{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:52Z","timestamp":1790068732806,"version":"4.0.1"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.cellsig.2020.109524","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T11:40:03Z","timestamp":1577965203000},"page":"109524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Role of oxygen and the HIF-pathway in polycystic kidney disease"],"prefix":"10.1016","volume":"69","author":[{"given":"Bjoern","family":"Buchholz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2020.109524_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1382","article-title":"Systems biology of oxygen homeostasis","volume":"9","author":"Samanta","year":"2017","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0010","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1073\/pnas.88.13.5680","article-title":"Hypoxia-inducible nuclear factors bind to an enhancer element located 3\u2032 to the human erythropoietin gene","volume":"88","author":"Semenza","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109524_bb0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2020.109524_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0025","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2020.109524_bb0030","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","article-title":"Mechanisms of hypoxia signalling: new implications for nephrology","volume":"15","author":"Sch\u00f6del","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0035","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846401","article-title":"Inherent DNA-binding specificities of the HIF-1\u03b1 and HIF-2\u03b1 transcription factors in chromatin","volume":"20","author":"Smythies","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2020.109524_bb0040","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1097\/01.ASN.0000017223.49823.2A","article-title":"Expression of hypoxia-inducible factor-1 alpha and \u22122 alpha in hypoxic and ischemic rat kidneys","volume":"13","author":"Rosenberger","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0045","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00109-007-0278-y","article-title":"Hypoxia and the HIF system in kidney disease","volume":"85","author":"Nangaku","year":"2007","journal-title":"J. Mol. Med.(Berlin, Germany)"},{"key":"10.1016\/j.cellsig.2020.109524_bb0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/1440-1681.12005","article-title":"Regulation of hypoxia-inducible factor in kidney disease","volume":"40","author":"Nangaku","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0055","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrneph.2011.109","article-title":"Why kidneys fail in autosomal dominant polycystic kidney disease","volume":"7","author":"Grantham","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0060","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.ki.5001725","article-title":"Evidence of angiogenesis and microvascular regression in autosomal-dominant polycystic kidney disease kidneys: a corrosion cast study","volume":"70","author":"Wei","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0065","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.2353\/ajpath.2009.080792","article-title":"Effects of increased renal tubular Vascular Endothelial Growth Factor (VEGF) on fibrosis, cyst formation, and glomerular disease","volume":"175","author":"Hakroush","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0070","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/micc.12022","article-title":"Polycystic kidneys have decreased vascular density: a micro-CT study","volume":"20","author":"Xu","year":"2013","journal-title":"Microcirculation"},{"key":"10.1016\/j.cellsig.2020.109524_bb0075","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2353\/ajpath.2007.060455","article-title":"Involvement of hypoxia-inducible transcription factors in polycystic kidney disease","volume":"170","author":"Bernhardt","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0080","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ijc.2910610422","article-title":"Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids","volume":"61","author":"Gross","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2020.109524_bb0085","first-page":"R1207","article-title":"Determinants of renal tissue hypoxia in a rat model of polycystic kidney disease","volume":"307","author":"Ow","year":"2014","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cellsig.2020.109524_bb0090","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00261-017-1236-y","article-title":"Quantitative MRI of kidneys in renal disease","volume":"43","author":"Kline","year":"2018","journal-title":"Abdom Radiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1078\/0940-2993-00183","article-title":"Immunohistochemical study on hypoxia in spontaneous polycystic liver and kidney disease in rats","volume":"53","author":"Yoshida","year":"2001","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0100","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1681\/ASN.2013030209","article-title":"Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion","volume":"25","author":"Buchholz","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0105","doi-asserted-by":"crossref","first-page":"F1235","DOI":"10.1152\/ajprenal.00348.2010","article-title":"Hypoxia-inducible factor-1alpha (HIF-1alpha) and autophagy in polycystic kidney disease (PKD)","volume":"300","author":"Belibi","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0110","article-title":"HIF-1\u03b1 promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease","volume":"0","author":"Kraus","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000488115","article-title":"Levels of endocan, angiopoietin-2, and hypoxia-inducible factor-1a in patients with autosomal dominant polycystic kidney disease and different levels of renal function","volume":"47","author":"Raptis","year":"2018","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0120","first-page":"1","article-title":"Systemic succinate, hypoxia-inducible Factor-1 alpha, and IL-1\u03b2 gene expression in autosomal dominant polycystic kidney disease with and without hypertension","author":"Kocyigit","year":"2019","journal-title":"Cardiorenal Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0125","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneph.2015.193","article-title":"HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond","volume":"12","author":"Maxwell","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0130","first-page":"264","article-title":"Comparative studies on uraemic anaemia in polycystic kidney disease and in other renal diseases","volume":"4","author":"Maggiore","year":"1976","journal-title":"Proc. Eur. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109524_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000183332","article-title":"Serum immunoreactive erythropoietin levels in patients with polycystic kidney disease as compared with other hemodialysis patients","volume":"39","author":"Chandra","year":"1985","journal-title":"Nephron"},{"key":"10.1016\/j.cellsig.2020.109524_bb0140","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1172\/JCI114280","article-title":"Erythropoietin in polycystic kidneys","volume":"84","author":"Eckardt","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109524_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00167","article-title":"Renal erythropoietin-producing cells in health and disease","volume":"6","author":"Souma","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0150","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/ejhg.2010.175","article-title":"von Hippel\u2013Lindau disease: a clinical and scientific review","volume":"19","author":"Maher","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.cellsig.2020.109524_bb0155","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.pathol.2.010506.092049","article-title":"Von Hippel-Lindau disease","volume":"2","author":"Kaelin","year":"2007","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0160","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-05-3241","article-title":"Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor","volume":"66","author":"Rankin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2020.109524_bb0165","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1158\/0008-5472.CAN-06-0501","article-title":"Primary cilium formation requires von hippel-lindau gene function in renal-derived cells","volume":"66","author":"Lutz","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2020.109524_bb0170","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0175","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1681\/ASN.2006020181","article-title":"Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein","volume":"17","author":"Esteban","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0180","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2007.02.005","article-title":"Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway","volume":"11","author":"Pollard","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2020.109524_bb0185","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ccr.2011.09.006","article-title":"Renal cyst formation in Fh1-deficient mice is independent of the Hif\/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling","volume":"20","author":"Adam","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2020.109524_bb0190","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ccr.2007.02.006","article-title":"HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity","volume":"11","author":"Gordan","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2020.109524_bb0195","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of \u03b1-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Xiao","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2020.109524_bb0200","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1074\/jbc.M800102200","article-title":"Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109524_bb0205","doi-asserted-by":"crossref","first-page":"F636","DOI":"10.1152\/ajprenal.00265.2011","article-title":"2-Hydroxyestradiol slows progression of experimental polycystic kidney disease","volume":"302","author":"Anderson","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejmech.2012.01.033","article-title":"Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors","volume":"49","author":"Xia","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cellsig.2020.109524_bb0215","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.86.15.6007","article-title":"Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP","volume":"86","author":"Mangoo-Karim","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cellsig.2020.109524_bb0220","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1523-1755.2004.00945.x","article-title":"Cyclic AMP, at the hub of the cystic cycle","volume":"66","author":"Torres","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0225","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ki.2008.659","article-title":"Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells","volume":"75","author":"Raphael","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00109-010-0715-1","article-title":"Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion","volume":"89","author":"Buchholz","year":"2011","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0235","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0034-5687(94)00125-J","article-title":"Pericellular PO2 and O2 consumption in monolayer cell cultures","volume":"100","author":"Metzen","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0240","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ki.2015.214","article-title":"Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis","volume":"88","author":"Schley","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0245","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MNH.0000000000000211","article-title":"The impact of hypoxia on nephrogenesis","volume":"25","author":"Buchholz","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.cellsig.2020.109524_bb0250","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1681\/ASN.2006030295","article-title":"Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator\/Na(+),K(+),2Cl(\u2212) co-transporter-dependent cystic dilation","volume":"17","author":"Magenheimer","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0255","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00109-015-1337-4","article-title":"Glucose promotes secretion-dependent renal cyst growth","volume":"94","author":"Kraus","year":"2016","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0260","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/dvg.20207","article-title":"Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells","volume":"44","author":"Lantinga-van Leeuwen","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.cellsig.2020.109524_bb0265","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/hmg\/ddm299","article-title":"Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice","volume":"16","author":"Lantinga-van Leeuwen","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2020.109524_bb0270","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.bbadis.2011.01.011","article-title":"Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease","volume":"1812","author":"Terryn","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109524_bb0275","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11302-016-9532-5","article-title":"P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells","volume":"12","author":"Kraus","year":"2016","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109524_bb0280","doi-asserted-by":"crossref","first-page":"e1899","DOI":"10.1038\/cddis.2015.273","article-title":"Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation","volume":"6","author":"Forschbach","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2020.109524_bb0285","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.V102218","article-title":"ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys","volume":"10","author":"Wilson","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0290","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1440-1681.2001.03451.x","article-title":"ATP release mechanisms, ATP receptors and purinergic signalling along the nephron","volume":"28","author":"Schwiebert","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0295","doi-asserted-by":"crossref","first-page":"F15","DOI":"10.1152\/ajprenal.00103.2006","article-title":"Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro","volume":"292","author":"Turner","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0300","first-page":"1","article-title":"Inhibition of the P2X7 receptor reduces cystogenesis in PKD","author":"Chang","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0305","article-title":"Extracellular nucleotides and P2 receptors in renal function","author":"Vallon","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2020.109524_bb0310","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nature07313","article-title":"TMEM16A confers receptor-activated calcium-dependent chloride conductance","volume":"455","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0315","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature13984","article-title":"X-ray structure of a calcium-activated TMEM16 lipid scramblase","volume":"516","author":"Brunner","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0320","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature25024","article-title":"Cryo-EM structures of the TMEM16A calcium-activated chloride channel","volume":"552","author":"Dang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26232","article-title":"Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A","volume":"6","author":"Paulino","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.cellsig.2020.109524_bb0330","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature24652","article-title":"Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM","volume":"552","author":"Paulino","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0335","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00424-011-0975-9","article-title":"Anoctamins","volume":"462","author":"Kunzelmann","year":"2011","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2020.109524_bb0340","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00424-013-1305-1","article-title":"Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?","volume":"466","author":"Kunzelmann","year":"2014","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2020.109524_bb0345","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/ki.2013.418","article-title":"Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells","volume":"85","author":"Buchholz","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0350","first-page":"1","article-title":"CFTR and TMEM16A are separate but functionally related Cl - channels","volume":"49","author":"Ousingsawat","year":"2011","journal-title":"Cell. Physiol. Biochem. Biochem."},{"key":"10.1016\/j.cellsig.2020.109524_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10910-0","article-title":"Epithelial chloride transport by CFTR requires TMEM16A","volume":"7","author":"Benedetto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2020.109524_bb0360","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00584629","article-title":"Characterization of potassium channels in respiratory cells. I. General properties","volume":"414","author":"Kunzelmann","year":"1989","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2020.109524_bb0365","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/ki.2008.246","article-title":"KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease","volume":"74","author":"Albaqumi","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0370","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature09583","article-title":"Calcium-dependent phospholipid scrambling by TMEM16F","volume":"468","author":"Suzuki","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0375","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1085\/jgp.201711957","article-title":"Known structures and unknown mechanisms of TMEM16 scramblases and channels","volume":"150","author":"Falzone","year":"2018","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0380","doi-asserted-by":"crossref","first-page":"18168","DOI":"10.1073\/pnas.1108094108","article-title":"Anoctamin 6 is an essential component of the outwardly rectifying chloride channel","volume":"108","author":"Martins","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109524_bb0385","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/cancers11030382","article-title":"Contribution of Anoctamins to cell survival and cell death","volume":"11","author":"Kunzelmann","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.cellsig.2020.109524_bb0390","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2014.01.032","article-title":"Hypoxia and hypoxia inducible factors in tumor metabolism","volume":"356","author":"Zeng","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2020.109524_bb0395","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1080\/07853890410018231","article-title":"Hypoxia-inducible factors and hypoxic cell death in tumour physiology","volume":"36","author":"Bacon","year":"2004","journal-title":"Ann. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0400","first-page":"C550","article-title":"Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery","volume":"301","author":"Semenza","year":"2011","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.cellsig.2020.109524_bb0405","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0410","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0096","article-title":"Role of anoctamins in cancer and apoptosis","volume":"369","author":"Wanitchakool","year":"2014","journal-title":"Philos. Trans. Royal Soc. B: Biol. Sci."},{"key":"10.1016\/j.cellsig.2020.109524_bb0415","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0420","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1681\/ASN.2015030231","article-title":"2-deoxy-d-glucose ameliorates PKD progression","volume":"27","author":"Chiaravalli","year":"2016","journal-title":"JASN"},{"key":"10.1016\/j.cellsig.2020.109524_bb0425","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1681\/ASN.2009040421","article-title":"Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1","volume":"21","author":"Shillingford","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0430","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1128\/MCB.22.20.7004-7014.2002","article-title":"Regulation of hypoxia-inducible factor 1\u03b1 expression and function by the mammalian target of rapamycin","volume":"22","author":"Hudson","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0435","doi-asserted-by":"crossref","first-page":"29083","DOI":"10.1074\/jbc.270.49.29083","article-title":"Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences","volume":"270","author":"Ebert","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109524_bb0440","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ebiom.2016.01.027","article-title":"Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease","volume":"5","author":"Menezes","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cellsig.2020.109524_bb0445","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1091\/mbc.e16-08-0597","article-title":"The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function","volume":"28","author":"Padovano","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cellsig.2020.109524_bb0450","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/ki.1991.87","article-title":"Cytokines in fluids from polycystic kidneys","volume":"39","author":"Gardner","year":"1991","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0455","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1097\/01.ASN.0000088720.61783.19","article-title":"Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease","volume":"14","author":"Zheng","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0460","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1681\/ASN.2011010084","article-title":"Macrophages promote cyst growth in polycystic kidney disease","volume":"22","author":"Karihaloo","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0465","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1172\/JCI80467","article-title":"Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease","volume":"125","author":"Chen","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109524_bb0470","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm1783","article-title":"A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease","volume":"14","author":"Li","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0475","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1681\/ASN.2018050518","article-title":"Mcp1 promotes macrophage-dependent cyst expansion in autosomal dominant polycystic kidney disease","volume":"29","author":"Cassini","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0480","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.2012.446","article-title":"Macrophages promote polycystic kidney disease progression","volume":"83","author":"Swenson-Fields","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0485","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molmed.2018.10.006","article-title":"Inflammation and hypoxia: HIF and PHD isoform selectivity","volume":"25","author":"Watts","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0490","first-page":"420","article-title":"Metabolic reprograming in macrophage polarization","volume":"5","author":"Galv\u00e1n-Pe\u00f1a","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11635","article-title":"HIF-1\u03b1-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity","volume":"7","author":"Semba","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2020.109524_bb0500","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.23650","article-title":"Regulation of STATs by polycystin-1 and their role in polycystic kidney disease","volume":"2","author":"Weimbs","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1016\/j.cellsig.2020.109524_bb0505","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072358","article-title":"STAT3 or USF2 contributes to HIF target gene specificity","volume":"8","author":"Pawlus","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109524_bb0510","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1189\/jlb.2HI1013-533R","article-title":"Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions","volume":"96","author":"Swain","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0515","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.kint.2016.09.028","article-title":"Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease","volume":"91","author":"Schellinger","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109524_bb0520","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCULATIONAHA.108.813303","article-title":"Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization","volume":"120","author":"C\u00e9line","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2020.109524_bb0525","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00018-019-03039-y","article-title":"Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria","volume":"76","author":"Thomas","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2020.109524_bb0530","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030207","article-title":"Hypoxia and hypoxia-inducible factors in kidney injury and repair","volume":"8","author":"Shu","year":"2019","journal-title":"Cells."},{"key":"10.1016\/j.cellsig.2020.109524_bb0535","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.0001-6772.2003.01206.x","article-title":"Reactive oxygen species and molecular regulation of renal oxygenation","volume":"179","author":"Zou","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.cellsig.2020.109524_bb0540","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1681\/ASN.2018010039","article-title":"Lipid peroxidation drives renal cyst growth in vitro through activation of TMEM16A","volume":"30","author":"Schreiber","year":"2019","journal-title":"JASN"},{"key":"10.1016\/j.cellsig.2020.109524_bb0545","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00467-018-4004-5","article-title":"Oxidative stress in autosomal dominant polycystic kidney disease: player and\/or early predictor for disease progression?","volume":"34","author":"Andries","year":"2019","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0550","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clinbiochem.2018.04.010","article-title":"Systemic redox biomarkers and their relationship to prognostic risk markers in autosomal dominant polycystic kidney disease and IgA nephropathy","volume":"56","author":"Tariq","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cellsig.2020.109524_bb0555","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/j.ackd.2019.04.004","article-title":"Hypoxia-inducible factor activators in renal Anemia: current clinical experience","volume":"26","author":"Sanghani","year":"2019","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.cellsig.2020.109524_bb0560","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1901713","article-title":"Roxadustat treatment for Anemia in patients undergoing long-term Dialysis","volume":"381","author":"Chen","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0565","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJMoa1813599","article-title":"Roxadustat for Anemia in patients with kidney disease not receiving Dialysis","volume":"381","author":"Chen","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109524_bb0570","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature19796","article-title":"Targeting renal cell carcinoma with a HIF-2 antagonist","volume":"539","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109524_bb0575","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/med.21477","article-title":"Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): a \u201cstructure\u2013activity relationship\u201d perspective","volume":"38","author":"Bhattarai","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cellsig.2020.109524_bb0580","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbcan.2018.07.002","article-title":"Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors","volume":"1870","author":"Samanta","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer."},{"key":"10.1016\/j.cellsig.2020.109524_bb0585","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/CCO.0b013e328356da72","article-title":"Glucose transporters in cancer metabolism","volume":"24","author":"Adekola","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0590","doi-asserted-by":"crossref","DOI":"10.1038\/s41581-019-0183-y","article-title":"The pathobiology of polycystic kidney disease from a metabolic viewpoint","author":"Menezes","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0595","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddr338","article-title":"Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways","volume":"20","author":"Takakura","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2020.109524_bb0600","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2010.12.008","article-title":"Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways","volume":"654","author":"Gao","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0605","doi-asserted-by":"crossref","first-page":"F1193","DOI":"10.1152\/ajprenal.00419.2010","article-title":"Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model","volume":"300","author":"Leonhard","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109524_bb0610","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4155\/fmc.10.281","article-title":"MIF as a disease target: ISO-1 as a proof-of-concept therapeutic","volume":"3","author":"Al-Abed","year":"2011","journal-title":"Future Med. Chem."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820300012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820300012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:56:17Z","timestamp":1760266577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656820300012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":122,"alternative-id":["S0898656820300012"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109524","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of oxygen and the HIF-pathway in polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109524"}}