{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:50:21Z","timestamp":1790769021047,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Huntington's Disease Network Seedfund","award":["579"],"award-info":[{"award-number":["579"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.cellsig.2016.12.005","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T13:32:07Z","timestamp":1481722327000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["SMAD transcription factors are altered in cell models of HD and regulate HTT expression"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-5245","authenticated-orcid":false,"given":"KR","family":"Bowles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Holmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ND","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SB","family":"Dunnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2016.12.005_bb0005","article-title":"Huntington disease","volume":"15005","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0010","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","article-title":"Onset and rate of striatal atrophy in preclinical Huntington disease","volume":"63","author":"Aylward","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0015","first-page":"215","article-title":"Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease","volume":"47","author":"Ciarmiello","year":"2006","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0020","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tins.2004.08.008","article-title":"Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect","volume":"27","author":"Levine","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0025","first-page":"89","volume":"Vol. 3","author":"Bowles","year":"2014"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0030","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1101\/gad.1167003","article-title":"Integration of Smad and MAPK pathways: a link and a linker revisited","volume":"17","author":"Massague","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0035","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0040","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1582-4934.2010.01011.x","article-title":"Early defect of transforming growth factor \u03b21 formation in Huntington's disease","volume":"15","author":"Battaglia","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbi.2014.09.011","article-title":"Plasma inflammatory biomarkers for Huntington's disease patients and mouse model","volume":"44","author":"Chang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/NEN.0b013e3181e4f733","article-title":"Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease","volume":"69","author":"Kandasamy","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0055","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.stemcr.2015.11.005","article-title":"Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human Huntington's disease neural stem cells","volume":"5","author":"Ring","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0060","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.stem.2012.04.026","article-title":"Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells","author":"An","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0075","doi-asserted-by":"crossref","first-page":"ra40","DOI":"10.1126\/scisignal.2000350","article-title":"Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks","volume":"2","author":"Huang","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0080","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of Biomolecular interaction networks Cytoscape: a software environment for integrated models of Biomolecular interaction networks","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0144864","article-title":"Huntingtin subcellular localisation is regulated by kinase signalling activity in the StHdhQ111 model of HD","volume":"10","author":"Bowles","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0090","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.yexcr.2003.07.007","article-title":"On and off: proteasome and TGF-?? Signaling","volume":"291","author":"Zhang","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0095","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1432-1033.2004.03994.x","article-title":"Nerve growth factor mediates activation of the Smad pathway in PC12 cells","volume":"271","author":"Lutz","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jhep.2010.10.041","article-title":"Dissecting the effect of targeting the epidermal growth factor receptor on TGF-\u03b2-induced-apoptosis in human hepatocellular carcinoma cells","volume":"55","author":"Caja","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0105","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1158\/0008-5472.CAN-11-1330","article-title":"EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction","volume":"71","author":"Jin","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/BJ20111584","article-title":"Cross-talk between TGF\u03b21 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition","volume":"443","author":"Kang","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0115","doi-asserted-by":"crossref","first-page":"33986","DOI":"10.1074\/jbc.M100093200","article-title":"Cross-talk between the p42\/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation","volume":"276","author":"Blanchette","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2011.09.024","article-title":"Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells","volume":"314","author":"Kim","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0125","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jcp.21078","article-title":"Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-B1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells","volume":"212","author":"Ding","year":"2007","journal-title":"J. Cell. P."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0130","doi-asserted-by":"crossref","first-page":"33437","DOI":"10.1074\/jbc.M802016200","article-title":"HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition","volume":"283","author":"Thuault","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024100","article-title":"Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2","volume":"6","author":"Teng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0140","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1111\/j.1349-7006.2009.01299.x","article-title":"Promoter-wide analysis of Smad4 binding sites in human epithelial cells","volume":"100","author":"Koinuma","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0145","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1073\/pnas.261714999","article-title":"DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities","volume":"99","author":"Zawel","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0150","series-title":"Tumor Suppressor Genes, InTech","first-page":"145","article-title":"Signaling mechanisms of transforming growth factor-\u03b2 ( TGF-\u03b2 ) in cancer : TGF-\u03b2 induces apoptosis in lung cells by a Smad-dependent mechanism","author":"Lim","year":"2005"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0155","doi-asserted-by":"crossref","first-page":"12747","DOI":"10.1073\/pnas.0605333103","article-title":"A FoxO-Smad synexpression group in human keratinocytes","volume":"103","author":"Gomis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0160","doi-asserted-by":"crossref","first-page":"22092","DOI":"10.3390\/ijms151222092","article-title":"TGFbeta1 protection against Abeta1-42-induced neuroinflammation and neurodegeneration in rats","volume":"15","author":"Shen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0165","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s11064-015-1634-x","article-title":"Endogenous TGF beta 1 plays a crucial role in functional recovery after traumatic brain injury associated with Smad3 signal in rats","volume":"40","author":"Wang","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0170","doi-asserted-by":"crossref","first-page":"18840","DOI":"10.1038\/srep18840","article-title":"Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q","volume":"6","author":"Cho","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0175","first-page":"1","article-title":"Transforming growth factor-\u03b21 acts via T\u03b2R-I on microglia to protect against MPP+-induced dopaminergic neuronal loss","volume":"51","author":"Liu","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0180","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neuron.2014.10.033","article-title":"Tgfbeta signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS","volume":"84","author":"Dias","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.cellsig.2016.12.005_bb0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nn1816","article-title":"Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons","volume":"10","author":"Zhang","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2015.07.013","article-title":"Huntingtin is required for ciliogenesis and neurogenesis during early Xenopus development","volume":"408","author":"Haremaki","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0195","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntingtin's disease CAG expansion","volume":"17","author":"White JK","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2016.12.005_bb0200","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington \u2019 s disease gene homolog Hdh","volume":"269","author":"Duyano","year":"1995","journal-title":"Science"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656816302972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656816302972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T21:21:47Z","timestamp":1536182507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656816302972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":39,"alternative-id":["S0898656816302972"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2016.12.005","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SMAD transcription factors are altered in cell models of HD and regulate HTT expression","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2016.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}