{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:34:33Z","timestamp":1785483273695,"version":"3.56.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grants","doi-asserted-by":"crossref","award":["HL126825"],"award-info":[{"award-number":["HL126825"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grants","doi-asserted-by":"crossref","award":["HL146111"],"award-info":[{"award-number":["HL146111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grants","doi-asserted-by":"crossref","award":["HL126950"],"award-info":[{"award-number":["HL126950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grants","doi-asserted-by":"crossref","award":["EY026766"],"award-info":[{"award-number":["EY026766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"California Tobacco-Related Disease Research Grants Program Office of the University of California, Grant Number","award":["27IR-0045"],"award-info":[{"award-number":["27IR-0045"]}]},{"name":"American Heart Association Predoctoral","award":["18PRE34030209"],"award-info":[{"award-number":["18PRE34030209"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.cellsig.2019.109357","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T20:02:48Z","timestamp":1562702568000},"page":"109357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["mAKAP\u03b2 signalosomes \u2013 A nodal regulator of gene transcription associated with pathological cardiac remodeling"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-5698","authenticated-orcid":false,"given":"Kimberly","family":"Dodge-Kafka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriah","family":"Gildart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Tokarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kapiloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.113.001878","article-title":"Pathological ventricular remodeling: mechanisms: part 1 of 2","volume":"128","author":"Burchfield","year":"2013","journal-title":"Circ."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109357_bb0010","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circ."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109357_bb0015","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke Statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circ."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1172\/JCI62839","article-title":"Signaling effectors underlying pathologic growth and remodeling of the heart","volume":"123","author":"van Berlo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109357_bb0025","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.15797.1","article-title":"Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture","volume":"7","author":"McKinsey","year":"2018","journal-title":"F1000Res"},{"issue":"8","key":"10.1016\/j.cellsig.2019.109357_bb0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5957","key":"10.1016\/j.cellsig.2019.109357_bb0035","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1175668","article-title":"Cell signaling in space and time: where proteins come together and when they\u2019re apart","volume":"326","author":"Scott","year":"2009","journal-title":"Sci."},{"key":"10.1016\/j.cellsig.2019.109357_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-pharmtox-011112-140204","article-title":"Creating order from chaos: cellular regulation by kinase anchoring","volume":"53","author":"Scott","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0045","doi-asserted-by":"crossref","first-page":"H1742","DOI":"10.1152\/ajpheart.00569.2011","article-title":"A-kinase anchoring proteins: scaffolding proteins in the heart","volume":"301","author":"Diviani","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109357_bb0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1161\/01.RES.88.3.291","article-title":"AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes","volume":"88","author":"Fink","year":"2001","journal-title":"Circ. Res."},{"issue":"5554","key":"10.1016\/j.cellsig.2019.109357_bb0055","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.1066843","article-title":"Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel","volume":"295","author":"Marx","year":"2002","journal-title":"Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109357_bb0060","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/sj.embor.7401081","article-title":"AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum","volume":"8","author":"Lygren","year":"2007","journal-title":"EMBO Rep."},{"issue":"44","key":"10.1016\/j.cellsig.2019.109357_bb0065","doi-asserted-by":"crossref","first-page":"33537","DOI":"10.1074\/jbc.M601809200","article-title":"AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor","volume":"281","author":"Gardner","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"Pt 16","key":"10.1016\/j.cellsig.2019.109357_bb0070","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1242\/jcs.112.16.2725","article-title":"mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes","volume":"112","author":"Kapiloff","year":"1999","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0075","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.molcel.2005.10.013","article-title":"Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha","volume":"20","author":"Michel","year":"2005","journal-title":"Mol. Cell"},{"issue":"16","key":"10.1016\/j.cellsig.2019.109357_bb0080","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.1074\/jbc.270.16.9327","article-title":"Cloning and characterization of A-Kinase anchor protein-100 (Akap100) - a protein that targets a-kinase to the sarcoplasmic-reticulum","volume":"270","author":"Mccartney","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0090","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/CIRCHEARTFAILURE.114.001266","article-title":"The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure","volume":"7","author":"Kritzer","year":"2014","journal-title":"Circ. Heart Fail."},{"issue":"Pt 17","key":"10.1016\/j.cellsig.2019.109357_bb0095","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1242\/jcs.114.17.3167","article-title":"mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope","volume":"114","author":"Kapiloff","year":"2001","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109357_bb0100","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/cvr\/cvy110","article-title":"PDE4 and mAKAPbeta are nodal organizers of beta2-ARs nuclear PKA signalling in cardiac myocytes","volume":"114","author":"Bedioune","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellsig.2019.109357_bb0105","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1242\/jcs.02675","article-title":"The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling","volume":"118","author":"Pare","year":"2005","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109357_bb0110","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yexcr.2004.10.009","article-title":"Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope","volume":"303","author":"Pare","year":"2005","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109357_bb0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/BST20170149","article-title":"Nesprin-1\/2: roles in nuclear envelope organisation, myogenesis and muscle disease","volume":"46","author":"Zhou","year":"2018","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0120","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cell.2012.03.046","article-title":"LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins","volume":"149","author":"Sosa","year":"2012","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.cellsig.2019.109357_bb0125","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1093\/hmg\/ddx116","article-title":"Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis","volume":"26","author":"Zhou","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0130","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1074\/jbc.M109.071910","article-title":"Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes","volume":"285","author":"Haque","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"Pt 1","key":"10.1016\/j.cellsig.2019.109357_bb0135","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1042\/BST0380278","article-title":"Nesprin isoforms: are they inside or outside the nucleus?","volume":"38","author":"Morris","year":"2010","journal-title":"Biochem. Soc. Trans."},{"issue":"7058","key":"10.1016\/j.cellsig.2019.109357_bb0140","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nature03966","article-title":"The protein Kinase a Anchoring Protein mAKAP coordinates two integrated cAMP effector pathways","volume":"437","author":"Dodge-Kafka","year":"2005","journal-title":"Nat."},{"issue":"26","key":"10.1016\/j.cellsig.2019.109357_bb0145","doi-asserted-by":"crossref","first-page":"23012","DOI":"10.1074\/jbc.M111.231993","article-title":"Phospholipase C epsilon scaffolds to muscle-specific a kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0150","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3892\/ijmm.2015.2119","article-title":"The role of mAKAPbeta in the process of cardiomyocyte hypertrophy induced by angiotensin II","volume":"35","author":"Guo","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.cellsig.2019.109357_bb0155","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.cellsig.2012.03.017","article-title":"Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation","volume":"24","author":"Vargas","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2019.109357_bb0160","article-title":"AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: positive loop between AKAP6 and myogenin","volume":"5","author":"Lee","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109357_bb0165","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.ebiom.2015.10.025","article-title":"Muscle A-kinase anchoring protein-alpha is an injury-specific signaling scaffold required for neurotrophic- and cyclic adenosine monophosphate-mediated survival","volume":"2","author":"Wang","year":"2015","journal-title":"EBioMed."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109357_bb0170","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tcm.2012.12.006","article-title":"HDAC-dependent ventricular remodeling","volume":"23","author":"Xie","year":"2013","journal-title":"Trends. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0175","doi-asserted-by":"crossref","first-page":"H199","DOI":"10.1152\/ajpheart.00271.2016","article-title":"A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease","volume":"311","author":"Wright","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0180","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.cellsig.2019.109357_bb0185","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"6808","key":"10.1016\/j.cellsig.2019.109357_bb0190","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/35040593","article-title":"Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation","volume":"408","author":"McKinsey","year":"2000","journal-title":"Nat."},{"issue":"19","key":"10.1016\/j.cellsig.2019.109357_bb0195","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1128\/MCB.24.19.8374-8385.2004","article-title":"Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5","volume":"24","author":"Vega","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109357_bb0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2008.08.030","article-title":"AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway","volume":"32","author":"Carnegie","year":"2008","journal-title":"Mol. Cell"},{"issue":"26","key":"10.1016\/j.cellsig.2019.109357_bb0205","doi-asserted-by":"crossref","first-page":"14400","DOI":"10.1073\/pnas.260501497","article-title":"Activation of the myocyte enhancer factor-2 transcription factor by calcium\/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5","volume":"97","author":"McKinsey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"10.1016\/j.cellsig.2019.109357_bb0210","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1073\/pnas.140199597","article-title":"Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization","volume":"97","author":"Grozinger","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.cellsig.2019.109357_bb0215","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1128\/MCB.20.18.6904-6912.2000","article-title":"Regulation of histone deacetylase 4 by binding of 14-3-3 proteins","volume":"20","author":"Wang","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0220","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nm1573","article-title":"SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes","volume":"13","author":"Berdeaux","year":"2007","journal-title":"Nat. Med."},{"issue":"14","key":"10.1016\/j.cellsig.2019.109357_bb0225","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1113\/jphysiol.2013.256263","article-title":"Opposing HDAC4 nuclear fluxes due to phosphorylation by beta-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres","volume":"591","author":"Liu","year":"2013","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0230","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1074\/jbc.M112.382358","article-title":"Acute beta-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation","volume":"288","author":"Chang","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.cellsig.2019.109357_bb0235","doi-asserted-by":"crossref","first-page":"15467","DOI":"10.1073\/pnas.1000462107","article-title":"PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy","volume":"107","author":"Ha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0240","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cardfail.2011.03.006","article-title":"beta-Adrenergic receptor stimulation and activation of protein kinase A protect against alpha1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5","volume":"17","author":"Sucharov","year":"2011","journal-title":"J. Card. Fail."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0245","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004861","article-title":"beta-Adrenergic stimulation induces Distone Deacetylase 5 (HDAC5) nuclear accumulation in cardiomyocytes by B55alpha-PP2A-mediated Dephosphorylation","volume":"6","author":"Weeks","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cellsig.2019.109357_bb0250","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2018.03.001","article-title":"Bidirectional regulation of HDAC5 by mAKAPbeta signalosomes in cardiac myocytes","volume":"118","author":"Dodge-Kafka","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"8","key":"10.1016\/j.cellsig.2019.109357_bb0255","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/emboj\/20.8.1921","article-title":"mAKAP assembles a protein kinase A\/PDE4 phosphodiesterase cAMP signaling module","volume":"20","author":"Dodge","year":"2001","journal-title":"EMBO J."},{"issue":"35","key":"10.1016\/j.cellsig.2019.109357_bb0260","doi-asserted-by":"crossref","first-page":"23540","DOI":"10.1074\/jbc.M109.030072","article-title":"An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes","volume":"284","author":"Kapiloff","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2019.109357_bb0265","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/BJ20040846","article-title":"PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex","volume":"381","author":"Carlisle Michel","year":"2004","journal-title":"Biochem. J."},{"issue":"28","key":"10.1016\/j.cellsig.2019.109357_bb0270","doi-asserted-by":"crossref","first-page":"16526","DOI":"10.1074\/jbc.271.28.16526","article-title":"Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation","volume":"271","author":"Sette","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.cellsig.2019.109357_bb0275","doi-asserted-by":"crossref","first-page":"11078","DOI":"10.1074\/jbc.M109.034868","article-title":"cAMP-stimulated protein phosphatase 2A activity associated with muscle a kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3","volume":"285","author":"Dodge-Kafka","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0280","doi-asserted-by":"crossref","first-page":"H109","DOI":"10.1152\/ajpheart.00034.2018","article-title":"Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP\/PKA signaling","volume":"315","author":"Suryavanshi","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"18","key":"10.1016\/j.cellsig.2019.109357_bb0285","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1016\/j.jmb.2013.06.014","article-title":"Protein kinase a and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP)","volume":"425","author":"Rababa\u2019h","year":"2013","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005230","article-title":"Discovery and fine-mapping of Glycaemic and obesity-related trait loci using high-density imputation","volume":"11","author":"Horikoshi","year":"2015","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109357_bb0295","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1124\/mol.109.059345","article-title":"Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling","volume":"76","author":"Dessauer","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109357_bb0300","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/CIRCRESAHA.111.245092","article-title":"Treatment of chronic heart failure with beta-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology","volume":"109","author":"Bristow","year":"2011","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109357_bb0305","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1091\/mbc.E14-10-1476","article-title":"G protein betagamma subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway","volume":"26","author":"Malik","year":"2015","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0310","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2013.02.047","article-title":"Phospholipase Cepsilon hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109357_bb0315","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ncb874","article-title":"A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK","volume":"4","author":"Enserink","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109357_bb0320","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.yjmcc.2009.10.023","article-title":"The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin","volume":"48","author":"Li","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"21","key":"10.1016\/j.cellsig.2019.109357_bb0325","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1128\/MCB.22.21.7603-7613.2002","article-title":"Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth","volume":"22","author":"Wilkins","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"32","key":"10.1016\/j.cellsig.2019.109357_bb0330","doi-asserted-by":"crossref","first-page":"22295","DOI":"10.1074\/jbc.M801296200","article-title":"NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure","volume":"283","author":"Bourajjaj","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0335","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","article-title":"Calcium-calcineurin signaling in the regulation of cardiac hypertrophy","volume":"322","author":"Wilkins","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2019.109357_bb0340","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.cellbio.14.1.167","article-title":"Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins","volume":"14","author":"Black","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109357_bb0345","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1242\/dev.126.10.2045","article-title":"Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene","volume":"126","author":"Naya","year":"1999","journal-title":"Dev."},{"issue":"23","key":"10.1016\/j.cellsig.2019.109357_bb0350","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1242\/dev.008367","article-title":"MEF2: a central regulator of diverse developmental programs","volume":"134","author":"Potthoff","year":"2007","journal-title":"Dev."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0355","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1172\/JCI33255","article-title":"The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice","volume":"118","author":"Kim","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"22","key":"10.1016\/j.cellsig.2019.109357_bb0360","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1093\/emboj\/20.22.6414","article-title":"Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway","volume":"20","author":"Wu","year":"2001","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0365","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.yexcr.2012.12.016","article-title":"Regulation of MEF2 transcriptional activity by calcineurin\/mAKAP complexes","volume":"319","author":"Li","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"5763","key":"10.1016\/j.cellsig.2019.109357_bb0370","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1126\/science.1122513","article-title":"A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation","volume":"311","author":"Shalizi","year":"2006","journal-title":"Sci."},{"issue":"5763","key":"10.1016\/j.cellsig.2019.109357_bb0375","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.1122511","article-title":"Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number","volume":"311","author":"Flavell","year":"2006","journal-title":"Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0380","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1074\/jbc.M509471200","article-title":"Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation","volume":"281","author":"Gregoire","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0385","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1074\/jbc.RA118.005465","article-title":"Muscle A-kinase-anchoring protein-beta-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"51","key":"10.1016\/j.cellsig.2019.109357_bb0390","doi-asserted-by":"crossref","first-page":"ra18","DOI":"10.1126\/scisignal.2000026","article-title":"mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha","volume":"1","author":"Wong","year":"2008","journal-title":"Sci. Signal."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109357_bb0395","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0400","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/35017054","article-title":"Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein","volume":"2","author":"Ohh","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0405","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cardiores.2006.03.015","article-title":"Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes","volume":"71","author":"Boivin","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109357_bb0410","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1006\/jmcc.1993.1116","article-title":"Norepinephrine in neonatal rat ventricular myocytes: association with the cell nucleus and binding to nuclear alpha 1- and beta-adrenergic receptors","volume":"25","author":"Buu","year":"1993","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109357_bb0415","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/01.RES.0000107197.99679.77","article-title":"Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction","volume":"94","author":"Bueno","year":"2004","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0420","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.153.4.699","article-title":"Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine\/isoleucine zippers","volume":"153","author":"Marx","year":"2001","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0425","doi-asserted-by":"crossref","first-page":"H1010","DOI":"10.1152\/ajpheart.00237.2013","article-title":"p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in alpha-tropomyosin Glu180Gly transgenic mice","volume":"305","author":"Passariello","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109357_bb0430","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","article-title":"Calcineurin: form and function","volume":"80","author":"Rusnak","year":"2000","journal-title":"Physiol. Rev."},{"issue":"37","key":"10.1016\/j.cellsig.2019.109357_bb0435","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1038\/sj.onc.1210613","article-title":"Class IIa histone deacetylases: regulating the regulators","volume":"26","author":"Martin","year":"2007","journal-title":"Oncogene"},{"issue":"21","key":"10.1016\/j.cellsig.2019.109357_bb0440","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1074\/jbc.270.21.12481","article-title":"Regulation of adenylyl cyclase by protein kinase A","volume":"270","author":"Iwami","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.cellsig.2019.109357_bb0445","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1074\/jbc.RA118.002354","article-title":"G protein betagamma subunits directly interact with and activate phospholipase C","volume":"293","author":"Madukwe","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109357_bb0450","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1074\/jbc.RA118.005465","article-title":"Muscle A-kinase-anchoring protein-beta-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819301536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819301536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:52:02Z","timestamp":1760266322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656819301536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":90,"alternative-id":["S0898656819301536"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109357","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mAKAP\u03b2 signalosomes \u2013 A nodal regulator of gene transcription associated with pathological cardiac remodeling","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109357"}}