{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:48:01Z","timestamp":1789685281018,"version":"4.0.1"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.cellsig.2017.07.003","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T05:17:23Z","timestamp":1500095843000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds"],"prefix":"10.1016","volume":"41","author":[{"given":"Amy E.","family":"Moritz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Benjamin","family":"Free","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Sibley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-6147(92)90025-2","volume":"13","author":"Sibley","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2013.00260","volume":"7","author":"Money","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2016.10.011","volume":"81","author":"Urs","year":"2017","journal-title":"Biol. Psychiatry"},{"issue":"10","key":"10.1016\/j.cellsig.2017.07.003_bb0020","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s12272-010-1005-8","volume":"33","author":"Cho","year":"2010","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/0964704X.2012.678199","volume":"22","author":"Madras","year":"2013","journal-title":"J. Hist. Neurosci."},{"issue":"6289","key":"10.1016\/j.cellsig.2017.07.003_bb0030","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/347146a0","volume":"347","author":"Sokoloff","year":"1990","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.cellsig.2017.07.003_bb0035","first-page":"501","volume":"311","author":"Giros","year":"1990","journal-title":"Acad. Sci. III"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0040","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.pharmtox.42.091101.144224","volume":"42","author":"Shi","year":"2002","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6007","key":"10.1016\/j.cellsig.2017.07.003_bb0045","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1197410","volume":"330","author":"Chien","year":"2010","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0006-8993(91)91456-B","volume":"564","author":"Bouthenet","year":"1991","journal-title":"Brain Res."},{"issue":"17","key":"10.1016\/j.cellsig.2017.07.003_bb0055","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1073\/pnas.89.17.8155","volume":"89","author":"Levesque","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.cellsig.2017.07.003_bb0060","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1073\/pnas.91.23.11271","volume":"91","author":"Murray","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0065","series-title":"Molecular Pharmacology of the Dopamine Receptors, Dopamine Handbook","volume":"Vol. 63","author":"Rankin","year":"2010"},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0070","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-3565(25)38500-9","volume":"268","author":"Tang","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0075","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1476-5381.1996.tb15572.x","volume":"118","author":"Gardner","year":"1996","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1124\/mol.52.3.508","volume":"52","author":"Robinson","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2017.07.003_bb0085","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1523\/JNEUROSCI.19-05-01698.1999","volume":"19","author":"Kuzhikandathil","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-3-642-25761-2_2","volume":"212","author":"Ginovart","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2017.07.003_bb0095","first-page":"292","volume":"4","author":"Riordan","year":"2011","journal-title":"Am. Health Drug Benefits"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-12-411546-0.00010-X","volume":"112","author":"Mogwitz","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0105","first-page":"114","volume":"7","author":"Chen","year":"2013","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.cellsig.2017.07.003_bb0110","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1158\/1535-7163.MCT-11-0268","volume":"10","author":"Visnyei","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0115","doi-asserted-by":"crossref","first-page":"882","DOI":"10.18632\/oncotarget.1801","volume":"5","author":"Li","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0120","volume":"6","author":"Cheng","year":"2015","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0125","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.bmc.2005.09.008","volume":"14","author":"Vangveravong","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0130","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.bmcl.2006.10.076","volume":"17","author":"Grundt","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0135","series-title":"Probe Reports from the NIH Molecular Libraries Program","author":"Xiao","year":"2010"},{"issue":"45","key":"10.1016\/j.cellsig.2017.07.003_bb0140","doi-asserted-by":"crossref","first-page":"18488","DOI":"10.1073\/pnas.1104807108","volume":"108","author":"Allen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.cellsig.2017.07.003_bb0145","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1016\/j.bmc.2011.04.021","volume":"19","author":"Vangveravong","year":"2011","journal-title":"Bioorg. Med. Chem."},{"issue":"16","key":"10.1016\/j.cellsig.2017.07.003_bb0150","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1021\/jm300603y","volume":"55","author":"Chen","year":"2012","journal-title":"J. Med. Chem."},{"issue":"23","key":"10.1016\/j.cellsig.2017.07.003_bb0155","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1021\/acs.jmedchem.6b01208","volume":"59","author":"Chen","year":"2016","journal-title":"J. Med. Chem."},{"issue":"50","key":"10.1016\/j.cellsig.2017.07.003_bb0160","doi-asserted-by":"crossref","first-page":"E8178","DOI":"10.1073\/pnas.1614347113","volume":"113","author":"Gee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.cellsig.2017.07.003_bb0165","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/cn300142q","volume":"3","author":"Luedtke","year":"2012","journal-title":"ACS Chem. Neurosci."},{"issue":"51","key":"10.1016\/j.cellsig.2017.07.003_bb0170","first-page":"159","volume":"2","author":"Mach","year":"2010","journal-title":"J. Nucl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1124\/jpet.111.190702","volume":"342","author":"Langlois","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.cellsig.2017.07.003_bb0180","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1021\/jm500126s","volume":"57","author":"Xiao","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0185","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fnins.2016.00451","volume":"10","author":"Maramai","year":"2016","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.cellsig.2017.07.003_bb0190","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.euroneuro.2015.07.012","volume":"25","author":"Pich","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"26","key":"10.1016\/j.cellsig.2017.07.003_bb0195","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.2174\/1381612821666150724100830","volume":"21","author":"Luedtke","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0200","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-444-63425-2.00011-8","volume":"211","author":"Le Foll","year":"2014","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0205","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/B978-0-12-420118-7.00007-X","volume":"69","author":"Keck","year":"2014","journal-title":"Adv. Pharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0210","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bcp.2012.06.023","volume":"84","author":"Newman","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0215","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1749-6632.2009.05149.x","volume":"1187","author":"Heidbreder","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"21","key":"10.1016\/j.cellsig.2017.07.003_bb0220","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1021\/jm0705612","volume":"50","author":"Micheli","year":"2007","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0225","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1124\/mol.113.088054","volume":"84","author":"Lane","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"16","key":"10.1016\/j.cellsig.2017.07.003_bb0230","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1021\/acs.jmedchem.6b00860","volume":"59","author":"Kumar","year":"2016","journal-title":"J. Med. Chem."},{"issue":"15","key":"10.1016\/j.cellsig.2017.07.003_bb0235","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.1021\/acs.jmedchem.5b00776","volume":"58","author":"Boateng","year":"2015","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2017.07.003_bb0240","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.euroneuro.2014.11.013","volume":"25","author":"Furman","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0245","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1021\/acs.jmedchem.6b01688","volume":"60","author":"Kumar","year":"2017","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0250","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0031-6997(24)01327-9","volume":"49","author":"Levant","year":"1997","journal-title":"Pharmacol. Rev."},{"issue":"11","key":"10.1016\/j.cellsig.2017.07.003_bb0255","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1021\/jm040190e","volume":"48","author":"Newman","year":"2005","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0260","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharmthera.2006.04.007","volume":"112","author":"Boeckler","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0265","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00213-007-0766-3","volume":"193","author":"Collins","year":"2007","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0270","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/mds.21191","volume":"22","author":"Barone","year":"2007","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0275","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/mds.21361","volume":"22","author":"Singer","year":"2007","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0280","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1124\/jpet.105.084202","volume":"314","author":"McCall","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.cellsig.2017.07.003_bb0285","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1016\/S0021-9258(20)65148-1","volume":"257","author":"Sibley","year":"1982","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0290","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0026-895X(25)14291-0","volume":"23","author":"Sibley","year":"1983","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0295","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/syn.20626","volume":"63","author":"Skinbjerg","year":"2009","journal-title":"Synapse"},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0300","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/syn.20013","volume":"52","author":"Narendran","year":"2004","journal-title":"Synapse"},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0305","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1021\/acs.jmedchem.5b01612","volume":"59","author":"Zou","year":"2016","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0310","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1021\/acs.jmedchem.6b01875","volume":"60","author":"Bonifazi","year":"2017","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0315","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-4886(03)00353-4","volume":"184","author":"Joyce","year":"2003","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0320","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.expneurol.2004.01.012","volume":"187","author":"Joyce","year":"2004","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.cellsig.2017.07.003_bb0325","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1471-4159.2005.03625.x","volume":"96","author":"Iravani","year":"2006","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0330","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s007020050014","volume":"107","author":"Vu","year":"2000","journal-title":"J. Neural Transm."},{"issue":"1\u20133","key":"10.1016\/j.cellsig.2017.07.003_bb0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0014-2999(03)02087-9","volume":"475","author":"Ramirez","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0340","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12640-013-9408-1","volume":"24","author":"Lao","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0345","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1741-7007-2-22","volume":"2","author":"Joyce","year":"2004","journal-title":"BMC Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2017.07.003_bb0350","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/archneurol.2009.32","volume":"66","author":"C.C.I. Parkinson Study Group","year":"2009","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0355","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ana.10609","volume":"54","author":"Whone","year":"2003","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.cellsig.2017.07.003_bb0360","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2174\/156802608785161457","volume":"8","author":"Kvernmo","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"issue":"8","key":"10.1016\/j.cellsig.2017.07.003_bb0365","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1474-4422(13)70117-0","volume":"12","author":"Schapira","year":"2013","journal-title":"Lancet Neurol."},{"issue":"2A","key":"10.1016\/j.cellsig.2017.07.003_bb0370","first-page":"224","volume":"42","author":"Sokoloff","year":"1992","journal-title":"Arzneimittelforschung"},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0375","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0026-895X(25)09903-1","volume":"45","author":"Chio","year":"1994","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0380","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0022-3565(25)12192-7","volume":"275","author":"Pugsley","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0385","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00001756-199501000-00026","volume":"6","author":"Sautel","year":"1995","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0922-4106(95)90013-6","volume":"290","author":"Mierau","year":"1995","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0395","doi-asserted-by":"crossref","first-page":"57S","DOI":"10.1042\/bst024057s","volume":"24","author":"Boyfield","year":"1996","journal-title":"Biochem. Soc. Trans."},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0400","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/sj.bjp.0702673","volume":"127","author":"Coldwell","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0405","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0014-2999(94)00738-S","volume":"272","author":"Gonzalez","year":"1995","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.cellsig.2017.07.003_bb0410","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0165-6147(00)89044-6","volume":"16","author":"Sokoloff","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.cellsig.2017.07.003_bb0415","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-5793(92)80918-7","volume":"312","author":"Seabrook","year":"1992","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0420","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","volume":"78","author":"Missale","year":"1998","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0425","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/sj.bjp.0702905","volume":"128","author":"Zaworski","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0430","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0922-4106(94)90182-1","volume":"268","author":"Pilon","year":"1994","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0435","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/(SICI)1098-2396(199610)24:2<156::AID-SYN7>3.0.CO;2-E","volume":"24","author":"Liu","year":"1996","journal-title":"Synapse"},{"issue":"40","key":"10.1016\/j.cellsig.2017.07.003_bb0440","doi-asserted-by":"crossref","first-page":"37409","DOI":"10.1074\/jbc.M106728200","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0445","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.105.085472","volume":"314","author":"Collins","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.cellsig.2017.07.003_bb0450","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0028-3908(99)00064-7","volume":"38","author":"Boulay","year":"1999","journal-title":"Neuropharmacology"},{"issue":"18","key":"10.1016\/j.cellsig.2017.07.003_bb0455","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/S0960-894X(99)00454-0","volume":"9","author":"Avenell","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0460","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1021\/jm049269+","volume":"48","author":"Boeckler","year":"2005","journal-title":"J. Med. Chem."},{"issue":"19","key":"10.1016\/j.cellsig.2017.07.003_bb0465","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1021\/jm800471h","volume":"51","author":"Chen","year":"2008","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0470","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0960-894X(01)00820-4","volume":"12","author":"Dutta","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0475","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(96)00454-2","volume":"312","author":"Piercey","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.cellsig.2017.07.003_bb0480","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-2999(98)00896-6","volume":"366","author":"Perachon","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"17","key":"10.1016\/j.cellsig.2017.07.003_bb0485","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/ajhp\/54.17.1922","volume":"54","year":"1997","journal-title":"Am. J. Health Syst. Pharm."},{"issue":"10","key":"10.1016\/j.cellsig.2017.07.003_bb0490","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2174\/156802661510150328223428","volume":"15","author":"Das","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0495","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pnpbp.2013.08.012","volume":"52","author":"Payer","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.cellsig.2017.07.003_bb0500","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1021\/ml200100t","volume":"2","author":"Chen","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.cellsig.2017.07.003_bb0505","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1002\/cmdc.201402398","volume":"9","author":"Chen","year":"2014","journal-title":"ChemMedChem"},{"issue":"16","key":"10.1016\/j.cellsig.2017.07.003_bb0510","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1016\/j.bmc.2004.06.019","volume":"12","author":"Dutta","year":"2004","journal-title":"Bioorg. Med. Chem."},{"issue":"24","key":"10.1016\/j.cellsig.2017.07.003_bb0515","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1021\/jm8008629","volume":"51","author":"Brown","year":"2008","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.cellsig.2017.07.003_bb0520","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/jnr.22405","volume":"88","author":"Li","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0525","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bcp.2010.08.026","volume":"81","author":"Kortagere","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0530","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/cmdc.201100140","volume":"6","author":"Gogoi","year":"2011","journal-title":"ChemMedChem"},{"issue":"12","key":"10.1016\/j.cellsig.2017.07.003_bb0535","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1021\/jm300268s","volume":"55","author":"Johnson","year":"2012","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0540","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00210-012-0811-6","volume":"386","author":"Kuzhikandathil","year":"2013","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"10","key":"10.1016\/j.cellsig.2017.07.003_bb0545","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/cn400106n","volume":"4","author":"Santra","year":"2013","journal-title":"ACS Chem. Neurosci."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0550","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/jm401883v","volume":"57","author":"Modi","year":"2014","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2017.07.003_bb0555","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jnc.12767","volume":"131","author":"Shah","year":"2014","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.cellsig.2017.07.003_bb0560","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1021\/cn500084x","volume":"5","author":"Modi","year":"2014","journal-title":"ACS Chem. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2017.07.003_bb0565","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11064-015-1808-6","volume":"41","author":"Zhen","year":"2016","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2017.07.003_bb0570","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12640-015-9548-6","volume":"28","author":"Voshavar","year":"2015","journal-title":"Neurotox. Res."},{"issue":"23","key":"10.1016\/j.cellsig.2017.07.003_bb0575","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1021\/acs.jmedchem.5b01031","volume":"58","author":"Das","year":"2015","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.cellsig.2017.07.003_bb0580","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1016\/j.bmc.2016.08.021","volume":"24","author":"Luo","year":"2016","journal-title":"Bioorg. Med. Chem."},{"issue":"10","key":"10.1016\/j.cellsig.2017.07.003_bb0585","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1021\/jm701524h","volume":"51","author":"Biswas","year":"2008","journal-title":"J. Med. Chem."},{"issue":"20","key":"10.1016\/j.cellsig.2017.07.003_bb0590","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.2174\/138161206777698891","volume":"12","author":"Mehta","year":"2006","journal-title":"Curr. Pharm. Des."},{"issue":"7","key":"10.1016\/j.cellsig.2017.07.003_bb0595","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/oby.2007.205","volume":"15","author":"Astrup","year":"2007","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0600","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bcpt.12653","volume":"119","author":"Simonsen","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0605","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2165\/00003495-200868030-00003","volume":"68","author":"Varon","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0610","first-page":"403039","author":"Hisahara","year":"2011","journal-title":"Int. J. Med. Chem."},{"key":"10.1016\/j.cellsig.2017.07.003_bb0615","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/B978-0-444-63425-2.00010-6","volume":"211","author":"Cepeda","year":"2014","journal-title":"Prog. Brain Res."},{"issue":"5","key":"10.1016\/j.cellsig.2017.07.003_bb0620","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2710.2009.01025.x","volume":"34","author":"Varga","year":"2009","journal-title":"J. Clin. Pharm. Ther."},{"issue":"3","key":"10.1016\/j.cellsig.2017.07.003_bb0625","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/psyg.12014","volume":"13","author":"Hori","year":"2013","journal-title":"Psychogeriatrics"},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0630","first-page":"18","volume":"7","author":"Yanofski","year":"2010","journal-title":"Psychiatry"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0635","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2015.12.029","volume":"109","author":"Lopez Vicchi","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0640","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2165\/00003495-199651060-00004","volume":"51","author":"Ciccarelli","year":"1996","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0645","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/mp.2011.93","volume":"17","author":"Gonzalez","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"10.1016\/j.cellsig.2017.07.003_bb0650","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0269881110387840","volume":"25","author":"Sood","year":"2011","journal-title":"J. Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.cellsig.2017.07.003_bb0655","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/B978-0-12-420118-7.00008-1","volume":"69","author":"Di Ciano","year":"2014","journal-title":"Adv. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2017.07.003_bb0660","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00213-005-2150-5","volume":"180","author":"Kudwa","year":"2005","journal-title":"Psychopharmacology"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865681730181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865681730181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T22:58:46Z","timestamp":1750633126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865681730181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":132,"alternative-id":["S089865681730181X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2017.07.003","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2017.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}