{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:09:54Z","timestamp":1792537794390,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Danish Natural Science Research Council"},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"crossref"}]},{"name":"A.P. Moller Foundation for the Advancement of Medical Science,"},{"name":"Arne Hansen Foundation"},{"name":"Else and Mogens Wedell-Weddelsborgs Foundation"},{"DOI":"10.13039\/501100002739","name":"Aarhus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.cellsig.2015.03.020","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T15:50:43Z","timestamp":1428249043000},"page":"1356-1368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha"],"prefix":"10.1016","volume":"27","author":[{"given":"Mariann F.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Greibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Skovbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders C.M.","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine R.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Stentoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina H.","family":"Kj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla S.","family":"Kronborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia M.","family":"Martensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2015.03.020_bb0005","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/j.ejca.2005.08.016","volume":"41","author":"Hodge","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0010","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0015","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00001813-200507000-00002","volume":"116","author":"Jing","year":"2005","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0020","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1128\/MCB.25.17.7432-7440.2005","volume":"25","author":"Niu","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0025","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1038\/sj.onc.1204990","volume":"20","author":"Burke","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1124\/mi.11.1.4","volume":"11","author":"Johnston","year":"2011","journal-title":"Mol. Interv."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.semcdb.2008.08.010","volume":"19","author":"Schindler","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3340297","volume":"334","author":"Heinrich","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1747-1028-5-14","volume":"5","author":"Jarnicki","year":"2010","journal-title":"Cell Div."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0055","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ab.2004.12.026","volume":"338","author":"Parker","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10545-010-9128-0","volume":"34","author":"Duthie","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.278","volume":"4","author":"Kerek","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0070","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ijc.21712","volume":"119","author":"Kelemen","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0075","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ygyno.2007.11.020","volume":"108","author":"Kalli","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0080","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/ijc.22811","volume":"121","author":"Hartmann","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0083-6729(03)01012-4","volume":"66","author":"Matherly","year":"2003","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0083-6729(08)00407-X","volume":"79","author":"Leamon","year":"2008","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0095","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cbpa.2009.03.022","volume":"13","author":"Low","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1517\/17425247.5.3.309","volume":"5","author":"Zhao","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(02)00145-4","volume":"12","author":"Sabharanjak","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1124\/jpet.106.117648","volume":"32","author":"Yang","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0115","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1681\/ASN.2004080711","volume":"16","author":"Birn","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0120","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrm778","volume":"3","author":"Christensen","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0125","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1111\/j.1742-4658.2005.04857.x","volume":"272","author":"Birn","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0130","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/ncomms3123","volume":"4","author":"Grapp","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1097-0215(19980105)75:1<125::AID-IJC19>3.0.CO;2-F","volume":"75","author":"Corona","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0140","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1158\/1078-0432.CCR-04-1225","volume":"10","author":"Chattopadhyay","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10555-007-9048-0","volume":"26","author":"Salazar","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0150","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/1535-7163.MCT-06-0343","volume":"6","author":"Chattopadhyay","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0155","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1517\/14656566.2010.489552","volume":"11","author":"Zain","year":"2010","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0160","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature12327","volume":"500","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0165","doi-asserted-by":"crossref","first-page":"15180","DOI":"10.1073\/pnas.1308827110","volume":"110","author":"Wibowo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0170","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nmeth.2089","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0175","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cyto.2008.01.008","volume":"42","author":"Kronborg","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0180","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bjc.6603597","volume":"96","author":"Chen","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0185","first-page":"2948","volume":"63","author":"Sriuranpong","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0190","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4049\/jimmunol.174.2.609","volume":"174","author":"Tanabe","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0195","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.cr.7310015","volume":"16","author":"Krause","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0200","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1517\/14728222.2013.830105","volume":"17","author":"Xu","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semcdb.2008.06.004","volume":"19","author":"Regis","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0210","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/intimm\/10.12.1881","volume":"10","author":"Autissier","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0215","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3177\/jnsv.54.353","volume":"54","author":"Zhang","year":"2008","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0220","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1179\/147683009X423418","volume":"12","author":"Zhang","year":"2009","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006292","volume":"4","author":"Basal","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0230","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.icb.7100113","volume":"86","author":"Kn\u00fcpfer","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1189\/jlb.1105674","volume":"80","author":"Rose-John","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/bdra.20581","volume":"85","author":"Blom","year":"2009","journal-title":"Birth Defects Res., Part A"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0245","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJMoa031145","volume":"350","author":"Rothenberg","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/13861","volume":"23","author":"Piedrahita","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/bdra.10045","volume":"67","author":"Tang","year":"2003","journal-title":"Birth Defects Res., Part A"},{"key":"10.1016\/j.cellsig.2015.03.020_bb0260","first-page":"321","volume":"23","author":"Han","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.001438","volume":"2","author":"Han","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.cellsig.2015.03.020_bb0270","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/dvdy.20126","volume":"231","author":"Yan","year":"2004","journal-title":"Dev. Dyn."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656815001199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656815001199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T18:51:31Z","timestamp":1537728691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656815001199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0898656815001199"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2015.03.020","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2015.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}