{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:23:39Z","timestamp":1770416619748,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300730"],"award-info":[{"award-number":["81300730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M630482"],"award-info":[{"award-number":["2018M630482"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research Project of Shandong","award":["2018GSF118193"],"award-info":[{"award-number":["2018GSF118193"]}]},{"name":"Applied Basic Research Project of Qingdao","award":["16-5-1-65-jch"],"award-info":[{"award-number":["16-5-1-65-jch"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.cellsig.2018.08.020","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T02:36:10Z","timestamp":1535682970000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis"],"prefix":"10.1016","volume":"52","author":[{"given":"Chengye","family":"Che","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2018.08.020_bb0005","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/bjophthalmol-2016-309656","article-title":"In vivo confocal microscopy appearance of Fusarium and Aspergillus species in fungal keratitis","volume":"101","author":"Chidambaram","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0010","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/infdis\/jir426","article-title":"Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium","volume":"204","author":"Karthikeyan","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000976","article-title":"Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis","volume":"6","author":"Leal","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0020","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1167\/iovs.16-20658","article-title":"Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani","volume":"58","author":"Kolar","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biomaterials.2014.11.052","article-title":"Synthetic \u03b2-sheet forming peptide amphiphiles for treatment of fungal keratitis","volume":"43","author":"Wu","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.cellsig.2018.08.020_bb0030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/icb.2016.73","article-title":"Role of MyD88 in adenovirus keratitis","volume":"95","author":"Zhou","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/imcb.12010","article-title":"Osteopontin contributes to effective neutrophil recruitment, IL-1\u03b2 production and apoptosis in Aspergillus fumigatus keratitis","volume":"96","author":"Zhao","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0040","first-page":"30","article-title":"Dectin-1 expression at early period of Aspergillus fumigatus infection in rat's corneal epithelium","volume":"6","author":"Che","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0045","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/jcp.25687","article-title":"Role of Wnt5a in the Pathogenesis of Inflammatory Diseases","volume":"232","author":"Pashirzad","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cca.2017.06.017","article-title":"Wnt5a and its signaling pathway in angiogenesis","volume":"471","author":"Shi","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cellsig.2018.08.020_bb0055","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.molimm.2008.08.281","article-title":"Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice","volume":"46","author":"Zhang","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0060","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ejcb.2010.11.004","article-title":"Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses","volume":"90","author":"Schaale","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9294018","article-title":"Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters","volume":"2017","author":"Szebeni","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0070","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4049\/jimmunol.1601927","article-title":"Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection","volume":"199","author":"Chakraborty","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0075","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/cr.2015.105","article-title":"Monocyte-derived Wnt5a regulates inflammatory lymphangiogenesis","volume":"26","author":"Sessa","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0080","first-page":"17824","article-title":"Wnt5a\/FZD5\/CaMKII signaling pathway mediates the effect of BML-111 on inflammatory reactions in sepsis","volume":"8","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0085","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11883-009-0036-4","article-title":"The wnt pathway: a macrophage effector molecule that triggers inflammation","volume":"11","author":"Pereira","year":"2009","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.cellsig.2018.08.020_bb0090","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.imlet.2014.08.015","article-title":"Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-\u03b3 production by CD4+ T cells","volume":"162 (","author":"Valencia","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0095","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/ATVBAHA.107.157438","article-title":"Wnt5A\/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10","volume":"28","author":"Pereira","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0100","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2337\/db14-1164","article-title":"Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion","volume":"64","author":"Fuster","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cellsig.2018.08.020_bb0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1167\/iovs.02-0446","article-title":"Experimental keratomycosis in a mouse model","volume":"44","author":"Wu","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003457","article-title":"HIF-1\u03b1 is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis","volume":"9","author":"Berger","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/infdis\/jiv016","article-title":"Matrix Metalloproteinase-13 as a Target for Suppressing Corneal Ulceration Caused by Pseudomonas aeruginosa Infection","volume":"212","author":"Gao","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0120","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2016.09.027","article-title":"LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis","volume":"40","author":"Gao","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0125","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1074\/jbc.M109.054338","article-title":"Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes","volume":"285","author":"Bilkovski","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0130","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.4260","article-title":"JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression","volume":"23","author":"Zhao","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0135","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/icb.2016.111","article-title":"Inhibition of MHC-I by Brucella abortus is an early event during infection and involves EGFR pathway","volume":"95","author":"Vel\u00e1squez","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/0471142956.cy1224s59","article-title":"Practical methods for molecular in vivo optical imaging","volume":"59","author":"Chen","year":"2012","journal-title":"Curr. Protoc. Cytom."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0145","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1167\/iovs.16-20824","article-title":"In Vivo Bioluminescence Imaging for Longitudinal monitoring of Inflammation in Animal Models of Uveitis","volume":"58","author":"Gutowski","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0150","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1128\/MCB.01572-13","article-title":"Interleukin-1\u03b2-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA","volume":"34","author":"Lee","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0155","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1167\/iovs.12-11477","article-title":"Targeted overexpression of TGF-\u03b1 in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling","volume":"54","author":"Yuan","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ydbio.2010.01.027","article-title":"Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2","volume":"340","author":"Kumar","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2014.12.002","article-title":"C-type lectins in immunity: recent developments","volume":"32","author":"Dambuza","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0170","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2017.09.008","article-title":"Dectin-1 is essential for IL-1\u03b2 production through JNK activation and apoptosis in Aspergillus fumigatus keratitis","volume":"52","author":"Yuan","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0175","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1128\/IAI.01317-10","article-title":"LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model","volume":"9","author":"Wu","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0180","first-page":"1245","article-title":"The role of LOX-1 on innate immunity against Aspergillus keratitis in mice","volume":"9","author":"He","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0185","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1128\/MCB.00641-14","article-title":"The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature","volume":"34","author":"Trinath","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0190","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/icb.2017.51","article-title":"Salvador JM. p38\u03b1 regulates cytokine-induced IFN\u03b3 secretion via the Mnk1\/eIF4E pathway in Th1 cells","volume":"95","author":"Salvador-Bern\u00e1ldez","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0195","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/icb.2017.73","article-title":"Role of NF-\u03baB\/GATA3 in the inhibition of lysyl oxidase by IL-1\u03b2 in human amnion fibroblasts","volume":"95","author":"Zhang","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0200","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.joca.2017.05.018","article-title":"Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes","volume":"25","author":"Huang","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2797","article-title":"Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR\u03b3t and dectin-2","volume":"15","author":"Taylor","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0210","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3109\/08830185.2012.749400","article-title":"Host defense at the ocular surface","volume":"32","author":"Pearlman","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0215","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1038\/emm.2013.48","article-title":"Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils","volume":"45","author":"Jung","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0220","doi-asserted-by":"crossref","first-page":"21028","DOI":"10.1074\/jbc.M113.546523","article-title":"Wnt5a promotes inflammatory responses via nuclear factor \u03baB (NF-\u03baB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cells","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0225","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1038\/s41598-017-03446-w","article-title":"Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0230","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/dna.2016.3418","article-title":"Wnt5a Deficiency Regulates Inflammatory Cytokine Secretion, Polarization, and Apoptosis in Mycobacterium tuberculosis-Infected Macrophages","volume":"36","author":"Chen","year":"2017","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0235","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/icb.2017.23","article-title":"Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling","volume":"95","author":"Kim","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cellsig.2018.08.020_bb0240","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/icb.2016.3","article-title":"Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides","volume":"94","author":"Thygesen","year":"2016","journal-title":"Immunol. Cell Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T19:50:01Z","timestamp":1537905001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656818302055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":48,"alternative-id":["S0898656818302055"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.08.020","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}