{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:19:12Z","timestamp":1788884352902,"version":"build-2803163510"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"DST-INSPIRE"},{"name":"DST-PURSE"},{"name":"DBT"},{"name":"Government of India and DBT"},{"name":"Government of West Bengal"},{"name":"UGC-UPEII"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.cellsig.2019.109521","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T16:49:22Z","timestamp":1577206162000},"page":"109521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine"],"prefix":"10.1016","volume":"68","author":[{"given":"Sayan","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreetama","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Sain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Adhikary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-4437","authenticated-orcid":false,"given":"Sreya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/br.2016.807","article-title":"Role of inflammatory cytokines in depression: focus on interleukin-1\u03b2","volume":"6","author":"Farooq","year":"2017","journal-title":"Biomed. Rep."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0010","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/ijnp\/pyx023","article-title":"Resolvin D1 and D2 reverse lipopolysaccharide-induced depression-like behaviors through the MTORC1 signaling pathway","volume":"20","author":"Deyama","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069123","article-title":"A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1\u03b2, [corrected] TNF-\u03b1 and IL-6 challenges in C57BL\/6 mice","volume":"8","author":"Skelly","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cellsig.2019.109521_bb0020","doi-asserted-by":"crossref","first-page":"209","DOI":"10.29252\/nirp.bcn.9.3.209","article-title":"The effects of iron oxide nanoparticles administration on depression symptoms induced by LPS in male Wistar rats","volume":"9","author":"Saeidienik","year":"2018","journal-title":"Basic Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109521_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0031-9384(00)00212-2","article-title":"Cholecystokinin receptors do not mediate the suppression of food-motivated behavior by lipopolysaccharide and interleukin-1 beta in mice","volume":"69","author":"Bret-Dibat","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.cellsig.2019.109521_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2014.01.008","article-title":"Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP\/pCREB\/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice","volume":"263","author":"Guo","year":"2014","journal-title":"Neuroscience."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0035","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10753-016-0376-5","article-title":"Lipopolysaccharide-induced behavioral alterations are alleviated by sodium phenylbutyrate via attenuation of oxidative stress and neuroinflammatory cascade","volume":"39","author":"Jangra","year":"2016","journal-title":"Inflammation."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0964-9","article-title":"Lentivirus-mediated interleukin-1\u03b2 (IL-1\u03b2) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice","volume":"14","author":"Li","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0045","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.cellsig.2015.03.013","article-title":"Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: role of fluoxetine","volume":"27","author":"Ghosh","year":"2015","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0050","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/imcb.12227","article-title":"Fluoxetine triggers selective apoptosis in inflammation-induced proliferating (Ki-67high) thymocytes","volume":"97","author":"Ghosh","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12974-019-1509-1","article-title":"The antidepressant effects of GM-CSF are mediated by the reduction of TLR4\/NF-\u0138B-induced IDO expression","volume":"16","author":"Hemmati","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0060","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11011-018-0246-y","article-title":"Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway","volume":"33","author":"Deng","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.cellsig.2019.109521_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbi.2012.08.008","article-title":"Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice","volume":"31","author":"Corona","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"22","key":"10.1016\/j.cellsig.2019.109521_bb0075","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Cz\u00e9h","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.cellsig.2019.109521_bb0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.12443","article-title":"Immune mechanisms linked to depression via oxidative stress and neuroprogression","volume":"144","author":"Bakunina","year":"2015","journal-title":"Immunology."},{"issue":"36","key":"10.1016\/j.cellsig.2019.109521_bb0085","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.2174\/138161212803523554","article-title":"The role of oxidative stress in depressive disorders","volume":"18","author":"Michel","year":"2012","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0090","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s12264-015-1548-2","article-title":"Molecular network of neuronal autophagy in the pathophysiology and treatment of depression","volume":"31","author":"Jia","year":"2015","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.cellsig.2019.109521_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2018.05.020","article-title":"The antidepressant effects of \u0251-tocopherol are related to activation of autophagy via the AMPK\/mTOR pathway","volume":"833","author":"Huang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2019.109521_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109521_bb0105","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/mp.2016.144","article-title":"Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression","volume":"22","author":"Bouvier","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"Pt B","key":"10.1016\/j.cellsig.2019.109521_bb0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2015.06.014","article-title":"p62 links autophagy and Nrf2 signaling","volume":"88","author":"Jiang","year":"2015","journal-title":"Free Radic. Biol. Med"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109521_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001755","article-title":"Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans","volume":"11","author":"Gassen","year":"2014","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2832-3-2","article-title":"Fluoxetine: a review on evidence based medicine","volume":"3","author":"Rossi","year":"2004","journal-title":"Ann. Gen Hosp. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2019.109521_bb0125","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1016\/S1353-8020(11)70066-9","article-title":"Fluoxetine protects neurons against microglial activation-mediated neurotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.cellsig.2019.109521_bb0130","doi-asserted-by":"crossref","first-page":"101711","DOI":"10.1016\/j.jchemneu.2019.101711","article-title":"Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats","volume":"103","author":"Zavvari","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.cellsig.2019.109521_bb0135","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cellsig.2019.109521_bb0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2009.04.053","article-title":"Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus","volume":"1281","author":"Jin","year":"2009","journal-title":"Brain Res."},{"issue":"44","key":"10.1016\/j.cellsig.2019.109521_bb0145","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","article-title":"A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo","volume":"25","author":"Shih","year":"2005","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109521_bb0150","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","author":"Bachmanov","year":"2002","journal-title":"Behav. Genet."},{"issue":"12","key":"10.1016\/j.cellsig.2019.109521_bb0155","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jnutbio.2013.07.005","article-title":"Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-\u03baB pathways","volume":"24","author":"Mukherjee","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109521_bb0160","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3109\/10715762.2015.1075016","article-title":"Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2\/NF-\u03baB and SAPK\/JNK pathway","volume":"49","author":"Choudhury","year":"2015","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.cellsig.2019.109521_bb0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jnutbio.2016.09.001","article-title":"Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells","volume":"38","author":"Choudhury","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.cellsig.2019.109521_bb0170","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/sj.npp.1300532","article-title":"Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration","volume":"29","author":"Strekalova","year":"2004","journal-title":"Neuropsychopharmacology."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0175","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/1087057112468765","article-title":"Rapid and specific measurements of superoxide using fluorescence spectroscopy","volume":"18","author":"Nazarewicz","year":"2013","journal-title":"J. Biomol. Screen."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/9780470942390.mo140169","article-title":"Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes","volume":"4","author":"Mustafi","year":"2014","journal-title":"Curr. Protoc. Mouse Biol."},{"issue":"5\u20136","key":"10.1016\/j.cellsig.2019.109521_bb0185","first-page":"31","article-title":"Are antidepressants effective in the acute and long-term treatment of depression?","volume":"9","author":"Pies","year":"2012","journal-title":"Sic et Non. Innov Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/npp.2013.342","article-title":"Innovative drugs to treat depression: did animal models fail to be predictive or did clinical trials fail to detect effects?","volume":"39","author":"Balzung","year":"2014","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.cellsig.2019.109521_bb0195","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbi.2015.01.016","article-title":"Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance","volume":"46","author":"Ramirez","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cellsig.2019.109521_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/1465-9921-8-35","article-title":"Anti-inflammatory properties of desipramine and fluoxetine","volume":"8","author":"Roumestan","year":"2007","journal-title":"Respir. Res."},{"key":"10.1016\/j.cellsig.2019.109521_bb0205","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9085273","article-title":"Systematic analysis of the cytokine and anhedonia response to peripheral lipopolysaccharide administration in rats","volume":"2016","author":"Biesmans","year":"2016","journal-title":"Biomed. Res. Int."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109521_bb0210","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109521_bb0215","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.4049\/jimmunol.177.10.7303","article-title":"Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression","volume":"177","author":"Martinez","year":"2006","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0220","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cellsig.2019.109521_bb0225","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2014.03.039","article-title":"The role of TLR4-mediated PTEN\/PI3K\/AKT\/NF-\u03baB signaling pathway in neuroinflammation in hippocampal neurons","volume":"269","author":"Zhao","year":"2014","journal-title":"Neuroscience."},{"key":"10.1016\/j.cellsig.2019.109521_bb0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2014.03.039","article-title":"The role of TLR4-mediated PTEN\/PI3K\/AKT\/NF-\u03baB signaling pathway in neuroinflammation in hippocampal neurons","volume":"269","author":"Zhao","year":"2014","journal-title":"Neuroscience."},{"issue":"36","key":"10.1016\/j.cellsig.2019.109521_bb0235","doi-asserted-by":"crossref","first-page":"26041","DOI":"10.1074\/jbc.M602222200","article-title":"NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages","volume":"281","author":"Cao","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0240","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/path.4870","article-title":"Activating the AKT2-nuclear factor-\u03baB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration","volume":"241","author":"Ghosh","year":"2017","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0245","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0250","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/ars.2018.7518","article-title":"Autophagy: a lysosome-dependent process with implications in cellular redox homeostasis and human disease","volume":"30","author":"Ryter","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"29","key":"10.1016\/j.cellsig.2019.109521_bb0255","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","article-title":"p62\/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription","volume":"285","author":"Jain","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109521_bb0260","doi-asserted-by":"crossref","first-page":"e2876","DOI":"10.1038\/cddis.2017.265","article-title":"Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2019.109521_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100771","article-title":"Immune mechanisms of stress susceptibility and resilience: lessons from animal models","volume":"54","author":"Tsyglakova","year":"2019","journal-title":"Front. Neuroendocrinol."},{"issue":"9","key":"10.1016\/j.cellsig.2019.109521_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092283","article-title":"The role of chemokines in the pathophysiology of major depressive disorder","volume":"20","author":"Milenkovic","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0275","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1475-7","article-title":"Role of inflammation in depression relapse","volume":"16","author":"Liu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2019.109521_bb0280","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2019.10.037","article-title":"Differences in the immune-inflammatory profiles of unipolar and bipolar depression","volume":"262","author":"Brunoni","year":"2019","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0285","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu005","article-title":"Lipopolysaccharide-induced depressive-like behavior is associated with \u03b1\u2081-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area","volume":"18","author":"Sekio","year":"2014","journal-title":"Int. J. Neuropsychopharmacol"},{"issue":"11","key":"10.1016\/j.cellsig.2019.109521_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24112035","article-title":"Antidepressant-like effect and mechanism of action of honokiol on the mouse lipopolysaccharide (LPS) depression model","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0295","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","article-title":"Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice","volume":"14","author":"O\u2019Connor","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cellsig.2019.109521_bb0300","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbi.2016.05.008","article-title":"Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors","volume":"57","author":"Ramirez","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0305","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1176\/appi.ajp.2013.13050709","article-title":"Antidepressant-induced liver injury: a review for clinicians","volume":"171","author":"Voican","year":"2014","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0310","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv126","article-title":"Drug-iduced liver injury during antidepressant treatment: results of AMSP, a drug surveillance program","volume":"19","author":"Friedrich","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109521_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186700","article-title":"Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression","volume":"12","author":"Lu","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cellsig.2019.109521_bb0320","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1813-9","article-title":"The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression","volume":"10","author":"Shu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2019.109521_bb0325","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbr.2014.08.018","article-title":"The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration","volume":"274","author":"Wang","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cellsig.2019.109521_bb0330","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fphar.2018.00183","article-title":"Curcumin prevents acute neuroinflammation and long-term memory impairment induced by systemic lipopolysaccharide in mice","volume":"9","author":"Sorrenti","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0335","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2174\/1570159X14666151208113700","article-title":"Inflammation in depression and the potential for anti-inflammatory treatment","volume":"14","author":"Kohler","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2019.109521_bb0340","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1139\/jpn.0441","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.cellsig.2019.109521_bb0345","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0350","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12974-018-1054-3","article-title":"Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats","volume":"15","author":"Wang","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.cellsig.2019.109521_bb0355","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbi.2008.09.002","article-title":"Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines","volume":"23","author":"Henry","year":"2009","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.cellsig.2019.109521_bb0360","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-018-0111-4","article-title":"Modulation of M1\/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo","volume":"50","author":"Bok","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0365","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cellsig.2019.109521_bb0370","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fnins.2018.00486","article-title":"Selanylimidazopyridine prevents lipopolysaccharide-induced depressive-like behavior in mice by targeting neurotrophins and inflammatory\/oxidative mediators","volume":"12","author":"Domingues","year":"2018","journal-title":"Front. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2019.109521_bb0375","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000494139","article-title":"Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative stress","volume":"103","author":"Cheng","year":"2019","journal-title":"Pharmacology."},{"key":"10.1016\/j.cellsig.2019.109521_bb0380","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1742-2094-8-125","article-title":"Curcumin is a potent modulator of microglial gene expression and migration","volume":"8","author":"Karlstetter","year":"2011","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.cellsig.2019.109521_bb0385","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.cellsig.2019.109521_bb0390","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/glia.20947","article-title":"Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson\u2019s disease","volume":"58","author":"Rojo","year":"2010","journal-title":"Glia."},{"issue":"1","key":"10.1016\/j.cellsig.2019.109521_bb0395","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","article-title":"The transcription factor Nrf2 is a therapeutic target against brain inflammation","volume":"181","author":"Innamorato","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2019.109521_bb0400","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3389\/fphar.2018.01536","article-title":"Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages","volume":"9","author":"Staurengo-Ferrari","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"22","key":"10.1016\/j.cellsig.2019.109521_bb0405","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1073\/pnas.231475998","article-title":"Depression, antidepressants, and the shrinking hippocampus","volume":"98","author":"Sapolsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.cellsig.2019.109521_bb0410","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.psyneuen.2013.03.020","article-title":"Nrf2 participates in depressive disorders through an anti-inflammatory mechanism","volume":"38","author":"Mart\u00edn-de-Saavedra","year":"2013","journal-title":"Psychoneuroendocrinology."},{"issue":"Suppl. 2","key":"10.1016\/j.cellsig.2019.109521_bb0415","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.cdd.4401751","article-title":"Autophagy and signaling: their role in cell survival and cell death","volume":"12","author":"Codogno","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cellsig.2019.109521_bb0420","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fpsyt.2019.00337","article-title":"Is there a role of autophagy in depression and antidepressant action?","volume":"10","author":"N Gassen","year":"2019","journal-title":"Front. Psychiatry."},{"key":"10.1016\/j.cellsig.2019.109521_bb0425","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bj\u00f8rk\u00f8y","year":"2009","journal-title":"Methods Enzymol."},{"issue":"8","key":"10.1016\/j.cellsig.2019.109521_bb0430","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1007\/s12035-015-9453-2","article-title":"Beclin-1 deficiency alters autophagosome formation, lysosome biogenesis and enhances neuronal vulnerability of HT22 hippocampal cells","volume":"53","author":"Fekadu","year":"2016","journal-title":"Mol. Neurobiol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819303171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656819303171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:54:03Z","timestamp":1760266443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656819303171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":86,"alternative-id":["S0898656819303171"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109521","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2019.109521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109521"}}