{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:41Z","timestamp":1791388121369,"version":"4.3.3"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RGP-120"],"award-info":[{"award-number":["RGP-120"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.cellsig.2018.09.006","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T12:39:32Z","timestamp":1536583172000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["S3I-201, a selective Stat3 inhibitor, restores neuroimmune function through upregulation of Treg signaling in autistic BTBR T+ Itpr3tf\/J mice"],"prefix":"10.1016","volume":"52","author":[{"given":"Sheikh F.","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Bakheet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musaad A.","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz M.S.","family":"Alsaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabry M.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2018.09.006_bb0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1474-4422(15)00151-9","article-title":"Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression","volume":"15","author":"Constantino","year":"2016","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.cellsig.2018.09.006_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40265-013-0021-7","article-title":"Pharmacotherapy for the core symptoms in autistic disorder: current status of the research","volume":"73","author":"Farmer","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jneuroim.2010.10.025","article-title":"Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders","volume":"232","author":"Ashwood","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0020","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/02646830500381930","article-title":"Immunity, neuroglia and neuroinflammation in autism","volume":"17","author":"Enstrom","year":"2005","journal-title":"International Review of Psychiatry"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0030","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0035","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pediatrneurol.2005.03.014","article-title":"Cerebrospinal fluid and serum markers of inflammation in autism","volume":"33","author":"Zimmerman","year":"2005","journal-title":"Pediatr. Neurol."},{"issue":"6","key":"10.1016\/j.cellsig.2018.09.006_bb0040","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1007\/s12035-016-9977-0","article-title":"Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism","volume":"54","author":"Ahmad","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.cellsig.2018.09.006_bb0045","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1007\/s12035-016-0066-1","article-title":"Resveratrol Ameliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-Related Transcription factor Signaling in a BTBR T + tf\/J Mouse Model of Autism","volume":"54","author":"Bakheet","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pnpbp.2017.10.001","article-title":"Upregulation of peripheral CXC and CC chemokine receptor expression on CD4+ T cells is associated with immune dysregulation in children with autism","volume":"81","author":"Ahmad","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0055","doi-asserted-by":"crossref","unstructured":"Xu N, Li X, Zhong Y. Inflammatory Cytokines: potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders. Mediat. Inflamm. 2015;531518.","DOI":"10.1155\/2015\/531518"},{"issue":"5","key":"10.1016\/j.cellsig.2018.09.006_bb0060","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1309\/AJCP7UBK8IBVMVNR","article-title":"Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay","volume":"136","author":"Martins","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ntt.2012.07.006","article-title":"Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment","volume":"36","author":"Goines","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2018.09.006_bb0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li","year":"2009","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.cellsig.2018.09.006_bb0075","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0080","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-2094-3-13","article-title":"Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions","volume":"3","author":"Skundric","year":"2006","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1742-2094-9-158","article-title":"Elevated serum levels of interleukin-17 a in children with autism","volume":"9","author":"Al-Ayadhi","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneuroim.2015.07.003","article-title":"Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma","volume":"286","author":"Akintunde","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cellsig.2017.04.014","article-title":"Adenosine A2A receptor modulates neuroimmune function through Th17\/retinoid-related orphan receptor gamma t (ROR\u03b3t) signaling in a BTBR T+ Itpr3tf\/J mouse model of autism","volume":"36","author":"Ansari","year":"2017","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.cellsig.2018.09.006_bb0100","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3844\/ajbbsp.2008.114.120","article-title":"Detection of IL-17 and IL-23 in Plasma Samples of Children with Autism","volume":"4","author":"Enstrom","year":"2008","journal-title":"Am. J. Biochem. Biotechnol."},{"issue":"10","key":"10.1016\/j.cellsig.2018.09.006_bb0105","article-title":"Th17 cell-mediated neuroinflammation is involved in neurodegeneration of a\u03b21-42-induced Alzheimer's disease model rats","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0110","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190546","article-title":"Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS","volume":"13","author":"Kelly","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0120","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ajpath.2010.10.043","article-title":"IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain","volume":"178","author":"Tzartos","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molimm.2016.12.019","article-title":"Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children","volume":"82","author":"Ahmad","year":"2017","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.cellsig.2018.09.006_bb0130","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1084\/jem.20131377","article-title":"T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice","volume":"211","author":"Clarkson","year":"2014","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.cellsig.2018.09.006_bb0135","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","article-title":"Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation","volume":"13","author":"Kebir","year":"2007","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2018.09.006_bb0140","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1096\/fj.201600989R","article-title":"Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling","volume":"31","author":"Wang","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0145","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.molimm.2010.02.001","article-title":"A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells","volume":"47","author":"Getnet","year":"2010","journal-title":"Mol. Immunol."},{"issue":"18","key":"10.1016\/j.cellsig.2018.09.006_bb0150","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.0609757104","article-title":"Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity","volume":"104","author":"Siddiquee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.cellsig.2018.09.006_bb0155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ki.2010.154","article-title":"A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"78","author":"Pang","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0895-3988(10)60072-4","article-title":"An association between immunosenescence and CD4(+)CD25(+) regulatory T cells: a systematic review","volume":"23","author":"Wang","year":"2010","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2013.10.016","article-title":"Essential role of IL-10\/STAT3 in chronic stress-induced immune suppression","volume":"36","author":"Hu","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.cellsig.2018.09.006_bb0170","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cyto.2009.07.003","article-title":"STAT3 in CD4+ T helper cell differentiation and inflammatory diseases","volume":"47","author":"Egwuagu","year":"2009","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.cellsig.2018.09.006_bb0175","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/npp.2009.201","article-title":"Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP","volume":"35","author":"Silverman","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2015.11.003","article-title":"Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory\/excitatory genes in the frontal cortex of an autism model","volume":"102","author":"Kratsman","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0185","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molimm.2016.08.017","article-title":"The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis","volume":"78","author":"Ahmad","year":"2016","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0190","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12017-018-8483-0","article-title":"Resveratrol Improves Neuroimmune Dysregulation through the Inhibition of Neuronal Toll-like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf\/J mice","volume":"20","author":"Ahmad","year":"2018","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mcn.2017.04.012","article-title":"Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T+ Itpr3tf\/J mice","volume":"82","author":"Ansari","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jneuroim.2017.08.002","article-title":"Adenosine A2A receptor signaling affects IL-21\/IL-22 cytokines and GATA3\/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf\/J mouse model of autism","volume":"311","author":"Ahmad","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0205","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cellsig.2017.02.014","article-title":"GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model","volume":"33","author":"Nadeem","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2016.09.004","article-title":"Resveratrol treatment attenuates chemokine receptor expression in the BTBR T+tf\/J mouse model of autism","volume":"77","author":"Bakheet","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0215","unstructured":"American Psychiatric Association (APA): Diagnostic and Statistical Manual of Mental Disorders. 5th edition. Washington, DC, USA: American Psychiatric Association. 2015."},{"issue":"5","key":"10.1016\/j.cellsig.2018.09.006_bb0220","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.biopsych.2015.08.036","article-title":"Immune Endophenotypes in Children with Autism Spectrum Disorder","volume":"81","author":"Careaga","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.04984.x","article-title":"Cytokines and glucocorticoid receptor signaling","volume":"1179","author":"Pace","year":"2009","journal-title":"Relevance to major depression. Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0230","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0235","doi-asserted-by":"crossref","unstructured":"Park JS, Kwok SK, Lim MA, Kim EK, Ryu JG, Kim SM, et al., STA-21, a promising STAT3 inhibitor that reciprocally regulates Th17 and Treg, inhibits osteoclastogenesis and alleviates autoimmune Inflammation Arthritis Rheum. 2014;66:918\u2013929.","DOI":"10.1002\/art.38305"},{"issue":"3","key":"10.1016\/j.cellsig.2018.09.006_bb0240","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000346196","article-title":"Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma","volume":"80","author":"Mano","year":"2013","journal-title":"Pathobiology"},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0245","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/jid.2010.255","article-title":"Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor","volume":"131","author":"Miyoshi","year":"2011","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jneumeth.2013.12.010","article-title":"Validation and implementation of a novel high-throughput behavioral phenotyping instrument for mice","volume":"224","author":"Brodkin","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cellsig.2018.09.006_bb0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fnins.2013.00158","article-title":"Inflammatory macrophage phenotype in BTBR T+tf\/J mice","volume":"7","author":"Onore","year":"2013","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0260","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.schres.2014.07.025","article-title":"Neuroimmune biomarkers in schizophrenia","volume":"176","author":"Tomasik","year":"2016","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0265","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.psyneuen.2015.02.007","article-title":"Isolation rearing impaired sensorimotor gating but increased pro-inflammatory cytokines and disrupted metabolic parameters in both sexes of rats","volume":"55","author":"Ko","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0270","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2040-2392-2-13","article-title":"Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study","volume":"2","author":"Goines","year":"2011","journal-title":"Mol Autism."},{"issue":"8","key":"10.1016\/j.cellsig.2018.09.006_bb0275","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/jir.2014.0020","article-title":"Is T-bet a potential therapeutic target in multiple sclerosis?","volume":"34","author":"Racke","year":"2014","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0280","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2567.2006.02385.x","article-title":"T-bet is essential for the progression of experimental autoimmune encephalomyelitis","volume":"118","author":"Nath","year":"2006","journal-title":"Immunology"},{"issue":"6276","key":"10.1016\/j.cellsig.2018.09.006_bb0285","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin17a pathway in mice promotes autismlike phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2018.09.006_bb0290","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2009.08.012","article-title":"Flavonoids, a prenatal prophylaxis via targeting JAK2\/STAT3 signaling to oppose IL-6\/MIA associated autism","volume":"217","author":"Parker-Athill","year":"2009","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0295","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imr.12169","article-title":"Regulatory T cells in autoimmune neuroinflammation","volume":"259","author":"Kleinewietfeld","year":"2014","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2018.09.006_bb0300","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/0883073809339393","article-title":"Frequency of CD4+CD25high regulatory T cells in the peripheral blood of Egyptian children with autism","volume":"25","author":"Mostafa","year":"2010","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0305","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1038\/srep07767","article-title":"Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice","volume":"5","author":"Singh","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2018.09.006_bb0310","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/eji.201343999","article-title":"Helios defines T cells being driven to tolerance in the periphery and thymus","volume":"44","author":"Ross","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2018.09.006_bb0315","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/imr.12199","article-title":"Complex interactions of transcription factors in mediating cytokine biology in T cells","volume":"261","author":"Li","year":"2014","journal-title":"Immunol. Rev."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T21:19:41Z","timestamp":1571865581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656818302262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":63,"alternative-id":["S0898656818302262"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.09.006","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S3I-201, a selective Stat3 inhibitor, restores neuroimmune function through upregulation of Treg signaling in autistic BTBR T+ Itpr3tf\/J mice","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}