{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:12:23Z","timestamp":1787238743536,"version":"build-2736575974"},"reference-count":160,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK084097"],"award-info":[{"award-number":["R01 DK084097"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001296","name":"PKD Foundation Research Grant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK106912"],"award-info":[{"award-number":["P30 DK106912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mayo Translation PKD Center","award":["P30 DK090728"],"award-info":[{"award-number":["P30 DK090728"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.cellsig.2019.109509","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T11:32:27Z","timestamp":1577100747000},"page":"109509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Epigenetics and cell cycle regulation in cystogenesis"],"prefix":"10.1016","volume":"68","author":[{"given":"Xiaogang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2019.109509_bb0005","first-page":"69","article-title":"Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment","volume":"3","author":"Halvorson","year":"2010","journal-title":"Int. J. Nephrol. Renov. Dis."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0010","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1681\/ASN.2013111184","article-title":"Predictors of autosomal dominant polycystic kidney disease progression","volume":"25","author":"Schrier","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0015","doi-asserted-by":"crossref","first-page":"A160","DOI":"10.1289\/ehp.114-a160","article-title":"Epigenetics: the science of change","volume":"114","author":"Weinhold","year":"2006","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2014.02.045","article-title":"Transgenerational epigenetic inheritance: myths and mechanisms","volume":"157","author":"Heard","year":"2014","journal-title":"Cell"},{"issue":"6990","key":"10.1016\/j.cellsig.2019.109509_bb0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","article-title":"Epigenetics in human disease and prospects for epigenetic therapy","volume":"429","author":"Egger","year":"2004","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cellsig.2019.109509_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/genes9090429","article-title":"Profiling DNA methylation based on next-generation sequencing approaches: new insights and clinical applications","volume":"9","author":"Barros-Silva","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.cellsig.2019.109509_bb0035","doi-asserted-by":"crossref","unstructured":"Gai, W. and K. Sun, Epigenetic Biomarkers in Cell-Free DNA and Applications in Liquid Biopsy. Genes (Basel), 2019. 10(1).","DOI":"10.3390\/genes10010032"},{"issue":"9","key":"10.1016\/j.cellsig.2019.109509_bb0040","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.tibtech.2018.04.002","article-title":"Single-cell DNA methylation profiling: technologies and biological applications","volume":"36","author":"Karemaker","year":"2018","journal-title":"Trends Biotechnol."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0045","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbadis.2010.10.008","article-title":"Epigenetics and autosomal dominant polycystic kidney disease","volume":"1812","author":"Li","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2019.109509_bb0050","series-title":"Polycystic Kidney Disease","article-title":"Epigenetics in ADPKD: understanding mechanisms and discovering treatment","author":"Li","year":"2015"},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.ackd.2009.12.004","article-title":"Determinants of renal disease variability in ADPKD","volume":"17","author":"Harris","year":"2010","journal-title":"Adv. Chronic Kidney Dis."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0060","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/nbt.1685","article-title":"Epigenetic modifications and human disease","volume":"28","author":"Portela","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"14","key":"10.1016\/j.cellsig.2019.109509_bb0065","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1021\/bi00816a016","article-title":"Reaction of sodium bisulfite with uracil, cytosine, and their derivatives","volume":"9","author":"Hayatsu","year":"1970","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12033-009-9239-8","article-title":"The current state of chromatin immunoprecipitation","volume":"45","author":"Collas","year":"2010","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.cellsig.2019.109509_bb0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/bs.mcb.2019.04.015","article-title":"Investigation of epigenetics in kidney cell biology","volume":"153","author":"Li","year":"2019","journal-title":"Methods Cell Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0080","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1172\/JCI64401","article-title":"Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease","volume":"123","author":"Zhou","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.cellsig.2019.109509_bb0085","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1093\/hmg\/ddv136","article-title":"Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD","volume":"24","author":"Zhou","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0090","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1172\/JCI90921","article-title":"Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ki.2011.296","article-title":"Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation","volume":"81","author":"Fan","year":"2012","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00439-013-1378-0","article-title":"Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development","volume":"133","author":"Woo","year":"2014","journal-title":"Hum. Genet."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0105","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/hmg\/ddt556","article-title":"SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1","volume":"23","author":"Zhou","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2019.109509_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6425","article-title":"An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth","volume":"5","author":"Shi","year":"2014","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109509_bb0115","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1158\/0008-5472.CAN-04-2158","article-title":"Regulation of DNA methyltransferase 1 by the pRb\/E2F1 pathway","volume":"65","author":"McCabe","year":"2005","journal-title":"Cancer Res."},{"issue":"20","key":"10.1016\/j.cellsig.2019.109509_bb0120","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1093\/emboj\/cdg542","article-title":"EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer","volume":"22","author":"Bracken","year":"2003","journal-title":"EMBO J."},{"issue":"5334","key":"10.1016\/j.cellsig.2019.109509_bb0125","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1126\/science.277.5334.1996","article-title":"Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1","volume":"277","author":"Chuang","year":"1997","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0130","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cell.2007.04.035","article-title":"HEF1-dependent Aurora a activation induces disassembly of the primary cilium","volume":"129","author":"Pugacheva","year":"2007","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0135","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MNH.0000000000000333","article-title":"Therapeutic microRNAs in polycystic kidney disease","volume":"26","author":"Yheskel","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0140","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1021\/ja910264z","article-title":"DNA methylation increases nucleosome compaction and rigidity","volume":"132","author":"Choy","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0145","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109509_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001134","article-title":"Orphan CpG islands identify numerous conserved promoters in the mammalian genome","volume":"6","author":"Illingworth","year":"2010","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0155","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0160","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019133","article-title":"DNA methylation in mammals","volume":"6","author":"Li","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"24","key":"10.1016\/j.cellsig.2019.109509_bb0165","doi-asserted-by":"crossref","first-page":"11995","DOI":"10.1073\/pnas.90.24.11995","article-title":"Number of CpG islands and genes in human and mouse","volume":"90","author":"Antequera","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.cellsig.2019.109509_bb0170","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1074\/jbc.R110.205286","article-title":"DNA methylation and demethylation in mammals","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0175","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2019.109509_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-018-0450-y","article-title":"Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma","volume":"10","author":"Hervouet","year":"2018","journal-title":"Clin. Epigenetics"},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0185","first-page":"246","article-title":"Role of epigenetics in biology and human diseases","volume":"20","author":"Moosavi","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.cellsig.2019.109509_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13148-015-0154-5","article-title":"The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects","volume":"7","author":"Kok","year":"2015","journal-title":"Clin. Epigenetics"},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0195","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00018-010-0624-z","article-title":"Epigenetic aberrations during oncogenesis","volume":"68","author":"Hatziapostolou","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"35","key":"10.1016\/j.cellsig.2019.109509_bb0200","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1038\/sj.onc.1205600","article-title":"CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future","volume":"21","author":"Esteller","year":"2002","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0205","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0210","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000494739","article-title":"Genome-scale single nucleotide resolution analysis of DNA methylation in human autosomal dominant polycystic kidney disease","volume":"48","author":"Bowden","year":"2018","journal-title":"Am. J. Nephrol."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0220","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026435","article-title":"Nonhistone lysine methylation in the regulation of cancer pathways","volume":"6","author":"Carlson","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"24","key":"10.1016\/j.cellsig.2019.109509_bb0225","doi-asserted-by":"crossref","first-page":"14173","DOI":"10.1073\/pnas.95.24.14173","article-title":"Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin","volume":"95","author":"Bednar","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0230","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/1947601911417176","article-title":"Histone modifiers in cancer: friends or foes?","volume":"2","author":"Cohen","year":"2011","journal-title":"Genes Cancer"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0235","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.15252\/embr.201540945","article-title":"The interplay of histone modifications - writers that read","volume":"16","author":"Zhang","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2019.109509_bb0240","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddv136","article-title":"Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD","author":"Zhou","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0245","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"22","key":"10.1016\/j.cellsig.2019.109509_bb0250","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1007\/s00018-015-2001-4","article-title":"Emerging roles of lysine methylation on non-histone proteins","volume":"72","author":"Zhang","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0255","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1593\/neo.12656","article-title":"RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation","volume":"14","author":"Cho","year":"2012","journal-title":"Neoplasia"},{"issue":"6887","key":"10.1016\/j.cellsig.2019.109509_bb0260","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0265","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0270","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/jmcb\/mjr025","article-title":"Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2","volume":"3","author":"Abu-Farha","year":"2011","journal-title":"J. Mol. Cell Biol."},{"issue":"43","key":"10.1016\/j.cellsig.2019.109509_bb0275","doi-asserted-by":"crossref","first-page":"17284","DOI":"10.1073\/pnas.1307959110","article-title":"Regulation of estrogen receptor alpha by histone methyltransferase SMYD2-mediated protein methylation","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0280","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ki.2009.128","article-title":"Autosomal dominant polycystic kidney disease: the last 3 years","volume":"76","author":"Torres","year":"2009","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0285","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1083\/jcb.201006173","article-title":"The cell biology of polycystic kidney disease","volume":"191","author":"Chapin","year":"2010","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0290","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1242\/dev.049437","article-title":"Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts","volume":"137","author":"Xia","year":"2010","journal-title":"Development"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049418","article-title":"HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"31","key":"10.1016\/j.cellsig.2019.109509_bb0300","doi-asserted-by":"crossref","first-page":"12786","DOI":"10.1073\/pnas.1301904110","article-title":"Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease","volume":"110","author":"Seeger-Nukpezah","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.cellsig.2019.109509_bb0305","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddr338","article-title":"Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways","volume":"20","author":"Takakura","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0310","article-title":"Regulation of STATs by polycystin-1 and their role in polycystic kidney disease","volume":"2","author":"Weimbs","year":"2013","journal-title":"JAKSTAT"},{"issue":"44","key":"10.1016\/j.cellsig.2019.109509_bb0315","doi-asserted-by":"crossref","first-page":"18067","DOI":"10.1073\/pnas.1111966108","article-title":"Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease","volume":"108","author":"Olsan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0320","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1073\/pnas.1011498108","article-title":"Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis","volume":"108","author":"Takiar","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"10.1016\/j.cellsig.2019.109509_bb0325","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","article-title":"Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling","volume":"17","author":"Lal","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0330","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/ki.2013.488","article-title":"Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease","volume":"85","author":"Wallace","year":"2014","journal-title":"Kidney Int."},{"issue":"14","key":"10.1016\/j.cellsig.2019.109509_bb0335","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0340","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ng.105","article-title":"THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia","volume":"40","author":"Tran","year":"2008","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109509_bb0345","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1681\/ASN.2013020176","article-title":"Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts","volume":"24","author":"Fan","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0350","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nm1775","article-title":"Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms","volume":"14","author":"Buettner","year":"2008","journal-title":"Nat. Med."},{"issue":"7075","key":"10.1016\/j.cellsig.2019.109509_bb0355","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature04376","article-title":"Epigenetic silencers and notch collaborate to promote malignant tumours by Rb silencing","volume":"439","author":"Ferres-Marco","year":"2006","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0360","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.cellsig.2007.06.014","article-title":"Phosphatidylinositol 3-kinase\/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation","volume":"19","author":"Sun","year":"2007","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0365","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1440-1797.2012.01567.x","article-title":"Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney","volume":"17","author":"Abraham","year":"2012","journal-title":"Nephrology (Carlton)"},{"issue":"13","key":"10.1016\/j.cellsig.2019.109509_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133276","article-title":"Long non-coding RNAs in kidney disease","volume":"20","author":"Ignarski","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0375","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrc.2017.99","article-title":"Non-coding RNA networks in cancer","volume":"18","author":"Anastasiadou","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"26","key":"10.1016\/j.cellsig.2019.109509_bb0380","doi-asserted-by":"crossref","first-page":"18648","DOI":"10.18632\/oncotarget.24307","article-title":"Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis","volume":"9","author":"Hu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2019.109509_bb0385","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: classification, biology and functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0390","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2019.109509_bb0395","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0300-9084(02)01402-5","article-title":"The expanding snoRNA world","volume":"84","author":"Bachellerie","year":"2002","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0400","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-018-0073-3","article-title":"PIWI-interacting RNAs: small RNAs with big functions","volume":"20","author":"Ozata","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cellsig.2019.109509_bb0405","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1480-9222-16-11","article-title":"The functional role of long non-coding RNAs and epigenetics","volume":"16","author":"Cao","year":"2014","journal-title":"Biol. Proced. Online"},{"issue":"1748","key":"10.1016\/j.cellsig.2019.109509_bb0410","article-title":"Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?","volume":"373","author":"Hanly","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0415","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.tcb.2015.07.002","article-title":"Control of chromatin structure by long noncoding RNA","volume":"25","author":"Bohmdorfer","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cellsig.2019.109509_bb0420","doi-asserted-by":"crossref","unstructured":"Bou Kheir, T.and A.H. Lund, Epigenetic dynamics across the cell cycle. Essays Biochem., 2010. 48(1): p. 107\u201320.","DOI":"10.1042\/bse0480107"},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0425","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2184.2003.00266.x","article-title":"The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer","volume":"36","author":"Vermeulen","year":"2003","journal-title":"Cell Prolif."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0430","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0962-8924(02)02380-2","article-title":"Checking on the fork: the DNA-replication stress-response pathway","volume":"12","author":"Osborn","year":"2002","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0435","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.devcel.2005.10.007","article-title":"The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice","volume":"9","author":"Nacerddine","year":"2005","journal-title":"Dev. Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2019.109509_bb0440","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.cdd.4401987","article-title":"BCL2 family in DNA damage and cell cycle control","volume":"13","author":"Zinkel","year":"2006","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0445","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI72272","article-title":"Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease","volume":"124","author":"Harris","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.cellsig.2019.109509_bb0450","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1101\/gad.813200","article-title":"The Rb\/E2F pathway: expanding roles and emerging paradigms","volume":"14","author":"Harbour","year":"2000","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0455","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0460","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1101\/gad.207001.112","article-title":"DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis","volume":"27","author":"Georgia","year":"2013","journal-title":"Genes Dev."},{"issue":"27","key":"10.1016\/j.cellsig.2019.109509_bb0465","doi-asserted-by":"crossref","first-page":"20436","DOI":"10.1074\/jbc.M000202200","article-title":"Histone deacetylases specifically down-regulate p53-dependent gene activation","volume":"275","author":"Juan","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7119","key":"10.1016\/j.cellsig.2019.109509_bb0470","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature05287","article-title":"Repression of p53 activity by Smyd2-mediated methylation","volume":"444","author":"Huang","year":"2006","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.cellsig.2019.109509_bb0475","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1038\/sj.onc.1204338","article-title":"Rb-mediated chromatin structure regulation and transcriptional repression","volume":"20","author":"Zhang","year":"2001","journal-title":"Oncogene"},{"issue":"38","key":"10.1016\/j.cellsig.2019.109509_bb0480","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/sj.onc.1209680","article-title":"Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes","volume":"25","author":"Macaluso","year":"2006","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0485","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1093\/nar\/28.10.2108","article-title":"Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)\/G(1) to S phase transition in normal and tumor cells","volume":"28","author":"Robertson","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0490","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4161\/epi.2.1.3880","article-title":"Variations in DNA methylation patterns during the cell cycle of HeLa cells","volume":"2","author":"Brown","year":"2007","journal-title":"Epigenetics"},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0495","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.14.7.804","article-title":"Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression","volume":"14","author":"Takahashi","year":"2000","journal-title":"Genes Dev."},{"issue":"19","key":"10.1016\/j.cellsig.2019.109509_bb0500","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/MCB.21.19.6484-6494.2001","article-title":"Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase","volume":"21","author":"Vandel","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0505","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/BJ20070151","article-title":"Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1","volume":"407","author":"Wong","year":"2007","journal-title":"Biochem. J."},{"issue":"20","key":"10.1016\/j.cellsig.2019.109509_bb0510","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1093\/nar\/gkn699","article-title":"NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations","volume":"36","author":"Gatta","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"17","key":"10.1016\/j.cellsig.2019.109509_bb0515","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1101\/gad.1014902","article-title":"Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes","volume":"16","author":"Rice","year":"2002","journal-title":"Genes Dev."},{"issue":"15","key":"10.1016\/j.cellsig.2019.109509_bb0520","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1093\/nar\/gkp518","article-title":"Establishment of histone modifications after chromatin assembly","volume":"37","author":"Scharf","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0525","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cell.2007.01.030","article-title":"Chromatin challenges during DNA replication and repair","volume":"128","author":"Groth","year":"2007","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0530","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1139\/o06-086","article-title":"The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle","volume":"84","author":"McManus","year":"2006","journal-title":"Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0535","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jcb.22266","article-title":"Dynamic changes in chromatin structure through post-translational modifications of histone H3 during replication origin activation","volume":"108","author":"Rampakakis","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0540","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s004120050256","article-title":"Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation","volume":"106","author":"Hendzel","year":"1997","journal-title":"Chromosoma"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0545","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1074\/mcp.M700070-MCP200","article-title":"Analysis of dynamic changes in post-translational modifications of human histones during cell cycle by mass spectrometry","volume":"6","author":"Bonenfant","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"issue":"24","key":"10.1016\/j.cellsig.2019.109509_bb0550","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1128\/MCB.00018-07","article-title":"Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells","volume":"27","author":"Kang","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0555","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00412-004-0281-9","article-title":"The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved","volume":"112","author":"Barber","year":"2004","journal-title":"Chromosoma"},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0560","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1101\/gad.1412706","article-title":"SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis","volume":"20","author":"Vaquero","year":"2006","journal-title":"Genes Dev."},{"issue":"5762","key":"10.1016\/j.cellsig.2019.109509_bb0565","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1124000","article-title":"Histone H4-K16 acetylation controls chromatin structure and protein interactions","volume":"311","author":"Shogren-Knaak","year":"2006","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0570","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1128\/MCB.01517-07","article-title":"Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle","volume":"28","author":"Pesavento","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"13","key":"10.1016\/j.cellsig.2019.109509_bb0575","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1074\/jbc.M505323200","article-title":"Dynamic changes in histone H3 lysine 9 methylations: identification of a mitosis-specific function for dynamic methylation in chromosome congression and segregation","volume":"281","author":"McManus","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5570","key":"10.1016\/j.cellsig.2019.109509_bb0580","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1069861","article-title":"A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells","volume":"296","author":"Ogawa","year":"2002","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.cellsig.2019.109509_bb0585","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/sj.onc.1209988","article-title":"PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors","volume":"26","author":"Deshpande","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0590","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/MCB.01236-06","article-title":"AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability","volume":"27","author":"Torrisani","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2019.109509_bb0595","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases","volume":"14","author":"Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0600","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/MCB.18.2.753","article-title":"Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes","volume":"18","author":"Lundberg","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109509_bb0605","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc2399","article-title":"Cellular mechanisms of tumour suppression by the retinoblastoma gene","volume":"8","author":"Burkhart","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2019.109509_bb0610","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02872","article-title":"Cyclin D activates the Rb tumor suppressor by mono-phosphorylation","volume":"3","author":"Narasimha","year":"2014","journal-title":"Elife"},{"issue":"42","key":"10.1016\/j.cellsig.2019.109509_bb0615","doi-asserted-by":"crossref","first-page":"31430","DOI":"10.1016\/S0021-9258(19)84055-3","article-title":"Cross-species and cross-compartmental aminoacylation of isoaccepting tRNAs by a class II tRNA synthetase","volume":"281","author":"Huang","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3\u20134","key":"10.1016\/j.cellsig.2019.109509_bb0620","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1947601913484496","article-title":"SIRT1: regulator of p53 Deacetylation","volume":"4","author":"Lee","year":"2013","journal-title":"Genes Cancer"},{"key":"10.1016\/j.cellsig.2019.109509_bb0625","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1476-4598-5-26","article-title":"Identification and characterization of Smyd2: a split SET\/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex","volume":"5","author":"Brown","year":"2006","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0630","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrc3256","article-title":"BET domain co-regulators in obesity, inflammation and cancer","volume":"12","author":"Belkina","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"23","key":"10.1016\/j.cellsig.2019.109509_bb0635","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1091\/mbc.e09-05-0380","article-title":"Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription","volume":"20","author":"Dey","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"7327","key":"10.1016\/j.cellsig.2019.109509_bb0640","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature09589","article-title":"Suppression of inflammation by a synthetic histone mimic","volume":"468","author":"Nicodeme","year":"2010","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cellsig.2019.109509_bb0645","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","article-title":"BET bromodomain inhibition as a therapeutic strategy to target c-Myc","volume":"146","author":"Delmore","year":"2011","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.cellsig.2019.109509_bb0650","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ncb1326","article-title":"Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2","volume":"7","author":"Li","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"17","key":"10.1016\/j.cellsig.2019.109509_bb0655","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.4161\/cc.21263","article-title":"Regulation of transcription and chromatin structure by pRB: here, there and everywhere","volume":"11","author":"Talluri","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cellsig.2019.109509_bb0660","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1101\/SQB.1991.056.01.020","article-title":"E2F transcription factor is a target for the RB protein and the cyclin A protein","volume":"56","author":"Nevins","year":"1991","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"6667","key":"10.1016\/j.cellsig.2019.109509_bb0665","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/35404","article-title":"Retinoblastoma protein recruits histone deacetylase to repress transcription","volume":"391","author":"Brehm","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0670","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)80940-X","article-title":"Rb interacts with histone deacetylase to repress transcription","volume":"92","author":"Luo","year":"1998","journal-title":"Cell"},{"issue":"6667","key":"10.1016\/j.cellsig.2019.109509_bb0675","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/35410","article-title":"Retinoblastoma protein represses transcription by recruiting a histone deacetylase","volume":"391","author":"Magnaghi-Jaulin","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0680","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/emboj\/21.4.779","article-title":"The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity","volume":"21","author":"Pradhan","year":"2002","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109509_bb0685","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/77124","article-title":"DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters","volume":"25","author":"Robertson","year":"2000","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109509_bb0690","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1093\/nar\/gkg406","article-title":"Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways","volume":"31","author":"Kimura","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0695","first-page":"275","article-title":"Epigenetic silencing of tumor suppressor genes: paradigms, puzzles, and potential","volume":"1865","author":"Kazanets","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5595","key":"10.1016\/j.cellsig.2019.109509_bb0700","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in Polycomb-group silencing","volume":"298","author":"Cao","year":"2002","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.cellsig.2019.109509_bb0705","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","article-title":"Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of Zeste protein","volume":"16","author":"Kuzmichev","year":"2002","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0710","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(02)00976-5","article-title":"Histone methyltransferase activity of a Drosophila Polycomb group repressor complex","volume":"111","author":"Muller","year":"2002","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0715","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/ncb2116","article-title":"Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2","volume":"12","author":"Chen","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"23","key":"10.1016\/j.cellsig.2019.109509_bb0720","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1101\/gad.1983810","article-title":"Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA","volume":"24","author":"Kaneko","year":"2010","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0725","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncb2139","article-title":"CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells","volume":"13","author":"Wei","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"7078","key":"10.1016\/j.cellsig.2019.109509_bb0730","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature04431","article-title":"The Polycomb group protein EZH2 directly controls DNA methylation","volume":"439","author":"Vire","year":"2006","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109509_bb0735","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/ndt\/gfy009","article-title":"Targeting epigenetic DNA and histone modifications to treat kidney disease","volume":"33","author":"Fontecha-Barriuso","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0740","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1681\/ASN.2013050461","article-title":"Understanding the epigenetic syntax for the genetic alphabet in the kidney","volume":"25","author":"Susztak","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.cellsig.2019.109509_bb0745","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ki.2015.148","article-title":"Recent developments in epigenetics of acute and chronic kidney diseases","volume":"88","author":"Reddy","year":"2015","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0750","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1158\/1078-0432.CCR-13-1733","article-title":"Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance","volume":"20","author":"Chen","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2019.109509_bb0755","doi-asserted-by":"crossref","DOI":"10.1016\/j.bdq.2019.100087","article-title":"The emerging role of cell-free DNA as a molecular marker for cancer management","volume":"17","author":"Bronkhorst","year":"2019","journal-title":"Biomol. Detect. Quantif."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0760","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1586\/erm.10.17","article-title":"DNA methylation as a universal biomarker","volume":"10","author":"Levenson","year":"2010","journal-title":"Expert. Rev. Mol. Diagn."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0765","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/ph5010094","article-title":"DNA methylation as clinically useful biomarkers-light at the end of the tunnel","volume":"5","author":"Levenson","year":"2012","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109509_bb0770","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jcp.2007.048470","article-title":"Detection of circulating fetal nucleic acids: a review of methods and applications","volume":"62","author":"Hung","year":"2009","journal-title":"J. Clin. Pathol."},{"issue":"26","key":"10.1016\/j.cellsig.2019.109509_bb0775","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1200\/JCO.2005.01.3516","article-title":"Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer","volume":"24","author":"Hoque","year":"2006","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0780","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.febslet.2007.01.051","article-title":"Circulating (cell-free) nucleic acids--a promising, non-invasive tool for early detection of several human diseases","volume":"581","author":"Swarup","year":"2007","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109509_bb0785","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.juro.2009.02.106","article-title":"CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer","volume":"182","author":"Ellinger","year":"2009","journal-title":"J. Urol."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109509_bb0790","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4161\/cbt.5.10.3240","article-title":"Circulating cell-free DNA: a novel biomarker for response to therapy in ovarian carcinoma","volume":"5","author":"Kamat","year":"2006","journal-title":"Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109509_bb0795","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.89.5.1827","article-title":"A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands","volume":"89","author":"Frommer","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109509_bb0800","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071414","article-title":"Histone deacetylase inhibitors as anticancer drugs","volume":"18","author":"Eckschlager","year":"2017","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819303055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819303055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:55:11Z","timestamp":1760266511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656819303055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":160,"alternative-id":["S0898656819303055"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109509","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetics and cell cycle regulation in cystogenesis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109509"}}