{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:49:46Z","timestamp":1790628586312,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.cellsig.2018.11.006","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T07:48:58Z","timestamp":1542008938000},"page":"179-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Neuroprotective effects of overexpressed microRNA-200a on activation of glaucoma-related retinal glial cells and apoptosis of ganglion cells via downregulating FGF7-mediated MAPK signaling pathway"],"prefix":"10.1016","volume":"54","author":[{"given":"Hui","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Long","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cellsig.2018.11.006_bb0005","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.ophtha.2014.01.021","article-title":"Optical coherence tomography angiography of optic disc perfusion in glaucoma","volume":"121","author":"Jia","year":"2014","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.cellsig.2018.11.006_bb0010","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.cellsig.2018.11.006_bb0015","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00401-016-1609-2","article-title":"Glaucoma: the retina and beyond","volume":"132","author":"Davis","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"15\u201316","key":"10.1016\/j.cellsig.2018.11.006_bb0020","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.molimm.2011.07.012","article-title":"Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma","volume":"48","author":"Jha","year":"2011","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.cellsig.2018.11.006_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ICU.0000000000000125","article-title":"Glial cell interactions and glaucoma","volume":"26","author":"Chong","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2018.11.006_bb0030","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1055\/s-0031-1281857","article-title":"Detection of retinal glial cell activation in glaucoma by time domain optical coherence tomography","volume":"229","author":"Grieshaber","year":"2012","journal-title":"Klin. Monatsbl. Augenheilkd."},{"key":"10.1016\/j.cellsig.2018.11.006_bb0035","unstructured":"F. Gao, M. Ji, J.H. Wu, Z.F. Wang, [Roles of retinal Muller cells in health and glaucoma], Sheng Li Xue Bao 65 (6) (2013) 654\u2013663."},{"issue":"5","key":"10.1016\/j.cellsig.2018.11.006_bb0040","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/jmcb\/mjv019","article-title":"Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles","volume":"7","author":"Liu","year":"2015","journal-title":"J. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2018.11.006_bb0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2353\/ajpath.2008.070897","article-title":"Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice","volume":"172","author":"Chikama","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.cellsig.2018.11.006_bb0050","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/ijo.2017.3927","article-title":"FGF7\/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1","volume":"50","author":"Huang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cellsig.2018.11.006_bb0055","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.biopha.2018.02.107","article-title":"GRGM-13 comprising 13 plant and animal products, inhibited oxidative stress induced apoptosis in retinal ganglion cells by inhibiting P2RX7\/p38 MAPK signaling pathway","volume":"101","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cellsig.2018.11.006_bb0060","first-page":"44","article-title":"Alterations in molecular pathways in the retina of early experimental glaucoma eyes","volume":"7","author":"Cao","year":"2015","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol"},{"issue":"4","key":"10.1016\/j.cellsig.2018.11.006_bb0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00417-011-1885-4","article-title":"MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2","volume":"250","author":"Cai","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2018.11.006_bb0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.febslet.2011.07.042","article-title":"MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early diabetic nephropathy","volume":"586","author":"Zhang","year":"2012","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.cellsig.2018.11.006_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000371853","article-title":"Micro-RNAs and their roles in eye disorders","volume":"53","author":"Raghunath","year":"2015","journal-title":"Ophthalmic Res."},{"issue":"9","key":"10.1016\/j.cellsig.2018.11.006_bb0080","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1167\/iovs.12-9832","article-title":"Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome","volume":"53","author":"Zhou","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2018.11.006_bb0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12038-013-9351-6","article-title":"MiR-200a enhances the migrations of A549 and SK-MES-1 cells by regulating the expression of TSPAN1","volume":"38","author":"Chen","year":"2013","journal-title":"J. Biosci."},{"issue":"3","key":"10.1016\/j.cellsig.2018.11.006_bb0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/art.38269","article-title":"MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK","volume":"66","author":"Murata","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cellsig.2018.11.006_bb0095","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2013.07.001","article-title":"Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy","volume":"59","author":"Dapper","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2018.11.006_bb0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/IJG.0000000000000201","article-title":"A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery","volume":"24","author":"Nassar","year":"2015","journal-title":"J. Glaucoma"},{"issue":"1","key":"10.1016\/j.cellsig.2018.11.006_bb0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2007.03.013","article-title":"The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium","volume":"306","author":"Fata","year":"2007","journal-title":"Dev. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2018.11.006_bb0110","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1210\/me.2016-1027","article-title":"FGFR2IIIb-MAPK activity is required for epithelial cell fate decision in the lower Mullerian Duct","volume":"30","author":"Terakawa","year":"2016","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.cellsig.2018.11.006_bb0115","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00439-014-1468-7","article-title":"Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma","volume":"133","author":"Bailey","year":"2014","journal-title":"Hum. Genet."},{"issue":"10","key":"10.1016\/j.cellsig.2018.11.006_bb0120","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ng.2390","article-title":"Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma","volume":"44","author":"Vithana","year":"2012","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.cellsig.2018.11.006_bb0125","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1074\/jbc.M109.037127","article-title":"Targeting of integrin beta1 and kinesin 2alpha by microRNA 183","volume":"285","author":"Li","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2018.11.006_bb0130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.molimm.2013.11.018","article-title":"Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease","volume":"58","author":"Achberger","year":"2014","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.cellsig.2018.11.006_bb0135","first-page":"1117","article-title":"MiR-200a inhibits cell proliferation and EMT by down-regulating the ASPH expression levels and affecting ERK and PI3K\/Akt pathways in human hepatoma cells","volume":"10","author":"Yao","year":"2018","journal-title":"Am. J. Transl. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2018.11.006_bb0140","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3892\/or.2017.5506","article-title":"miR-200a targets gelsolin: a novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells","volume":"37","author":"Xu","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellsig.2018.11.006_bb0145","first-page":"2526","article-title":"Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma","volume":"19","author":"Levkovitch-Verbin","year":"2013","journal-title":"Mol. Vis."},{"issue":"3","key":"10.1016\/j.cellsig.2018.11.006_bb0150","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/cne.21186","article-title":"Differential mRNA distribution of components of the ERK\/MAPK signalling cascade in the adult mouse brain","volume":"500","author":"Di Benedetto","year":"2007","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.cellsig.2018.11.006_bb0155","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3892\/ijmm.2016.2676","article-title":"Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways","volume":"38","author":"Yu","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2018.11.006_bb0160","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1167\/iovs.10-6908","article-title":"Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK\/NF-kappaB pathway","volume":"52","author":"Hu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2018.11.006_bb0165","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.7314\/APJCP.2014.15.11.4671","article-title":"miR-200a inhibits tumor proliferation by targeting AP-2gamma in neuroblastoma cells","volume":"15","author":"Gao","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.cellsig.2018.11.006_bb0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.exer.2016.03.012","article-title":"Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1\/ZEB2 up-regulation and EMT processing","volume":"146","author":"Wu","year":"2016","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.cellsig.2018.11.006_bb0175","first-page":"1195","article-title":"MiR-200c suppresses the migration of retinoblastoma cells by reversing epithelial mesenchymal transition","volume":"10","author":"Shao","year":"2017","journal-title":"Int. J. Ophthalmol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656818302766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T11:29:58Z","timestamp":1546428598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656818302766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":35,"alternative-id":["S0898656818302766"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.11.006","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effects of overexpressed microRNA-200a on activation of glaucoma-related retinal glial cells and apoptosis of ganglion cells via downregulating FGF7-mediated MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2018.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}