\/j.cellsig.2012.10.007_bb0030","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","volume":"82","author":"Friedman","year":"1985","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"40","key":"10.1016\/j.cellsig.2012.10.007_bb0035","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.3748\/wjg.v12.i40.6473","volume":"12","author":"Takahara","year":"2006","journal-title":"World Journal of Gastroenterology"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2012.10.007_bb0040","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ncponc0354","volume":"2","author":"Baylin","year":"2005","journal-title":"Nature Clinical Practice Oncology"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.blre.2005.01.006","volume":"20","author":"Galm","year":"2006","journal-title":"Blood Reviews"},{"issue":"2","key":"10.1016\/j.cellsig.2012.10.007_bb0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-0749.2007.00367.x","volume":"20","author":"Rothhammer","year":"2007","journal-title":"Pigment Cell Research"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ki.2010.335","volume":"79","author":"Dwivedi","year":"2011","journal-title":"Kidney International"},{"issue":"21","key":"10.1016\/j.cellsig.2012.10.007_bb0060","doi-asserted-by":"crossref","first-page":"9700","DOI":"10.1073\/pnas.91.21.9700","volume":"91","author":"Herman","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/j.cellsig.2012.10.007_bb0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/5947","volume":"21","author":"Jones","year":"1999","journal-title":"Nature Genetics"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/71750","volume":"24","author":"Fuks","year":"2000","journal-title":"Nature Genetics"},{"issue":"10","key":"10.1016\/j.cellsig.2012.10.007_bb0075","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/emboj\/20.10.2536","volume":"20","author":"Fuks","year":"2001","journal-title":"EMBO Journal"},{"issue":"21","key":"10.1016\/j.cellsig.2012.10.007_bb0080","doi-asserted-by":"crossref","first-page":"9783","DOI":"10.1073\/pnas.1004297107","volume":"107","author":"Dickstein","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.cellsig.2012.10.007_bb0085","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/77124","volume":"25","author":"Robertson","year":"2000","journal-title":"Nature Genetics"},{"issue":"3","key":"10.1016\/j.cellsig.2012.10.007_bb0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/77023","volume":"25","author":"Rountree","year":"2000","journal-title":"Nature Genetics"},{"issue":"10","key":"10.1016\/j.cellsig.2012.10.007_bb0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tcb.2010.08.003","volume":"20","author":"De Carvalho","year":"2010","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.cellsig.2012.10.007_bb0100","first-page":"45","volume":"301","author":"Brenner","year":"2006","journal-title":"Current Topics in Microbiology and Immunology"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0105","first-page":"631","volume":"10","author":"Turek-Plewa","year":"2005","journal-title":"Cellular and Molecular Biology Letters"},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2012.10.007_bb0110","first-page":"9","volume":"9","author":"del Senno","year":"1986","journal-title":"Cancer Detection and Prevention"},{"issue":"20","key":"10.1016\/j.cellsig.2012.10.007_bb0115","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/jnci\/djj447","volume":"98","author":"Mack","year":"2006","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.cellsig.2012.10.007_bb0120","doi-asserted-by":"crossref","first-page":"D599","DOI":"10.2741\/szyf","volume":"6","author":"Szyf","year":"2001","journal-title":"Frontiers in Bioscience"},{"issue":"18","key":"10.1016\/j.cellsig.2012.10.007_bb0125","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","volume":"342","author":"Blobe","year":"2000","journal-title":"The New England Journal of Medicine"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2012.10.007_bb0130","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1111\/j.1440-1746.2007.05295.x","volume":"23","author":"Mann","year":"2008","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"6","key":"10.1016\/j.cellsig.2012.10.007_bb0135","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0140","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiological Reviews"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0145","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1053\/j.gastro.2004.08.028","volume":"127","author":"Rippe","year":"2004","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0150","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1515\/BC.2008.048","volume":"389","author":"Gelato","year":"2008","journal-title":"Biological Chemistry"},{"issue":"11","key":"10.1016\/j.cellsig.2012.10.007_bb0155","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.bcp.2006.06.016","volume":"72","author":"Quina","year":"2006","journal-title":"Biochemical Pharmacology"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","volume":"264","author":"Bian","year":"2012","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"2\u20133","key":"10.1016\/j.cellsig.2012.10.007_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tox.2011.10.011","volume":"290","author":"Tao","year":"2011","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.cellsig.2012.10.007_bb0170","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1128\/MCB.22.7.2124-2135.2002","volume":"22","author":"Biniszkiewicz","year":"2002","journal-title":"Molecular and Cellular Biology"},{"issue":"5","key":"10.1016\/j.cellsig.2012.10.007_bb0175","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nm.2135","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nature Medicine"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0180","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/bdrc.20163","volume":"87","author":"Cheung","year":"2009","journal-title":"Birth Defects Research. Part C, Embryo Today: Reviews"},{"issue":"7","key":"10.1016\/j.cellsig.2012.10.007_bb0185","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1074\/jbc.M209923200","volume":"278","author":"Kimura","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.cellsig.2012.10.007_bb0190","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death and Differentiation"},{"issue":"5","key":"10.1016\/j.cellsig.2012.10.007_bb0195","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.gde.2004.07.007","volume":"14","author":"Kadesch","year":"2004","journal-title":"Current Opinion in Genetics and Development"},{"issue":"36","key":"10.1016\/j.cellsig.2012.10.007_bb0200","doi-asserted-by":"crossref","first-page":"34115","DOI":"10.1074\/jbc.M105747200","volume":"276","author":"Kokura","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.cellsig.2012.10.007_bb0205","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1097-2765(03)00276-4","volume":"12","author":"Stancheva","year":"2003","journal-title":"Molecular Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2012.10.007_bb0210","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hep.510300406","volume":"30","author":"Marra","year":"1999","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.cellsig.2012.10.007_bb0215","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.M212927200","volume":"278","author":"Reif","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.cellsig.2012.10.007_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc969","volume":"3","author":"Downward","year":"2003","journal-title":"Nature Reviews. Cancer"},{"issue":"14","key":"10.1016\/j.cellsig.2012.10.007_bb0225","doi-asserted-by":"crossref","first-page":"R563","DOI":"10.1016\/j.cub.2005.07.010","volume":"15","author":"Mitin","year":"2005","journal-title":"Current Biology"},{"issue":"6","key":"10.1016\/j.cellsig.2012.10.007_bb0230","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cell.2005.04.017","volume":"121","author":"Kolfschoten","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2012.10.007_bb0235","doi-asserted-by":"crossref","first-page":"d793","DOI":"10.2741\/gressner","volume":"7","author":"Gressner","year":"2002","journal-title":"Frontiers in Bioscience"},{"issue":"10","key":"10.1016\/j.cellsig.2012.10.007_bb0240","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/labinvest.2009.77","volume":"89","author":"Liu","year":"2009","journal-title":"Laboratory Investigation"},{"issue":"2\u20133","key":"10.1016\/j.cellsig.2012.10.007_bb0245","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1386-5056(01)00160-5","volume":"62","author":"Phuong","year":"2001","journal-title":"International Journal of Medical Informatics"},{"issue":"2","key":"10.1016\/j.cellsig.2012.10.007_bb0250","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/hmg\/9.2.283","volume":"9","author":"Guanti","year":"2000","journal-title":"Human Molecular Genetics"},{"issue":"7","key":"10.1016\/j.cellsig.2012.10.007_bb0255","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1158\/0008-5472.CAN-08-3070","volume":"69","author":"Hino","year":"2009","journal-title":"Cancer Research"},{"issue":"7","key":"10.1016\/j.cellsig.2012.10.007_bb0260","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ncb1897","volume":"11","author":"Kato","year":"2009","journal-title":"Nature Cell Biology"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656812002872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656812002872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T01:56:44Z","timestamp":1588816604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656812002872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0898656812002872"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2012.10.007","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}