{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:05:43Z","timestamp":1769083543996,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["1116\/1"],"award-info":[{"award-number":["1116\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["974\/2"],"award-info":[{"award-number":["974\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2014-A151"],"award-info":[{"award-number":["2014-A151"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.cellsig.2017.07.007","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T21:01:39Z","timestamp":1499893299000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Phospholipase D1 is a regulator of platelet-mediated inflammation"],"prefix":"10.1016","volume":"38","author":[{"given":"Meike","family":"Klier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Sarah","family":"Gowert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"J\u00e4ckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margitta","family":"Elvers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2017.07.007_bb0005","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1128\/MCB.23.9.3103-3115.2003","article-title":"Transmodulation between phospholipase D and c-Src enhances cell proliferation","volume":"23","author":"Ahn","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0010","article-title":"Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment","volume":"8","author":"Ali","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archsurg.2007.73","article-title":"Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis","volume":"143","author":"Bluth","year":"2008","journal-title":"AMA Arch. Surg."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.187.3.329","article-title":"Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha","volume":"187","author":"Bombeli","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0025","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/ATVBAHA.113.303113","article-title":"Platelet glycoprotein Ib-IX as a regulator of systemic inflammation","volume":"34","author":"Corken","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ncomms1144","article-title":"The phospholipase D1 pathway modulates macroautophagy","volume":"1","author":"Dall'Armi","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0035","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1160\/TH16-01-0036","article-title":"The VWF-GPIb axis in ischaemic stroke: lessons from animal models","volume":"116","author":"Denorme","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf6240","article-title":"Platelets contribute to amyloid-beta aggregation in cerebral vessels through integrin alphaIIbbeta3-induced outside-in signaling and clusterin release","volume":"9","author":"Donner","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000551","article-title":"Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1","volume":"3","author":"Elvers","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2016.04.001","article-title":"Phospholipase D enzymes facilitate IL-17- and TNFalpha-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF)","volume":"174","author":"Friday","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0055","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI27196","article-title":"Platelets in inflammation and atherogenesis","volume":"115","author":"Gawaz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0060","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/01.CIR.96.6.1809","article-title":"Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction","volume":"96","author":"Gawaz","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090523","article-title":"Blood platelets in the progression of Alzheimer's disease","volume":"9","author":"Gowert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.174.4.785","article-title":"Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production","volume":"174","author":"Hawrylowicz","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0080","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1128\/MCB.01519-12","article-title":"Phospholipase D1 has a pivotal role in interleukin-1beta-driven chronic autoimmune arthritis through regulation of NF-kappaB, hypoxia-inducible factor 1alpha, and FoxO3a","volume":"33","author":"Kang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0085","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.4049\/jimmunol.1500259","article-title":"Nouvelle cuisine: platelets served with inflammation","volume":"194","author":"Kapur","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0090","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1124\/mol.107.040105","article-title":"Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells","volume":"74","author":"Knoepp","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0095","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nm1780","article-title":"Aggravation of viral hepatitis by platelet-derived serotonin","volume":"14","author":"Lang","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1160\/TH13-06-0490","article-title":"Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis","volume":"111","author":"Lei","year":"2014","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0105","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/blood.V94.11.3829","article-title":"Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo","volume":"94","author":"Massberg","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0110","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/01.CIR.0000033597.45947.0F","article-title":"Engagement of glycoprotein IIb\/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells","volume":"106","author":"May","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0115","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1538-7836.2006.01966.x","article-title":"von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively","volume":"4","author":"McCarty","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0120","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.95.10.2387","article-title":"Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets","volume":"95","author":"Neumann","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0125","doi-asserted-by":"crossref","first-page":"16419","DOI":"10.1523\/JNEUROSCI.3317-10.2010","article-title":"Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits","volume":"30","author":"Oliveira","year":"2010","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2017.07.007_bb0130","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jth.12235","article-title":"Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2","volume":"11","author":"Ozaki","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0135","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.molimm.2007.01.033","article-title":"Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b\/CD18","volume":"44","author":"Powner","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0140","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1084\/jem.190.6.803","article-title":"The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin","volume":"190","author":"Romo","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0145","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/nm1102-1227","article-title":"Platelets in atherothrombosis","volume":"8","author":"Ruggeri","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0150","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.ajpath.2014.06.005","article-title":"Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice","volume":"184","author":"Schonberger","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0155","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood-2014-01-453134","article-title":"Src family kinases: at the forefront of platelet activation","volume":"124","author":"Senis","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010506","article-title":"Phospholipase D1 mediates TNFalpha-induced inflammation in a murine model of TNFalpha-induced peritonitis","volume":"5","author":"Sethu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2017.07.007_bb0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1084\/jem.192.2.193","article-title":"Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b\/CD18)","volume":"192","author":"Simon","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0170","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/ATVBAHA.113.302030","article-title":"Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke\u2013brief report","volume":"33","author":"Stegner","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0175","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/ATVBAHA.110.207480","article-title":"Platelet-leukocyte interactions in cardiovascular disease and beyond","volume":"30","author":"Totani","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0180","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"von Bruhl","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0185","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2017.07.007_bb0190","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1161\/ATVBAHA.113.302339","article-title":"Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality","volume":"33","author":"Yin","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656817301869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656817301869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T04:43:53Z","timestamp":1656823433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656817301869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":38,"alternative-id":["S0898656817301869"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2017.07.007","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phospholipase D1 is a regulator of platelet-mediated inflammation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2017.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}