{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:03:36Z","timestamp":1790615016502,"version":"4.1.0"},"reference-count":411,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK090728"],"award-info":[{"award-number":["DK090728"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK44863"],"award-info":[{"award-number":["DK44863"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.cellsig.2020.109649","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T02:34:02Z","timestamp":1587609242000},"page":"109649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling"],"prefix":"10.1016","volume":"72","author":[{"given":"Caroline R.","family":"Sussman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad T.","family":"Chebib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente E.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2020.109649_bb0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev-pharmtox-032112-135923","article-title":"Structure-function of the G protein-coupled receptor superfamily","volume":"53","author":"Katritch","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0010","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1096\/fj.11-193649","article-title":"Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes","volume":"26","author":"Wann","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2020.109649_bb0015","doi-asserted-by":"crossref","first-page":"836","DOI":"10.14348\/molcells.2015.0263","article-title":"Structural studies of G protein-coupled receptors","volume":"38","author":"Zhang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0020","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev-biochem-060614-033910","article-title":"The molecular basis of G protein-coupled receptor activation","volume":"87","author":"Weis","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41594-017-0011-7","article-title":"Structure and dynamics of GPCR signaling complexes","volume":"25","author":"Hilger","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/FJC.0000000000000482","article-title":"G protein-coupled receptor Signaling through beta-Arrestin-dependent mechanisms","volume":"70","author":"Jean-Charles","year":"2017","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0035","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tibs.2018.11.011","article-title":"New binding sites, new opportunities for GPCR drug discovery","volume":"44","author":"Chan","year":"2019","journal-title":"Trends Biochem. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2020.109649_bb0040","first-page":"S17","article-title":"THE CONCISE GUIDE TO PHARMACOLOGY 2017\/18: G protein-coupled receptors","volume":"174","author":"Alexander","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0045","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ygcen.2004.12.018","article-title":"The GRAFS classification system of G-protein coupled receptors in comparative perspective","volume":"142","author":"Schioth","year":"2005","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0050","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/pr.114.009647","article-title":"International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors","volume":"67","author":"Hamann","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb0055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41573-019-0039-y","article-title":"Adhesion G protein-coupled receptors: opportunities for drug discovery","volume":"18","author":"Bassilana","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cellsig.2020.109649_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fcell.2018.00009","article-title":"Adhesion GPCRs in kidney development and disease","volume":"6","author":"Cazorla-Vazquez","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.cellsig.2020.109649_bb0065","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1074\/jbc.M116.763656","article-title":"Activation of adhesion G protein-coupled receptors: AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES","volume":"292","author":"Demberg","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0070","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28360","article-title":"Mechano-dependent signaling by Latrophilin\/CIRL quenches cAMP in proprioceptive neurons","volume":"6","author":"Scholz","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.cellsig.2020.109649_bb0075","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1016\/j.jmb.2016.08.002","article-title":"Regulation, signaling, and physiological functions of G-proteins","volume":"428","author":"Syrovatkina","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0080","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1111\/bph.14023","article-title":"GPCR signalling from within the cell","volume":"175","author":"Jong","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0085","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.drudis.2019.09.003","article-title":"Nuclear G-protein-coupled receptors as putative novel pharmacological targets","volume":"24","author":"Ribeiro-Oliveira","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cellsig.2020.109649_bb0090","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrd.2018.135","article-title":"Targeting G protein-coupled receptor signalling by blocking G proteins","volume":"17","author":"Campbell","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cellsig.2020.109649_bb0095","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1007\/s00018-019-03275-2","article-title":"G-protein betagamma subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling","volume":"76","author":"Smrcka","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0100","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bbadis.2017.01.020","article-title":"Targeting GPCR-Gbetagamma-GRK2 signaling as a novel strategy for treating cardiorenal pathologies","volume":"1863","author":"Rudomanova","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb0105","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41569-019-0220-3","article-title":"G protein-coupled receptor kinases as therapeutic targets in the heart","volume":"16","author":"Pfleger","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0110","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1007\/s00018-019-03274-3","article-title":"G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub","volume":"76","author":"Penela","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0115","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1124\/pr.116.013367","article-title":"The diverse roles of arrestin scaffolds in G protein-coupled receptor signaling","volume":"69","author":"Peterson","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.tibs.2018.03.005","article-title":"Structural basis of arrestin-dependent signal transduction","volume":"43","author":"Chen","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tips.2010.02.002","article-title":"Signaling by internalized G-protein-coupled receptors","volume":"31","author":"Calebiro","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ceb.2013.10.003","article-title":"GPCR signaling along the endocytic pathway","volume":"27","author":"Irannejad","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.1109237","article-title":"Transduction of receptor signals by beta-arrestins","volume":"308","author":"Lefkowitz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2020.109649_bb0140","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nchembio.1611","article-title":"Endosomal generation of cAMP in GPCR signaling","volume":"10","author":"Vilardaga","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0145","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1074\/jbc.R114.617951","article-title":"G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes","volume":"290","author":"Tsvetanova","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cell.2016.07.004","article-title":"GPCR-G protein-beta-arrestin super-complex mediates sustained G protein signaling","volume":"166","author":"Thomsen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0155","doi-asserted-by":"crossref","first-page":"15054","DOI":"10.1038\/ncomms15054","article-title":"A new inhibitor of the beta-arrestin\/AP2 endocytic complex reveals interplay between GPCR internalization and signalling","volume":"8","author":"Beautrait","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2020.109649_bb0160","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.tips.2018.08.003","article-title":"Therapeutic targeting of endosomal G-protein-coupled receptors","volume":"39","author":"Thomsen","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0165","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41580-018-0049-3","article-title":"Mechanisms of signalling and biased agonism in G protein-coupled receptors","volume":"19","author":"Wootten","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0170","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00109-017-1606-5","article-title":"beta-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1\/beta-catenin signaling in mice","volume":"96","author":"Xu","year":"2018","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.cellsig.2020.109649_bb0175","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphar.2019.00124","article-title":"Therapeutic potential of targeting ss-arrestin","volume":"10","author":"Bond","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0180","article-title":"Biased GPCR signaling: possible mechanisms and inherent limitations","volume":"107540","author":"Gurevich","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb0185","doi-asserted-by":"crossref","first-page":"18571","DOI":"10.1074\/jbc.REV119.007060","article-title":"Regulator of G-protein signaling (RGS) proteins as drug targets: progress and future potentials","volume":"294","author":"O\u2019Brien","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1124\/jpet.115.222695","article-title":"Activators of G protein signaling in the kidney","volume":"353","author":"Park","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb0195","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","article-title":"The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains","volume":"10","author":"Hughes","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb0200","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0092-8674(95)90339-9","article-title":"Polycystic kidney disease: the complete structure of the PKD1 gene and its protein","volume":"81","author":"International Polycystic Kidney Disease Consortium","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0205","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/emboj.2012.26","article-title":"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis","volume":"31","author":"Arac","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2020.109649_bb0210","doi-asserted-by":"crossref","first-page":"16981","DOI":"10.1073\/pnas.252484899","article-title":"Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations","volume":"99","author":"Qian","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0215","doi-asserted-by":"crossref","first-page":"18688","DOI":"10.1073\/pnas.0708217104","article-title":"Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure","volume":"104","author":"Yu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0220","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","article-title":"The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro","volume":"251","author":"Parnell","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2020.109649_bb0225","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","article-title":"PKD1 interacts with PKD2 through a probable coiled-coil domain","volume":"16","author":"Qian","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb0230","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"Tsiokas","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0235","first-page":"4063","article-title":"Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site","volume":"128","author":"Su","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.devcel.2011.10.028","article-title":"The gamma-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism","volume":"22","author":"Merrick","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0245","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.devcel.2005.12.005","article-title":"Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease","volume":"10","author":"Low","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0250","doi-asserted-by":"crossref","first-page":"e12305","DOI":"10.1371\/journal.pone.0012305","article-title":"Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1","volume":"5","author":"Woodward","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109649_bb0255","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1128\/MCB.00687-14","article-title":"Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease","volume":"34","author":"Kurbegovic","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/cells5010003","article-title":"The role of G-protein-coupled receptor proteolysis site cleavage of polycystin-1 in renal physiology and polycystic kidney disease","volume":"5","author":"Trudel","year":"2016","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2020.109649_bb0265","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1074\/jbc.M110483200","article-title":"Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2","volume":"277","author":"Delmas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0270","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.03-0319fje","article-title":"Gating of the polycystin ion channel signaling complex in neurons and kidney cells","volume":"18","author":"Delmas","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2020.109649_bb0275","doi-asserted-by":"crossref","first-page":"55455","DOI":"10.1074\/jbc.M402905200","article-title":"Polycystin-1 activates the calcineurin\/NFAT (nuclear factor of activated T-cells) signaling pathway","volume":"279","author":"Puri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0280","doi-asserted-by":"crossref","first-page":"10243","DOI":"10.1074\/jbc.M109.070821","article-title":"Polycystin-1 protein level determines activity of the Galpha12\/JNK apoptosis pathway","volume":"285","author":"Yu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0285","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cellsig.2010.09.005","article-title":"Identification of polycystin-1 and Galpha12 binding regions necessary for regulation of apoptosis","volume":"23","author":"Yu","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb0290","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1242\/jcs.190496","article-title":"Galpha12 is required for renal cystogenesis induced by Pkd1 inactivation","volume":"129","author":"Wu","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0295","doi-asserted-by":"crossref","DOI":"10.1242\/dev.158931","article-title":"Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney","volume":"145","author":"Zhang","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.cellsig.2020.109649_bb0300","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1074\/jbc.273.11.6013","article-title":"The polycystic kidney disease 1 gene product mediates protein kinase C a-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1","volume":"273","author":"Arnould","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0305","doi-asserted-by":"crossref","first-page":"19566","DOI":"10.1074\/jbc.M201875200","article-title":"Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins","volume":"277","author":"Parnell","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0310","doi-asserted-by":"crossref","first-page":"24352","DOI":"10.1074\/jbc.M702804200","article-title":"Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha","volume":"282","author":"Yanamadala","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0315","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1681\/ASN.2014111074","article-title":"The POLYCYSTIN-1, lipoxygenase, and alpha-toxin domain regulates polycystin-1 trafficking","volume":"27","author":"Xu","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0320","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI64313","article-title":"Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity","volume":"122","author":"Hopp","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb0325","doi-asserted-by":"crossref","first-page":"F677","DOI":"10.1152\/ajprenal.00119.2017","article-title":"The regulatory 1alpha subunit of protein kinase A modulates renal cystogenesis","volume":"313","author":"Ye","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0330","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1038\/s41598-017-09549-8","article-title":"Hypoxia induces cancer-associated cAMP\/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII","volume":"7","author":"Simko","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb0335","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.cellsig.2012.08.007","article-title":"cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells","volume":"24","author":"Shaikh","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb0340","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1111\/j.1742-4658.2007.05890.x","article-title":"CREB and cAMP response element-mediated gene expression in the ischemic brain","volume":"274","author":"Kitagawa","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.cellsig.2020.109649_bb0345","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00109-012-0988-7","article-title":"Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease","volume":"91","author":"Poth","year":"2013","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.cellsig.2020.109649_bb0350","doi-asserted-by":"crossref","first-page":"21827","DOI":"10.1074\/jbc.M603952200","article-title":"Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation","volume":"281","author":"Brennan","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0355","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1073\/pnas.96.11.6371","article-title":"Interaction between RGS7 and polycystin","volume":"96","author":"Kim","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0360","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1681\/ASN.V1171253","article-title":"Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model","volume":"11","author":"Guay-Woodford","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0365","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1681\/ASN.2009121224","article-title":"Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD","volume":"21","author":"Nadella","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0370","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s13104-018-3467-6","article-title":"Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease","volume":"11","author":"Keri","year":"2018","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.cellsig.2020.109649_bb0375","doi-asserted-by":"crossref","first-page":"21462","DOI":"10.1073\/pnas.1216830110","article-title":"G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease","volume":"109","author":"Kwon","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0380","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2020.109649_bb0385","doi-asserted-by":"crossref","first-page":"e48336","DOI":"10.15252\/embr.201948336","article-title":"The ion channel function of polycystin-1 in the polycystin-1\/polycystin-2 complex","volume":"20","author":"Wang","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb0390","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization and localization of a novel kidney polycystin-1\/polycystin-2 complex","volume":"277","author":"Newby","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0395","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1074\/jbc.M209996200","article-title":"Polycystin-1 activates and stabilizes the polycystin-2 channel","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0400","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/dbio.1997.8729","article-title":"The fucose sulfate polymer of egg jelly binds to sperm REJ and is the inducer of the sea urchin sperm acrosome reaction","volume":"192","author":"Vacquier","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.09.048","article-title":"The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs","volume":"167","author":"Shen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb0410","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nsmb.3343","article-title":"Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)","volume":"24","author":"Grieben","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0415","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat9819","article-title":"Structure of the human PKD1-PKD2 complex","volume":"361","author":"Su","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2020.109649_bb0420","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1093\/hmg\/ddy223","article-title":"A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD","volume":"27","author":"Parnell","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb0425","doi-asserted-by":"crossref","first-page":"36431","DOI":"10.1074\/jbc.M109.068916","article-title":"Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0430","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1159\/000330080","article-title":"Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K\/Akt pathway","volume":"27","author":"Santoso","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0435","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1073\/pnas.0610324104","article-title":"Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2","volume":"104","author":"Anyatonwu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0440","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","article-title":"Specific association of the gene product of PKD2 with the TRPC1 channel","volume":"96","author":"Tsiokas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0445","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/embor.2008.29","article-title":"Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits","volume":"9","author":"Bai","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb0450","doi-asserted-by":"crossref","first-page":"34400","DOI":"10.1074\/jbc.M109.015149","article-title":"A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7","volume":"284","author":"Miyagi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0455","doi-asserted-by":"crossref","first-page":"F909","DOI":"10.1152\/ajprenal.00606.2007","article-title":"Mediation of angiotensin II-induced Ca2+ signaling by polycystin 2 in glomerular mesangial cells","volume":"294","author":"Du","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0460","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200805124","article-title":"TRPP2 and TRPV4 form a polymodal sensory channel complex","volume":"182","author":"Kottgen","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0465","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/embor.2013.170","article-title":"Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells","volume":"14","author":"Peyronnet","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb0470","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1113\/jphysiol.2014.271346","article-title":"Polycystins and partners: proposed role in mechanosensitivity","volume":"592","author":"Retailleau","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0475","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0272-6386(97)90496-0","article-title":"Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease","volume":"30","author":"Yamaguchi","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb0480","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm935","article-title":"Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist","volume":"9","author":"Gattone","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0485","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1681\/ASN.2006020136","article-title":"Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease","volume":"17","author":"Smith","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0490","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1053\/j.gastro.2006.12.039","article-title":"Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3\u2032,5\u2032-cyclic monophosphate","volume":"132","author":"Masyuk","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0495","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/01.RES.0000163278.68142.8a","article-title":"[Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype","volume":"96","author":"Kip","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb0500","first-page":"C1409","article-title":"Altered pHi regulation and Na+\/HCO3\u2212 transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse","volume":"292","author":"Banizs","year":"2007","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb0505","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ceca.2012.03.002","article-title":"Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release","volume":"51","author":"Mekahli","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cellsig.2020.109649_bb0510","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00424-008-0561-y","article-title":"PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta","volume":"457","author":"Morel","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2020.109649_bb0515","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddg190","article-title":"Pkd2 haploinsufficiency alters intracellular calcium in vascular smooth muscle cells","volume":"12","author":"Qian","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb0520","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1007\/s000180050364","article-title":"Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)","volume":"55","author":"Kakkar","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0525","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cellsig.2007.10.024","article-title":"Kinetic properties of Ca2+\/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+","volume":"20","author":"Goraya","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb0530","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1681\/ASN.2015010057","article-title":"Modulation of polycystic kidney disease severity by PDE1 and PDE3 subfamilies","volume":"27","author":"Ye","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0535","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ki.2009.438","article-title":"Cyclic nucleotide signaling in polycystic kidney disease","volume":"77","author":"Wang","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0540","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1681\/ASN.2013010077","article-title":"Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease","volume":"25","author":"Rees","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0545","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.kint.2017.08.005","article-title":"Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease","volume":"93","author":"Wang","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0550","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1681\/ASN.2013040421","article-title":"Phosphodiesterase 1A modulates cystogenesis in zebrafish","volume":"25","author":"Sussman","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0555","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.1016214108","article-title":"Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases","volume":"108","author":"Choi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0560","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/hep.24723","article-title":"Altered store operated calcium entry increases cyclic 3\u2032,5\u2032-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes","volume":"55","author":"Spirli","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0565","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.1998.78.4.1165","article-title":"Epithelial transport in polycystic kidney disease","volume":"78","author":"Sullivan","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb0570","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1681\/ASN.V95903","article-title":"Chloride and fluid secretion in polycystic kidney disease","volume":"9","author":"Sullivan","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0575","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bbadis.2010.11.005","article-title":"Cyclic AMP-mediated cyst expansion","volume":"1812","author":"Wallace","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109649_bb0580","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway","volume":"57","author":"Yamaguchi","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0585","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.V1171179","article-title":"cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells","volume":"11","author":"Hanaoka","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0590","doi-asserted-by":"crossref","first-page":"40419","DOI":"10.1074\/jbc.M405079200","article-title":"Calcium restriction allows cAMP activation of the B-Raf\/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0595","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1681\/ASN.2005060645","article-title":"Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells","volume":"17","author":"Yamaguchi","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0600","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/mol.117.111062","article-title":"G protein-coupled receptors as targets for approved drugs: how many targets and how many drugs?","volume":"93","author":"Sriram","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0605","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1681\/ASN.2018121268","article-title":"Germline-derived gain-of-function variants of Gsalpha-coding GNAS gene identified in nephrogenic syndrome of inappropriate antidiuresis","volume":"30","author":"Miyado","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0610","doi-asserted-by":"crossref","first-page":"F931","DOI":"10.1152\/ajprenal.00604.2013","article-title":"The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors","volume":"306","author":"Juul","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0615","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrneph.2013.22","article-title":"Vasopressin: a novel target for the prevention and retardation of kidney disease?","volume":"9","author":"Bankir","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0620","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/joim.12645","article-title":"Vasopressin: physiology, assessment and osmosensation","volume":"282","author":"Bankir","year":"2017","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0625","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(01)00328-5","article-title":"Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects","volume":"51","author":"Bankir","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb0630","doi-asserted-by":"crossref","first-page":"E5160","DOI":"10.1073\/pnas.1508836112","article-title":"Receptor sequestration in response to beta-arrestin-2 phosphorylation by ERK1\/2 governs steady-state levels of GPCR cell-surface expression","volume":"112","author":"Paradis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0635","first-page":"457","article-title":"Histogenesis of the renal cysts in adult (autosomal dominant) polycystic kidney disease: a histochemical study","volume":"1","author":"Verani","year":"1988","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0640","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1523-1755.1998.00990.x","article-title":"Regulation of cAMP production in initial and terminal inner medullary collecting ducts","volume":"54","author":"Yasuda","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0645","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2215\/CJN.11311111","article-title":"Vasopressin, copeptin, and renal concentrating capacity in patients with autosomal dominant polycystic kidney disease without renal impairment","volume":"7","author":"Zittema","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0650","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrneph.2012.139","article-title":"Polycystic kidney disease: an early urea-selective urine-concentrating defect in ADPKD","volume":"8","author":"Bankir","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0655","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2215\/CJN.04560510","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease","volume":"6","author":"Meijer","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0660","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1093\/ndt\/gfs070","article-title":"Copeptin, a surrogate marker for vasopressin, is associated with kidney function decline in subjects with autosomal dominant polycystic kidney disease","volume":"27","author":"Boertien","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb0665","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.ajkd.2012.08.038","article-title":"Relationship of copeptin, a surrogate marker for arginine vasopressin, with change in total kidney volume and GFR decline in autosomal dominant polycystic kidney disease: results from the CRISP cohort","volume":"61","author":"Boertien","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb0670","doi-asserted-by":"crossref","first-page":"F1166","DOI":"10.1152\/ajprenal.00196.2007","article-title":"Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL","volume":"293","author":"Mutig","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0675","doi-asserted-by":"crossref","first-page":"F351","DOI":"10.1152\/ajprenal.00049.2006","article-title":"Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct","volume":"292","author":"Carmosino","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0680","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<309::AID-DVG14>3.0.CO;2-5","article-title":"Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease","volume":"24","author":"Gattone","year":"1999","journal-title":"Dev. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb0685","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm1004","article-title":"Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease","volume":"10","author":"Torres","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0690","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1681\/ASN.2004121090","article-title":"Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat","volume":"16","author":"Wang","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0695","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1093\/ndt\/gfr069","article-title":"Therapeutic potential of vasopressin V2 receptor antagonist in a mouse model for autosomal dominant polycystic kidney disease: optimal timing and dosing of the drug","volume":"26","author":"Meijer","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb0700","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1681\/ASN.2008040345","article-title":"Increased expression of secreted frizzled-related protein 4 in polycystic kidneys","volume":"20","author":"Romaker","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0705","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.1620454114","article-title":"Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease","volume":"114","author":"Ciolek","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb0710","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00243.2011","article-title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl(\u2212) secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","volume":"301","author":"Reif","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0715","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1681\/ASN.2006030251","article-title":"Increased water intake decreases progression of polycystic kidney disease in the PCK rat","volume":"17","author":"Nagao","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0720","doi-asserted-by":"crossref","first-page":"F261","DOI":"10.1152\/ajprenal.00345.2014","article-title":"Effects of hydration in rats and mice with polycystic kidney disease","volume":"308","author":"Hopp","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0725","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1681\/ASN.2007060688","article-title":"Vasopressin directly regulates cyst growth in polycystic kidney disease","volume":"19","author":"Wang","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0730","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1124\/jpet.114.213256","article-title":"Tolvaptan delays the onset of end-stage renal disease in a polycystic kidney disease model by suppressing increases in kidney volume and renal injury","volume":"349","author":"Aihara","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb0735","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","article-title":"Tolvaptan in patients with autosomal dominant polycystic kidney disease","volume":"367","author":"Torres","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0740","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1056\/NEJMoa1710030","article-title":"Tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"377","author":"Torres","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0745","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2215\/CJN.03530411","article-title":"Tolvaptan in autosomal dominant polycystic kidney disease: three years\u2019 experience","volume":"6","author":"Higashihara","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0750","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jcph.880","article-title":"Pharmacokinetics and pharmacodynamics of tolvaptan in autosomal dominant polycystic kidney disease: phase 2 trials for dose selection in the pivotal phase 3 trial","volume":"57","author":"Shoaf","year":"2017","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0755","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/ndt\/gfx043","article-title":"Multicenter, open-label, extension trial to evaluate the long-term efficacy and safety of early versus delayed treatment with tolvaptan in autosomal dominant polycystic kidney disease: the TEMPO 4:4 trial","volume":"33","author":"Torres","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb0760","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2215\/CJN.01520218","article-title":"Long-term effect of tolvaptan on renal function in autosomal dominant polycystic kidney disease","volume":"13","author":"Edwards","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0765","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/frne.1999.0183","article-title":"Somatostatin and its receptor family","volume":"20","author":"Patel","year":"1999","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0770","article-title":"Somatostatin in renal physiology and autosomal dominant polycystic kidney disease","author":"Messchendorp","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb0775","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0928-4257(00)00206-0","article-title":"Signal transduction of somatostatin receptors negatively controlling cell proliferation","volume":"94","author":"Ferjoux","year":"2000","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.cellsig.2020.109649_bb0780","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1196\/annals.1294.012","article-title":"Molecular signaling of somatostatin receptors","volume":"1014","author":"Lahlou","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0785","first-page":"599","article-title":"Antagonism of vasopressin-induced water flow by somatostatin","volume":"24","author":"Strandhoy","year":"1979","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0790","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0014-5793(86)81180-2","article-title":"Somatostatin and alpha 2-adrenergic agonists selectively inhibit vasopressin-induced cyclic AMP accumulation in MDCK cells","volume":"198","author":"Friedlander","year":"1986","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cellsig.2020.109649_bb0795","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/cs0840455","article-title":"Somatostatin as a modulator of distal nephron water permeability","volume":"84","author":"Ray","year":"1993","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.cellsig.2020.109649_bb0800","first-page":"8","article-title":"Effect of somatostatin on vasopressin-induced antidiuresis and renal cyclic AMP of rats","volume":"7","author":"Winkler","year":"1982","journal-title":"Miner. Electrolyte Metab."},{"key":"10.1016\/j.cellsig.2020.109649_bb0805","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.1988.31","article-title":"Reversal of somatostatin inhibition of AVP-induced cAMP by pertussis toxin","volume":"33","author":"Ishikawa","year":"1988","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0810","first-page":"1574","article-title":"Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction","volume":"143","author":"Tracy","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0815","first-page":"G110","article-title":"Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes","volume":"269","author":"Tietz","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb0820","first-page":"680","article-title":"Octreotide inhibits hepatic fibrosis, bile duct proliferation and bacterial translocation in obstructive jaundice","volume":"50","author":"Turkcapar","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0825","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1369\/jhc.2008.950998","article-title":"Expression of somatostatin and somatostatin receptor subtypes 1-5 in human normal and diseased kidney","volume":"56","author":"Bhandari","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0830","doi-asserted-by":"crossref","first-page":"F457","DOI":"10.1152\/ajprenal.2001.280.3.F457","article-title":"Segmental expression of somatostatin receptor subtypes sst(1) and sst(2) in tubules and glomeruli of human kidney","volume":"280","author":"Balster","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0835","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJM199601253340408","article-title":"Octreotide","volume":"334","author":"Lamberts","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0840","first-page":"227","article-title":"Pasireotide: a novel treatment for patients with acromegaly","volume":"10","author":"Cuevas-Ramos","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb0845","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/hep.26140","article-title":"Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases","volume":"58","author":"Masyuk","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0850","doi-asserted-by":"crossref","first-page":"e0177934","DOI":"10.1371\/journal.pone.0177934","article-title":"Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease","volume":"12","author":"Kugita","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109649_bb0855","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1681\/ASN.2013121312","article-title":"Tolvaptan plus pasireotide shows enhanced efficacy in an ADPKD1 model","volume":"1","author":"Hopp","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0860","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1523-1755.2005.00395.x","article-title":"Safety and efficacy of long-acting somatostatin treatment in autosomal dominant polcysytic kidney disease","volume":"68","author":"Ruggenenti","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb0865","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1681\/ASN.2009121291","article-title":"Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease","volume":"21","author":"Hogan","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0870","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0140-6736(13)61407-5","article-title":"Effect of longacting somatostatin analogue on kidney and cyst growth in autosomal dominant polycystic kidney disease (ALADIN): a randomised, placebo-controlled, multicentre trial","volume":"382","author":"Caroli","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2020.109649_bb0875","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1001\/jama.2018.15870","article-title":"Effect of lanreotide on kidney function in patients with autosomal dominant polycystic kidney disease: the DIPAK 1 randomized clinical trial","volume":"320","author":"Meijer","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.cellsig.2020.109649_bb0880","doi-asserted-by":"crossref","first-page":"e1002777","DOI":"10.1371\/journal.pmed.1002777","article-title":"Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): a randomized, double-blind, placebo-controlled, multicenter trial","volume":"16","author":"Perico","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb0885","doi-asserted-by":"crossref","first-page":"e032620","DOI":"10.1136\/bmjopen-2019-032620","article-title":"Long-acting somatostatin analogue treatments in autosomal dominant polycystic kidney disease and polycystic liver disease: a systematic review and meta-analysis","volume":"10","author":"Griffiths","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.cellsig.2020.109649_bb0890","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2009.07.052","article-title":"Lanreotide reduces the volume of polycystic liver: a randomized, double-blind, placebo-controlled trial","volume":"137","author":"van Keimpema","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0895","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2215\/CJN.05380709","article-title":"Reducing polycystic liver volume in ADPKD: effects of somatostatin analogue octreotide","volume":"5","author":"Caroli","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0900","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2036.2011.04923.x","article-title":"The long-term outcome of patients with polycystic liver disease treated with lanreotide","volume":"35","author":"Chrispijn","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb0905","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/ndt\/gfs152","article-title":"Somatostatin analog therapy for severe polycystic liver disease: results after 2 years","volume":"27","author":"Hogan","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb0910","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1053\/j.gastro.2013.04.055","article-title":"Young women with polycystic liver disease respond best to somatostatin analogues: a pooled analysis of individual patient data","volume":"145","author":"Gevers","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0915","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.mayocp.2015.05.011","article-title":"Efficacy of 4 years of octreotide Long-acting release therapy in patients with severe polycystic liver disease","volume":"90","author":"Hogan","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.cellsig.2020.109649_bb0920","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2015.12.049","article-title":"Long-term effects of octreotide on liver volume in patients with polycystic kidney and liver disease","volume":"14","author":"Pisani","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0925","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.04.018","article-title":"Lanreotide reduces liver growth in patients with autosomal dominant polycystic liver and kidney disease","volume":"157","author":"van Aerts","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0930","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1196\/annals.1317.013","article-title":"Secretin: a pleiotrophic hormone","volume":"1070","author":"Chu","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb0935","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/BF01263096","article-title":"Plasma secretin concentrations in fasting and postprandial state in man","volume":"23","author":"Chey","year":"1978","journal-title":"Am J Dig Dis"},{"key":"10.1016\/j.cellsig.2020.109649_bb0940","first-page":"G1016","article-title":"Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat","volume":"256","author":"Green","year":"1989","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb0945","first-page":"E539","article-title":"Plasma secretin concentrations in fasting and postprandial states in dog","volume":"236","author":"Kim","year":"1979","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb0950","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0074-7696(07)65004-9","article-title":"Multiple actions of secretin in the human body","volume":"265","author":"Lam","year":"2008","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0955","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/gast.2001.26280","article-title":"Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver","volume":"121","author":"Hirata","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0960","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0196-9781(86)90107-5","article-title":"Secretin receptors in the rat kidney: adenylate cyclase activation and renal effects","volume":"7","author":"Charlton","year":"1986","journal-title":"Peptides"},{"key":"10.1016\/j.cellsig.2020.109649_bb0965","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/00365518709168918","article-title":"Distribution of the increased cardiac output secondary to the vasodilating and inotropic effects of secretin","volume":"47","author":"Gunnes","year":"1987","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb0970","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0196-9781(00)00189-3","article-title":"Dual effect of secretin on nephron filtration and proximal reabsorption depending on the route of administration","volume":"21","author":"Romano","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.cellsig.2020.109649_bb0975","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/MCB.01088-06","article-title":"Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption","volume":"27","author":"Chu","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0980","doi-asserted-by":"crossref","first-page":"F1089","DOI":"10.1152\/ajprenal.00242.2012","article-title":"Insignificant effect of secretin in rodent models of polycystic kidney and liver disease","volume":"303","author":"Wang","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb0985","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1016\/S0021-9258(19)49566-5","article-title":"Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism","volume":"267","author":"Kato","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb0990","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0016-5085(99)70242-8","article-title":"Bile acid feeling induces cholangiocyte proliferatio and secretion: evidence for bile acid-redulated ductal secretion","volume":"116","author":"Alpini","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb0995","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0016-5085(96)70027-6","article-title":"Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion","volume":"111","author":"Lesage","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1000","doi-asserted-by":"crossref","first-page":"20413","DOI":"10.1074\/jbc.M302108200","article-title":"Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes","volume":"278","author":"Tietz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.23657","article-title":"Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation","volume":"52","author":"Glaser","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1010","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hep.1840110406","article-title":"Functional similarities of hepatic cystic and biliary epithelium: studies of fluid constituents and in vivo secretion in response to secretin","volume":"11","author":"Everson","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1015","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1020","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.dld.2013.10.021","article-title":"The bile acid TGR5 membrane receptor: from basic research to clinical application","volume":"46","author":"Duboc","year":"2014","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb1030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrgastro.2013.151","article-title":"Bile acid receptors as targets for drug development","volume":"11","author":"Schaap","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1035","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1681\/ASN.2018030271","article-title":"Bile acid G protein-coupled membrane receptor TGR5 modulates aquaporin 2-mediated water homeostasis","volume":"29","author":"Li","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1040","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/hep.29284","article-title":"TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate\/Galphas signaling","volume":"66","author":"Masyuk","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2017.10.006","article-title":"Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney","volume":"134","author":"Wang","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.cellsig.2020.109649_bb1050","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.physiol.70.113006.100614","article-title":"Physiological regulation of prostaglandins in the kidney","volume":"70","author":"Hao","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1055","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/pr.110.003517","article-title":"International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress","volume":"63","author":"Woodward","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1096\/fj.02-0460fje","article-title":"Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease","volume":"17","author":"Aukema","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2020.109649_bb1065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11745-013-3859-2","article-title":"Renal cyclooxygenase products are higher and lipoxygenase products are lower in early disease in the pcy mouse model of adolescent nephronophthisis","volume":"49","author":"Yamaguchi","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.cellsig.2020.109649_bb1070","doi-asserted-by":"crossref","first-page":"F821","DOI":"10.1152\/ajprenal.00257.2006","article-title":"Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease","volume":"293","author":"Sankaran","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1075","doi-asserted-by":"crossref","first-page":"F897","DOI":"10.1152\/ajprenal.00332.2005","article-title":"Selectivity of cyclooxygenase isoform activity and prostanoid production in normal and diseased Han:SPRD-cy rat kidneys","volume":"290","author":"Warford-Woolgar","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1080","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1523-1755.2004.00843.x","article-title":"Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells","volume":"66","author":"Belibi","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1085","doi-asserted-by":"crossref","first-page":"F1622","DOI":"10.1152\/ajprenal.00036.2007","article-title":"EP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells","volume":"293","author":"Elberg","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1090","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/mnfr.201300332","article-title":"Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD-Cy rat","volume":"58","author":"Ibrahim","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1095","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3181\/0811-RM-315","article-title":"Dietary soy protein selectively reduces renal prostanoids and cyclooxygenases in polycystic kidney disease","volume":"234","author":"Peng","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.cellsig.2020.109649_bb1100","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jnutbio.2011.04.016","article-title":"A dietary conjugated linoleic acid treatment that slows renal disease progression alters renal cyclooxygenase-2-derived prostanoids in the Han: SPRD-cy rat","volume":"23","author":"Wakefield","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.prostaglandins.2014.10.005","article-title":"Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease","volume":"116\u2013117","author":"Ibrahim","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.cellsig.2020.109649_bb1110","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1007\/s11033-012-1611-2","article-title":"Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF\/Raf\/MAPK\/ERK signaling pathway","volume":"39","author":"Xu","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb1115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/ijms.27719","article-title":"Nonselective cyclooxygenase inhibition retards cyst progression in a murine model of autosomal dominant polycystic kidney disease","volume":"16","author":"Zhang","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1120","doi-asserted-by":"crossref","first-page":"F1425","DOI":"10.1152\/ajprenal.00010.2012","article-title":"Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia","volume":"303","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1125","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/ndt\/gfl071","article-title":"Gene profiling of polycystic kidneys","volume":"21","author":"Schieren","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb1130","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1152\/ajprenal.00454.2004","article-title":"Prostacyclin signaling in the kidney: implications for health and disease","volume":"289","author":"Nasrallah","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1135","doi-asserted-by":"crossref","first-page":"20451","DOI":"10.1074\/jbc.M010270200","article-title":"An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells","volume":"276","author":"Klussmann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122539","article-title":"Prostaglandin E2 in the regulation of water transport in renal collecting ducts","volume":"18","author":"Li","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1145","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pharmthera.2005.06.019","article-title":"Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism","volume":"109","author":"Nagano","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb1150","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ncpendmet0388","article-title":"Clinical lessons from the calcium-sensing receptor","volume":"3","author":"Brown","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2020.109649_bb1155","first-page":"F611","article-title":"Localization of the extracellular Ca2+\/polyvalent cation-sensing protein in rat kidney","volume":"274","author":"Riccardi","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb1160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00424-002-0914-x","article-title":"Renal physiology of the extracellular calcium-sensing receptor","volume":"445","author":"Ward","year":"2002","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2020.109649_bb1165","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.200507054","article-title":"Termination of cAMP signals by Ca2+ and Gai via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations","volume":"171","author":"Gerbino","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1170","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1681\/ASN.2008090927","article-title":"Calcimimetic inhibits late-stage cyst growth in ADPKD","volume":"20","author":"Gattone","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1175","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/ki.2011.139","article-title":"Calcimimetics inhibit renal pathology in rodent nephronophthisis","volume":"80","author":"Chen","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1180","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ndt\/gfn527","article-title":"Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease","volume":"24","author":"Wang","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb1185","series-title":"Amercian Society of Nephrology Kidney Week 2019. Washington D.C.","article-title":"Dual targeting of the G protein-coupled REceptors CaSR and VZR for treating autosomal dominant polycystic kidney disease","author":"Di Mise","year":"2019"},{"key":"10.1016\/j.cellsig.2020.109649_bb1190","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.1038\/s41598-018-23732-5","article-title":"Activation of calcium-sensing receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells","volume":"8","author":"Di Mise","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb1195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fmolb.2018.00077","article-title":"Activation of the calcium-sensing receptor corrects the impaired mitochondrial energy status observed in renal polycystin-1 knockdown cells modeling autosomal dominant polycystic kidney disease","volume":"5","author":"Di Mise","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1200","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11302-012-9294-7","article-title":"G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions","volume":"8","author":"Jacobson","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109649_bb1205","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s40256-019-00345-5","article-title":"Adenosine and the cardiovascular system","volume":"19","author":"Reiss","year":"2019","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.cellsig.2020.109649_bb1210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mam.2017.01.004","article-title":"Adenosine contribution to normal renal physiology and chronic kidney disease","volume":"55","author":"Oyarzun","year":"2017","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb1215","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.00038.2018","article-title":"Extracellular nucleotides and P2 receptors in renal function","volume":"100","author":"Vallon","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11302-017-9596-x","article-title":"CD39-adenosinergic axis in renal pathophysiology and therapeutics","volume":"14","author":"Kishore","year":"2018","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109649_bb1225","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev.physiol.66.032102.111604","article-title":"The extracellular cyclic AMP-adenosine pathway in renal physiology","volume":"66","author":"Jackson","year":"2004","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1230","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1152\/ajprenal.00571.2012","article-title":"Extracellular 2\u2032,3\u2019-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells","volume":"304","author":"Jackson","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1235","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1159\/000488270","article-title":"Activation of adenylyl cyclase causes stimulation of adenosine receptors","volume":"45","author":"Pleli","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1240","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1124\/jpet.103.057166","article-title":"Adenosine biosynthesis in the collecting duct","volume":"307","author":"Jackson","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb1245","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bbadis.2009.03.001","article-title":"Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells","volume":"1792","author":"Aguiari","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109649_bb1250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/bj1520023","article-title":"The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates","volume":"152","author":"Beis","year":"1975","journal-title":"Biochem. J."},{"key":"10.1016\/j.cellsig.2020.109649_bb1255","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/bj2330309","article-title":"Extracellular ATP: effects, sources and fate","volume":"233","author":"Gordon","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.cellsig.2020.109649_bb1260","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0005-2736(03)00210-4","article-title":"Extracellular ATP as a signaling molecule for epithelial cells","volume":"1615","author":"Schwiebert","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109649_bb1265","doi-asserted-by":"crossref","first-page":"F763","DOI":"10.1152\/ajprenal.0337.2000","article-title":"Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys","volume":"282","author":"Schwiebert","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1270","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.V102218","article-title":"ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys","volume":"10","author":"Wilson","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1275","doi-asserted-by":"crossref","first-page":"F1464","DOI":"10.1152\/ajprenal.90542.2008","article-title":"Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells","volume":"296","author":"Xu","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1280","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11302-008-9102-6","article-title":"Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts","volume":"4","author":"Hovater","year":"2008","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109649_bb1285","doi-asserted-by":"crossref","first-page":"F15","DOI":"10.1152\/ajprenal.00103.2006","article-title":"Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro","volume":"292","author":"Turner","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1290","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/ki.2013.418","article-title":"Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells","volume":"85","author":"Buchholz","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1295","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00109-010-0715-1","article-title":"Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion","volume":"89","author":"Buchholz","year":"2011","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.cellsig.2020.109649_bb1300","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1681\/ASN.2013030209","article-title":"Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion","volume":"25","author":"Buchholz","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1305","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11302-016-9532-5","article-title":"P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells","volume":"12","author":"Kraus","year":"2016","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109649_bb1310","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-physiol-021909-135825","article-title":"Intrarenal purinergic signaling in the control of renal tubular transport","volume":"72","author":"Praetorius","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1315","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1748-1716.2009.02002.x","article-title":"Released nucleotides amplify the cilium-dependent, flow-induced [Ca2+]i response in MDCK cells","volume":"197","author":"Praetorius","year":"2009","journal-title":"Acta Physiol. (Oxford)"},{"key":"10.1016\/j.cellsig.2020.109649_bb1320","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2012.10.003","article-title":"Primary cilium-dependent sensing of urinary flow and paracrine purinergic signaling","volume":"24","author":"Praetorius","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1325","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fphys.2013.00238","article-title":"Renal epithelial cells can release ATP by vesicular fusion","volume":"4","author":"Bjaelde","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1330","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ceca.2013.02.002","article-title":"Shear stress-induced Ca(2)(+) mobilization in MDCK cells is ATP dependent, no matter the primary cilium","volume":"53","author":"Rodat-Despoix","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cellsig.2020.109649_bb1335","doi-asserted-by":"crossref","first-page":"F341","DOI":"10.1152\/ajprenal.00190.2009","article-title":"AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct","volume":"297","author":"Odgaard","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1340","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.00544.2009","article-title":"Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct","volume":"300","author":"Yip","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1345","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1096\/fj.07-8807com","article-title":"Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption","volume":"21","author":"Rieg","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2020.109649_bb1350","first-page":"F863","article-title":"Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct","volume":"269","author":"Kishore","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb1355","first-page":"F216","article-title":"Protein kinase C inhibits arginine vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism","volume":"264","author":"Teitelbaum","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb1360","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11302-007-9072-0","article-title":"Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals","volume":"4","author":"Hovater","year":"2008","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.cellsig.2020.109649_bb1365","doi-asserted-by":"crossref","first-page":"F1715","DOI":"10.1152\/ajprenal.90311.2008","article-title":"Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice","volume":"295","author":"Zhang","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1370","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.physiol.62.1.621","article-title":"Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism","volume":"62","author":"Aperia","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1375","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/j.2040-4603.2011.tb00359.x","article-title":"Dopamine and renal function and blood pressure regulation","volume":"1","author":"Armando","year":"2011","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1380","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/MNH.0000000000000104","article-title":"Antihypertensive mechanisms of intra-renal dopamine","volume":"24","author":"Zhang","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.cellsig.2020.109649_bb1385","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1172\/JCI57324","article-title":"Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice","volume":"121","author":"Zhang","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb1390","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/HYPERTENSIONAHA.110.157727","article-title":"Dopamine receptors: important antihypertensive counterbalance against hypertensive factors","volume":"57","author":"Zeng","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.cellsig.2020.109649_bb1395","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/HYPERTENSIONAHA.111.172080","article-title":"Dopamine receptor type 5 in the primary cilia has dual chemo- and mechano-sensory roles","volume":"58","author":"Abdul-Majeed","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.cellsig.2020.109649_bb1400","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ki.2014.241","article-title":"Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans","volume":"87","author":"Lorthioir","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1405","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/ndt\/10.8.1332","article-title":"Borderline hypertensive autosomal dominant polycystic kidney disease patients have enhanced production of renal dopamine. Normalization of renal haemodynamics by DOPA infusion","volume":"10","author":"Barendregt","year":"1995","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb1410","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1242\/dev.049437","article-title":"Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts","volume":"137","author":"Xia","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cellsig.2020.109649_bb1415","doi-asserted-by":"crossref","first-page":"e0216220","DOI":"10.1371\/journal.pone.0216220","article-title":"Dopamine receptor antagonists as potential therapeutic agents for ADPKD","volume":"14","author":"Paul","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109649_bb1420","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1172\/JCI119724","article-title":"Genetic identification of two major modifier loci of polycystic kidney disease progression in PCY mice","volume":"100","author":"Woo","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb1425","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/ndt\/gft014","article-title":"Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD\/Mhm (cy\/+) substrain of the Hannover Sprague-Dawley rat","volume":"28","author":"Boehn","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109649_bb1430","doi-asserted-by":"crossref","first-page":"G683","DOI":"10.1152\/ajpgi.00302.2002","article-title":"Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity","volume":"284","author":"Glaser","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1435","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081682","article-title":"Sympathetic overactivity in chronic kidney disease: consequences and mechanisms","volume":"18","author":"Kaur","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1440","doi-asserted-by":"crossref","first-page":"6","DOI":"10.23876\/j.krcp.18.0143","article-title":"Renal sympathetic nerve activation via alpha2-adrenergic receptors in chronic kidney disease progression","volume":"38","author":"Jang","year":"2019","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.cellsig.2020.109649_bb1445","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1139\/y92-098","article-title":"Anatomy of the renal innervation: intrarenal aspects and ganglia of origin","volume":"70","author":"Barajas","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1450","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1681\/ASN.V12112427","article-title":"Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension","volume":"12","author":"Klein","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1455","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1681\/ASN.V4121995","article-title":"Isoproterenol induces mitogenesis in MCT and LLC-PK1 tubular cells","volume":"4","author":"Wolf","year":"1994","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1460","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3181\/0802-RM-54","article-title":"Contribution of renal innervation to hypertension in rat autosomal dominant polycystic kidney disease","volume":"233","author":"Gattone","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.cellsig.2020.109649_bb1465","doi-asserted-by":"crossref","first-page":"104587","DOI":"10.1016\/j.phrs.2019.104587","article-title":"beta-blockers: their new life from hypertension to cancer and migraine","volume":"151","author":"Fumagalli","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1470","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/1078-0432.CCR-11-0641","article-title":"Molecular pathways: beta-adrenergic signaling in cancer","volume":"18","author":"Cole","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1475","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1124\/pr.115.011833","article-title":"Endothelin","volume":"68","author":"Davenport","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1480","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.coph.2014.12.007","article-title":"Endothelin receptors, renal effects and blood pressure","volume":"21","author":"Boesen","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1485","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.semnephrol.2015.03.004","article-title":"Endothelin and tubulointerstitial renal disease","volume":"35","author":"Ong","year":"2015","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1490","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0272-6386(12)80212-5","article-title":"Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: possible evidence of heterogeneity in cystogenesis","volume":"24","author":"Munemura","year":"1994","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb1495","article-title":"Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney disease","volume":"93","author":"Ong","year":"2003","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1500","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1681\/ASN.V441064","article-title":"Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice","volume":"4","author":"Nakamura","year":"1993","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1505","doi-asserted-by":"crossref","first-page":"S342","DOI":"10.1097\/00005344-199800001-00095","article-title":"The endothelin system in polycystic kidneys of Han:SPRD rats","volume":"31","author":"Hocher","year":"1998","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1510","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1172\/JCI119297","article-title":"Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension","volume":"99","author":"Hocher","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb1515","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ki.1995.307","article-title":"An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration","volume":"48","author":"Ong","year":"1995","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1520","first-page":"134","article-title":"Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function","volume":"2","author":"Ong","year":"1994","journal-title":"Exp. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1525","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.mnh.0000186852.15889.1a","article-title":"The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure","volume":"15","author":"Kohan","year":"2006","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.cellsig.2020.109649_bb1530","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/01.ASN.0000042165.63601.65","article-title":"ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease","volume":"14","author":"Hocher","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1535","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1681\/ASN.2006090994","article-title":"Endothelin B receptor blockade accelerates disease progression in a murine model of autosomal dominant polycystic kidney disease","volume":"18","author":"Chang","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1540","doi-asserted-by":"crossref","first-page":"F692","DOI":"10.1152\/ajprenal.00100.2005","article-title":"Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure","volume":"289","author":"Ge","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1545","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1124\/jpet.116.234930","article-title":"Endothelin ETA receptor blockade, by activating ETB receptors, increases vascular permeability and induces exaggerated fluid retention","volume":"361","author":"Vercauteren","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb1550","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellsig.2018.03.002","article-title":"Adenylate cyclases: receivers, transducers, and generators of signals","volume":"46","author":"Bassler","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb1555","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1124\/pr.116.013078","article-title":"International Union of Basic and Clinical Pharmacology. CI. Structures and small molecule modulators of mammalian adenylyl cyclases","volume":"69","author":"Dessauer","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1560","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pharmthera.2017.01.001","article-title":"Adenylyl cyclase signalling complexes \u2013 pharmacological challenges and opportunities","volume":"172","author":"Halls","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb1565","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1681\/ASN.2006111218","article-title":"Identification of a forskolin-like molecule in human renal cysts","volume":"18","author":"Putnam","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1570","doi-asserted-by":"crossref","first-page":"F1412","DOI":"10.1152\/ajprenal.00692.2011","article-title":"Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells","volume":"303","author":"Pinto","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1575","doi-asserted-by":"crossref","first-page":"F859","DOI":"10.1152\/ajprenal.00109.2009","article-title":"Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse","volume":"298","author":"Strait","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1580","doi-asserted-by":"crossref","first-page":"F78","DOI":"10.1152\/ajprenal.00397.2011","article-title":"Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice","volume":"302","author":"Roos","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1585","doi-asserted-by":"crossref","first-page":"F597","DOI":"10.1152\/ajprenal.00505.2013","article-title":"Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure","volume":"306","author":"Kittikulsuth","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1590","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2016.10.032","article-title":"Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease","volume":"66","author":"Spirli","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1595","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2018.05.014","article-title":"A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion","volume":"121","author":"Zhang","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1600","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2007.05.038","article-title":"Type 5 adenylyl cyclase disruption increases longevity and protects against stress","volume":"130","author":"Yan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb1605","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/jpet.116.232538","article-title":"A food and drug administration-approved antiviral agent that inhibits adenylyl cyclase type 5 protects the ischemic heart even when administered after reperfusion","volume":"357","author":"Bravo","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb1610","doi-asserted-by":"crossref","first-page":"H2622","DOI":"10.1152\/ajpheart.00190.2012","article-title":"Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase","volume":"302","author":"Iwatsubo","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1615","doi-asserted-by":"crossref","first-page":"F1705","DOI":"10.1152\/ajprenal.00723.2012","article-title":"Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla","volume":"305","author":"Kortenoeven","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1620","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2369-13-109","article-title":"Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease","volume":"13","author":"Liu","year":"2012","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1625","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1630","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1635","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1476-5381.2011.01729.x","article-title":"Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments","volume":"165","author":"Keravis","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1640","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/er.2013-1053","article-title":"Clinical and molecular genetics of the phosphodiesterases (PDEs)","volume":"35","author":"Azevedo","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1645","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1523-1755.1999.00233.x","article-title":"Cyclic-3\u2032,5\u2032-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney","volume":"55","author":"Dousa","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109649_bb1650","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1681\/ASN.2015010047","article-title":"Phosphodiesterase isoform regulation of cell proliferation and fluid secretion in autosomal dominant polycystic kidney disease","volume":"27","author":"Pinto","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1655","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1172\/JCI109254","article-title":"Modulation of cyclic nucleotides in islated rat glomeruli: role of histamine, carbamylcholine, parathyroid hormone, and angiotensin-II","volume":"62","author":"Torres","year":"1978","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109649_bb1660","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1620\/tjem.193.207","article-title":"Nephron distribution of total low Km cyclic AMP phosphodiesterase in mouse, rat and rabbit kidney","volume":"193","author":"Kusano","year":"2001","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb1665","first-page":"F957","article-title":"Cyclic 3\u2032,5\u2032-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells","volume":"262","author":"Yamaki","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2020.109649_bb1670","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cellsig.2004.12.017","article-title":"Ca2+\u2212calmodulin-dependent phosphodiesterase (PDE1): current perspectives","volume":"17","author":"Goraya","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb1675","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.272.11.6823","article-title":"Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)","volume":"272","author":"Degerman","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2020.109649_bb1680","first-page":"I83","article-title":"PDE3 cyclic nucleotide phosphodiesterases and the compartmentation of cyclic nucleotide-mediated signalling in cardiac myocytes","volume":"97","author":"Movsesian","year":"2002","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1685","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/153537020623100308","article-title":"Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells","volume":"231","author":"Cheng","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.cellsig.2020.109649_bb1690","doi-asserted-by":"crossref","first-page":"F940","DOI":"10.1152\/ajprenal.00079.2004","article-title":"Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4","volume":"287","author":"Cheng","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1695","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-2143(97)90125-6","article-title":"Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid","volume":"130","author":"Matousovic","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb1700","doi-asserted-by":"crossref","first-page":"26238","DOI":"10.1074\/jbc.M110.214155","article-title":"Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins","volume":"286","author":"Begum","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1705","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.RES.0000261934.56938.38","article-title":"cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling","volume":"100","author":"Houslay","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1710","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1016\/j.febslet.2005.03.089","article-title":"Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract","volume":"579","author":"Baillie","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cellsig.2020.109649_bb1715","article-title":"PDE4-mediated cAMP signalling","volume":"5","author":"Fertig","year":"2018","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.cellsig.2020.109649_bb1720","doi-asserted-by":"crossref","first-page":"13320","DOI":"10.1073\/pnas.1822113116","article-title":"Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases","volume":"116","author":"Omar","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb1725","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1186\/s12864-017-4247-8","article-title":"PDE1A polymorphism contributes to the susceptibility of nephrolithiasis","volume":"18","author":"Yang","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cellsig.2020.109649_bb1730","doi-asserted-by":"crossref","first-page":"e0181087","DOI":"10.1371\/journal.pone.0181087","article-title":"Generation and phenotypic characterization of Pde1a mutant mice","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109649_bb1735","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41573-019-0033-4","article-title":"Therapeutic targeting of 3\u2032,5\u2032-cyclic nucleotide phosphodiesterases: inhibition and beyond","volume":"18","author":"Baillie","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cellsig.2020.109649_bb1740","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2010.04.010","article-title":"Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD","volume":"139","author":"Gradilone","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1745","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1681\/ASN.2012050442","article-title":"TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease","volume":"24","author":"Zaika","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1750","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1124\/mol.108.050567","article-title":"Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion","volume":"75","author":"Tradtrantip","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1755","first-page":"D678","article-title":"Specificity in the cAMP\/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA","volume":"5","author":"Skalhegg","year":"2000","journal-title":"Front. Biosci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1760","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00021.2003","article-title":"Localized effects of cAMP mediated by distinct routes of protein kinase A","volume":"84","author":"Tasken","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2020.109649_bb1765","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1055\/s-0032-1316292","article-title":"Protein kinase A alterations in endocrine tumors","volume":"44","author":"Yu","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1770","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/en.2004-0900","article-title":"Minireview: PRKAR1A: normal and abnormal functions","volume":"145","author":"Bossis","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cellsig.2020.109649_bb1775","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00294-002-0308-9","article-title":"Molecular mechanisms controlling the localisation of protein kinase A","volume":"41","author":"Griffioen","year":"2002","journal-title":"Curr. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb1780","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbadis.2007.09.003","article-title":"Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency","volume":"1782","author":"Li","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109649_bb1785","doi-asserted-by":"crossref","first-page":"9260","DOI":"10.1073\/pnas.132051799","article-title":"PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb1790","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1074\/jbc.274.9.5370","article-title":"PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I","volume":"274","author":"Zimmermann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1795","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1073\/pnas.87.24.9595","article-title":"Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells","volume":"87","author":"Meinkoth","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb1800","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2091-12-7","article-title":"Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform","volume":"12","author":"Stakkestad","year":"2011","journal-title":"BMC Biochem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1805","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nchembio.799","article-title":"Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP","volume":"8","author":"Sample","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1810","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17681","article-title":"Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain","volume":"6","author":"Ilouz","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.cellsig.2020.109649_bb1815","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1677\/ERC-09-0068","article-title":"Mouse models of altered protein kinase A signaling","volume":"16","author":"Kirschner","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.cellsig.2020.109649_bb1820","doi-asserted-by":"crossref","first-page":"8851","DOI":"10.1073\/pnas.92.19.8851","article-title":"Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase","volume":"92","author":"Brandon","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb1825","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1073\/pnas.94.20.11067","article-title":"Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase","volume":"94","author":"Burton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2020.109649_bb1830","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/382622a0","article-title":"Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A","volume":"382","author":"Cummings","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2020.109649_bb1835","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1523\/JNEUROSCI.18-10-03639.1998","article-title":"Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice","volume":"18","author":"Brandon","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1840","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1158\/0008-5472.CAN-05-0580","article-title":"A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues","volume":"65","author":"Kirschner","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1845","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/CIRCULATIONAHA.107.759233","article-title":"Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis","volume":"117","author":"Yin","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2020.109649_bb1850","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/me.2006-0428","article-title":"Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis","volume":"22","author":"Yin","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1855","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1593\/neo.08652","article-title":"Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production","volume":"10","author":"Jones","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.cellsig.2020.109649_bb1860","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","author":"Kirschner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb1865","doi-asserted-by":"crossref","first-page":"21233","DOI":"10.1074\/jbc.M001964200","article-title":"Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones","volume":"275","author":"Orellana","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1870","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.npep.2005.10.002","article-title":"Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function","volume":"40","author":"Dalton","year":"2006","journal-title":"Neuropeptides"},{"key":"10.1016\/j.cellsig.2020.109649_bb1875","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1093\/hmg\/ddv320","article-title":"Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+\/\u2212 mice","volume":"24","author":"Liu","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2020.109649_bb1880","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/jmcb\/mjs027","article-title":"Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing","volume":"4","author":"Piazzon","year":"2012","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1885","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00335-002-2241-0","article-title":"Positional cloning of jcpk\/bpk locus of the mouse","volume":"14","author":"Cogswell","year":"2003","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.cellsig.2020.109649_bb1890","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/humu.21610","article-title":"Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia","volume":"33","author":"Kraus","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cellsig.2020.109649_bb1895","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1128\/MCB.20.10.3442-3448.2000","article-title":"Deficient gene expression in protein kinase inhibitor alpha null mutant mice","volume":"20","author":"Gangolli","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1900","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/a-0753-4943","article-title":"Carney complex","volume":"127","author":"Kamilaris","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.cellsig.2020.109649_bb1905","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/bcp.13820","article-title":"Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone","volume":"85","author":"Rotman","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1910","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcell.2015.00026","article-title":"PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors","volume":"3","author":"Berthon","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1915","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41598-017-18956-w","article-title":"Conformational landscape of the PRKACA-DNAJB1 chimeric kinase, the driver for fibrolamellar hepatocellular carcinoma","volume":"8","author":"Tomasini","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2020.109649_bb1920","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/iub.1601","article-title":"TRAF3 delays cyst formation induced by NF-kappaB signaling","volume":"69","author":"Sun","year":"2017","journal-title":"IUBMB Life"},{"key":"10.1016\/j.cellsig.2020.109649_bb1925","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1681\/ASN.2011050442","article-title":"Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement","volume":"23","author":"Zhou","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1930","doi-asserted-by":"crossref","first-page":"F1223","DOI":"10.1152\/ajprenal.00697.2016","article-title":"Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease","volume":"313","author":"Hama","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1935","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1681\/ASN.2012050486","article-title":"A Pkd1-Fbn1 genetic interaction implicates TGF-beta signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease","volume":"25","author":"Liu","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1940","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0092-8674(00)80222-6","article-title":"The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism","volume":"89","author":"Zhong","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb1945","doi-asserted-by":"crossref","first-page":"20827","DOI":"10.1074\/jbc.C100195200","article-title":"Cyclic AMP-independent activation of protein kinase A by vasoactive peptides","volume":"276","author":"Dulin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb1950","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1955","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.122re4","article-title":"Pharmacological PKA inhibition: all may not be what it seems","volume":"1","author":"Murray","year":"2008","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb1960","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.arcmed.2018.12.008","article-title":"Protein Kinase A as a promising target for heart failure drug development","volume":"49","author":"Saad","year":"2018","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1965","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1128\/MCB.24.5.2169-2180.2004","article-title":"A transforming growth factor beta-induced Smad3\/Smad4 complex directly activates protein kinase A","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1970","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.molmed.2006.05.008","article-title":"AKAP signaling complexes: getting to the heart of the matter","volume":"12","author":"McConnachie","year":"2006","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cellsig.2020.109649_bb1975","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.bbamcr.2015.11.024","article-title":"Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology","volume":"1863","author":"Diviani","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2020.109649_bb1980","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2015.07.010","article-title":"A historical overview of protein kinases and their targeted small molecule inhibitors","volume":"100","author":"Roskoski","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2020.109649_bb1985","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1476-5381.2011.01796.x","article-title":"A-kinase anchoring proteins as potential drug targets","volume":"166","author":"Troger","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb1990","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tips.2013.10.005","article-title":"AKAP signaling complexes: pointing towards the next generation of therapeutic targets?","volume":"34","author":"Esseltine","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2020.109649_bb1995","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fphar.2015.00192","article-title":"Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins","volume":"6","author":"Calejo","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109649_bb2000","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pharmthera.2017.12.004","article-title":"Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders","volume":"185","author":"Wild","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2020.109649_bb2005","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1016\/S0021-9258(18)42221-1","article-title":"Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain","volume":"267","author":"Carr","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2010","doi-asserted-by":"crossref","first-page":"16816","DOI":"10.1016\/S0021-9258(18)41856-X","article-title":"Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79","volume":"267","author":"Carr","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.molcel.2006.09.006","article-title":"Molecular basis of AKAP specificity for PKA regulatory subunits","volume":"24","author":"Gold","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2020.109649_bb2020","doi-asserted-by":"crossref","first-page":"17111","DOI":"10.1074\/jbc.M112.447326","article-title":"Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection","volume":"288","author":"Gold","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2025","doi-asserted-by":"crossref","first-page":"21535","DOI":"10.1074\/jbc.M603223200","article-title":"Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor","volume":"281","author":"Carlson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1021\/cb400900r","article-title":"Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides","volume":"9","author":"Wang","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb2035","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1021\/acschembio.5b00009","article-title":"PKA-type I selective constrained peptide disruptors of AKAP complexes","volume":"10","author":"Wang","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cellsig.2020.109649_bb2040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cellsig.2017.09.011","article-title":"The role of A-kinase anchoring proteins in cancer development","volume":"40","author":"Reggi","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2020.109649_bb2045","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1074\/jbc.275.19.14360","article-title":"Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin","volume":"275","author":"Sun","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2050","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1074\/jbc.M110.160614","article-title":"Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes","volume":"286","author":"Christian","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109649_bb2055","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/s41467-018-03771-2","article-title":"AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus","volume":"9","author":"Ando","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820301261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820301261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:24:25Z","timestamp":1777580665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656820301261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":411,"alternative-id":["S0898656820301261"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109649","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109649"}}