{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:19:53Z","timestamp":1793711993597,"version":"4.6.1"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.cellsig.2019.109482","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T12:09:06Z","timestamp":1574338146000},"page":"109482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":216,"special_numbering":"C","title":["The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-4783","authenticated-orcid":false,"given":"Mois\u00e9s","family":"Selman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2019.109482_bb0005","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet."},{"key":"10.1016\/j.cellsig.2019.109482_bb0010","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0015","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S2213-2600(14)70101-8","article-title":"Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001-11","volume":"2","author":"Raghu","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0020","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrd.2017.170","article-title":"Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease","volume":"16","author":"Mora","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cellsig.2019.109482_bb0025","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0022-2019","article-title":"Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis","volume":"28","author":"Collins","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.cellsig.2019.109482_bb0030","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy","volume":"134","author":"Selman","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0035","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1513\/pats.200601-003TK","article-title":"Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers","volume":"3","author":"Selman","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.cellsig.2019.109482_bb0040","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1164\/rccm.201312-2221PP","article-title":"Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model","volume":"189","author":"Selman","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0045","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa1013660","article-title":"A common MUC5B promoter polymorphism and pulmonary fibrosis","volume":"364","author":"Seibold","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0050","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1038\/s41467-018-07768-9","article-title":"Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice","volume":"9","author":"Hancock","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2019.109482_bb0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ng.2609","article-title":"Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis","volume":"45","author":"Fingerlin","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2019.109482_bb0060","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S2213-2600(13)70045-6","article-title":"Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study","volume":"1","author":"Noth","year":"2013","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0065","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S2213-2600(17)30387-9","article-title":"Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study","volume":"5","author":"Allen","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S2213-2600(18)30135-8","article-title":"Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study","volume":"6","author":"Dressen","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.201810-1891OC","article-title":"Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis","volume":"200","author":"Moore","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0080","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa066157","article-title":"Telomerase mutations in families with idiopathic pulmonary fibrosis","volume":"356","author":"Armanios","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0085","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1073\/pnas.0701009104","article-title":"Adult-onset pulmonary fibrosis caused by mutations in telomerase","volume":"104","author":"Tsakiri","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109482_bb0090","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1378\/chest.13-2224","article-title":"A novel dyskerin (DKC1) mutation is associated with familial interstitial pneumonia","volume":"146","author":"Kropski","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.cellsig.2019.109482_bb0095","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1378\/chest.14-1947","article-title":"Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis","volume":"147","author":"Alder","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.cellsig.2019.109482_bb0100","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ng.3278","article-title":"Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening","volume":"47","author":"Stuart","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2019.109482_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf7837","article-title":"Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis\u2013emphysema","volume":"8","author":"Stanley","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0110","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.1073\/pnas.0804280105","article-title":"Short telomeres are a risk factor for idiopathic pulmonary fibrosis","volume":"105","author":"Alder","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109482_bb0115","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.201406-1162OC","article-title":"Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease","volume":"191","author":"Kropski","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0120","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1164\/rccm.200112-123OC","article-title":"Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred","volume":"165","author":"Thomas","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86704","article-title":"Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis","volume":"1","author":"Naikawadi","year":"2016","journal-title":"JCI Insight."},{"key":"10.1016\/j.cellsig.2019.109482_bb0130","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1172\/JCI99287","article-title":"Expression of mutant Sftpc in murine alveolar epithelial drives spontaneous lung fibrosis","volume":"128","author":"Nureki","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1164\/ajrccm.155.1.9001319","article-title":"Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis","volume":"155","author":"Baumgartner","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0140","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1164\/ajrccm.158.6.9804105","article-title":"Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis","volume":"158","author":"Tobin","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0145","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0140-6736(96)90465-1","article-title":"Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis","volume":"347","author":"Hubbard","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2019.109482_bb0150","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ccell.2017.08.006","article-title":"Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations","volume":"32","author":"Vaz","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0155","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1038\/s41598-018-30781-3","article-title":"Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke","volume":"8","author":"Glass","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.116.001506","article-title":"Epigenetic signatures of cigarette smoking","volume":"9","author":"Joehanes","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.cellsig.2019.109482_bb0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1164\/rccm.201205-0888OC","article-title":"Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis","volume":"187","author":"Dakhlallah","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.200911-1698OC","article-title":"Inhibition and role of let-7d in idiopathic pulmonary fibrosis","volume":"182","author":"Pandit","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158367","article-title":"miR-34 miRNAs regulate cellular senescence in type II alveolar epithelial cells of patients with idiopathic pulmonary fibrosis","volume":"11","author":"Disayabutr","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109482_bb0180","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell."},{"key":"10.1016\/j.cellsig.2019.109482_bb0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1164\/ajrccm.162.3.9911119","article-title":"Frequent genetic alterations at the microsatellite level in cytologic sputum samples of patients with idiopathic pulmonary fibrosis","volume":"162","author":"Vassilakis","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0190","first-page":"8527","article-title":"Aberrations in the fragile histidine triad (FHIT) gene in idiopathic pulmonary fibrosis","volume":"61","author":"Uematsu","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2019.109482_bb0195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1582-4934.2002.tb00188.x","article-title":"MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis","volume":"6","author":"Demopoulos","year":"2002","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0200","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI66370","article-title":"Telomeres and age-related disease: how telomere biology informs clinical paradigms","volume":"123","author":"Armanios","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189467","article-title":"Short telomere length in IPF lung associates with fibrotic lesions and predicts survival","volume":"12","author":"Snetselaar","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109482_bb0210","first-page":"L510","article-title":"GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis","volume":"317","author":"Zhang","year":"2019","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine."},{"key":"10.1016\/j.cellsig.2019.109482_bb0220","first-page":"L391","article-title":"Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-\u03b2-induced senescence of human bronchial epithelial cells","volume":"300","author":"Minagawa","year":"2011","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0225","first-page":"L56","article-title":"Insufficient autophagy in idiopathic pulmonary fibrosis","volume":"304","author":"Araya","year":"2013","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0230","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90558","article-title":"Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis","volume":"1","author":"Xu","year":"2016","journal-title":"JCI Insight."},{"key":"10.1016\/j.cellsig.2019.109482_bb0235","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.1504780112","article-title":"Telomere dysfunction causes alveolar stem cell failure","volume":"112","author":"Alder","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109482_bb0240","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.18632\/aging.102262","article-title":"PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation","volume":"11","author":"Qiu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cellsig.2019.109482_bb0245","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12858","article-title":"Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-\u03baB activation","volume":"18","author":"Tian","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0250","first-page":"L1049","article-title":"Activation of the mTORC1\/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium","volume":"316","author":"Summer","year":"2019","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0255","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/acel.12643","article-title":"Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease","volume":"16","author":"Jiang","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0260","first-page":"L415","article-title":"miR-34a promotes fibrosis in aged lungs by inducing alveolar epithelial dysfunctions","volume":"312","author":"Cui","year":"2017","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0265","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1165\/rcmb.2016-0163OC","article-title":"miR-34a inhibits lung fibrosis by inducing lung fibroblast senescence","volume":"56","author":"Cui","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0270","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0275","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201947865","article-title":"Mitochondria orchestrate proteostatic and metabolic stress responses","volume":"20","author":"Andr\u00e9asson","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0280","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI74942","article-title":"PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis","volume":"125","author":"Bueno","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0285","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12720","article-title":"ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis","volume":"17","author":"Bueno","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0290","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1096\/fj.201601077R","article-title":"SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis","volume":"31","author":"Jablonski","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2019.109482_bb0295","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1172\/JCI87440","article-title":"Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis","volume":"127","author":"Mora","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218003","article-title":"PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses","volume":"14","author":"Bueno","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109482_bb0305","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12931-016-0404-x","article-title":"Detection and quantification of epithelial progenitor cell populations in human healthy and IPF lungs","volume":"17","author":"Smirnova","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.cellsig.2019.109482_bb0310","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature."},{"key":"10.1016\/j.cellsig.2019.109482_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058658","article-title":"The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium","volume":"8","author":"Seibold","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109482_bb0320","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122211","article-title":"CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling","volume":"3","author":"Habiel","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2019.109482_bb0325","doi-asserted-by":"crossref","DOI":"10.1165\/rcmb.2019-0047OC","article-title":"The oncogene ECT2 contributes to a hyperplastic, proliferative lung epithelial cell phenotype in IPF","author":"Ulke","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0330","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI114808","article-title":"Platelet-derived growth factor in idiopathic pulmonary fibrosis","volume":"86","author":"Antoniades","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0335","doi-asserted-by":"crossref","first-page":"7026","DOI":"10.1074\/jbc.M111.276311","article-title":"Interactions between \u03b2-catenin and transforming growth factor-\u03b2 signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)","volume":"287","author":"Zhou","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2019.109482_bb0340","first-page":"651","article-title":"Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis","volume":"143","author":"Piguet","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0345","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1165\/ajrcmb.16.2.9032126","article-title":"Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines","volume":"16","author":"Saleh","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0350","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1183\/09031936.01.00074101","article-title":"Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF","volume":"17","author":"Pan","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cellsig.2019.109482_bb0355","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.biocel.2008.02.012","article-title":"Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis","volume":"40","author":"Andersson-Sj\u00f6land","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0020251","article-title":"Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis","volume":"2","author":"Pardo","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0365","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1164\/rccm.200706-805OC","article-title":"Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation","volume":"177","author":"Horan","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0370","first-page":"L978","article-title":"Role of sonic hedgehog in idiopathic pulmonary fibrosis","volume":"303","author":"Bola\u00f1os","year":"2012","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0375","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.ajpath.2012.08.019","article-title":"The hedgehog system machinery controls transforming growth factor-\u03b2-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis","volume":"181","author":"Cigna","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0380","first-page":"L615","article-title":"FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro","volume":"310","author":"Joannes","year":"2016","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0385","article-title":"Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles","volume":"5","author":"Parimon","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2019.109482_bb0390","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1183\/13993003.00398-2016","article-title":"Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis","volume":"48","author":"Selman","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cellsig.2019.109482_bb0395","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-016-0343-6","article-title":"Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis","volume":"17","author":"Pardo","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.cellsig.2019.109482_bb0400","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1073\/pnas.092134099","article-title":"Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans","volume":"99","author":"Zuo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109482_bb0405","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.biocel.2007.11.020","article-title":"Approaching the degradome in idiopathic pulmonary fibrosis","volume":"40","author":"Pardo","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0410","doi-asserted-by":"crossref","first-page":"25964","DOI":"10.1074\/jbc.M113.459784","article-title":"Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption","volume":"288","author":"Herrera","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2019.109482_bb0415","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.ajpath.2011.06.041","article-title":"Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis","volume":"179","author":"Yamashita","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0420","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.201202-0302OC","article-title":"Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans","volume":"186","author":"Yu","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0425","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1165\/rcmb.2017-0223OC","article-title":"Upregulation and nuclear location of MMP28 in alveolar epithelium of idiopathic pulmonary fibrosis","volume":"59","author":"Maldonado","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0430","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1164\/rccm.200308-1151OC","article-title":"Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis","volume":"170","author":"Cosgrove","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0435","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2119\/molmed.2013.00123","article-title":"Transforming growth factor-\u03b21 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway","volume":"20","author":"Cui","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0440","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/jth.13623","article-title":"Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis","volume":"15","author":"Lin","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cellsig.2019.109482_bb0445","first-page":"2550","article-title":"Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury","volume":"119","author":"Scotton","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2019.109482_bb0450","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"EMT: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell."},{"key":"10.1016\/j.cellsig.2019.109482_bb0455","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"Rock","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109482_bb0460","first-page":"L71","article-title":"Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis","volume":"301","author":"Marmai","year":"2011","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109482_bb0465","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1164\/rccm.201712-2410OC","article-title":"Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis","volume":"199","author":"Reyfman","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0470","article-title":"Single cell RNA-seq reveals ectopic and aberrant lung resident cell populations in idiopathic pulmonary fibrosis","author":"Adams","year":"2019","journal-title":"BioRxiv"},{"key":"10.1016\/j.cellsig.2019.109482_bb0475","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00441-016-2537-0","article-title":"Developmental pathways in lung regeneration","volume":"367","author":"Stabler","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cellsig.2019.109482_bb0480","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cell.2011.10.001","article-title":"Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection","volume":"147","author":"Kumar","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0485","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.stem.2017.08.014","article-title":"Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells","volume":"21","author":"Jacob","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cellsig.2019.109482_bb0490","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1016\/j.celrep.2019.05.077","article-title":"Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells","volume":"27","author":"Strikoudis","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0495","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fphar.2016.00430","article-title":"Induced pluripotent stem cells inhibit bleomycin-induced pulmonary fibrosis in mice through suppressing TGF-\u03b21\/smad-mediated epithelial to mesenchymal transition","volume":"7","author":"Zhou","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0500","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1517\/14712598.2016.1124085","article-title":"Cell-based therapies for the treatment of idiopathic pulmonary fibrosis (IPF) disease","volume":"16","author":"Ghadiri","year":"2016","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.cellsig.2019.109482_bb0505","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/sctm.17-0185","article-title":"Amnion epithelial cell-derived exosomes restrict lung injury and enhance endogenous lung repair","volume":"7","author":"Tan","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005544","article-title":"Influenza virus infects epithelial stem\/progenitor cells of the distal lung: impact on Fgfr2b-driven epithelial repair","volume":"12","author":"Quantius","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cellsig.2019.109482_bb0515","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1164\/rccm.200811-1794OC","article-title":"Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"180","author":"Gupte","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0520","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.stemcr.2019.04.003","article-title":"FGF10-FGFR2B signaling generates basal cells and drives alveolar epithelial regeneration by bronchial epithelial stem cells after lung injury","volume":"12","author":"Yuan","year":"2019","journal-title":"Stem. Cell. Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0525","doi-asserted-by":"crossref","first-page":"37445","DOI":"10.1038\/srep37445","article-title":"Developmental reprogramming in mesenchymal stromal cells of human subjects with idiopathic pulmonary fibrosis","volume":"6","author":"Chanda","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0530","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.5966\/sctm.2015-0337","article-title":"Hepatocyte growth factor is required for mesenchymal stromal cell protection against bleomycin-induced pulmonary fibrosis","volume":"5","author":"Cahill","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.cellsig.2019.109482_bb0535","doi-asserted-by":"crossref","first-page":"41901","DOI":"10.1038\/srep41901","article-title":"Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells","volume":"7","author":"Nita","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0540","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/hum.2012.098","article-title":"Targeted gene transfer of hepatocyte growth factor to alveolar type II epithelial cells reduced lung fibrosis in rats","volume":"24","author":"Gazdhar","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.cellsig.2019.109482_bb0545","article-title":"Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury","volume":"6","author":"Sisson","year":"2018","journal-title":"Phys. Rep."},{"key":"10.1016\/j.cellsig.2019.109482_bb0550","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pupt.2011.04.001","article-title":"Resolvin D1 protects mice from LPS-induced acute lung injury","volume":"24","author":"Wang","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2019.109482_bb0555","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.4049\/jimmunol.177.9.5902","article-title":"Resolvin D series and protectin D1 mitigate acute kidney injury","volume":"177","author":"Duffield","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2019.109482_bb0560","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/labinvest.2017.114","article-title":"ResolvinD1 stimulates epithelial wound repair and inhibits TGF-\u03b2-induced EMT whilst reducing fibroproliferation and collagen production","volume":"98","author":"Zheng","year":"2018","journal-title":"Lab. Investig."},{"key":"10.1016\/j.cellsig.2019.109482_bb0565","doi-asserted-by":"crossref","first-page":"100941","DOI":"10.1016\/j.arr.2019.100941","article-title":"Targeting normal and cancer senescent cells as a strategy of senotherapy","volume":"55","author":"Sikora","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cellsig.2019.109482_bb0570","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02367-2016","article-title":"Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo","volume":"50","author":"Lehmann","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cellsig.2019.109482_bb0575","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1056\/NEJMoa1515319","article-title":"Danazol treatment for telomere diseases","volume":"374","author":"Townsley","year":"2016","journal-title":"N. Engl. J. Med."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819302785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819302785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:53:44Z","timestamp":1760266424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656819302785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":115,"alternative-id":["S0898656819302785"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109482","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109482"}}