{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:46:00Z","timestamp":1790952360957,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"am","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001296","name":"PKD Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.cellsig.2020.109760","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:36:11Z","timestamp":1598672171000},"page":"109760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease"],"prefix":"10.1016","volume":"75","author":[{"given":"Daniel J.","family":"Atwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn N.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Holditch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Pokhrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Thorburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-2358","authenticated-orcid":false,"given":"Katharina","family":"Hopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Edelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cellsig.2020.109760_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semnephrol.2013.11.005","article-title":"Polycystic kidney disease: a case of suppressed autophagy?","volume":"34","author":"Ravichandran","year":"2014","journal-title":"Semin. Nephrol."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0015","first-page":"158","article-title":"Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model","volume":"26","author":"Zhu","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00441-017-2628-6","article-title":"Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD)","volume":"369","author":"Peintner","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cellsig.2020.109760_bb0025","doi-asserted-by":"crossref","first-page":"109518","DOI":"10.1016\/j.cellsig.2019.109518","article-title":"Apoptosis and autophagy in polycystic kidney disease (PKD)","volume":"68","author":"Nowak","year":"2020","journal-title":"Cell. Signal."},{"issue":"7182","key":"10.1016\/j.cellsig.2020.109760_bb0030","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0035","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1247\/csf.27.421","article-title":"Autophagosome formation in mammalian cells","volume":"27","author":"Mizushima","year":"2002","journal-title":"Cell Struct. Funct."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/cr.2013.161","article-title":"Autophagy and human diseases","volume":"24","author":"Jiang","year":"2014","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev-biophys-060414-034248","article-title":"Mechanisms of autophagy","volume":"44","author":"Noda","year":"2015","journal-title":"Annu. Rev. Biophys."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109760_bb0050","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4161\/auto.7.12.18025","article-title":"Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex","volume":"7","author":"Ishibashi","year":"2011","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0055","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4161\/auto.22931","article-title":"Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation","volume":"9","author":"Walczak","year":"2013","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ncb0310-207","article-title":"p62, an autophagy hero or culprit?","volume":"12","author":"Rusten","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109760_bb0070","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1172\/JCI122035","article-title":"An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia","volume":"129","author":"Saito","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109760_bb0075","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature08455","article-title":"Discovery of Atg5\/Atg7-independent alternative macroautophagy","volume":"461","author":"Nishida","year":"2009","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.cellsig.2020.109760_bb0080","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.febslet.2015.09.021","article-title":"Autophagy and proteins involved in vesicular trafficking","volume":"589","author":"Amaya","year":"2015","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109760_bb0085","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1462-5822.2012.01792.x","article-title":"The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during group a Streptococcus infection","volume":"14","author":"Nozawa","year":"2012","journal-title":"Cell. Microbiol."},{"issue":"12","key":"10.1016\/j.cellsig.2020.109760_bb0090","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1091\/mbc.e08-01-0080","article-title":"Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG","volume":"19","author":"Itakura","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109760_bb0095","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109760_bb0100","doi-asserted-by":"crossref","first-page":"F1235","DOI":"10.1152\/ajprenal.00348.2010","article-title":"Hypoxia-inducible factor-1alpha (HIF-1alpha) and autophagy in polycystic kidney disease (PKD)","volume":"300","author":"Belibi","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109760_bb0105","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/ki.2010.250","article-title":"Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease","volume":"78","author":"Zafar","year":"2010","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0110","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1073\/pnas.1011498108","article-title":"Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis","volume":"108","author":"Takiar","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"10.1016\/j.cellsig.2020.109760_bb0115","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1021\/acs.jpcb.6b02517","article-title":"The role of Trehalose for the stabilization of proteins","volume":"120","author":"Olsson","year":"2016","journal-title":"J. Phys. Chem. B"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00239-014-9645-9","article-title":"Why Can\u2019t vertebrates synthesize Trehalose?","volume":"79","author":"Arg\u00fcelles","year":"2014","journal-title":"J. Mol. Evol."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109760_bb0125","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1002\/jcp.26583","article-title":"Autophagy induction by trehalose: molecular mechanisms and therapeutic impacts","volume":"233","author":"Hosseinpour-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cellsig.2020.109760_bb0130","series-title":"Carbohydrate Chemistry for Food Scientists","first-page":"49","article-title":"3 - Oligosaccharides","author":"BeMiller","year":"2019"},{"key":"10.1016\/j.cellsig.2020.109760_bb0135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm985","article-title":"Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease","volume":"10","author":"Tanaka","year":"2004","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109760_bb0140","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/bph.14623","article-title":"Trehalose as a promising therapeutic candidate for the treatment of parkinson's disease","volume":"176","author":"Khalifeh","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.cellsig.2020.109760_bb0145","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109760_bb0150","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1007\/s12035-015-9173-7","article-title":"Treatment with Trehalose prevents behavioral and neurochemical deficits produced in an AAV \u03b1-Synuclein rat model of Parkinson\u2019s disease","volume":"53","author":"He","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0160","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biomaterials.2013.10.024","article-title":"Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods","volume":"35","author":"Wei","year":"2014","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.cellsig.2020.109760_bb0165","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI64313","article-title":"Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity","volume":"122","author":"Hopp","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1681\/ASN.2013121312","article-title":"Tolvaptan plus pasireotide shows enhanced efficacy in a PKD1 model","volume":"26","author":"Hopp","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0175","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.kint.2018.06.025","article-title":"CD8(+) T cells modulate autosomal dominant polycystic kidney disease progression","volume":"94","author":"Kleczko","year":"2018","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu11010042","article-title":"Effect of trehalose supplementation on autophagy and cystogenesis in a mouse model of polycystic kidney disease","volume":"11","author":"Chou","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.cellsig.2020.109760_bb0185","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuro.2014.07.006","article-title":"Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model","volume":"44","author":"Sarkar","year":"2014","journal-title":"NeuroToxicology"},{"issue":"11","key":"10.1016\/j.cellsig.2020.109760_bb0190","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1681\/ASN.2010091011","article-title":"IL-33 exacerbates acute kidney injury","volume":"22","author":"Akcay","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0195","doi-asserted-by":"crossref","first-page":"F261","DOI":"10.1152\/ajprenal.00345.2014","article-title":"Effects of hydration in rats and mice with polycystic kidney disease","volume":"308","author":"Hopp","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109760_bb0200","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/cdd.2013.187","article-title":"Regulation of autophagy by the Rab GTPase network","volume":"21","author":"Ao","year":"2014","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0205","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0210","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/EBC20170035","article-title":"Regulation of selective autophagy: the p62\/SQSTM1 paradigm","volume":"61","author":"Lamark","year":"2017","journal-title":"Essays Biochem."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109760_bb0215","doi-asserted-by":"crossref","first-page":"F187","DOI":"10.1152\/ajprenal.00051.2019","article-title":"A study of sirolimus and an mTOR kinase inhibitor (TORKi) in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease (ADPKD)","volume":"317","author":"Holditch","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109760_bb0220","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4161\/auto.19315","article-title":"ATG5, autophagy and lung function in asthma","volume":"8","author":"Poon","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2020.109760_bb0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","article-title":"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1","volume":"39","author":"Hampe","year":"2006","journal-title":"Nat. Genet."},{"issue":"6762","key":"10.1016\/j.cellsig.2020.109760_bb0230","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/45257","article-title":"Induction of autophagy and inhibition of tumorigenesis by beclin 1","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.cellsig.2020.109760_bb0235","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/sj.bjc.6605904","article-title":"Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia","volume":"103","author":"Koukourakis","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2020.109760_bb0240","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/ard.2010.140111","article-title":"Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population","volume":"70","author":"Zhou","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109760_bb0250","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109760_bb0255","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1172\/JCI78945","article-title":"Phosphatidylinositol 3-kinase signaling determines kidney size","volume":"125","author":"Chen","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2020.109760_bb0260","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1038\/ncomms14338","article-title":"mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases","volume":"8","author":"Palmieri","year":"2017","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.cellsig.2020.109760_bb0265","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.18632\/oncotarget.2037","article-title":"GSK-3 as potential target for therapeutic intervention in cancer","volume":"5","author":"McCubrey","year":"2014","journal-title":"Oncotarget"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820302370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820302370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:00:07Z","timestamp":1760266807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656820302370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":51,"alternative-id":["S0898656820302370"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109760","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109760"}}