{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:22:15Z","timestamp":1771676535266,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cellsig.2020.109872","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T19:07:42Z","timestamp":1607195262000},"page":"109872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related peripheral neuropathy"],"prefix":"10.1016","volume":"78","author":[{"given":"Yanyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumou","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellsig.2020.109872_bb0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41408-018-0075-6","article-title":"Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma","volume":"8","author":"Terpos","year":"2018","journal-title":"Blood Cancer J."},{"issue":"21","key":"10.1016\/j.cellsig.2020.109872_bb0010","doi-asserted-by":"crossref","first-page":"30876","DOI":"10.18632\/oncotarget.9021","article-title":"Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109872_bb0015","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/leu.2011.346","article-title":"Management of treatment-emergent peripheral neuropathy in multiple myeloma","volume":"26","author":"Richardson","year":"2012","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0020","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/s41467-019-09555-6","article-title":"Multiple myeloma immunoglobulin lambda translocations portend poor prognosis","volume":"10","author":"Barwick","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109872_bb0025","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1177\/1534735418803758","article-title":"Prevention of Bortezomib-related peripheral neuropathy with docosahexaenoic acid and \u03b1-lipoic acid in patients with multiple myeloma: preliminary data","volume":"17","author":"Maschio","year":"2018","journal-title":"Integr. Cancer Ther."},{"issue":"28","key":"10.1016\/j.cellsig.2020.109872_bb0030","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1200\/JCO.2013.54.5418","article-title":"Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density","volume":"32","author":"Kosturakis","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2020.109872_bb0035","series-title":"Biological Roles and Mechanisms of Circular RNA in Human Cancers. (1178\u20136930 (Print))","author":"Tang","year":"2020"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12929-019-0523-z","article-title":"The emerging roles and functions of circular RNAs and their generation","volume":"26","author":"Yu","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cellsig.2020.109872_bb0045","series-title":"Circular RNA hsa_circ_0006848 Related to Ribosomal Protein L6 Acts as a Novel Biomarker for Early Gastric Cancer. (1875\u20138630 (Electronic))","author":"Lu","year":"2019"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109872_bb0050","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s12253-019-00716-y","article-title":"Hsa_circ_0065149 is an indicator for early gastric cancer screening and prognosis prediction","volume":"26","author":"Shao","year":"2019","journal-title":"Pathol. Oncol. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109872_bb0055","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bbrc.2018.10.026","article-title":"Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661\/MTA1 pathway","volume":"505","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13046-018-0822-3","article-title":"Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis","volume":"37","author":"Li","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2020.109872_bb0065","series-title":"Role of Circular RNA in Hematological Malignancies","author":"Mei","year":"2019"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12885-020-6515-2","article-title":"Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13046-019-1071-9","article-title":"CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p\/MAPK4 pathway","volume":"38","author":"Feng","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0080","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1186\/s12885-019-6088-0","article-title":"Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Cancer"},{"issue":"24","key":"10.1016\/j.cellsig.2020.109872_bb0085","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.7150\/jca.31752","article-title":"Potential therapeutic roles of exosomes in multiple myeloma: a systematic review","volume":"10","author":"Li","year":"2019","journal-title":"J. Cancer"},{"issue":"17","key":"10.1016\/j.cellsig.2020.109872_bb0090","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood-2016-09-742296","article-title":"Prognostic role of circulating exosomal miRNAs in multiple myeloma","volume":"129","author":"Manier","year":"2017","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.cellsig.2020.109872_bb0095","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1089\/omi.2016.0072","article-title":"Deciphering cell-to-cell communication in acquisition of cancer traits: extracellular membrane vesicles are regulators of tissue biomechanics","volume":"20","author":"Pokharel","year":"2016","journal-title":"Omics"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2020.109872_bb0100","article-title":"PO-45 - The role of microvesicles in multiple myeloma progression","volume":"140","author":"Zarfati","year":"2016","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109872_bb0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/path.4712","article-title":"Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression","volume":"239","author":"Wang","year":"2016","journal-title":"J. Pathol."},{"issue":"11","key":"10.1016\/j.cellsig.2020.109872_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-018-0139-7","article-title":"Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts","volume":"8","author":"Faict","year":"2018","journal-title":"Blood Cancer J."},{"issue":"4","key":"10.1016\/j.cellsig.2020.109872_bb0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/hon.2639","article-title":"Serum exosomal microRNAs as novel biomarkers for multiple myeloma","volume":"37","author":"Zhang","year":"2019","journal-title":"Hematol. Oncol."},{"issue":"25","key":"10.1016\/j.cellsig.2020.109872_bb0120","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2014-05-576116","article-title":"Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1","volume":"124","author":"Umezu","year":"2014","journal-title":"Blood"},{"issue":"41","key":"10.1016\/j.cellsig.2020.109872_bb0125","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1038\/s41388-018-0359-0","article-title":"Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis","volume":"37","author":"Li","year":"2018","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.cellsig.2020.109872_bb0130","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1158\/1535-7163.MCT-15-0185","article-title":"Sphingosine Kinase-1 protects multiple myeloma from apoptosis driven by Cancer-specific inhibition of RTKs","volume":"14","author":"Tsukamoto","year":"2015","journal-title":"Mol. Cancer Ther."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109872_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004566","article-title":"Histone methyltransferase MMSET\/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation","volume":"10","author":"Popovic","year":"2014","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109872_bb0140","first-page":"1678","article-title":"The PI3K\/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma","volume":"41","author":"Wang","year":"2019","journal-title":"Oncol. Rep."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109872_bb0145","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3324\/haematol.2012.066175","article-title":"The PI3K\/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma","volume":"98","author":"Chatterjee","year":"2013","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109872_bb0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/jnc.14627","article-title":"Increased \u03b12\u03b4-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain","volume":"148","author":"Chen","year":"2019","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.cellsig.2020.109872_bb0155","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1113\/jphysiol.2012.250522","article-title":"Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain","volume":"591","author":"Yan","year":"2013","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.cellsig.2020.109872_bb0160","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4103\/1673-5374.208596","article-title":"Critical signaling pathways during Wallerian degeneration of peripheral nerve","volume":"12","author":"Cheng","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cellsig.2020.109872_bb0165","article-title":"High glucose-induced PC12 cell death by increasing glutamate production and decreasing methyl group metabolism","volume":"2016","author":"Chen","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cellsig.2020.109872_bb0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2019.04.014","article-title":"Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice","volume":"151","author":"Manjavachi","year":"2019","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.cellsig.2020.109872_bb0175","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.18632\/oncotarget.6658","article-title":"Novel strategies to target the ubiquitin proteasome system in multiple myeloma","volume":"7","author":"Lub","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.cellsig.2020.109872_bb0180","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.yexcr.2014.09.018","article-title":"HIF-1\u03b1 inhibition blocks the cross talk between multiple myeloma plasma cells and tumor microenvironment","volume":"328","author":"Borsi","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cellsig.2020.109872_bb0185","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.blre.2018.11.003","article-title":"The impact of NF-\u03baB signaling on pathogenesis and current treatment strategies in multiple myeloma","volume":"34","author":"Vr\u00e1bel","year":"2019","journal-title":"Blood Rev."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109872_bb0190","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.5187","article-title":"Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes","volume":"247","author":"Frassanito","year":"2019","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.cellsig.2020.109872_bb0195","first-page":"1061","article-title":"Inhibition of multiple myeloma-derived exosomes uptake suppresses the functional response in bone marrow stromal cell","volume":"54","author":"Zheng","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cellsig.2020.109872_bb0200","doi-asserted-by":"crossref","first-page":"6852917","DOI":"10.1155\/2019\/6852917","article-title":"Presence of circulating miR-145, miR-155, and miR-382 in exosomes isolated from serum of breast Cancer patients and healthy donors","volume":"2019","author":"Gonzalez-Villasana","year":"2019","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cellsig.2020.109872_bb0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcell.2018.00018","article-title":"Exosome-based cell-cell communication in the tumor microenvironment","volume":"6","author":"Maia","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2020.109872_bb0210","series-title":"Erratum: LncRNA AFAP1-AS Functions as a Competing Endogenous RNA to Regulate RAP1B Expression by sponging miR-181a in the HSCR: Erratum","author":"Chen","year":"2018"},{"key":"10.1016\/j.cellsig.2020.109872_bb0215","first-page":"12(2)","article-title":"The non-coding RNA landscape of plasma cell dyscrasias","author":"Morelli","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.cellsig.2020.109872_bb0220","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/1878-0261.12629","article-title":"Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer","volume":"14","author":"Wang","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cellsig.2020.109872_bb0225","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2020.01.022","article-title":"Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression","volume":"475","author":"Chen","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2020.109872_bb0230","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.neuropharm.2017.06.027","article-title":"Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord","volume":"123","author":"Xie","year":"2017","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.cellsig.2020.109872_bb0235","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.celrep.2018.04.107","article-title":"NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury","volume":"23","author":"Inquimbert","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2020.109872_bb0240","first-page":"20(21)","article-title":"Differential expression of neuroinflammatory mRNAs in the rat sciatic nerve following chronic constriction injury and pain-relieving nanoemulsion NSAID delivery to infiltrating macrophages","author":"Stevens","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cellsig.2020.109872_bb0245","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3109\/00207454.2013.789873","article-title":"Gene silencing of NR2B-containing NMDA receptor by intrathecal injection of short hairpin RNA reduces formalin-induced nociception in C57BL\/6 mouse","volume":"123","author":"Zhang","year":"2013","journal-title":"Int. J. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2020.109872_bb0250","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1124\/jpet.107.120071","article-title":"Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia","volume":"322","author":"Gabra","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820303491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656820303491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:06:06Z","timestamp":1760267166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656820303491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"alternative-id":["S0898656820303491"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109872","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related peripheral neuropathy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2020.109872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109872"}}