{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:00Z","timestamp":1790876640939,"version":"4.1.0"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["DK090728"],"award-info":[{"award-number":["DK090728"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.cellsig.2020.109698","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T06:21:17Z","timestamp":1592634077000},"page":"109698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease"],"prefix":"10.1016","volume":"73","author":[{"given":"Sonu","family":"Kashyap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianna D.","family":"Zeidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C.S.","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Nunes","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cellsig.2020.109698_bb0005","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.bbadis.2011.03.002","article-title":"Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs","volume":"1812","author":"Tan","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"9569","key":"10.1016\/j.cellsig.2020.109698_bb0010","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/ndt\/gfv456","article-title":"Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA working groups on inherited kidney disorders and European renal best practice","volume":"31","author":"Gansevoort","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0020","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2009010014","article-title":"Homer W. Smith award: insights into the pathogenesis of polycystic kidney disease from gene discovery","volume":"20","author":"Harris","year":"2008","journal-title":"J. Am. Soci. Nephrol., 2009."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109698_bb0025","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/ndt\/gft521","article-title":"Defective metabolism in polycystic kidney disease: potential for therapy and open questions","volume":"29","author":"Rowe","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2020.109698_bb0030","series-title":"Polycystic Kidney Disease","first-page":"161","article-title":"Energy metabolism, metabolic sensors, and nutritional interventions in polycystic kidney disease","author":"Kashyap","year":"2019"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1681\/ASN.2017050483","article-title":"Genetic complexity of autosomal dominant polycystic kidney and liver diseases","volume":"29","author":"Cornec-Le Gall","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0040","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","article-title":"The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I","volume":"87","author":"Qian","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","article-title":"Polycystic kidney disease","volume":"4","author":"Bergmann","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0050","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.cellsig.2020.109698_bb0055","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbadis.2011.02.008","article-title":"Cilium, centrosome and cell cycle regulation in polycystic kidney disease","volume":"1812","author":"Lee","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0065","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","article-title":"The polycystic kidney Disease-1 protein, Polycystin-1, binds and activates heterotrimeric G-Proteinsin vitro","volume":"251","author":"Parnell","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","article-title":"PKD1 induces p21waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2","volume":"109","author":"Bhunia","year":"2002","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0075","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1681\/ASN.2005050534","article-title":"Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase\/Akt signaling pathway","volume":"17","author":"Boca","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0080","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1073\/pnas.1011498108","article-title":"Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis","volume":"108","author":"Takiar","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2020.109698_bb0085","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41581-018-0051-1","article-title":"Metabolism and mitochondria in polycystic kidney disease research and therapy","volume":"14","author":"Padovano","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2020.109698_bb0090","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0095","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1681\/ASN.2015030231","article-title":"2-deoxy-D-glucose ameliorates PKD progression","volume":"27","author":"Chiaravalli","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146654","article-title":"Inhibition of aerobic glycolysis attenuates disease progression in polycystic kidney disease","volume":"11","author":"Riwanto","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2020.109698_bb0105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ebiom.2016.01.027","article-title":"Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease","volume":"5","author":"Menezes","year":"2016","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0110","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1038\/s41598-018-20856-6","article-title":"A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed","volume":"8","author":"Lin","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0115","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.ekir.2019.08.010","article-title":"Erythropoietin and fibroblast growth factor 23 in autosomal dominant polycystic kidney disease patients","volume":"4","author":"Hanudel","year":"2019","journal-title":"Kidney Int. Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109698_bb0120","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2215\/CJN.12821216","article-title":"Fibroblast growth factor 23 and kidney disease progression in autosomal dominant polycystic kidney disease","volume":"12","author":"Chonchol","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0125","first-page":"C487","article-title":"Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD","volume":"269","author":"Du","year":"1995","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"10","key":"10.1016\/j.cellsig.2020.109698_bb0130","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.bbadis.2010.10.004","article-title":"Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells","volume":"1812","author":"Zheleznova","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/edrv-16-2-143","article-title":"Molecular and cellular aspects of the insulin-like growth factor I receptor","volume":"16","author":"LeRoith","year":"1995","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0140","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions*","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00592-010-0227-z","article-title":"The IGF system","volume":"48","author":"Annunziata","year":"2011","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.cellsig.2020.109698_bb0150","first-page":"10(27)","article-title":"ROLE of IGF-1 system in the modulation of longevity: controversies and new insights from a centenarians\u2019 perspective","author":"Vitale","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cellsig.2020.109698_bb0155","first-page":"6(77)","article-title":"The role of the insulin\/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link","author":"Bowers","year":"2015","journal-title":"Front. Endocrinol."},{"issue":"18","key":"10.1016\/j.cellsig.2020.109698_bb0160","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/jnci\/92.18.1472","article-title":"Role of the insulin-like growth factor family in Cancer development and progression","volume":"92","author":"Yu","year":"2000","journal-title":"JNCI"},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0165","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/mp.54.5.311","article-title":"Insulin-like growth factor 1 (IGF-1): a growth hormone","volume":"54","author":"Laron","year":"2001","journal-title":"Mol. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-015-0291-7","article-title":"The role of the insulin-like growth factor-1 system in breast cancer","volume":"14","author":"Christopoulos","year":"2015","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0175","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1681\/ASN.V371378","article-title":"Growth factor gene expression in kidney of murine polycystic kidney disease","volume":"3","author":"Nakamura","year":"1993","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0180","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1523-1755.2001.00465.x","article-title":"Dietary soy protein effects on disease and IGF-I in male and female Han:SPRD-cy rats","volume":"59","author":"Aukema","year":"2001","journal-title":"Kidney Int."},{"issue":"13","key":"10.1016\/j.cellsig.2020.109698_bb0185","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","article-title":"Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks","volume":"18","author":"Song","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.ki.5002229","article-title":"Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras\/Raf dependent signalling pathway","volume":"72","author":"Parker","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2020.109698_bb0195","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2013.1588","article-title":"Rosiglitazone inhibits insulin-like growth factor-1-induced polycystic kidney disease cell growth and p70S6 kinase activation","volume":"8","author":"Liu","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0200","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1681\/ASN.2015020132","article-title":"Food restriction ameliorates the development of polycystic kidney disease","volume":"27","author":"Warner","year":"2016","journal-title":"JASN"},{"key":"10.1016\/j.cellsig.2020.109698_bb0205","first-page":"5(4)","article-title":"Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis","author":"Kashyap","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0210","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/edrv-10-1-68","article-title":"Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations","volume":"10","author":"Daughaday","year":"1989","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0215","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1073\/pnas.73.7.2365","article-title":"Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II","volume":"73","author":"Rinderknecht","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5980","key":"10.1016\/j.cellsig.2020.109698_bb0220","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/310781a0","article-title":"Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor","volume":"310","author":"Brissenden","year":"1984","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/08977199109000267","article-title":"Structure, evolution, expression and regulation of insulin-like growth factors I and II","volume":"5","author":"Rotwein","year":"1991","journal-title":"Growth Factors"},{"issue":"Pt 1","key":"10.1016\/j.cellsig.2020.109698_bb0230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/jphysiol.2002.032136","article-title":"Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise","volume":"547","author":"Hameed","year":"2003","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0235","first-page":"567","article-title":"Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro","volume":"23","author":"Philippou","year":"2009","journal-title":"In Vivo"},{"issue":"8","key":"10.1016\/j.cellsig.2020.109698_bb0240","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/ddl041","article-title":"Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human","volume":"15","author":"Monk","year":"2006","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0245","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/hmg\/ddh070","article-title":"Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits","volume":"13","author":"Rodr\u00edguez","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0250","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000343995","article-title":"Insulin-like growth factor 2 in development and disease: a mini-review","volume":"59","author":"Bergman","year":"2013","journal-title":"Gerontology"},{"issue":"10","key":"10.1016\/j.cellsig.2020.109698_bb0255","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/j.1460-2075.1986.tb04528.x","article-title":"Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity","volume":"5","author":"Ullrich","year":"1986","journal-title":"EMBO J."},{"issue":"Pt 1","key":"10.1016\/j.cellsig.2020.109698_bb0260","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/bj3270209","article-title":"Insulin receptor\/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting","volume":"327","author":"Bailyes","year":"1997","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0265","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0303-7207(97)04050-1","article-title":"Distribution of insulin\/insulin-like growth factor-I hybrid receptors in human tissues","volume":"129","author":"Federici","year":"1997","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0270","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1242\/jcs.1985.Supplement_3.5","article-title":"Insulin-Like Growth Factor Receptors","author":"Nissley","year":"1985","journal-title":". J. Cell Sci. Suppl."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0275","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrc3215","article-title":"The insulin and insulin-like growth factor receptor family in neoplasia: an update","volume":"12","author":"Pollak","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"02\/03","key":"10.1016\/j.cellsig.2020.109698_bb0280","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-2007-978725","article-title":"Type-2 IGF receptor: a multi-ligand binding protein","volume":"31","author":"Braulke","year":"1999","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cellsig.2020.109698_bb0285","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fendo.2018.00117","article-title":"IGF-binding proteins: why do they exist and why are there so many?","volume":"9","author":"Allard","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0290","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1210\/endo.138.12.5714","article-title":"Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action","volume":"138","author":"Mohseni-Zadeh","year":"1997","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0295","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1054\/ghir.2000.0180","article-title":"Characterization of an amino-terminal fragment of insulin-like growth factor binding protein-3 and its effects in MCF-7 breast cancer cells","volume":"10","author":"Salahifar","year":"2000","journal-title":"Growth Hormon. IGF Res."},{"issue":"27","key":"10.1016\/j.cellsig.2020.109698_bb0300","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1074\/jbc.273.27.16836","article-title":"Differential expression and biological effects of insulin-like growth factor-binding Protein-4 and -5 in vascular smooth muscle cells","volume":"273","author":"Duan","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.cellsig.2020.109698_bb0305","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1073\/pnas.96.13.7324","article-title":"Normal growth and development in the absence of hepatic insulin-like growth factor I","volume":"96","author":"Yakar","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cellsig.2020.109698_bb0310","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fendo.2012.00038","article-title":"Insulin-like growth factor binding proteins: a structural perspective","volume":"3","author":"Forbes","year":"2012","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0315","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1210\/jcem-67-2-265","article-title":"Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex","volume":"67","author":"Baxter","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.cellsig.2020.109698_bb0320","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1074\/jbc.273.11.6074","article-title":"Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit","volume":"273","author":"Twigg","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0325","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1210\/endo.130.1.1370153","article-title":"Tissue distribution and regulation of insulin-like growth factor (IGF)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: comparison with IGF-I mRNA expression","volume":"130","author":"Albiston","year":"1992","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0330","first-page":"553","article-title":"Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans","volume":"84","author":"Olivecrona","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"17","key":"10.1016\/j.cellsig.2020.109698_bb0335","doi-asserted-by":"crossref","first-page":"10188","DOI":"10.1073\/pnas.95.17.10188","article-title":"Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia","volume":"95","author":"Tazuke","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0340","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.febslet.2005.03.077","article-title":"Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3\u2019UTR","volume":"579","author":"Averous","year":"2005","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0345","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2265.1993.tb02377.x","article-title":"The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting","volume":"39","author":"Cotterill","year":"1993","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0350","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/bbrc.1994.1438","article-title":"Insulin and glucocorticoids regulate IGFBP-1 expression via a common promoter region","volume":"200","author":"Robertson","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0355","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1083\/jcb.121.3.679","article-title":"Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I","volume":"121","author":"Jones","year":"1993","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109698_bb0360","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1091\/mbc.9.9.2383","article-title":"Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I","volume":"9","author":"Parker","year":"1998","journal-title":"Mol. Biol. Cell"},{"issue":"22","key":"10.1016\/j.cellsig.2020.109698_bb0365","doi-asserted-by":"crossref","first-page":"10553","DOI":"10.1073\/pnas.90.22.10553","article-title":"Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence","volume":"90","author":"Jones","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0370","first-page":"F899","article-title":"Heparin binding domain of insulin-like growth factor binding protein-5 stimulates mesangial cell migration","volume":"273","author":"Abrass","year":"1997","journal-title":"Am. J. Phys."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109698_bb0375","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/ijc.26201","article-title":"IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis","volume":"130","author":"Zhang","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"31","key":"10.1016\/j.cellsig.2020.109698_bb0380","doi-asserted-by":"crossref","first-page":"23462","DOI":"10.1074\/jbc.M002208200","article-title":"Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit","volume":"275","author":"Schedlich","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.cellsig.2020.109698_bb0385","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1074\/jbc.273.29.18347","article-title":"Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells","volume":"273","author":"Schedlich","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0390","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1161\/01.RES.0000124761.62846.DF","article-title":"Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells","volume":"94","author":"Xu","year":"2004","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0395","first-page":"761","article-title":"The insulin-like growth factor-binding protein (IGFBP) superfamily","volume":"20","author":"Hwa","year":"1999","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0400","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0955-2235(95)00012-7","article-title":"Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth","volume":"6","author":"Rajah","year":"1995","journal-title":"Prog. Growth Factor Res."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0405","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/mgme.1999.2920","article-title":"Novel aspects of the insulin-like growth factor binding proteins","volume":"68","author":"Wetterau","year":"1999","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0410","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1095\/biolreprod56.4.1050","article-title":"Proteolytic activity degrading insulin-like growth factor-binding protein\u22122, \u22123, \u22124, and \u22125 in healthy growing and Atretic follicles in the pig Ovary1","volume":"56","author":"Besnard","year":"1997","journal-title":"Biol. Reprod."},{"issue":"48","key":"10.1016\/j.cellsig.2020.109698_bb0415","doi-asserted-by":"crossref","first-page":"37638","DOI":"10.1074\/jbc.M006107200","article-title":"The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding Protein-5 in fibroblast medium","volume":"275","author":"Busby","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.cellsig.2020.109698_bb0420","doi-asserted-by":"crossref","first-page":"18574","DOI":"10.1074\/jbc.M002172200","article-title":"ADAM 12, a Disintegrin metalloprotease, interacts with insulin-like growth factor-binding Protein-3","volume":"275","author":"Shi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2020.109698_bb0425","doi-asserted-by":"crossref","unstructured":"Clay Bunn, R. and J.L. Fowlkes, Insulin-like growth factor binding protein proteolysis. Trends Endocrinol. Metab., 2003. 14(4): 176\u2013181.","DOI":"10.1016\/S1043-2760(03)00049-3"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0430","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ando.2016.04.015","article-title":"PAPP-A and the IGF system","volume":"77","author":"Monget","year":"2016","journal-title":"Ann. Endocrinol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0435","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/bj3580359","article-title":"Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-a (PAPP-A): classification as a metzincin","volume":"358","author":"BOLDT","year":"2001","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0440","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","article-title":"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A","volume":"96","author":"Lawrence","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0445","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1242\/dev.00997","article-title":"Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development","volume":"131","author":"Conover","year":"2004","journal-title":"Development"},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2020.109698_bb0450","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(01)02760-0","article-title":"Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A","volume":"504","author":"Laursen","year":"2001","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0455","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1095\/biolreprod.102.007609","article-title":"Pregnancy-associated plasma protein-a is involved in insulin-like growth factor binding Protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine Preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation1","volume":"68","author":"Monget","year":"2003","journal-title":"Biol. Reprod."},{"issue":"24","key":"10.1016\/j.cellsig.2020.109698_bb0460","doi-asserted-by":"crossref","first-page":"21849","DOI":"10.1074\/jbc.M102191200","article-title":"Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase","volume":"276","author":"Overgaard","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0465","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four human pregnancy-associated plasma proteins","volume":"118","author":"Lin","year":"1974","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0470","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1095\/biolreprod61.4.1083","article-title":"Messenger ribonucleic acid levels of pregnancy-associated plasma protein-a and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues1","volume":"61","author":"Overgaard","year":"1999","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0475","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM199908123410701","article-title":"Integrated screening for Down\u2019s syndrome based on tests performed during the first and second trimesters","volume":"341","author":"Wald","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0480","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1172\/JCI116272","article-title":"Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies","volume":"91","author":"Conover","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0485","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jbmr.5650090115","article-title":"Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology","volume":"9","author":"Durham","year":"1994","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0490","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1210\/endo.136.6.7538463","article-title":"Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells","volume":"136","author":"Parker","year":"1995","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0495","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1210\/endo.142.12.8517","article-title":"Pregnancy-associated plasma protein-a (PAPP-A) in ovine, bovine, porcine, and equine ovarian follicles: involvement in IGF binding Protein-4 proteolytic degradation and mRNA expression during follicular development","volume":"142","author":"Mazerbourg","year":"2001","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0500","first-page":"847","article-title":"Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro","volume":"86","author":"Byun","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0505","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.ATV.21.3.335","article-title":"Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty","volume":"21","author":"Bayes-Genis","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0510","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1210\/jcem.84.12.6342","article-title":"Evidence that the insulin-like growth factor binding Protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-a","volume":"84","author":"Conover","year":"1999","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0515","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1210\/jcem.87.5.8448","article-title":"Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation","volume":"87","author":"Giudice","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0520","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ghir.2006.11.003","article-title":"Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs","volume":"17","author":"Boldt","year":"2007","journal-title":"Growth Hormon. IGF Res."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0525","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12079-015-0259-9","article-title":"The role of PAPP-A in the IGF system: location, location, location","volume":"9","author":"Oxvig","year":"2015","journal-title":"J. Cell Commun. Signal."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0530","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tem.2012.02.008","article-title":"Key questions and answers about pregnancy-associated plasma protein-a","volume":"23","author":"Conover","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"17","key":"10.1016\/j.cellsig.2020.109698_bb0535","doi-asserted-by":"crossref","first-page":"12243","DOI":"10.1016\/S0021-9258(18)31378-4","article-title":"Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein","volume":"268","author":"Oxvig","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0540","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1074\/jbc.M608454200","article-title":"Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor","volume":"282","author":"Glerup","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0545","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1210\/me.2006-0522","article-title":"Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding Protein-4 and -5","volume":"21","author":"Laursen","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0550","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1210\/en.2007-0274","article-title":"Transgenic overexpression of pregnancy-associated plasma protein-a increases the somatic growth and skeletal muscle mass in mice","volume":"148","author":"Rehage","year":"2007","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0555","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1210\/en.2006-1055","article-title":"Pregnancy-associated plasma protein-a increases osteoblast proliferation in vitro and bone formation in vivo","volume":"147","author":"Qin","year":"2006","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0560","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ghir.2010.01.001","article-title":"Inactivation of insulin-like-growth factors diminished the anabolic effects of pregnancy-associated plasma protein-A (PAPP-A) on bone in mice","volume":"20","author":"Phang","year":"2010","journal-title":"Growth Hormon. IGF Res."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0565","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1074\/jbc.M114.611665","article-title":"Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis","volume":"290","author":"Jepsen","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0570","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1210\/en.2003-1313","article-title":"Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines","volume":"145","author":"Resch","year":"2004","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0575","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ghir.2007.09.001","article-title":"Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells","volume":"18","author":"Conover","year":"2008","journal-title":"Growth Hormon. IGF Res."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109698_bb0580","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9378(81)90957-1","article-title":"Pregnancy-associated plasma protein A: circulating levels during normal pregnancy","volume":"139","author":"Folkersen","year":"1981","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0585","first-page":"2680","article-title":"The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface","volume":"81","author":"Han","year":"1996","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0590","first-page":"134","article-title":"Role of growth factors on fetal growth and maturation","volume":"22","author":"Takeda","year":"1993","journal-title":"Ann. Acad. Med. Singap."},{"issue":"Suppl. 2","key":"10.1016\/j.cellsig.2020.109698_bb0595","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/humrep\/14.suppl_2.90","article-title":"Role of the IGF system in trophoblast invasion and pre-eclampsia","volume":"14","author":"Irwin","year":"1999","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0600","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/jcem.87.4.8430","article-title":"Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth","volume":"87","author":"Smith","year":"2002","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0605","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/uog.6280","article-title":"First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia","volume":"33","author":"Poon","year":"2009","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0610","first-page":"227","article-title":"Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study","volume":"43","author":"Giudice","year":"2015"},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0615","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1210\/en.2006-0493","article-title":"Targeted disruption of the pregnancy-associated plasma protein-a gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to Neointimal hyperplasia after vascular injury","volume":"147","author":"Resch","year":"2006","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.cellsig.2020.109698_bb0620","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1210\/jc.2003-030193","article-title":"Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin","volume":"88","author":"Chen","year":"2003","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0625","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1210\/jcem.85.12.7169","article-title":"Pregnancy-associated plasma protein-a gene expression in human ovaries is restricted to healthy follicles and corpora Lutea","volume":"85","author":"Hourvitz","year":"2000","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0630","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/endo.143.5.8769","article-title":"The regulated expression of the pregnancy-associated plasma protein-a in the rodent ovary: a proposed role in the development of dominant follicles and of corpora Lutea","volume":"143","author":"Hourvitz","year":"2002","journal-title":"Endocrinology"},{"issue":"14","key":"10.1016\/j.cellsig.2020.109698_bb0635","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa003147","article-title":"Pregnancy-associated plasma protein A as a marker of acute coronary syndromes","volume":"345","author":"Bayes-Genis","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0640","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/MAJ.0b013e31818967a3","article-title":"Relationship between pregnancy-associated plasma protein-A and lung Cancer","volume":"337","author":"Bulut","year":"2009","journal-title":"Am J Med Sci"},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0645","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.exger.2012.06.017","article-title":"Role of PAPP-A in aging and age-related disease","volume":"48","author":"Conover","year":"2013","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0650","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JME-17-0236","article-title":"40 YEARS OF IGF1: PAPP-A and cancer","volume":"61","author":"Cheryl","year":"2018","journal-title":"J. Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109698_bb0655","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/CIRCRESAHA.106.146183","article-title":"Genetic deletion of pregnancy-associated plasma protein-a is associated with resistance to atherosclerotic lesion development in apolipoprotein E\u2013deficient mice challenged with a high-fat diet","volume":"100","author":"Harrington","year":"2007","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0660","first-page":"H284","article-title":"Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development","volume":"299","author":"Conover","year":"2010","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0665","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.mehy.2007.05.043","article-title":"PAPP-A: a possible pathogenic link to the instability of atherosclerotic plaque","volume":"70","author":"Li","year":"2008","journal-title":"Med. Hypotheses"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0670","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/eurheartj\/ehp429","article-title":"Pregnancy-associated plasma protein-A is an independent short-time predictor of mortality in patients on maintenance haemodialysis","volume":"31","author":"Etter","year":"2009","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0675","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000078701","article-title":"Increased levels of pregnancy-associated plasma protein A are associated with mortality in hemodialysis patients: preliminary results","volume":"22","author":"Kalousov\u00e1","year":"2004","journal-title":"Blood Purif."},{"issue":"11","key":"10.1016\/j.cellsig.2020.109698_bb0680","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1210\/jc.2004-0787","article-title":"Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index","volume":"89","author":"Aso","year":"2004","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0685","first-page":"37","article-title":"Pregnancy-associated plasma protein-A in patients with cerebrovascular diseases--a pilot study","volume":"107","author":"Fialov\u00e1","year":"2006","journal-title":"Prague Med. Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0690","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2174\/156800909789271495","article-title":"Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy","volume":"9","author":"Veeken","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"issue":"29","key":"10.1016\/j.cellsig.2020.109698_bb0695","doi-asserted-by":"crossref","first-page":"22583","DOI":"10.1074\/jbc.M002915200","article-title":"Transactivation of the EGF receptor mediates IGF-1-stimulated Shc phosphorylation and ERK1\/2 activation in COS-7 cells","volume":"275","author":"Roudabush","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.cellsig.2020.109698_bb0700","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/jnci\/djs258","article-title":"Insulin-like growth factor receptor inhibitors: baby or the bathwater?","volume":"104","author":"Yee","year":"2012","journal-title":"JNCI"},{"issue":"11","key":"10.1016\/j.cellsig.2020.109698_bb0705","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1210\/me.2015-1157","article-title":"Minireview: were the IGF signaling inhibitors all bad?","volume":"29","author":"Beckwith","year":"2015","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109698_bb0710","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4161\/cbt.11.8.14689","article-title":"Targeting the insulin-like growth factor network in cancer therapy","volume":"11","author":"Heidegger","year":"2011","journal-title":"Cancer Biol. Therapy"},{"issue":"24","key":"10.1016\/j.cellsig.2020.109698_bb0715","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1074\/jbc.M802429200","article-title":"Inhibition of the proteolytic activity of pregnancy-associated plasma protein-a by targeting substrate exosite binding","volume":"283","author":"Mikkelsen","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0720","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.18632\/oncotarget.1629","article-title":"Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity","volume":"5","author":"Mikkelsen","year":"2014","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0725","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1158\/1535-7163.MCT-14-0880","article-title":"A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts","volume":"14","author":"Becker","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cellsig.2020.109698_bb0730","article-title":"Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity","author":"Mohrin","year":"2020","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0735","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/imt-2018-0130","article-title":"Future perspectives of therapeutic monoclonal antibodies","volume":"11","author":"Tsumoto","year":"2019","journal-title":"Immunotherapy"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0740","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-032620","article-title":"Long-acting somatostatin analogue treatments in autosomal dominant polycystic kidney disease and polycystic liver disease: a systematic review and meta-analysis","volume":"10","author":"Griffiths","year":"2020","journal-title":"BMJ Open"},{"issue":"9903","key":"10.1016\/j.cellsig.2020.109698_bb0745","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0140-6736(13)61407-5","article-title":"Effect of longacting somatostatin analogue on kidney and cyst growth in autosomal dominant polycystic kidney disease (ALADIN): a randomised, placebo-controlled, multicentre trial","volume":"382","author":"Caroli","year":"2013","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.cellsig.2020.109698_bb0750","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1001\/jama.2018.15870","article-title":"Effect of lanreotide on kidney function in patients with autosomal dominant polycystic kidney disease: the DIPAK 1 randomized clinical trial","volume":"320","author":"Meijer","year":"2018","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0755","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002777","article-title":"Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): a randomized, double-blind, placebo-controlled, multicenter trial","volume":"16","author":"Perico","year":"2019","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109698_bb0760","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mce.2008.02.002","article-title":"Antitumor effects of somatostatin","volume":"286","author":"Pyronnet","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cellsig.2020.109698_bb0765","doi-asserted-by":"crossref","unstructured":"Grozinsky-Glasberg, S., et al., Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms. 2008. 15(3): p. 701.","DOI":"10.1677\/ERC-07-0288"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0770","first-page":"1046","article-title":"Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma","volume":"75","author":"Cohen","year":"1992","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109698_bb0775","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1210\/endo.137.7.8770886","article-title":"7S nerve growth factor is an insulin-like growth factor-binding protein protease","volume":"137","author":"Rajah","year":"1996","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0780","doi-asserted-by":"crossref","first-page":"E465","DOI":"10.1152\/ajpendo.1996.271.3.E465","article-title":"IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments","volume":"271","author":"Booth","year":"1996","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109698_bb0785","doi-asserted-by":"crossref","first-page":"E1005","DOI":"10.1152\/ajpendo.1997.273.5.E1005","article-title":"Insulin-like growth factor (IGF)-binding protein-5-(201\u2014218) region regulates hydroxyapatite and IGF-I binding","volume":"273","author":"Campbell","year":"1997","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109698_bb0790","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/endo.139.4.5945","article-title":"Insulin-like growth factor-binding Protein-5 is cleaved by physiological concentrations of thrombin*","volume":"139","author":"Zheng","year":"1998","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0795","first-page":"847","article-title":"Pregnancy-associated plasma protein-a accounts for the insulin-like growth factor (IGF)-binding Protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the Mitogenic activity of IGF by degrading IGFBP-4 in Vitro1","volume":"86","author":"Byun","year":"2001","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0800","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/bbrc.2000.3835","article-title":"ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3","volume":"278","author":"Loechel","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"51","key":"10.1016\/j.cellsig.2020.109698_bb0805","doi-asserted-by":"crossref","first-page":"15394","DOI":"10.1021\/bi026458q","article-title":"ADAM-9 is an insulin-like growth factor binding Protein-5 protease produced and secreted by human osteoblasts","volume":"41","author":"Mohan","year":"2002","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0810","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1210\/endo.135.6.7527335","article-title":"Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases","volume":"135","author":"Fowlkes","year":"1994","journal-title":"Endocrinology"},{"issue":"41","key":"10.1016\/j.cellsig.2020.109698_bb0815","doi-asserted-by":"crossref","first-page":"25742","DOI":"10.1016\/S0021-9258(18)47310-3","article-title":"Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures","volume":"269","author":"Fowlkes","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0820","first-page":"L151","article-title":"Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis","volume":"269","author":"Cohen","year":"1995","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109698_bb0825","first-page":"L1014","article-title":"Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells","volume":"271","author":"Rajah","year":"1996","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"10","key":"10.1016\/j.cellsig.2020.109698_bb0830","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1016\/S0021-9258(17)37248-4","article-title":"Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D","volume":"269","author":"Conover","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0835","first-page":"987","article-title":"Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells","volume":"80","author":"Conover","year":"1995","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109698_bb0840","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/(SICI)1097-4652(199705)171:2<196::AID-JCP10>3.0.CO;2-C","article-title":"Acid-activated insulin-like growth factor binding protein protease activity of Cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma","volume":"171","author":"Nunn","year":"1997","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109698_bb0845","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1210\/endo.138.9.5418","article-title":"Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by Cathepsin D*","volume":"138","author":"Claussen","year":"1997","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109698_bb0850","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3892\/mmr.2013.1588","article-title":"Rosiglitazone inhibits insulin-like growth factor-1-induced polycystic kidney disease cell growth and p70S6 kinase activation","volume":"8","author":"Liu","year":"2013","journal-title":"Mol. Med. Rep."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820301753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820301753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:10:04Z","timestamp":1786633804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656820301753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":170,"alternative-id":["S0898656820301753"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109698","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109698"}}