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Chem."},{"issue":"5453","key":"10.1016\/j.cellsig.2020.109880_bb0445","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"issue":"5296","key":"10.1016\/j.cellsig.2020.109880_bb0450","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","article-title":"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways","volume":"275","author":"Ichijo","year":"1997","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.cellsig.2020.109880_bb0455","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/joca.2000.0388","article-title":"Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence","volume":"9","author":"Clancy","year":"2001","journal-title":"Osteoarthr. 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A."},{"issue":"2","key":"10.1016\/j.cellsig.2020.109880_bb0485","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1139\/cjpp-2013-0228","article-title":"C-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis","volume":"92","author":"Ye","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cellsig.2020.109880_bb0490","doi-asserted-by":"crossref","first-page":"1434538","DOI":"10.1155\/2019\/1434538","article-title":"Bax targeted by miR-29a regulates chondrocyte apoptosis in osteoarthritis","volume":"2019","author":"Miao","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.cellsig.2020.109880_bb0495","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3892\/mmr.2014.1981","article-title":"C-Jun transactivates Puma gene expression to promote osteoarthritis","volume":"9","author":"Lu","year":"2014","journal-title":"Mol. Med. 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