{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:40:33Z","timestamp":1761676833843,"version":"build-2065373602"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.cellsig.2019.109492","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T12:08:26Z","timestamp":1575374906000},"page":"109492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Ghrelin induces autophagy and CXCR4 expression via the SIRT1\/AMPK axis in lymphoblastic leukemia cell lines"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-5267","authenticated-orcid":false,"given":"Masoud","family":"Heshmati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Javad","family":"Sanaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh","family":"Nahid-Samiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedayatollah","family":"Shirzad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Saeid","family":"Jami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"GhatrehSamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2019.109492_bb0005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbcan.2017.02.002","article-title":"Ghrelin and cancer progression","volume":"1868","author":"Lin","year":"2017","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.cellsig.2019.109492_bb0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(03)02083-1","article-title":"Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin","volume":"476","author":"Bedendi","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0015","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1210\/jc.2003-031964","article-title":"Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans","author":"Broglio","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0020","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/jc.2004-1069","article-title":"Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes","volume":"90","author":"Gauna","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ghir.2008.12.001","article-title":"Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system","volume":"19","author":"Hattori","year":"2009","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.obmed.2016.12.001","article-title":"Abundant ghrelin gene expression by monocytes: Putative implications for fat accumulation and obesity","volume":"5","author":"Seim","year":"2017","journal-title":"Obesity Medicine"},{"key":"10.1016\/j.cellsig.2019.109492_bb0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bbrc.2003.08.024","article-title":"Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness","volume":"309","author":"Duxbury","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2019.109492_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.regpep.2010.03.011","article-title":"Ghrelin: a potential therapeutic target for cancer","volume":"163","author":"Nikolopoulos","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.cellsig.2019.109492_bb0045","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1007\/s00125-012-2671-5","article-title":"The ghrelin O-acyltransferase-ghrelin system reduces TNF-\u03b1-induced apoptosis and autophagy in human visceral adipocytes","volume":"55","author":"Rodr\u00edguez","year":"2012","journal-title":"Diabetologia."},{"key":"10.1016\/j.cellsig.2019.109492_bb0050","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.2147\/DDDT.S89096","article-title":"Ghrelin reduces liver impairment in a model of concanavalin a-induced acute hepatitis in mice","volume":"9","author":"Mao","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.cellsig.2019.109492_bb0055","first-page":"21","article-title":"Ghrelin Reduces TNF-\u03b1-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD","volume":"104","author":"Ezquerro","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/srep39942","article-title":"Acylated and desacyl ghrelin are associated with hepatic lipogenesis, \u03b2-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats","volume":"6","author":"Ezquerro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2019.109492_bb0065","first-page":"46","article-title":"The role of chemokine receptor CXCR4 in breast cancer metastasis","volume":"3","author":"Mukherjee","year":"2013","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0070","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nature03703","article-title":"In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment","volume":"435","author":"Sipkins","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2019.109492_bb0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/leu.2008.299","article-title":"CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers","volume":"23","author":"Burger","year":"2009","journal-title":"Leukemia."},{"key":"10.1016\/j.cellsig.2019.109492_bb0080","article-title":"Abstract A06: the chemokine receptor CXCR4 is essential for the maintenance of T cell acute lymphoblastic leukemia","volume":"21","author":"Pitt","year":"2015","journal-title":"Tumor Microenvironment"},{"key":"10.1016\/j.cellsig.2019.109492_bb0085","series-title":"Infect. Inflamm. Impacts Oncog.","first-page":"191","article-title":"Involvement of chemokine receptors in organ-specific metastasis","author":"Zlotnik","year":"2006"},{"key":"10.1016\/j.cellsig.2019.109492_bb0090","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","article-title":"Metabolic control of autophagy","volume":"159","author":"Galluzzi","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.cellsig.2019.109492_bb0095","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrm2245","article-title":"Autophagy: from phenomenology to molecular understanding in less than a decade","volume":"8","author":"Klionsky","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0100","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2019.109492_bb0105","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1159\/000430377","article-title":"Ghrelin attenuated lipotoxicity via autophagy induction and nuclear factor-kappaB inhibition","volume":"37","author":"Mao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cellsig.2019.109492_bb0110","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/35044114","article-title":"A ubiquitin-like system mediates protein lipidation","volume":"408","author":"Ichimura","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2019.109492_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0120","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.febslet.2010.01.018","article-title":"Atg8-family interacting motif crucial for selective autophagy","volume":"584","author":"Noda","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cellsig.2019.109492_bb0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.200907015","article-title":"FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport","volume":"188","author":"Pankiv","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0130","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2019.109492_bb0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phrs.2012.07.004","article-title":"p62\/SQSTM1\/A170: physiology and pathology","volume":"66","author":"Komatsu","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0140","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","article-title":"Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice","volume":"131","author":"Komatsu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0145","article-title":"Galangin induces autophagy via deacetylation of LC3 by SIRT1 in HepG2 cells","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2019.109492_bb0150","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2019.109492_bb0155","series-title":"Death Recept. Cogn. Ligands Cancer","first-page":"183","article-title":"Autophagy in cancer and chemotherapy","author":"Yousefi","year":"2009"},{"key":"10.1016\/j.cellsig.2019.109492_bb0160","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1089\/scd.2010.0465","article-title":"SIRT1 deficiency downregulates PTEN\/JNK\/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells","volume":"20","author":"Chae","year":"2011","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.cellsig.2019.109492_bb0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0170","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2019.109492_bb0175","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1182\/blood-2010-03-273011","article-title":"SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse","volume":"117","author":"Ou","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2019.109492_bb0180","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0185","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0195","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Canto","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2019.109492_bb0200","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cmet.2018.02.008","article-title":"The homeostatic force of ghrelin","volume":"27","author":"Yanagi","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0205","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s12288-016-0758-8","article-title":"Antiproliferative and apoptosis-inducing activities of Thymoquinone in lymphoblastic Leukemia cell line","volume":"33","author":"Soltani","year":"2017","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"10.1016\/j.cellsig.2019.109492_bb0210","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.prp.2018.04.001","article-title":"SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells","volume":"214","author":"Fatehi","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.cellsig.2019.109492_bb0215","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.18632\/oncotarget.24483","article-title":"Dynamic changes during the treatment of pancreatic cancer","volume":"9","author":"Wolff","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2019.109492_bb0220","unstructured":"C. Chemical, (S)-EX-527 (848193\u201368-0) | Cayman Chemical (n.d.). https:\/\/www.caymanchem.com\/product\/10009798."},{"key":"10.1016\/j.cellsig.2019.109492_bb0225","unstructured":"Cayman Chemical Company, Dorsomorphin (866405\u201364-3) | Cayman Chemical, 2019 (n.d.). https:\/\/www.caymanchem.com\/product\/11967 (accessed October 3, 2019)."},{"key":"10.1016\/j.cellsig.2019.109492_bb0230","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molcel.2014.12.013","article-title":"Deacetylation of nuclear LC3 drives autophagy initiation under starvation","volume":"57","author":"Huang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0235","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1182\/blood.V96.5.1709","article-title":"Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study","volume":"96","author":"Abshire","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2019.109492_bb0240","doi-asserted-by":"crossref","first-page":"469","DOI":"10.17219\/acem\/37148","article-title":"How have advances in our understanding of the molecular genetics of paediatric leukaemia led to improved targeted therapies for these diseases?","volume":"23","author":"Szychot","year":"2014","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.cellsig.2019.109492_bb0245","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1210\/jcem.86.9.7866","article-title":"GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils","volume":"86","author":"Hattori","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0250","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/acel.12446","article-title":"AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation","volume":"15","author":"Han","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0255","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/mnfr.201400161","article-title":"Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK\/SIRT1 signaling pathway","volume":"58","author":"Jin","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0260","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1158\/1078-0432.CCR-15-0490","article-title":"Autophagy, metabolism, and cancer","volume":"21","author":"White","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0265","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2016.03.046","article-title":"Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice","volume":"35","author":"Talero","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0270","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10557-013-6442-4","article-title":"Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK\/SIRT1 pathway","volume":"27","author":"Guo","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.cellsig.2019.109492_bb0275","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/1535370216637940","article-title":"Resveratrol attenuated TNF-alpha-induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK\/SIRT1 signaling pathway","volume":"241","author":"Wang","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.cellsig.2019.109492_bb0280","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000328516","article-title":"Resveratrol-activated AMPK\/SIRT1\/autophagy in cellular models of Parkinson\u2019s disease","volume":"19","author":"Wu","year":"2011","journal-title":"Neurosignals"},{"key":"10.1016\/j.cellsig.2019.109492_bb0285","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1021\/acs.jafc.5b02876","article-title":"Sirtuin 1 (SIRT1) deacetylase activity and NAD(+)\/NADH ratio are imperative for capsaicin-mediated programmed cell death","volume":"63","author":"Lee","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cellsig.2019.109492_bb0290","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/annrheumdis-2014-205740","article-title":"Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis","volume":"75","author":"Zerr","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cellsig.2019.109492_bb0295","first-page":"L83","article-title":"TGF-beta-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?","volume":"304","author":"Warburton","year":"2013","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cellsig.2019.109492_bb0300","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1101\/gad.2016111","article-title":"Pancreatic cancers require autophagy for tumor growth","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2019.109492_bb0305","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2019.109492_bb0310","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1245\/s10434-011-2159-4","article-title":"SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis","volume":"19","author":"Chen","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0315","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.08.011","article-title":"Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses","volume":"123","author":"Chen","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0320","doi-asserted-by":"crossref","first-page":"25992","DOI":"10.1074\/jbc.M111.229401","article-title":"miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells","volume":"286","author":"Eades","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2019.109492_bb0325","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1158\/0008-5472.CAN-08-1107","article-title":"PTEN acetylation modulates its interaction with PDZ domain","volume":"68","author":"Ikenoue","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2019.109492_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/0174b439-c62b-42e8-a420-3defbfe5c8e9","article-title":"Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells","volume":"6","author":"Orecchia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109492_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002020","article-title":"The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth","volume":"3","author":"Firestein","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2019.109492_bb0340","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/onc.2008.388","article-title":"Deacetylation of cortactin by SIRT1 promotes cell migration","volume":"28","author":"Zhang","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2019.109492_bb0345","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2008.09.079","article-title":"Inhibition of transcriptional activity of c-JUN by SIRT1","volume":"376","author":"Gao","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2019.109492_bb0350","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ncb1857","article-title":"STAT3 inhibition of gluconeogenesis is downregulated by SirT1","volume":"11","author":"Nie","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0355","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cell.2008.10.025","article-title":"SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging","volume":"135","author":"Oberdoerffer","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109492_bb0360","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.201005160","article-title":"SIRT1 contributes to telomere maintenance and augments global homologous recombination","volume":"191","author":"Palacios","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109492_bb0365","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2019.109492_bb0370","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cmet.2008.02.011","article-title":"Hypothalamic CaMKK2 contributes to the regulation of energy balance","volume":"7","author":"Anderson","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2019.109492_bb0375","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.peptides.2013.02.011","article-title":"The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index","volume":"43","author":"Goebel-Stengel","year":"2013","journal-title":"Peptides"},{"author":"Nonprofit, MOLT-4 (ATCC\u00ae CRL-1582TM\u2122)","key":"10.1016\/j.cellsig.2019.109492_bb0380"},{"key":"10.1016\/j.cellsig.2019.109492_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2018.03.024","article-title":"CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance","volume":"425","author":"Hu","year":"2018","journal-title":"Cancer Lett."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819302888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819302888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:56:12Z","timestamp":1760266572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656819302888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":77,"alternative-id":["S0898656819302888"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109492","relation":{},"ISSN":["0898-6568"],"issn-type":[{"type":"print","value":"0898-6568"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin induces autophagy and CXCR4 expression via the SIRT1\/AMPK axis in lymphoblastic leukemia cell lines","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109492"}}